BACKGROUND By comprehensively analyzing the blood flow parameters of the umbilical and middle cerebral arteries,doctors can more accurately identify fetal intrauterine distress,as well as assess its severity,so that t...BACKGROUND By comprehensively analyzing the blood flow parameters of the umbilical and middle cerebral arteries,doctors can more accurately identify fetal intrauterine distress,as well as assess its severity,so that timely interventions can be implemented to safeguard the health and safety of the fetus.AIM To identify the relationship between ultrasound parameters of the umbilical and middle cerebral arteries and intrauterine distress.METHODS Clinical data of pregnant women admitted between January 2021 and January 2023 were collected and divided into the observation and control groups(n=50 each),according to the presence or absence of intrauterine distress.The ultrasound hemodynamic parameters of the uterine artery(UtA),fetal middle cerebral artery(MCA),and umbilical artery(UmA)were compared with neonatal outcomes and occurrence of intrauterine distress in the two groups.RESULTS Comparison of ultrasonic hemodynamic parameters,resistance index(RI),pulsatility index(PI),and systolic maximal blood flow velocity of UmA compared to diastolic blood flow velocity(S/D),revealed higher values of fetal MCA,PI,and S/D of UmA in pregnant women with UtA compared to controls(P<0.05),while there was no difference between the two groups in terms of RI(P<0.05)The incidence of a neonatal Apgar score of 8-10 points was lower in the observation group(66.7%)than in the control group(90.0%),and neonatal weight(2675.5±27.6 g)was lower than in the control group(3117.5±31.2 g).Further,cesarean section rate was higher in the observation group(70.0%)than in the control group(11.7%),and preterm labor rate was higher in the observation group(40.0%)than in the control group(10.0%).The incidence of fetal distress,neonatal growth restriction and neonatal asphyxia were also higher in the observation group(all P<0.05).CONCLUSION Fetal MCA,UmA,and maternal UtA hemodynamic abnormalities all develop in pregnant women with intrauterine distress during late pregnancy,which suggests that clinical attention should be paid to them,and monitoring should be strengthened to provide guidance for clinical intervention.展开更多
Neuro D plays a key regulatory effect on differentiation of neural stem cells into mature neurons in the brain.Thus,we assumed that electroacupuncture at Baihui（DU20） acupoint in newborn rats exposed to in utero fet...Neuro D plays a key regulatory effect on differentiation of neural stem cells into mature neurons in the brain.Thus,we assumed that electroacupuncture at Baihui（DU20） acupoint in newborn rats exposed to in utero fetal distress would influence expression of Neuro D.Electroacupuncture at Baihui was performed for 20 minutes on 3-day-old（Day 3） newborn Sprague-Dawley rats exposed to in utero fetal distress;electroacupuncture parameters consisted of sparse and dense waves at a frequency of 2–10 Hz.Real-time fluorescent quantitative PCR results demonstrated that m RNA expression of Neuro D,a molecule that indicates Neuro D,increased with prolonged time in brains of newborn rats,and peaked on Day 22.The level of m RNA expression was similar between Day 16 and Day 35.These findings suggest that electro acupuncture at Baihui acupoint could effectively increase m RNA expression of molecules involved in Neuro D in the brains of newborn rats exposed to in utero fetal distress.展开更多
Fetal distress is one of the main factors to cesarean section in obstetrics and gynecology. If the fetus lack of oxygen in uterus, threat to the fetal health and fetal death could happen. Cardiotocography (CTG) is the...Fetal distress is one of the main factors to cesarean section in obstetrics and gynecology. If the fetus lack of oxygen in uterus, threat to the fetal health and fetal death could happen. Cardiotocography (CTG) is the most widely used technique to monitor the fetal health and fetal heart rate (FHR) is an important index to identify occurs of fetal distress. This study is to propose discriminant analysis (DA), decision tree (DT), and artificial neural network (ANN) to evaluate fetal distress. The results show that the accuracies of DA, DT and ANN are 82.1%, 86.36% and 97.78%, respectively.展开更多
