Mutations in mitochondrial DNA(mtDNA)are maternally inherited and have the potential to cause severe disorders.Mitochondrial replacement therapies,including spindle,polar body,and pronuclear transfers,are promising st...Mutations in mitochondrial DNA(mtDNA)are maternally inherited and have the potential to cause severe disorders.Mitochondrial replacement therapies,including spindle,polar body,and pronuclear transfers,are promising strategies for preventing the hereditary transmission of mtDNA diseases.While pronuclear transfer has been used to generate mitochondrial replacement mouse models and human embryos,its application in non-human primates has not been previously reported.In this study,we successfully generated four healthy cynomolgus monkeys(Macaca fascicularis)via female pronuclear transfer.These individuals all survived for more than two years and exhibited minimal mtDNA carryover(3.8%–6.7%),as well as relatively stable mtDNA heteroplasmy dynamics during development.The successful establishment of this nonhuman primate model highlights the considerable potential of pronuclear transfer in reducing the risk of inherited mtDNA diseases and provides a valuable preclinical research model for advancing mitochondrial replacement therapies in humans.展开更多
The tragic features of V.S.Naipaul’s short story collection Miguel Street are more typical in the female characters.This paper attempts to analyze the typical female tragic characters in the book.Starting from their ...The tragic features of V.S.Naipaul’s short story collection Miguel Street are more typical in the female characters.This paper attempts to analyze the typical female tragic characters in the book.Starting from their stories and experiences,it deeply explores the survival pressure and challenges faced by females on the post-colonial land under the influence of colonial rule.Through in-depth analysis of typical female tragedies,the author tries to provide more possibilities for the survival of post-colonial females,and further illustrates that the tragedy of post-colonial females is caused by marginal males and imperial colonial hegemony in Miguel Street.展开更多
Mature wild-type yellow catfish( Pelteobagrus fulvidraco Richardson) individuals with excellent traits have been screened from the Yangtze River as broodstock to establish the germplasm bank of pure-line yellow catfis...Mature wild-type yellow catfish( Pelteobagrus fulvidraco Richardson) individuals with excellent traits have been screened from the Yangtze River as broodstock to establish the germplasm bank of pure-line yellow catfish by artificial gynogenesis technique and hormonal sex reversal method. Based on pure lines of yellow catfish,super-males and physiological females of yellow catfish were selected by GMT technique,hormonal sex reversal method and test-crossing to establish the germplasm bank of YY physiological females( YY♀). The propagation system of male yellow catfish( XY♂) was established based on the combination of super-males( YY♂) and pure-line female( XX♀) for large-scale production of pure-line yellow catfish males,which effectively overcome the disadvantages in the production of common fingerlings and male fingerlings using low-grade fish with slow growth and small size at the bottom of the fish grader as broodfish,such as progeny germplasm degeneration,loss of growth vigor and reduction of breeding benefits. The technical route of breeding pure-line YY physiological females( YY♀) and YY super-males( YY♂) laid the foundation for large-scale production of environmentally friendly yellow catfish males with pure germplasm and strong stress resistance,and provided an efficient,stable,healthy,environmentally friendly,energy-saving and income-increasing approach for sustainable development of yellow catfish breeding industry.展开更多
The study investigated business clothing for females that are suitable for effective workplace job performance in Nigeria.It identified fabric characteristics of females’business clothing already used;fabric characte...The study investigated business clothing for females that are suitable for effective workplace job performance in Nigeria.It identified fabric characteristics of females’business clothing already used;fabric characteristics needed and deign style preference suitable for females’business clothing for workplace job performance.The study was guided by four research questions and two hypotheses.Population was 4,806 female civil servants in Delta state,Nigeria.Multi-stage sampling technique was utilized to select 136 females.Structured questionnaire was employed to collect data and descriptive statistics and t-test were used for data analysis.Finding showed that cotton,nylon,lacra fabrics,light and medium fabric weight,blue,black,gray,colors,cool texture,rough,smooth surface plain,stripe and flowered design among others were fabric characteristics of business clothing are being used in workplace.But prefer and need cotton,nylon,lacra,light weight,black,blue,gray,brown colours,cool,plain,surface fabrics.Net,organza,heavy weight,white,yellow,toweling fabrics were not preferred.Findings further showed that straight gown,waist flared and gathered gowns,skirt,blouse and suit/jacket,straight,shirt,long sleeves,garment with or without collar,below knee length,peter and convertible collars,among others were highly preferred design styles of clothes.In conclusion,office workers determine what they wear to perform workplace daily jobs promotes self-confidence,comfort,professional worth and productivity.It was recommended that female employees should not downplay appropriate work attires for comfort and organizational productivity to satisfy fashion trends.展开更多
