Background:We investigated whether and to what extent the ratio between circulating fibrinogen (Fg) and its degradation products (FDP)reflects the severity of coronary artery disease (CAD) in type 2 diabetic patients....Background:We investigated whether and to what extent the ratio between circulating fibrinogen (Fg) and its degradation products (FDP)reflects the severity of coronary artery disease (CAD) in type 2 diabetic patients.Methods:Plasma levels of Fg and FDP were determined,and Fg/FDP ratio was calculated in 344 consecutive patients with type 2 diabetes and chest pain on exertion undergoing coronary angiography.The severity of CAD was evaluated by the number of significant CAD (＞50％ luminal diameter narrowing) and Gensini score.Results:Plasma Fg was higher,but Fg/FDP ratio was lower in patients with significant CAD (n =255) compared with those without (n =89),due to a disproportionate increase in FDP.Fg and FDP correlated positively,while Fg/FDP ratio negatively,with the number of diseased coronary arteries and the tertile of Gensini score (all P values for trend ＜ 0.01).After adjusting for age,sex,risk factors for CAD,lipid profiles,glycosylated hemoglobin A1c,creatinine,leukocyte count,and high-sensitivity C-reactive protein,Fg/FDP ratio remained an independent determinant for multivessel coronary disease (MVD) (odds ratio [OR],0.869; 95％ confidence interval [CI],0.788-0.958,P =0.005) and high tertile of Gensini score (OR,0.797,95％ CI,0.682-0.930,P =0.004).The area under the curve of Fg/FDP ratio was larger than that of Fg for predicting the presence of MVD (0.647 vs.0.563,P =0.048) and Gensini score ≥ 30 (0.656 vs.0.53 8,P =0.026).Conclusions:Elevated plasma Fg and FDP level and reduced Fg/FDP ratio are associated with presence of CAD,and Fg/FDP ratio is superior to Fg in reflecting severe coronary atherosclerosis for patients with type 2 diabetes.展开更多
【目的】探讨检测急性肺栓塞患者的血浆脑钠肽（BNP）、肌钙蛋白I（cTnI）及D‐二聚体（D‐dimer）水平变化的临床意义。【方法】选择本院2009年1月至2013年12月收治的急性肺栓塞患者64例，根据患者病情分为大面积肺栓塞组（ n ＝27）...【目的】探讨检测急性肺栓塞患者的血浆脑钠肽（BNP）、肌钙蛋白I（cTnI）及D‐二聚体（D‐dimer）水平变化的临床意义。【方法】选择本院2009年1月至2013年12月收治的急性肺栓塞患者64例，根据患者病情分为大面积肺栓塞组（ n ＝27）和非大面积肺栓塞组（ n ＝37），对两组患者血浆cTnI、BNP及D‐dimer水平进行测定，观察比较两组患者各指标水平的变化及右心功能和病死率。【结果】大面积肺栓塞组BN P、血浆cTnI水平明显高于非大面积肺栓塞组，两组比较差异有显著性（ P ＜0．05）；两组D‐dimer浓度比较差异无统计学意义（ P ＞0．05）；大面积肺栓塞组的右心功能不全者和病死率均高于非大面积肺栓塞组，两组比较差异有统计学意义（ P ＜0．05）。【结论】检测BNP、cTnI及D‐dimer水平对APE患者临床诊断、临床决策及预后判断具有重要的临床意义。展开更多
目的分析D-二聚体(DD)、纤维蛋白(原)降解产物(FDP)在肝细胞肝癌(hepatocellular carcinoma,HCC)与乙肝肝硬化(hepatitis B cirrhosis,HBC)中表达的差异性,以及DD与FDP阳性表达与不同临床特征HCC的相关性。方法回顾性分析2018年9月—202...目的分析D-二聚体(DD)、纤维蛋白(原)降解产物(FDP)在肝细胞肝癌(hepatocellular carcinoma,HCC)与乙肝肝硬化(hepatitis B cirrhosis,HBC)中表达的差异性,以及DD与FDP阳性表达与不同临床特征HCC的相关性。方法回顾性分析2018年9月—2020年9月包头市肿瘤医院收治的100例HCC患者的临床资料,将其作为研究组;分析同期收治的102例HBC患者的临床资料,将其作为对照组。两组患者均进行DD与FDP检测,比较两组DD与FDP水平与阳性率;不同临床特征[原发肿瘤局部淋巴结远处转移(tumor,nodalinvolvement,metastasis,TNM)分期、病理类型、淋巴结转移情况]的HCC患者DD与FDP阳性表达情况,对DD、FDP阳性表达与不同临床特征进行相关性分析。结果研究组DD与FDP水平均高于对照组,差异有统计学意义(P<0.05)。研究组DD阳性率为52.00%、FDP阳性率为65.00%均高于对照组的24.51%、31.37%,差异有统计学意义(χ^(2)=16.177、22.876,P<0.05)。TNM分期Ⅲ~Ⅳ期HCC患者的DD、FDP阳性表达率高于Ⅰ~Ⅱ期,有淋巴结转移情况的HCC患者的DD、FDP阳性表达率高于无淋巴结转移者,差异有统计学意义(P<0.05);鳞癌与腺癌的DD、FDP阳性表达率对比,差异无统计学意义(P>0.05)。经Spearman相关性分析显示,DD、FDP与HCC患者TNM分期、淋巴结转移均呈正相关性(P<0.05)。结论HCC患者DD、FDP水平可见明显改变,动态监测两种指标可以为疾病诊疗工作提供客观的参考,具有一定的临床应用价值。展开更多