Cardiotocography is one of the most widely used technique for recording changes in fetal heart rate (FHR) and uterine contractions. Assessing cardiotocography is crucial in that it leads to iden- tifying fetuses which...Cardiotocography is one of the most widely used technique for recording changes in fetal heart rate (FHR) and uterine contractions. Assessing cardiotocography is crucial in that it leads to iden- tifying fetuses which suffer from lack of oxygen, i.e. hypoxia. This situation is defined as fetal dis- tress and requires fetal intervention in order to prevent fetus death or other neurological disease caused by hypoxia. In this study a computer-based approach for analyzing cardiotocogram in- cluding diagnostic features for discriminating a pathologic fetus. In order to achieve this aim adaptive boosting ensemble of decision trees and various other machine learning algorithms are employed.展开更多
Introduction: The use of traditional preparations for the induction or acceleration of labor remains a common practice in our country in particular and in Africa in general with sometimes derogatory outcomes for the m...Introduction: The use of traditional preparations for the induction or acceleration of labor remains a common practice in our country in particular and in Africa in general with sometimes derogatory outcomes for the mother and the fetus. Goal: The objective was to assess immediate maternal and neonatal outcomes in women who reported having used the traditional pharmacopoeia for utero-tonic purposes. Methodology: We conducted a multi-centric cross- sectional study with prospective data collection in the maternities of the Laquintinie Hospital, Bonassama District and Nylon Hospitals. It took place over a period of seven months, from 1st October 2016 to 31st April 2017. This included all women who reported having used the unconventional pharmacopoeia for utero-tonic purposes before or after contractions started. The student and Chi-square tests were interpreted at the statistical threshold of 5% and the 95% confidence intervals. Results: We recruited 168 cases, 68.5% of the 245 women interviewed. The mean age was 27.1 ± 0.41 years;55% of our respondents had a secondary level of education;80% of them were admitted at term and 43% were multiparous. Nulliparity predisposed to traditional pharmacopoeia use (RR = 1.55, CI = 0.79 - 3.03) but primiparity reduced this risk (RR = 0.4, CI = 0.24 - 0.926). Stimulation of labor was the first indication in 85% of women, the rectal evacuation enema was the main route used (67%). The majority of plants used were those of the families Asteraceae, Anthericaceae, and Malvaceae. In per partum, 42% had a brilliant dilatation;there was a statistically significant association between the occurrence of dynamic dystocia (CI = 0.28 - 1.54, p = 0.006) and the risk of perineal tear (RR = 3.13, CI = 1.68 - 5.85;p = 0.007). The APGAR score at 5 min of life was less than 7 in 64% of cases (p = 0.027). The caesarean section rate was 69%. Conclusion: Traditional products with uterotonic effects are frequently used and unregulated with its corollary of materno-fetal complications.展开更多
背景呼吸窘迫综合征(RDS)是导致早产儿死亡的重要原因,需不断加强临床预防及治疗,但目前关于脐血维生素A、E水平与早产儿发生RDS的关系研究报道较少。目的探讨脐血维生素A、E水平与早产儿发生RDS的关系。方法选取2021年1月—2022年1月...背景呼吸窘迫综合征(RDS)是导致早产儿死亡的重要原因,需不断加强临床预防及治疗,但目前关于脐血维生素A、E水平与早产儿发生RDS的关系研究报道较少。目的探讨脐血维生素A、E水平与早产儿发生RDS的关系。方法选取2021年1月—2022年1月在石家庄市第四医院出生的早产儿304例,根据RDS发生情况将其分为RDS组120例与非RDS组184例。收集与早产儿发生RDS可能相关的临床特征并检测脐血维生素A、E水平;早产儿发生RDS及RDS严重程度的影响因素分析采用多因素Logistic回归分析。结果RDS组早产儿胎龄、出生体质量小于非RDS组,1 min Apgar评分≤7分比例、5 min Apgar评分≤7分比例、维生素A缺乏发生率高于非RDS组,脐血维生素A、E水平低于非RDS组(P<0.05)。RDS组早产儿中轻症86例,重症34例;重症RDS早产儿脐血维生素A水平低于轻症RDS早产儿,维生素A缺乏发生率高于轻症RDS早产儿(P<0.05)。多因素Logistic回归分析结果显示,脐血维生素A水平为早产儿发生RDS的影响因素[OR=2.208,95%CI(1.156,4.218),P<0.05];维生素A缺乏为早产儿发生重症RDS的影响因素[OR=6.835,95%CI(2.537,18.416),P<0.05]。结论发生RDS的早产儿脐血维生素A、E水平较低,脐血维生素A水平为早产儿发生RDS及其严重程度的影响因素,建议在妊娠期适当补充维生素A以减少早产儿RDS的发生及减轻其严重程度。展开更多