The gut microbiota is recognized as an endocrine organ with the capacity to influence distant organs and associated biological pathways.Recent advan-cements underscore the critical role of gut microbial homeostasis in...The gut microbiota is recognized as an endocrine organ with the capacity to influence distant organs and associated biological pathways.Recent advan-cements underscore the critical role of gut microbial homeostasis in female health;with dysbiosis potentially leading to diseases among women such as polycystic ovarian syndrome,endometriosis,breast cancer,cervical cancer,and ovarian cancer etc.Despite this,there has been limited discussion on the underlying mechanisms.This editorial explores the three potential mechanisms through which gut microbiota dysbiosis may impact the development of diseases among women,namely,the immune system,the gut microbiota-estrogen axis,and the metabolite pathway.We focused on approaches for treating diseases in women by addressing gut microbiota imbalances through probiotics,prebiotics supple-mentation,and fecal microbiota transplantation(FMT).Future studies should focus on determining the molecular mechanisms underlying associations between dysbiosis of gut microbiota and female diseases to realize precision medicine,with FMT emerging as a promising intervention.展开更多
Background:Hepatitis B virus(HBV)infection is prevalent in sub-Saharan Africa,including Nigeria,and is frequently observed in individuals co-infected with human immunodeficiency virus(HIV).Objective:This study aims to...Background:Hepatitis B virus(HBV)infection is prevalent in sub-Saharan Africa,including Nigeria,and is frequently observed in individuals co-infected with human immunodeficiency virus(HIV).Objective:This study aims to evaluate the prevalence of serological markers for hepatitis B virus and identify the associated risk factors among women with HIV undergoing highly active antiretroviral therapy(HAART)in Ogun State,Nigeria.Methods:Ethical approval was obtained from the Babcock University Health Research Ethics Committee(BUHREC)to recruit a total of 110 adult women infected with HIV,receiving treatment at the HIV clinics of Babcock University Teaching Hospital(BUTH)in Ilishan-Remo and General Hospital in Ijebu-Ode,both located in Ogun State,Nigeria.The participants’HIV status were confirmed using three rapid diagnostic kits:Determine(Abbott Laboratories,Tokyo,Japan),Unigold HIV(Trinity Biotech Plc Bray,Co.Wicklow,Ireland),and 1/2 Stat Pak(Abbott Laboratories,Tokyo,Japan)(Chembio Diagnostic Systems,New York,USA).Additionally,an HBV 5 in 1 Panel manufactured by Innovation Biotechnology Co.,Ltd in Beijing,China,was employed to detect HBV markers qualitatively in serum samples.Results:Out of the 110 subjects that voluntarily participated in the study,4(3.6%)tested positive for HBsAg,2(1.8%)tested positive for HBsAb,81(73.6%)tested positive for HBeAg,3(2.7%)tested positive for HBeAb,and 65(59.1%)tested positive for HBcAb.There was no significant correlation between the occurrence of HBsAg and the socio-demographic characteristics of the participants(P>0.05).Various risk factors were identified,including lack of knowledge about HBV,absence of HBV vaccination history,history of blood transfusion,organ transplant,and engaging in unprotected sex,among others.Conclusion:The findings highlight the presence of HBV infection among HIV-positive women undergoing HAART in Ogun State,Nigeria,particularly within the age groups of 18–25 years and 26–30 years.These results emphasize the necessity for continuous and targeted public health interventions among this specific population.展开更多
BACKGROUND Women have a 3%lifetime chance of developing an inguinal hernia,which is not as common in men.Due to its cosmetic benefits,single-incision laparoscopic transabdominal preperitoneal(SIL-TAPP)inguinal hernia ...BACKGROUND Women have a 3%lifetime chance of developing an inguinal hernia,which is not as common in men.Due to its cosmetic benefits,single-incision laparoscopic transabdominal preperitoneal(SIL-TAPP)inguinal hernia repair is becoming in-creasingly popular in the management of inguinal hernia in women.However,there are no studies comparing the safety and applicability of SIL-TAPP repair with conventional laparoscopic transabdominal preperitoneal(CL-TAPP)inguinal hernia repair for the treatment of inguinal hernia in women.AIM To compare the outcomes of SIL-TAPP and CL-TAPP repair in adult female patients with inguinal hernia and to estimate the safety and applicability of SIL-TAPP repair in adult female inguinal hernia patients.METHODS We retrospectively compared the clinical information and follow-up data of fe-male inguinal hernia patients who underwent SIL-TAPP inguinal hernia repair and those who underwent CL-TAPP inguinal hernia repair at the Affiliated Hos-pital of Nantong University from February 2018 to December 2020 and assessed the long-term and short-term outcomes of both cohorts.RESULTS This study included 123 patients,with 71 undergoing SIL-TAPP repair and 52 un-dergoing CL-TAPP repair.The two cohorts of patients and inguinal hernia charac-teristics were similar,with no statistically meaningful difference.The rate of intraoperative inferior epigastric vessel injury was lower in patients in the SIL-TAPP cohort(0,0%)than in patients in the CL-TAPP cohort(4,7.7%)and was significantly different(P<0.05).In addition,the median[interquartile range(IQR)]total hospitalization costs were significantly lower in patients in the SIL-TAPP cohort[$3287(3218-3325)]than in patients in the CL-TAPP cohort[$3511(3491-3599)].Postoperatively,the occurrence rate of trocar site hernia was lower in the SIL-TAPP cohort(0,0%)than in the CL-TAPP cohort(4,7.7%),and the median(IQR)cosmetic score was significantly higher in the SIL-TAPP cohort[10(10-10)]than in the CL-TAPP cohort[9(9-10)].CONCLUSION SIL-TAPP repair did not increase the incidence of intraoperative and postoperative complications in female in-guinal hernia patients.Moreover,female inguinal hernia patients who underwent SIL-TAPP repair had a lower probability of trocar site hernia and inferior epigastric vessel injury than female inguinal hernia patients who un-derwent CL-TAPP repair.In addition,female inguinal hernia patients who underwent SIL-TAPP repair reported a more aesthetically pleasing postoperative abdominal incision.Therefore,SIL-TAPP repair is a better option for the treatment of inguinal hernias in women.展开更多