基金the grants from Chinese Natural Science Foundation，Shanghai Science and Technology Key Project
文摘Background:We investigated whether and to what extent the ratio between circulating fibrinogen (Fg) and its degradation products (FDP)reflects the severity of coronary artery disease (CAD) in type 2 diabetic patients.Methods:Plasma levels of Fg and FDP were determined,and Fg/FDP ratio was calculated in 344 consecutive patients with type 2 diabetes and chest pain on exertion undergoing coronary angiography.The severity of CAD was evaluated by the number of significant CAD (＞50％ luminal diameter narrowing) and Gensini score.Results:Plasma Fg was higher,but Fg/FDP ratio was lower in patients with significant CAD (n =255) compared with those without (n =89),due to a disproportionate increase in FDP.Fg and FDP correlated positively,while Fg/FDP ratio negatively,with the number of diseased coronary arteries and the tertile of Gensini score (all P values for trend ＜ 0.01).After adjusting for age,sex,risk factors for CAD,lipid profiles,glycosylated hemoglobin A1c,creatinine,leukocyte count,and high-sensitivity C-reactive protein,Fg/FDP ratio remained an independent determinant for multivessel coronary disease (MVD) (odds ratio [OR],0.869; 95％ confidence interval [CI],0.788-0.958,P =0.005) and high tertile of Gensini score (OR,0.797,95％ CI,0.682-0.930,P =0.004).The area under the curve of Fg/FDP ratio was larger than that of Fg for predicting the presence of MVD (0.647 vs.0.563,P =0.048) and Gensini score ≥ 30 (0.656 vs.0.53 8,P =0.026).Conclusions:Elevated plasma Fg and FDP level and reduced Fg/FDP ratio are associated with presence of CAD,and Fg/FDP ratio is superior to Fg in reflecting severe coronary atherosclerosis for patients with type 2 diabetes.
文摘【目的】探讨检测急性肺栓塞患者的血浆脑钠肽（BNP）、肌钙蛋白I（cTnI）及D‐二聚体（D‐dimer）水平变化的临床意义。【方法】选择本院2009年1月至2013年12月收治的急性肺栓塞患者64例，根据患者病情分为大面积肺栓塞组（ n ＝27）和非大面积肺栓塞组（ n ＝37），对两组患者血浆cTnI、BNP及D‐dimer水平进行测定，观察比较两组患者各指标水平的变化及右心功能和病死率。【结果】大面积肺栓塞组BN P、血浆cTnI水平明显高于非大面积肺栓塞组，两组比较差异有显著性（ P ＜0．05）；两组D‐dimer浓度比较差异无统计学意义（ P ＞0．05）；大面积肺栓塞组的右心功能不全者和病死率均高于非大面积肺栓塞组，两组比较差异有统计学意义（ P ＜0．05）。【结论】检测BNP、cTnI及D‐dimer水平对APE患者临床诊断、临床决策及预后判断具有重要的临床意义。
文摘目的分析D-二聚体(DD)、纤维蛋白(原)降解产物(FDP)在肝细胞肝癌(hepatocellular carcinoma,HCC)与乙肝肝硬化(hepatitis B cirrhosis,HBC)中表达的差异性,以及DD与FDP阳性表达与不同临床特征HCC的相关性。方法回顾性分析2018年9月—2020年9月包头市肿瘤医院收治的100例HCC患者的临床资料,将其作为研究组;分析同期收治的102例HBC患者的临床资料,将其作为对照组。两组患者均进行DD与FDP检测,比较两组DD与FDP水平与阳性率;不同临床特征[原发肿瘤局部淋巴结远处转移(tumor,nodalinvolvement,metastasis,TNM)分期、病理类型、淋巴结转移情况]的HCC患者DD与FDP阳性表达情况,对DD、FDP阳性表达与不同临床特征进行相关性分析。结果研究组DD与FDP水平均高于对照组,差异有统计学意义(P<0.05)。研究组DD阳性率为52.00%、FDP阳性率为65.00%均高于对照组的24.51%、31.37%,差异有统计学意义(χ^(2)=16.177、22.876,P<0.05)。TNM分期Ⅲ~Ⅳ期HCC患者的DD、FDP阳性表达率高于Ⅰ~Ⅱ期,有淋巴结转移情况的HCC患者的DD、FDP阳性表达率高于无淋巴结转移者,差异有统计学意义(P<0.05);鳞癌与腺癌的DD、FDP阳性表达率对比,差异无统计学意义(P>0.05)。经Spearman相关性分析显示,DD、FDP与HCC患者TNM分期、淋巴结转移均呈正相关性(P<0.05)。结论HCC患者DD、FDP水平可见明显改变,动态监测两种指标可以为疾病诊疗工作提供客观的参考,具有一定的临床应用价值。