文摘BACKGROUND By comprehensively analyzing the blood flow parameters of the umbilical and middle cerebral arteries,doctors can more accurately identify fetal intrauterine distress,as well as assess its severity,so that timely interventions can be implemented to safeguard the health and safety of the fetus.AIM To identify the relationship between ultrasound parameters of the umbilical and middle cerebral arteries and intrauterine distress.METHODS Clinical data of pregnant women admitted between January 2021 and January 2023 were collected and divided into the observation and control groups(n=50 each),according to the presence or absence of intrauterine distress.The ultrasound hemodynamic parameters of the uterine artery(UtA),fetal middle cerebral artery(MCA),and umbilical artery(UmA)were compared with neonatal outcomes and occurrence of intrauterine distress in the two groups.RESULTS Comparison of ultrasonic hemodynamic parameters,resistance index(RI),pulsatility index(PI),and systolic maximal blood flow velocity of UmA compared to diastolic blood flow velocity(S/D),revealed higher values of fetal MCA,PI,and S/D of UmA in pregnant women with UtA compared to controls(P<0.05),while there was no difference between the two groups in terms of RI(P<0.05)The incidence of a neonatal Apgar score of 8-10 points was lower in the observation group(66.7%)than in the control group(90.0%),and neonatal weight(2675.5±27.6 g)was lower than in the control group(3117.5±31.2 g).Further,cesarean section rate was higher in the observation group(70.0%)than in the control group(11.7%),and preterm labor rate was higher in the observation group(40.0%)than in the control group(10.0%).The incidence of fetal distress,neonatal growth restriction and neonatal asphyxia were also higher in the observation group(all P<0.05).CONCLUSION Fetal MCA,UmA,and maternal UtA hemodynamic abnormalities all develop in pregnant women with intrauterine distress during late pregnancy,which suggests that clinical attention should be paid to them,and monitoring should be strengthened to provide guidance for clinical intervention.
基金supported by the Natural Science Foundation of Fujian Province of China,No.2015J01133the Professor Academic Development Foundation of Fujian Medical University of China,No.JS11003
文摘Neuro D plays a key regulatory effect on differentiation of neural stem cells into mature neurons in the brain.Thus,we assumed that electroacupuncture at Baihui（DU20） acupoint in newborn rats exposed to in utero fetal distress would influence expression of Neuro D.Electroacupuncture at Baihui was performed for 20 minutes on 3-day-old（Day 3） newborn Sprague-Dawley rats exposed to in utero fetal distress;electroacupuncture parameters consisted of sparse and dense waves at a frequency of 2–10 Hz.Real-time fluorescent quantitative PCR results demonstrated that m RNA expression of Neuro D,a molecule that indicates Neuro D,increased with prolonged time in brains of newborn rats,and peaked on Day 22.The level of m RNA expression was similar between Day 16 and Day 35.These findings suggest that electro acupuncture at Baihui acupoint could effectively increase m RNA expression of molecules involved in Neuro D in the brains of newborn rats exposed to in utero fetal distress.
文摘Fetal distress is one of the main factors to cesarean section in obstetrics and gynecology. If the fetus lack of oxygen in uterus, threat to the fetal health and fetal death could happen. Cardiotocography (CTG) is the most widely used technique to monitor the fetal health and fetal heart rate (FHR) is an important index to identify occurs of fetal distress. This study is to propose discriminant analysis (DA), decision tree (DT), and artificial neural network (ANN) to evaluate fetal distress. The results show that the accuracies of DA, DT and ANN are 82.1%, 86.36% and 97.78%, respectively.