This essay offers a comprehensive comparative analysis of female warriors in the Marvel Cinematic Universe(MCU)and Wuxia films.Both genres portray powerful and empowered female characters who defy societal expectation...This essay offers a comprehensive comparative analysis of female warriors in the Marvel Cinematic Universe(MCU)and Wuxia films.Both genres portray powerful and empowered female characters who defy societal expectations and embody resilience,effectively challenging gender norms and promoting female empowerment.However,despite their strength,many of these women warriors face certain narrative factors,such as the male gaze and a predetermined fate,which can restrict their agency and curtail their full potential.And it is within the realm of Wuxia films that the captivating element of cross-dressing among female warriors emerges,providing a nuanced exploration of identity and the constraints imposed by society.展开更多
Nowadays,the pace of work and life is accelerating rapidly,accompanied by significant changes in work content and family structure.Enterprises and employees are encountering various pressures and conflicts.Female empl...Nowadays,the pace of work and life is accelerating rapidly,accompanied by significant changes in work content and family structure.Enterprises and employees are encountering various pressures and conflicts.Female employees,in particular,are experiencing increasing pressure in both social labor and family affairs,resulting in ongoing conflicts between work and life.Achieving a balance between these two domains is crucial for female employees.This article aims to analyze the influencing factors of work-life balance for female employees and to propose useful strategies to help them improve it.展开更多
This study investigates the effects of technical cheerleading and dance cheerleading on the psychological health of female college students by utilizing the Symptom Checklist-90(SCL-90),the Comprehensive Diagnostic Sc...This study investigates the effects of technical cheerleading and dance cheerleading on the psychological health of female college students by utilizing the Symptom Checklist-90(SCL-90),the Comprehensive Diagnostic Scale for Interpersonal Relationships,and the Social Adaptability Diagnostic Scale.The findings indicate the following:(1)Technical cheerleading has a highly significant impact on sensitivity in interpersonal relationships,paranoia,and psychoticism,and a significant effect on anxiety and hostility;dance cheerleading has a highly significant effect on paranoia;(2)Both technical and dance cheerleading have minimal impact on the overall score distribution of interpersonal relationships among female college students,but the dimensions of their effects differ;(3)The impact of technical cheerleading on the social adaptability of female college students is more pronounced than that of dance cheerleading.展开更多
The goal of this study was to gain a fundamental understanding of RnRH 1 and 3, as well as FSH and LH action, in ovarian follicles during oocyte growth by examining changes in ovarian gene transcription in blue gouram...The goal of this study was to gain a fundamental understanding of RnRH 1 and 3, as well as FSH and LH action, in ovarian follicles during oocyte growth by examining changes in ovarian gene transcription in blue gourami females (Trichogaster trichopterus). The levels of target ovarian mRNAs were determined by quantitative real-time PCR. GnRH1 mRNA levels were higher in oocytes at the previtellogenic stage compared to the vitellogenic and follicular oocytes maturation (FOM) stages. No significant differences in GnRH3 mRNA levels were detected among oocytes during the different stages of development. βLH and βFSH mRNA levels were lower in oocytes at the vitellogenic stage compared to the previtellogenic stage. The high transcription of GnRH 1 and 3 in the brain and of FSH and LH in the pituitary of blue gourami as was found in previous studies in our laboratory, compared to mRNA levels changed in ovary during oogenesis, supporting the hypothesis that differences exist between the function of endocrine and autocrine/paracrine of these hormones.展开更多
This study is examined the effect of past and present lifestyle habits and nutrition on the os-teo-sono assessment index (OSI) in pre- and post-menopausal females. The subjects were 200 premenopausal females (38.8...This study is examined the effect of past and present lifestyle habits and nutrition on the os-teo-sono assessment index (OSI) in pre- and post-menopausal females. The subjects were 200 premenopausal females (38.8±10.3years) and 156 postmenopausal females (59.2±5.9 ye- ars). BMD (Body mineral density) was estimated by right-calcaneal OSI using an ultrasonic transmission method with an AOS-100 device (ALOKA). The number of postmenopau- sal fe-males in the close examination and guidance required groups (80 cases: 51.3 %) (OSI < 2.428) was significantly higher than that of premeno-pausal females (44 cases: 22.0 %) (χ2=33.105: P<0.000). In premenopausal females, the proportion of subjects that had not taken vitamin D in the past (in junior high school and high school) was significantly higher in the close examination- guidance required group (OSI < 2.428) than in the normal group (OSI ≧ 2.428). However, in postmenopausal females, there was no signifi-cant difference in past and present lifestyle habits and nutrition between the close exami-nation-guidance required group and the normal group. In premenopausal females, it was deter-mined that the intake of vitamin D during pu-berty increased the absorption of calcium sig-nificantly.展开更多
