The microbiome plays a critical role in the process of conception and the outcomes of pregnancy.Disruptions in microbiome homeostasis in women of reproductive age can lead to various pregnancy complications,which sign...The microbiome plays a critical role in the process of conception and the outcomes of pregnancy.Disruptions in microbiome homeostasis in women of reproductive age can lead to various pregnancy complications,which significantly impact maternal and fetal health.Recent studies have associated the microbiome in the female reproductive tract(FRT)with assisted reproductive technology(ART)outcomes,and restoring microbiome balance has been shown to improve fertility in infertile couples.This review provides an overview of the role of the microbiome in female reproductive health,including its implications for pregnancy outcomes and ARTs.Additionally,recent advances in the use of microbial biomarkers as indicators of pregnancy disorders are summarized.A comprehensive understanding of the characteristics of the microbiome before and during pregnancy and its impact on reproductive health will greatly promote maternal and fetal health.Such knowledge can also contribute to the development of ARTs and microbiome-based interventions.展开更多
基金supported by grants from the National Key R&D Program of China(Grant Nos.2022YFA1303900,2021YFA1301000,and 2022YFC2704702)the National Natural Science Foundation of China(Grant Nos.32001082 and 32025009)the Strategic Priority Research Program of Chinese Academy of Sciences(Grant No.XDB38020300).
文摘The microbiome plays a critical role in the process of conception and the outcomes of pregnancy.Disruptions in microbiome homeostasis in women of reproductive age can lead to various pregnancy complications,which significantly impact maternal and fetal health.Recent studies have associated the microbiome in the female reproductive tract(FRT)with assisted reproductive technology(ART)outcomes,and restoring microbiome balance has been shown to improve fertility in infertile couples.This review provides an overview of the role of the microbiome in female reproductive health,including its implications for pregnancy outcomes and ARTs.Additionally,recent advances in the use of microbial biomarkers as indicators of pregnancy disorders are summarized.A comprehensive understanding of the characteristics of the microbiome before and during pregnancy and its impact on reproductive health will greatly promote maternal and fetal health.Such knowledge can also contribute to the development of ARTs and microbiome-based interventions.
