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Cardiac papillary fibroelastoma:The need for a timely diagnosis 被引量:2
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作者 Srikanth Yandrapalli Bella Mehta +6 位作者 Pratik Mondal Tanush Gupta Pallavi Khattar John Fallon Randy Goldberg Sachin Sule Wilbert S Aronow 《World Journal of Clinical Cases》 SCIE 2017年第1期9-13,共5页
Cardiac papillary fibroelastomas(CPFs) are the second most common primary cardiac tumors and the most common cardiac valvular tumors. Although they are histologically benign and usually asymptomatic, CPFs can lead to ... Cardiac papillary fibroelastomas(CPFs) are the second most common primary cardiac tumors and the most common cardiac valvular tumors. Although they are histologically benign and usually asymptomatic, CPFs can lead to serious and life-threatening complications like myocardial infarction, stroke, pulmonary embolus, cardiac arrest etc. CPFs represent a rare entity in clinical medicine and literature regarding their management is limited. We report two cases which illustrate such complications arising from undiagnosed CPFs on the aortic valve. We further stress on the importance of identifying CPFs early so that they can be managed appropriately based on recommendations from the available literature. 展开更多
关键词 Lambl’s excrescences AORTIC valve CARDIAC TUMORS CARDIAC PAPILLARY fibroelastoma SUDDEN CARDIAC death
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Atypical presentation of a ventricular papillary fibroelastoma 被引量:1
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作者 Julio Perez-Downes Harold Dietzius +2 位作者 Saif Ibrahim Vasant Jayasankar Leslie Oberst 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2017年第8期534-535,共2页
Papillary fibroelastoma cardiac tumor. The most is the most common valvular common non-valvular site these minors present is the left ventricle, where they usually manifest as ischemic strokes or myocardial infarction... Papillary fibroelastoma cardiac tumor. The most is the most common valvular common non-valvular site these minors present is the left ventricle, where they usually manifest as ischemic strokes or myocardial infarction. Although these tumors also have a risk of embolization into the peripheral system, reports of such events are exceedingly rare. 展开更多
关键词 fibroelastoma ISCHEMIA MYOCARDIUM NEOPLASM THROMBOSIS
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Surgical Resection of Mitral Valve Papillary Fibroelastoma: A Robot-Assisted, Minimally Invasive Approach with Three-Dimensional Transesophageal Echocardiography Imaging 被引量:1
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作者 Crystal R. Bonnichsen Harold M. Burkhart +1 位作者 Kyle W. Klarich Rakesh M. Suri 《World Journal of Cardiovascular Surgery》 2012年第2期10-13,共4页