Background: Breast diseases cover several conditions. The majority of breast diseases are noncancerous. Some of these lesions are clinically unremarkable, which needed minimal intervention. However, some symptoms may ...Background: Breast diseases cover several conditions. The majority of breast diseases are noncancerous. Some of these lesions are clinically unremarkable, which needed minimal intervention. However, some symptoms may be of clinical value and attract the attention of both the patient and the attending physician, especially when they become persistent. The study aimed to assess the prevalence, pattern, types, and clinical profile of breast diseases among females in the South-western region, during the period from 2018-2020. Methods: A retrospective record-based descriptive approach was used through reviewing medical records of all cases with breast disease attended King Khalid Hospital during the period from January 2018 to January 2020. Data extracted throng pre-structured questionnaire. Results: The study included 211 cases whose ages ranged from 18 to 58 years old with a mean age of 28.9 ± 12.8 years. Breast mass was the most recorded complaint (95.1%) followed with breast pain (32%), skin changes. Benign findings based on the final pathology report were recorded for more than two thirds of the cases, with the most common finding were fibroadenoma. Excisional biopsy and modified radical mastectomy were the most reported surgical interventions. Conclusions: In conclusion, the study revealed that the majority of the cases had benign breast disease (BBD), where fibroadenoma was the most frequent.展开更多
Introduction: Breast cancer is the most common cancer in the Iranian female population, and the incidence of the disease is rising. Early detection in association with staging or grading the tumor is the most effectiv...Introduction: Breast cancer is the most common cancer in the Iranian female population, and the incidence of the disease is rising. Early detection in association with staging or grading the tumor is the most effective method to increase survival rates. Studies have revealed that cortactin overexpression may play a role in the final stages of tumor progression and affects invasion and cellular motility. The aim of this study is to evaluate cortactin gene expression among Iranian female patients with breast cancer. Materials and Methods: Samples belonging to 70 breast cancer patients were randomly selected from the Imam Khomeini tumor bank. Normal and tumor tissues were prepared and stored at -80°C. Cortactin gene expression was evaluated by real-time PCR. Finally the data, along with demographic and clinical parameters, were analyzed using Prism 5.0 software, followed by t-test and ANOVA analysis. Results: Cortactin gene expression among tumor tissues increased 95.71% in comparison with normal tissues. A significant correlation between cortactin gene expression and lymph nodes’ involvement (P = 0.0077) and tumor stage (P = 0.0030) was observed. However, tumor grade (P = 0.8598), tumor size (P = 0.3058), and patient’s age (P = 0.4135) had no significant correlation with the gene’s expression level. Discussion: This study demonstrated that the cortactin gene’s overexpression in breast cancer may enhance lymph nodes’ involvement. This study also found that the gene’s expression was raised significantly in progressed stages of the cancer. Therefore, cortactin gene overexpression is an important factor indicating breast cells’ invasion. Conclusion: The cortactin gene’s expression level can be considered an accurate indicator for female breast cancer and also an appropriate biomarker for this cancer in clinical evaluations.展开更多
Nowadays the modern females get out of home, fighting with males to display their wonderful life and demonstrate the wonderful characters, so we will ask the question what qualities do the modern females belong? By an...Nowadays the modern females get out of home, fighting with males to display their wonderful life and demonstrate the wonderful characters, so we will ask the question what qualities do the modern females belong? By analyzing the novel Jane Eyre, it is easy to see the qualities of heroine such as independence, desiring of knowledge, exploring true love and emphasizing on spirit world and so on. This paper explains that it is important for modern females to build up their excellent qualities in order to deal with a lot of barriers in their future way.展开更多
The effect of temperature on the life history characteristics of amictic females (AF), unfertilized mictic females (UMF) and fertilized mictic females (FMF) in Brachionus calyciflorus was studied with replicated indiv...The effect of temperature on the life history characteristics of amictic females (AF), unfertilized mictic females (UMF) and fertilized mictic females (FMF) in Brachionus calyciflorus was studied with replicated individual cultures at 20℃,25℃ and 30℃, and with algae Scenedesmus obliquus for their food. There were highly significant effects of both temperature and female type, independently and interactively, on the duration of juvenile and post-reproduction periods, and the number of eggs produced by the rotifer per life cycle. Among all the temperature-female type combinations, all the juvenile periods of FMF, and the post-reproduction periods of UMF and FMF at 20℃, were the longest, and the number of eggs produced by an UMF at 30℃ was the highest. There were highly significant effects of both temperature and female type on the duration of the reproduction period, but no clear correlation was observed between temperature and female type. The reproduction period of AF was longer than that of UMF and FMF. Only temperature influenced significantly the mean life-span of the three types of females. The duration of juvenile, reproduction and post-reproduction periods as well as the life-span of the three types of females were all reduced very significantly with rise of temperature, but the rates of reduction varied with female type. Among the three types of females, the number of eggs produced per life cycle by an UMF was the highest, and that of a FMF was the lowest. A significant relationship between the number of eggs produced per life cycle and temperature was observed only in the UMF.展开更多