文摘Cardiotocography is one of the most widely used technique for recording changes in fetal heart rate (FHR) and uterine contractions. Assessing cardiotocography is crucial in that it leads to iden- tifying fetuses which suffer from lack of oxygen, i.e. hypoxia. This situation is defined as fetal dis- tress and requires fetal intervention in order to prevent fetus death or other neurological disease caused by hypoxia. In this study a computer-based approach for analyzing cardiotocogram in- cluding diagnostic features for discriminating a pathologic fetus. In order to achieve this aim adaptive boosting ensemble of decision trees and various other machine learning algorithms are employed.
文摘Introduction: The use of traditional preparations for the induction or acceleration of labor remains a common practice in our country in particular and in Africa in general with sometimes derogatory outcomes for the mother and the fetus. Goal: The objective was to assess immediate maternal and neonatal outcomes in women who reported having used the traditional pharmacopoeia for utero-tonic purposes. Methodology: We conducted a multi-centric cross- sectional study with prospective data collection in the maternities of the Laquintinie Hospital, Bonassama District and Nylon Hospitals. It took place over a period of seven months, from 1st October 2016 to 31st April 2017. This included all women who reported having used the unconventional pharmacopoeia for utero-tonic purposes before or after contractions started. The student and Chi-square tests were interpreted at the statistical threshold of 5% and the 95% confidence intervals. Results: We recruited 168 cases, 68.5% of the 245 women interviewed. The mean age was 27.1 ± 0.41 years;55% of our respondents had a secondary level of education;80% of them were admitted at term and 43% were multiparous. Nulliparity predisposed to traditional pharmacopoeia use (RR = 1.55, CI = 0.79 - 3.03) but primiparity reduced this risk (RR = 0.4, CI = 0.24 - 0.926). Stimulation of labor was the first indication in 85% of women, the rectal evacuation enema was the main route used (67%). The majority of plants used were those of the families Asteraceae, Anthericaceae, and Malvaceae. In per partum, 42% had a brilliant dilatation;there was a statistically significant association between the occurrence of dynamic dystocia (CI = 0.28 - 1.54, p = 0.006) and the risk of perineal tear (RR = 3.13, CI = 1.68 - 5.85;p = 0.007). The APGAR score at 5 min of life was less than 7 in 64% of cases (p = 0.027). The caesarean section rate was 69%. Conclusion: Traditional products with uterotonic effects are frequently used and unregulated with its corollary of materno-fetal complications.
文摘背景呼吸窘迫综合征(RDS)是导致早产儿死亡的重要原因,需不断加强临床预防及治疗,但目前关于脐血维生素A、E水平与早产儿发生RDS的关系研究报道较少。目的探讨脐血维生素A、E水平与早产儿发生RDS的关系。方法选取2021年1月—2022年1月在石家庄市第四医院出生的早产儿304例,根据RDS发生情况将其分为RDS组120例与非RDS组184例。收集与早产儿发生RDS可能相关的临床特征并检测脐血维生素A、E水平;早产儿发生RDS及RDS严重程度的影响因素分析采用多因素Logistic回归分析。结果RDS组早产儿胎龄、出生体质量小于非RDS组,1 min Apgar评分≤7分比例、5 min Apgar评分≤7分比例、维生素A缺乏发生率高于非RDS组,脐血维生素A、E水平低于非RDS组(P<0.05)。RDS组早产儿中轻症86例,重症34例;重症RDS早产儿脐血维生素A水平低于轻症RDS早产儿,维生素A缺乏发生率高于轻症RDS早产儿(P<0.05)。多因素Logistic回归分析结果显示,脐血维生素A水平为早产儿发生RDS的影响因素[OR=2.208,95%CI(1.156,4.218),P<0.05];维生素A缺乏为早产儿发生重症RDS的影响因素[OR=6.835,95%CI(2.537,18.416),P<0.05]。结论发生RDS的早产儿脐血维生素A、E水平较低,脐血维生素A水平为早产儿发生RDS及其严重程度的影响因素,建议在妊娠期适当补充维生素A以减少早产儿RDS的发生及减轻其严重程度。