Papillary fibroelastomas (PFEs) are benign tumors of the endocardium that most frequently affect cardiac valves and typically present with embolic symptoms such as stroke or transient ischemic attack (TIA). Surgical e... Papillary fibroelastomas (PFEs) are benign tumors of the endocardium that most frequently affect cardiac valves and typically present with embolic symptoms such as stroke or transient ischemic attack (TIA). Surgical excision is usually recommended for left-sided tumors and is associated with excellent long-term outcomes. The use of a robot-assisted, minimally invasive surgical approach for management of mitral valve disease is growing, and has been associated with shorter hospital stays and improved early quality of life. Three-dimensional (3D) transesophageal echocardiography (TEE) offers several advantages in the assessment of mitral valve disease and cardiac tumors, including the ability to precisely locate the site of attachment of the mass and the spatial relationships to surrounding structures. These factors are particularly important when planning a surgical approach. We report two cases of mitral valve PFEs which were successfully removed using a robot-assisted, minimally invasive surgical approach with 3D TEE imaging. This approach to treatment of PFEs is an attractive alternative to the traditional approach involving median sternotomy. 展开更多
关键词 PAPILLARY fibroelastoma ROBOTIC Surgery Three-Dimensional TRANSESOPHAGEAL ECHOCARDIOGRAPHY
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Papillary fibroelastoma of aortic valve:a case report and review of the literature 被引量:1
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作者 Cheng Wei Xiao Yingbin Zhong Qianjin 《Journal of Medical Colleges of PLA(China)》 CAS 2008年第2期121-125,共5页
Papillary fibroelastoma, a rare primary benign tumor, can be found anywhere in the heart, but most commonly involves the cardiac valves. Most papillary fibroelastomas do not cause symptoms and are usually incidental f... Papillary fibroelastoma, a rare primary benign tumor, can be found anywhere in the heart, but most commonly involves the cardiac valves. Most papillary fibroelastomas do not cause symptoms and are usually incidental found by routine echocardiography or at autopsy. However, with the advent of echocardiography, more and more patients are diagnosed in life. Early diagnosis of this condition becomes very important since it represents a surgically correctable cause for systemic emboli, stroke, myocardial infarction, and sudden cardiac death. The echocardiographic findings should be confirmed by histology because the clinical differential diagnoses includes myxoma, vegetation, thrombi, lipoma, and pseudopapillary fibroelastoma. We reported a case of papillary fibroelastoma of the aortic valve and presented a comprehensive review of the literature. 展开更多
关键词 Papillary fibroelastoma Aortic valve
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Papillary fibroelastoma of the aortic valve:An unusual cause of angina
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作者 Madan Raj Aryal Madan Badal +2 位作者 Naba Raj Mainali Leena Jalota Rajesh Pradhan 《World Journal of Cardiology》 CAS 2013年第4期102-105,共4页