基金supported by the National Natural Science Foundation of China (82021001,31825018)National Key Research and Development Program of China (2022YFF0710901)+3 种基金Shanghai Municipal Science and Technology Major Project (2018SHZDZX05)Strategic Priority Research Program of the Chinese Academy of Sciences (XDB32060100)Biological Resources Program of Chinese Academy of Sciences (KFJ-BRP-005)National Science and Technology Innovation 2030 Major Program 2021ZD0200900。
文摘Mutations in mitochondrial DNA(mtDNA)are maternally inherited and have the potential to cause severe disorders.Mitochondrial replacement therapies,including spindle,polar body,and pronuclear transfers,are promising strategies for preventing the hereditary transmission of mtDNA diseases.While pronuclear transfer has been used to generate mitochondrial replacement mouse models and human embryos,its application in non-human primates has not been previously reported.In this study,we successfully generated four healthy cynomolgus monkeys(Macaca fascicularis)via female pronuclear transfer.These individuals all survived for more than two years and exhibited minimal mtDNA carryover(3.8%–6.7%),as well as relatively stable mtDNA heteroplasmy dynamics during development.The successful establishment of this nonhuman primate model highlights the considerable potential of pronuclear transfer in reducing the risk of inherited mtDNA diseases and provides a valuable preclinical research model for advancing mitochondrial replacement therapies in humans.
文摘The tragic features of V.S.Naipaul’s short story collection Miguel Street are more typical in the female characters.This paper attempts to analyze the typical female tragic characters in the book.Starting from their stories and experiences,it deeply explores the survival pressure and challenges faced by females on the post-colonial land under the influence of colonial rule.Through in-depth analysis of typical female tragedies,the author tries to provide more possibilities for the survival of post-colonial females,and further illustrates that the tragedy of post-colonial females is caused by marginal males and imperial colonial hegemony in Miguel Street.
基金Supported by Implementation Plan of Subsidy Project for the Reform and Construction of Grassroots Agricultural Technology Extension System
文摘Mature wild-type yellow catfish( Pelteobagrus fulvidraco Richardson) individuals with excellent traits have been screened from the Yangtze River as broodstock to establish the germplasm bank of pure-line yellow catfish by artificial gynogenesis technique and hormonal sex reversal method. Based on pure lines of yellow catfish,super-males and physiological females of yellow catfish were selected by GMT technique,hormonal sex reversal method and test-crossing to establish the germplasm bank of YY physiological females( YY♀). The propagation system of male yellow catfish( XY♂) was established based on the combination of super-males( YY♂) and pure-line female( XX♀) for large-scale production of pure-line yellow catfish males,which effectively overcome the disadvantages in the production of common fingerlings and male fingerlings using low-grade fish with slow growth and small size at the bottom of the fish grader as broodfish,such as progeny germplasm degeneration,loss of growth vigor and reduction of breeding benefits. The technical route of breeding pure-line YY physiological females( YY♀) and YY super-males( YY♂) laid the foundation for large-scale production of environmentally friendly yellow catfish males with pure germplasm and strong stress resistance,and provided an efficient,stable,healthy,environmentally friendly,energy-saving and income-increasing approach for sustainable development of yellow catfish breeding industry.
文摘The study investigated business clothing for females that are suitable for effective workplace job performance in Nigeria.It identified fabric characteristics of females’business clothing already used;fabric characteristics needed and deign style preference suitable for females’business clothing for workplace job performance.The study was guided by four research questions and two hypotheses.Population was 4,806 female civil servants in Delta state,Nigeria.Multi-stage sampling technique was utilized to select 136 females.Structured questionnaire was employed to collect data and descriptive statistics and t-test were used for data analysis.Finding showed that cotton,nylon,lacra fabrics,light and medium fabric weight,blue,black,gray,colors,cool texture,rough,smooth surface plain,stripe and flowered design among others were fabric characteristics of business clothing are being used in workplace.But prefer and need cotton,nylon,lacra,light weight,black,blue,gray,brown colours,cool,plain,surface fabrics.Net,organza,heavy weight,white,yellow,toweling fabrics were not preferred.Findings further showed that straight gown,waist flared and gathered gowns,skirt,blouse and suit/jacket,straight,shirt,long sleeves,garment with or without collar,below knee length,peter and convertible collars,among others were highly preferred design styles of clothes.In conclusion,office workers determine what they wear to perform workplace daily jobs promotes self-confidence,comfort,professional worth and productivity.It was recommended that female employees should not downplay appropriate work attires for comfort and organizational productivity to satisfy fashion trends.
