Effect of Chromium on CCT Diagrams of Novel Air-Cooled Bainite Steels Analyzed by Neural Network

The quantitative effects of chromium content on continuous cooling transformation （CCT） diagrams of novel air-cooled bainite steels were analyzed using artificial neural network models. The results showed that the chromium may retard the high and medium-temperature martensite transformation.

Network analysis and molecular docking of the mechanism of Shengmai decoction in treating patients with severe novel coronavirus pneumonia

Background:Studies have shown that,Shengmai injection(Shengmai decoction)which has been included in the diagnosis and treatment of coronavirus disease 2019(COVID-19),is effective in the early treatment of patients with severe COVID-19.However,the mechanism of its intervention in severe stage of COVID-19 at molecular level is still unclear.Therefore,it is necessary to further explore the mechanism of Shengmai decoction in the treatment of patients with severe COVID-19 based on network pharmacology.Methods:The Traditional Chinese Medicine Systems Pharmacology,BATMAN,UniProt databases and the published literatures which contain the reported compounds that have therapeutic effects on COVID-19 were used to screen out the active ingredients and targets of Shengmai decoction,and the“drug-active compound-target”network was constructed.The GeneCards database was used to screen out the targets of COVID-19.The protein-protein interaction network map was constructed by mapping two genes,and the network of active ingredients,targets and disease was constructed using Cytoscape software.Thereafter,Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses of the key targets were performed using the Metascape Site Maintenance website and David databases.The Gene Ontology function and Kyoto Encyclopedia of Genes and Genomes pathway enrichment of the mapping targets were analyzed.Results:The active component-target network contained 73 main compounds and 457 targets.The first five main active components(hydroquinone,guanosine,ophiopogon C,ophiopogon B,ophiopogon D)were obtained by topological analysis of 33 common targets.Using the Matthews correlation coefficient algorithm,the key targets included albumin,tumor necrosis factor,and cyclic adenosine response element binding.Compounds in Shengmai decoction were found to have good binding effect and strong interaction with caspase-8,caspase-3,apoptosis regulator Bcl-2,tumor necrosis factor,C-C motif chemokine 3,to inhibit the inflammatory response and improve lung injury.Additionally,31 biological processes were obtained by Gene Ontology enrichment,mainly related to lipopolysaccharide response and cytokine-mediated signal pathways,and 71 biological processes were obtained by Kyoto Encyclopedia of Genes and Genomes enrichment,mainly related to pulmonary tuberculosis,hepatitis B,and mitogen-activated protein kinase signal pathways.Conclusion:Shengmai decoction has multicomponent,multitarget and multichannel characteristics,which can provide an important theoretical basis to treat patients with severe COVID-19.

Quantitative analysis of Ni effect on CCT diagrams of novel air-cooled bainite steels using artificial neural network models

The quantitative effect of Ni content on continuous cooling transformation （CCT） diagrams of novel air-cooled bainite steels was analyzed using artificial neural network models. The results showed that Ni may retard the high- and medium-temperature transformation and martensite transformation. The results conform to the materials science theories.

A network pharmacology approach to explore the mechanism of action of Yiqi Fumai lyophilized injection in the treatment of novel coronavirus disease

Background:Shengmai decoction,which has been included in the diagnosis and treatment of coronavirus disease 2019(COVID-19),is effective in the early treatment of patients with severe COVID-19.Yiqi Fumai lyophilized injection(YQFM)is a modern Chinese medicine preparation of the Shengmai decoction.The mechanism of its intervention at the molecular level in the severe stage of COVID-19 remains unclear.Therefore,it is necessary to investigate the mechanism of YQFM in the treatment of patients with severe COVID-19.Methods:The corresponding target genes of the main active ingredients in YQFM and COVID-19 were obtained by using multiple databases and literature retrieval.A protein-protein interaction network was constructed,and enrichment analysis of the target was performed using Cytoscape 3.8.1.Lastly,the docking of all the identified compounds with angiotensin-converting enzyme II was confirmed by applying molecular docking technology.Results:YQFM has anti-inflammatory effects on RAW267.4 macrophages.The main active compounds of YQFM are all effective anti-inflammatory agents,and these active compounds also show beneficial physiological functions,such as anti-oxidation,anti-bacterial,and anticancer activities.Gene Ontology analysis showed enrichment in the following pathways:lipopolysaccharides,interleukins,NF-kappa B,interleukin-2 and others,revealing that YQFM may play a role in the treatment of patients with severe COVID-19 through these pathways.Conclusion:YQFM has multicomponent and multitarget characteristics,and it could reduce lung injury by inhibiting inflammatory reactions,promoting antiviral activities,and regulating immunity,among other functions,to treat patients with severe COVID-19.