Papillary fibroelastoma of the aortic valve is an uncommon benign tumor of the heart that can present with embolic events.We report a case of 54-year-old lady with exertional chest pain and prior history of ST segment... Papillary fibroelastoma of the aortic valve is an uncommon benign tumor of the heart that can present with embolic events.We report a case of 54-year-old lady with exertional chest pain and prior history of ST segment elevation myocardial infarction who was subsequently found to have a fibroelastoma of the aortic valve.The absence of angiographically significant coronary artery disease and resolution of anginal symptoms post-surgery in our patient points to the possibility of fibroelastoma causing these anginal symptoms.Although uncommon,fibroelastoma are being recognized more frequently with the help of transesophageal echocardiography.Hence,in the absence of significant coronary artery disease,we emphasize the importance of consideration of papillary fibroelastoma of the aortic valve as a cause of angina.We also discuss the key aspects of the fibroelastoma including presentation,diagnostic modalities and treatment options. 展开更多
关键词 PAPILLARY fibroelastoma ANGINA AORTIC valve Surgical resection EMBOLIC event
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Coinciding anomalous coronary artery and papillary fibroelastoma
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作者 Saif Ibrahim Nachiket Patel +1 位作者 Farah Al-Saffar Jean Touchan 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2016年第11期924-926,共3页
The primary cardiac tumors are extremely rare tumors that arise from the normal cardiac tissues. There are benign variants (mostly myxoma) and malignant tumors. Fibroelastoma (FE) is the most common primary tumor,... The primary cardiac tumors are extremely rare tumors that arise from the normal cardiac tissues. There are benign variants (mostly myxoma) and malignant tumors. Fibroelastoma (FE) is the most common primary tumor, of which myxoma is the most common subtype followed by papillary fibroelastomas (PFE). 展开更多
关键词 Anomalous coronary artery Cardiac tumors fibroelastoma Valvular tumors
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Papillary Fibroelastoma of the Papillary Muscle of the Tricuspid Valve: Reconstruction of the Papillary Muscle
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作者 Susumu Isoda Tamizo Kimura +3 位作者 Kenji Nishimura Nozomu Yamanaka Shingo Nakamura Tadaaki Maehara 《Open Journal of Thoracic Surgery》 2013年第3期69-72,共4页
Cardiac papillary fibroelastoma is the third most frequent primary cardiac tumor, after myxoma and fibroma. A papillary fibroelastoma that arises from the papillary muscle is rare. We removed a papillary fibroelastoma... Cardiac papillary fibroelastoma is the third most frequent primary cardiac tumor, after myxoma and fibroma. A papillary fibroelastoma that arises from the papillary muscle is rare. We removed a papillary fibroelastoma located at the anterior papillary muscle of the tricuspid valve. The papillary muscle needed reconstruction. We used the loop technique to adjust the length of the papillary muscle and performed annuloplasty by using an artificial ring. 展开更多
关键词 PAPILLARY fibroelastoma PAPILLARY MUSCLE TRICUSPID VALVE VALVE PLASTY