基金Supported by Science and Technology Plan of Liaoning Province,No.2022JH2/101500063.
文摘The gut microbiota is recognized as an endocrine organ with the capacity to influence distant organs and associated biological pathways.Recent advan-cements underscore the critical role of gut microbial homeostasis in female health;with dysbiosis potentially leading to diseases among women such as polycystic ovarian syndrome,endometriosis,breast cancer,cervical cancer,and ovarian cancer etc.Despite this,there has been limited discussion on the underlying mechanisms.This editorial explores the three potential mechanisms through which gut microbiota dysbiosis may impact the development of diseases among women,namely,the immune system,the gut microbiota-estrogen axis,and the metabolite pathway.We focused on approaches for treating diseases in women by addressing gut microbiota imbalances through probiotics,prebiotics supple-mentation,and fecal microbiota transplantation(FMT).Future studies should focus on determining the molecular mechanisms underlying associations between dysbiosis of gut microbiota and female diseases to realize precision medicine,with FMT emerging as a promising intervention.
文摘Background:Hepatitis B virus(HBV)infection is prevalent in sub-Saharan Africa,including Nigeria,and is frequently observed in individuals co-infected with human immunodeficiency virus(HIV).Objective:This study aims to evaluate the prevalence of serological markers for hepatitis B virus and identify the associated risk factors among women with HIV undergoing highly active antiretroviral therapy(HAART)in Ogun State,Nigeria.Methods:Ethical approval was obtained from the Babcock University Health Research Ethics Committee(BUHREC)to recruit a total of 110 adult women infected with HIV,receiving treatment at the HIV clinics of Babcock University Teaching Hospital(BUTH)in Ilishan-Remo and General Hospital in Ijebu-Ode,both located in Ogun State,Nigeria.The participants’HIV status were confirmed using three rapid diagnostic kits:Determine(Abbott Laboratories,Tokyo,Japan),Unigold HIV(Trinity Biotech Plc Bray,Co.Wicklow,Ireland),and 1/2 Stat Pak(Abbott Laboratories,Tokyo,Japan)(Chembio Diagnostic Systems,New York,USA).Additionally,an HBV 5 in 1 Panel manufactured by Innovation Biotechnology Co.,Ltd in Beijing,China,was employed to detect HBV markers qualitatively in serum samples.Results:Out of the 110 subjects that voluntarily participated in the study,4(3.6%)tested positive for HBsAg,2(1.8%)tested positive for HBsAb,81(73.6%)tested positive for HBeAg,3(2.7%)tested positive for HBeAb,and 65(59.1%)tested positive for HBcAb.There was no significant correlation between the occurrence of HBsAg and the socio-demographic characteristics of the participants(P>0.05).Various risk factors were identified,including lack of knowledge about HBV,absence of HBV vaccination history,history of blood transfusion,organ transplant,and engaging in unprotected sex,among others.Conclusion:The findings highlight the presence of HBV infection among HIV-positive women undergoing HAART in Ogun State,Nigeria,particularly within the age groups of 18–25 years and 26–30 years.These results emphasize the necessity for continuous and targeted public health interventions among this specific population.
基金Supported by Wu Jieping Medical Foundation,No.320.6750.18396Nantong“14th Five-Year”Science and Education to Strengthen Health Project,General Surgery Medical Key Discipline,No.42and Nantong Municipal Commission of Health and Family Planning,No.MS2022005.