Considerations on Novel Network Routing Mechanism

Routing is the cornerstone of network architecture, and a new routing mechanism is a requisite for constructing new network architecture. The current routing mechanism of the Internet layer is basically the single next-hop routing mechanism, which is the root of transmission congestion in the network. To solve this congestion problem, a fundamental measure is to change the route selection mode of current routing mechanism to allow parallel transmission over multiple routes. Currently, Border Gateway Protocol (BGP) is the only inter-domain routing protocol used in the Internet, but the routing system using BGP suffers scalability problem. To solve the scalability issue of the current inter-domain routing system, a new hierarchical routing system, i.e. Scalable Inter-Domain Routing Architecture (s-idra), is suggested. In addition to scalability, the current routing system is facing other challenges including security, Quality of Service (QoS), multicasting, mobility and dynamic network topology. Therefore, the research on routing protocols, especially the protocol for the new network architecture, is still a tough task and has a long way to go.

Novel Minimum Passive Element Realization of All-Pass Network Using A Modified Current Conveyor

1. IntroductionA large number of networks for realizing first and second order transfer functions using a currentconveyor have been reported in the literature. Especially, the networks that can offer highinput impedance attract attention, for high input impedance has the advantage that the networksmay be used in cascade without requiring impedance matching device. In the Higashimura and

NOVELL网络常见错误的检测与排除

论述用Ｃ语言编程实现的ＮＯＶＥＬＬ网络常见错误数据库的设计，及其常见错误检测与排除系统的主程序编程技术，并提供常见错误信息的利用与故障排除实例．

NOVELL网融入因特网的应用实例

随着Internet网络技术的发展和企业内部基础网络设施的改善，许多原有运行在Novell局域网上基于DOS和数据库的信息管理系统，迫切需要能融入TCP／IP互联网络，以实现全局范围内的数据共享，并能保留原有系统功能和保护已有投资利益．本文介绍了一种解决此类问题的网络互联方案．实际的联网结果表明。

Novell网的安全策略研究

介绍了利用 Netware操作系统自身的功能来检查 Novell的安全漏洞 ,讨论了网络病毒的防范措施对超级用户的管理和利用超级用户进行网络的安全管理等维护措施。

Novell局域网入网登录界面及其管理程序的设计

针对 Novell局域网入网调用应用程序的步骤较复杂 ,Netware提供设计的菜单界面为西文 ,安全性不甚高的情况 ,设计了“登录程序”及“登录管理系统”两个软件。该软件具有入网登录方便。

Novell 网络环境下多用户数据库访问冲突的解决方法

使用登记文件来记录Ｎｏｖｅｌ网络文件服务器上共享数据库的使用情况，解决多用户数据库的访问冲突问题．以Ｎｏｖｅｌ网络ＦｏｘＰｒｏｆｏｒＤｏｓ为例，详细说明了这种方法的实现技术．

解除NOVELL网络超级用户口令的方案

给出了NOVELL网络中超级用户口令遗失的五种应急方案和策略。这五种方案可以重置超级用户口令 ,而且完全不破坏原来的网络系统和数据资源 ,具有很强的实用性。

NOVELL网络无盘工作站自动注册入网的几种方法

本文介绍了 Ｎｏｖｅｌｌ网络无盘站自动注册入岗的两种方法.

Novell Netware和WindowsNT互连技术

在对网络协议软件的接口技术和网络体系结构分析的基础上，阐述了Netware和WindowsNT互连的可能性，并以Netware和WindowsNT互连的实现方法为例，说明异种网络操作系统互连的实现具有广泛的实用价值。

Novell局域网的建立、软件安装和设置

以Novell公司的NetWare，4．11版软件为例，从服务器和工作站硬件的基本要求、网络拓扑、服务器软件安装的准备工作、安装Ntware服务器软件、退出服务器控制台、工作站软件的安装、用户权限的设置等几个方面，简要介绍Novell网络系统的建立、软件安装、权限设置等操作过程，以期对检验人员认识医学检验信息管理系统软件的网络运行平台有所帮助。

Novell网教学环境的优化

结合网络教学中遇到的实际问题 ,提出了相应的解决办法 .介绍了Novell网教学环境的规划 ,分析了如何将规划中的一些要素以最优的方式组合起来 ,建立一个易操作又安全的教学网络 .

Novell网络在医学计算机教学上的应用

本文介绍了 Novell网络的概况 ,以及 Novell教学网的功能设计、运行机制及性能特点。

Novell网络系统安全性分析

对Novell网络系统的安全性作广泛深入地分析,提出应用系统中增强Novell网安全性的几种重要方法。

基于Novell网络的FTP服务器

本文以 Hell Soft公司的产品 FTPD模块为例 ,介绍在 Novell网络上建立 FTP服务器的方法和步骤 ,进而详细介绍其配置文件设置方法及其各参数含义。

Novell网络环境下SYBASE数据库远程访问解决方案

论述了在Ｎｏｖｅｌｌ远程组网环境下，使用ＳＹＢＡＳＥ数据库实现远程访问的解决方案，这种方案已在实际系统中得到了证实。