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Assessment of Papillary Fibroelastoma of the Semilunar Valves by Three-Dimensional Echocardiography
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作者 Leonel Avendano-Pérez Nydia Avila-Vanzzini Nilda Espinola-Zavaleta 《World Journal of Cardiovascular Diseases》 2017年第12期429-434,共6页
Papillary fibroelastoma is an uncommon tumor. Recognitions of this tumor have been improved thanks to modern imaging advances, which have made more patients to be identified, but at the same time, the management of th... Papillary fibroelastoma is an uncommon tumor. Recognitions of this tumor have been improved thanks to modern imaging advances, which have made more patients to be identified, but at the same time, the management of this disease is still controversial. There aren’t enough studies to basic clinical actions. We present 2 interesting cases involving the semilunar valves. The purpose of presenting these cases is to review this rare disease and the superiority of the three-dimensional echocardiography in their diagnosis. 展开更多
关键词 Heart Tumor Papillary fibroelastoma Pulmonary Valve Aortic Valve ECHOCARDIOGRAPHY
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MITRAL VALVE PAPILLARY FIBROELASTOMA:CASE REPORT
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作者 黄英 蒋米尔 Yves GLOCK 《Journal of Shanghai Second Medical University(Foreign Language Edition)》 2003年第2期129-131,共3页
Objective To evaluate the transesophageal echocardiography(TEE) and surgical treatment to cardiac papillary fibroelastomas (CPFE). Methods CPFE is a rare benign tumor occuring mainly in valves and often revealed by se... Objective To evaluate the transesophageal echocardiography(TEE) and surgical treatment to cardiac papillary fibroelastomas (CPFE). Methods CPFE is a rare benign tumor occuring mainly in valves and often revealed by serious cerebral, coronary and peripheral embolism or even sudden death. We report a case of mitral PFE diagnosed by transesophageal echocardiography (TEE), and surgical resection was performed. Results Surgical intervention is successful, and the follow-up courses are uneventful. Conclusion TEE is helpful to diagnosis and guiding the operation. Operation is recommended to prevent recurrent embolization complications. 展开更多
关键词 mitral valve fibroelastoma transesophageal echocardiography surgical treatment
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风湿性心脏病合并二尖瓣乳头状弹力纤维瘤1例
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作者 卢绍华 杨扬 杨思远 《安徽医药》 CAS 2024年第5期986-988,F0003,共4页
目的探究发生于心脏瓣膜的乳头状弹力纤维瘤的临床及病理特征,为临床治疗提供参考。方法对1例风湿性心脏病合并二尖瓣腱索乳头状弹力纤维瘤病人,进行手术治疗,对二尖瓣肿物的标本行病理检查进行形态学研究,并复习文献。结果心脏乳头状... 目的探究发生于心脏瓣膜的乳头状弹力纤维瘤的临床及病理特征,为临床治疗提供参考。方法对1例风湿性心脏病合并二尖瓣腱索乳头状弹力纤维瘤病人,进行手术治疗,对二尖瓣肿物的标本行病理检查进行形态学研究,并复习文献。结果心脏乳头状弹力纤维瘤病人多无特殊症状。心脏超声表现为二尖瓣腱索见一条索状稍强回声。组织学表现为:肿瘤呈乳头状突起,表面被覆单层立方上皮细胞,中心为无血管的轴心区,主要部分是特征性的淡红色的弹力纤维组织。结论风湿性心脏病是一种常见的心脏疾病,而乳头状弹力纤维瘤是一种少见且发病隐匿的心脏肿瘤,病人常无明显症状,可引起栓塞风险。该例肿瘤位于二尖瓣乳头肌腱索处很罕见。术前行超声心动图及手术完整切除肿瘤是提高心脏乳头状弹力纤维瘤病人诊断率及治疗的关键。 展开更多
关键词 心脏乳头状弹力纤维瘤 风湿性心脏病 心脏肿瘤 瓣膜置换 手术治疗