文摘BACKGROUND Women have a 3%lifetime chance of developing an inguinal hernia,which is not as common in men.Due to its cosmetic benefits,single-incision laparoscopic transabdominal preperitoneal(SIL-TAPP)inguinal hernia repair is becoming in-creasingly popular in the management of inguinal hernia in women.However,there are no studies comparing the safety and applicability of SIL-TAPP repair with conventional laparoscopic transabdominal preperitoneal(CL-TAPP)inguinal hernia repair for the treatment of inguinal hernia in women.AIM To compare the outcomes of SIL-TAPP and CL-TAPP repair in adult female patients with inguinal hernia and to estimate the safety and applicability of SIL-TAPP repair in adult female inguinal hernia patients.METHODS We retrospectively compared the clinical information and follow-up data of fe-male inguinal hernia patients who underwent SIL-TAPP inguinal hernia repair and those who underwent CL-TAPP inguinal hernia repair at the Affiliated Hos-pital of Nantong University from February 2018 to December 2020 and assessed the long-term and short-term outcomes of both cohorts.RESULTS This study included 123 patients,with 71 undergoing SIL-TAPP repair and 52 un-dergoing CL-TAPP repair.The two cohorts of patients and inguinal hernia charac-teristics were similar,with no statistically meaningful difference.The rate of intraoperative inferior epigastric vessel injury was lower in patients in the SIL-TAPP cohort(0,0%)than in patients in the CL-TAPP cohort(4,7.7%)and was significantly different(P<0.05).In addition,the median[interquartile range(IQR)]total hospitalization costs were significantly lower in patients in the SIL-TAPP cohort[$3287(3218-3325)]than in patients in the CL-TAPP cohort[$3511(3491-3599)].Postoperatively,the occurrence rate of trocar site hernia was lower in the SIL-TAPP cohort(0,0%)than in the CL-TAPP cohort(4,7.7%),and the median(IQR)cosmetic score was significantly higher in the SIL-TAPP cohort[10(10-10)]than in the CL-TAPP cohort[9(9-10)].CONCLUSION SIL-TAPP repair did not increase the incidence of intraoperative and postoperative complications in female in-guinal hernia patients.Moreover,female inguinal hernia patients who underwent SIL-TAPP repair had a lower probability of trocar site hernia and inferior epigastric vessel injury than female inguinal hernia patients who un-derwent CL-TAPP repair.In addition,female inguinal hernia patients who underwent SIL-TAPP repair reported a more aesthetically pleasing postoperative abdominal incision.Therefore,SIL-TAPP repair is a better option for the treatment of inguinal hernias in women.
文摘This essay offers a comprehensive comparative analysis of female warriors in the Marvel Cinematic Universe(MCU)and Wuxia films.Both genres portray powerful and empowered female characters who defy societal expectations and embody resilience,effectively challenging gender norms and promoting female empowerment.However,despite their strength,many of these women warriors face certain narrative factors,such as the male gaze and a predetermined fate,which can restrict their agency and curtail their full potential.And it is within the realm of Wuxia films that the captivating element of cross-dressing among female warriors emerges,providing a nuanced exploration of identity and the constraints imposed by society.
文摘Nowadays,the pace of work and life is accelerating rapidly,accompanied by significant changes in work content and family structure.Enterprises and employees are encountering various pressures and conflicts.Female employees,in particular,are experiencing increasing pressure in both social labor and family affairs,resulting in ongoing conflicts between work and life.Achieving a balance between these two domains is crucial for female employees.This article aims to analyze the influencing factors of work-life balance for female employees and to propose useful strategies to help them improve it.
文摘This study investigates the effects of technical cheerleading and dance cheerleading on the psychological health of female college students by utilizing the Symptom Checklist-90(SCL-90),the Comprehensive Diagnostic Scale for Interpersonal Relationships,and the Social Adaptability Diagnostic Scale.The findings indicate the following:(1)Technical cheerleading has a highly significant impact on sensitivity in interpersonal relationships,paranoia,and psychoticism,and a significant effect on anxiety and hostility;dance cheerleading has a highly significant effect on paranoia;(2)Both technical and dance cheerleading have minimal impact on the overall score distribution of interpersonal relationships among female college students,but the dimensions of their effects differ;(3)The impact of technical cheerleading on the social adaptability of female college students is more pronounced than that of dance cheerleading.
文摘The goal of this study was to gain a fundamental understanding of RnRH 1 and 3, as well as FSH and LH action, in ovarian follicles during oocyte growth by examining changes in ovarian gene transcription in blue gourami females (Trichogaster trichopterus). The levels of target ovarian mRNAs were determined by quantitative real-time PCR. GnRH1 mRNA levels were higher in oocytes at the previtellogenic stage compared to the vitellogenic and follicular oocytes maturation (FOM) stages. No significant differences in GnRH3 mRNA levels were detected among oocytes during the different stages of development. βLH and βFSH mRNA levels were lower in oocytes at the vitellogenic stage compared to the previtellogenic stage. The high transcription of GnRH 1 and 3 in the brain and of FSH and LH in the pituitary of blue gourami as was found in previous studies in our laboratory, compared to mRNA levels changed in ovary during oogenesis, supporting the hypothesis that differences exist between the function of endocrine and autocrine/paracrine of these hormones.
文摘This study is examined the effect of past and present lifestyle habits and nutrition on the os-teo-sono assessment index (OSI) in pre- and post-menopausal females. The subjects were 200 premenopausal females (38.8±10.3years) and 156 postmenopausal females (59.2±5.9 ye- ars). BMD (Body mineral density) was estimated by right-calcaneal OSI using an ultrasonic transmission method with an AOS-100 device (ALOKA). The number of postmenopau- sal fe-males in the close examination and guidance required groups (80 cases: 51.3 %) (OSI < 2.428) was significantly higher than that of premeno-pausal females (44 cases: 22.0 %) (χ2=33.105: P<0.000). In premenopausal females, the proportion of subjects that had not taken vitamin D in the past (in junior high school and high school) was significantly higher in the close examination- guidance required group (OSI < 2.428) than in the normal group (OSI ≧ 2.428). However, in postmenopausal females, there was no signifi-cant difference in past and present lifestyle habits and nutrition between the close exami-nation-guidance required group and the normal group. In premenopausal females, it was deter-mined that the intake of vitamin D during pu-berty increased the absorption of calcium sig-nificantly.
