Growth hormone releasing peptide (GHRP-2) is a synthetic hexapep-tide which specifically stimulates secretion of growth hormone (GH) by fetal pitu-itary somatotrophs through a new membrane receptor, which is different...Growth hormone releasing peptide (GHRP-2) is a synthetic hexapep-tide which specifically stimulates secretion of growth hormone (GH) by fetal pitu-itary somatotrophs through a new membrane receptor, which is different from growth hormone releasing hormone (GHRH) and somatostatin (SMS) receptors.We used cell cultures of human fetal pituitary somatotroph cells to investigate the effect of GHRH, GHRP-2 and somatostatin on GH secretion. The results showed that the mechanism of GHRH/SMS and GHRP-2 was different- This indicated that a different intracellular signal transduction system might also play a crucial role in the regulation of GH secretion.展开更多
文摘Growth hormone releasing peptide (GHRP-2) is a synthetic hexapep-tide which specifically stimulates secretion of growth hormone (GH) by fetal pitu-itary somatotrophs through a new membrane receptor, which is different from growth hormone releasing hormone (GHRH) and somatostatin (SMS) receptors.We used cell cultures of human fetal pituitary somatotroph cells to investigate the effect of GHRH, GHRP-2 and somatostatin on GH secretion. The results showed that the mechanism of GHRH/SMS and GHRP-2 was different- This indicated that a different intracellular signal transduction system might also play a crucial role in the regulation of GH secretion.
