human fetuses and 15 SD rats were used in this study. The distribution of theANPlike substance in the hearts of human fetuses and rats was studied. The results were as follows:①In human fetus ANP-like substance was f...human fetuses and 15 SD rats were used in this study. The distribution of theANPlike substance in the hearts of human fetuses and rats was studied. The results were as follows:①In human fetus ANP-like substance was found throughout in the atrial wall, but more intensely in the inner layer. It lacked in the ventricular wall. ②In young rat atrum, ANP-like substance wasdistributed over the whole wall, but richer in the cells beneath the endocardium and epicardium. In adult rat atrium, distribution of ANP-like substance was more intensely beneath the epicardium than that near the lumen. In the ventricle, ANP-like substance was found only in the young rat, especially on the left side of interventricular septum (IVS). So the distribution of ANP in rat hearts changes with age. ③In the sinus node (SAN) and atrioventricular node (AVN) of both human fetuses and rats showed a small amount of ANP-like substance, and more in peripheral part of the nodes, but thereactive intensity was weaker than that of the atrial wall. The presence of ANP in conduction system may have some functional significance to influence the pulse conduction.展开更多
Objective in order to investigate the fetal scarless wound heaiing, we developed an in vivo modelto observe the process of wound healing occurring in SD- rat fetus. Methods SD-rat fetuses were givenfull- thickness inc...Objective in order to investigate the fetal scarless wound heaiing, we developed an in vivo modelto observe the process of wound healing occurring in SD- rat fetus. Methods SD-rat fetuses were givenfull- thickness incisional wounds in the upper lips under ether anesthesia. Wound specimens were removedsuccessively 12,24,48,72h postwounding (PW) from fetus and 1,3,5,7d PW from adult rats for histologicalexamination. Results In the fetus, re-epithelialization of the skin wound was completed by 24h PW withoutapparent acute inflammatory response. Regenerated skin wound with normal architecture and elements wascompleted by 72h postoperation, indistinguishable from the surrounding normal skin. While in the adult rats, thewounds showed an acute inflammatory response resulting in thickened epithelia and scar formation. ConclusionFetal wound is characterized by rapid and eficient healing without scar formation followed by real skinregeneration.展开更多
文摘human fetuses and 15 SD rats were used in this study. The distribution of theANPlike substance in the hearts of human fetuses and rats was studied. The results were as follows:①In human fetus ANP-like substance was found throughout in the atrial wall, but more intensely in the inner layer. It lacked in the ventricular wall. ②In young rat atrum, ANP-like substance wasdistributed over the whole wall, but richer in the cells beneath the endocardium and epicardium. In adult rat atrium, distribution of ANP-like substance was more intensely beneath the epicardium than that near the lumen. In the ventricle, ANP-like substance was found only in the young rat, especially on the left side of interventricular septum (IVS). So the distribution of ANP in rat hearts changes with age. ③In the sinus node (SAN) and atrioventricular node (AVN) of both human fetuses and rats showed a small amount of ANP-like substance, and more in peripheral part of the nodes, but thereactive intensity was weaker than that of the atrial wall. The presence of ANP in conduction system may have some functional significance to influence the pulse conduction.
文摘Objective in order to investigate the fetal scarless wound heaiing, we developed an in vivo modelto observe the process of wound healing occurring in SD- rat fetus. Methods SD-rat fetuses were givenfull- thickness incisional wounds in the upper lips under ether anesthesia. Wound specimens were removedsuccessively 12,24,48,72h postwounding (PW) from fetus and 1,3,5,7d PW from adult rats for histologicalexamination. Results In the fetus, re-epithelialization of the skin wound was completed by 24h PW withoutapparent acute inflammatory response. Regenerated skin wound with normal architecture and elements wascompleted by 72h postoperation, indistinguishable from the surrounding normal skin. While in the adult rats, thewounds showed an acute inflammatory response resulting in thickened epithelia and scar formation. ConclusionFetal wound is characterized by rapid and eficient healing without scar formation followed by real skinregeneration.