文摘Background: Breast diseases cover several conditions. The majority of breast diseases are noncancerous. Some of these lesions are clinically unremarkable, which needed minimal intervention. However, some symptoms may be of clinical value and attract the attention of both the patient and the attending physician, especially when they become persistent. The study aimed to assess the prevalence, pattern, types, and clinical profile of breast diseases among females in the South-western region, during the period from 2018-2020. Methods: A retrospective record-based descriptive approach was used through reviewing medical records of all cases with breast disease attended King Khalid Hospital during the period from January 2018 to January 2020. Data extracted throng pre-structured questionnaire. Results: The study included 211 cases whose ages ranged from 18 to 58 years old with a mean age of 28.9 ± 12.8 years. Breast mass was the most recorded complaint (95.1%) followed with breast pain (32%), skin changes. Benign findings based on the final pathology report were recorded for more than two thirds of the cases, with the most common finding were fibroadenoma. Excisional biopsy and modified radical mastectomy were the most reported surgical interventions. Conclusions: In conclusion, the study revealed that the majority of the cases had benign breast disease (BBD), where fibroadenoma was the most frequent.
文摘Introduction: Breast cancer is the most common cancer in the Iranian female population, and the incidence of the disease is rising. Early detection in association with staging or grading the tumor is the most effective method to increase survival rates. Studies have revealed that cortactin overexpression may play a role in the final stages of tumor progression and affects invasion and cellular motility. The aim of this study is to evaluate cortactin gene expression among Iranian female patients with breast cancer. Materials and Methods: Samples belonging to 70 breast cancer patients were randomly selected from the Imam Khomeini tumor bank. Normal and tumor tissues were prepared and stored at -80°C. Cortactin gene expression was evaluated by real-time PCR. Finally the data, along with demographic and clinical parameters, were analyzed using Prism 5.0 software, followed by t-test and ANOVA analysis. Results: Cortactin gene expression among tumor tissues increased 95.71% in comparison with normal tissues. A significant correlation between cortactin gene expression and lymph nodes’ involvement (P = 0.0077) and tumor stage (P = 0.0030) was observed. However, tumor grade (P = 0.8598), tumor size (P = 0.3058), and patient’s age (P = 0.4135) had no significant correlation with the gene’s expression level. Discussion: This study demonstrated that the cortactin gene’s overexpression in breast cancer may enhance lymph nodes’ involvement. This study also found that the gene’s expression was raised significantly in progressed stages of the cancer. Therefore, cortactin gene overexpression is an important factor indicating breast cells’ invasion. Conclusion: The cortactin gene’s expression level can be considered an accurate indicator for female breast cancer and also an appropriate biomarker for this cancer in clinical evaluations.
文摘Nowadays the modern females get out of home, fighting with males to display their wonderful life and demonstrate the wonderful characters, so we will ask the question what qualities do the modern females belong? By analyzing the novel Jane Eyre, it is easy to see the qualities of heroine such as independence, desiring of knowledge, exploring true love and emphasizing on spirit world and so on. This paper explains that it is important for modern females to build up their excellent qualities in order to deal with a lot of barriers in their future way.
基金NSFC (No .3 9870 15 8) ,NaturalScienceFoundationofAnhuiProvince (No .10 0 3 3 0 No .0 42 416)andtheExcellentYouthFoundation (No .0 40 43 0 5 0 )
文摘The effect of temperature on the life history characteristics of amictic females (AF), unfertilized mictic females (UMF) and fertilized mictic females (FMF) in Brachionus calyciflorus was studied with replicated individual cultures at 20℃,25℃ and 30℃, and with algae Scenedesmus obliquus for their food. There were highly significant effects of both temperature and female type, independently and interactively, on the duration of juvenile and post-reproduction periods, and the number of eggs produced by the rotifer per life cycle. Among all the temperature-female type combinations, all the juvenile periods of FMF, and the post-reproduction periods of UMF and FMF at 20℃, were the longest, and the number of eggs produced by an UMF at 30℃ was the highest. There were highly significant effects of both temperature and female type on the duration of the reproduction period, but no clear correlation was observed between temperature and female type. The reproduction period of AF was longer than that of UMF and FMF. Only temperature influenced significantly the mean life-span of the three types of females. The duration of juvenile, reproduction and post-reproduction periods as well as the life-span of the three types of females were all reduced very significantly with rise of temperature, but the rates of reduction varied with female type. Among the three types of females, the number of eggs produced per life cycle by an UMF was the highest, and that of a FMF was the lowest. A significant relationship between the number of eggs produced per life cycle and temperature was observed only in the UMF.