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成人心脏乳头状弹力纤维瘤的临床和超声心动图特征 被引量:10
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作者 韩建成 滕飞 +6 位作者 杨旭 孙琳 谷孝艳 张烨 赵映 高爽 何怡华 《中国医学影像技术》 CSCD 北大核心 2017年第10期1497-1500,共4页
目的探讨心脏乳头状弹力纤维瘤(CPF)的临床和超声心动图表现。方法回顾性分析经手术病理证实的13例CPF患者的临床表现、超声心动图特征、手术方式及预后。结果 13例患者临床表现不具特异性,为不同程度胸闷、气短等症状。所有肿瘤均为单... 目的探讨心脏乳头状弹力纤维瘤(CPF)的临床和超声心动图表现。方法回顾性分析经手术病理证实的13例CPF患者的临床表现、超声心动图特征、手术方式及预后。结果 13例患者临床表现不具特异性,为不同程度胸闷、气短等症状。所有肿瘤均为单发,位于瓣膜9例(9/13,69.23%),其中主动脉瓣4例、二尖瓣3例、三尖瓣2例;位于心腔4例(4/13,30.77%),其中右心房2例、右心室1例、左心室1例。肿瘤最大径>2mm者8例,最大径≤2mm者5例。超声检出8例,未检出5例。8例接受肿瘤切除,5例接受瓣膜置换术。结论 CPF临床表现不特异,当肿瘤体积较小时,超声心动图常无法发现;心脏瓣膜为其常见部位,尤其是主动脉瓣。CPF预后良好。 展开更多
关键词 心脏肿瘤 乳头状弹力纤维瘤 超声心动描记术
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10例心脏乳头状弹力纤维瘤临床病理分析 被引量:7
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作者 滕飞 陈东 +7 位作者 方微 商建峰 武迎 崔亚艳 付稳 石凤茹 李彦玮 连国亮 《心肺血管病杂志》 CAS 2015年第8期640-642,共3页
目的:探讨心脏乳头状弹力纤维瘤的临床病理特征、诊断和鉴别诊断、治疗及预后特点,为临床诊断及治疗提供依据。方法:采用HE染色、免疫组织化学及特殊染色技术对10例原发性心脏乳头状弹力纤维瘤进行形态学研究,回顾性分析其临床资料及病... 目的:探讨心脏乳头状弹力纤维瘤的临床病理特征、诊断和鉴别诊断、治疗及预后特点,为临床诊断及治疗提供依据。方法:采用HE染色、免疫组织化学及特殊染色技术对10例原发性心脏乳头状弹力纤维瘤进行形态学研究,回顾性分析其临床资料及病理学特征。结果:镜下见肿瘤呈细乳头状结构,乳头轴心由弹力纤维构成,表面被覆单层扁平或立方上皮细胞,免疫组化:乳头状表面被覆的上皮Vim和CD34(+),乳头轴心则S-100蛋白(+),弹力纤维染色(+)。结论:心脏乳头状弹力纤维瘤患者缺乏特征性临床症状和体征,易与心脏相关疾病混淆。组织病理学特点,免疫组化标记及特殊染色有助于肿瘤的诊断和鉴别诊断。 展开更多
关键词 病理学 弹力纤维瘤 原发性 心脏
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心脏非粘液性原发肿瘤的病理学研究 被引量:10
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作者 宋来凤 朱晓东 +2 位作者 吕凤英 司文学 王亚光 《中国循环杂志》 CSCD 1995年第2期103-105,共3页
我院1965年至1993年间,共检出心脏原发肿瘤236例,其中16例为非粘液性肿瘤,占同期心脏原发肿瘤的6.8%。包括脉管瘤7例,间叶细胞瘤5例,间皮细胞瘤、脂肪瘤、横纹肌肉瘤及纤维弹力瘤各1例。良性和恶性肿瘤各8例。
关键词 心脏肿瘤 原发性 间皮细胞瘤 病理学
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心脏乳头状弹力纤维瘤2例临床病理观察 被引量:3
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作者 张桃桃 张华 +2 位作者 张娇娇 南鹏飞 王鸿雁 《诊断病理学杂志》 2019年第1期19-21,共3页
目的探讨心脏乳头状弹力纤维瘤的临床病理特征、免疫组化、特殊染色及鉴别诊断。方法对2例心脏乳头状弹力纤维瘤进行组织学观察、免疫组化染色、弹力纤维染色和临床随访,并复习相关文献。结果 2例病理大体观察均呈灰白色、分叶乳头状,... 目的探讨心脏乳头状弹力纤维瘤的临床病理特征、免疫组化、特殊染色及鉴别诊断。方法对2例心脏乳头状弹力纤维瘤进行组织学观察、免疫组化染色、弹力纤维染色和临床随访,并复习相关文献。结果 2例病理大体观察均呈灰白色、分叶乳头状,在固定液中类似"海葵样";组织学形态表现一致,均呈乳头状结构,中心为纤维样轴心,周围包绕黏液样基质,表面被覆内皮细胞。免疫组化:表面被覆细胞CD34、CD31和vimentin均(+),CK、CR、CD117和D2-40(-),其中1例S-100(+);弹力纤维染色均(+)。结论心脏乳头状弹力纤维瘤是一种罕见的心脏良性肿瘤,组织病理学特点结合免疫组化标记及特殊染色有助于该肿瘤的确诊。 展开更多
关键词 乳头状弹力纤维瘤 心脏 免疫组化 特殊染色
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心脏乳头状弹力纤维瘤6例临床病理分析 被引量:3
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作者 刘建英 张真路 《临床肿瘤学杂志》 CAS 2014年第6期553-555,共3页
目的分析心脏乳头状弹力纤维瘤的临床病理学特征,为临床诊疗及判断预后提供依据。方法对我院10年间收治的6例心脏乳头状纤维瘤进行HE染色及弹力纤维EVG染色,回顾性分析其临床资料及病理学特征。结果肿瘤典型外观呈"海葵样"。... 目的分析心脏乳头状弹力纤维瘤的临床病理学特征,为临床诊疗及判断预后提供依据。方法对我院10年间收治的6例心脏乳头状纤维瘤进行HE染色及弹力纤维EVG染色,回顾性分析其临床资料及病理学特征。结果肿瘤典型外观呈"海葵样"。镜下呈分支细乳头状,表面被覆一层内皮细胞。弹力纤维染色可见较多弹力纤维。术后随访3个月~8年,6例患者均恢复情况良好,无复发。结论心脏乳头状弹力纤维瘤非常罕见,为心脏原发性良性肿瘤,好发于心脏瓣膜上;其临床症状缺乏特异性,临床诊断困难,但其组织形态学的特征典型,病理学检查易诊断。 展开更多
关键词 心脏乳头状弹力纤维瘤 临床表现 病理学特征
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心脏乳头状弹力纤维瘤的研究进展 被引量:1
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作者 刘佳霓 唐红 《中华老年多器官疾病杂志》 2013年第7期557-560,共4页
心脏乳头状弹力纤维瘤(PFEs)是一种罕见的良性心脏肿瘤,通常位于左心瓣膜上。PFEs对心脏血流动力学和瓣膜功能影响微弱,所以大多数患者无临床症状,但也可能会出现危及生命的并发症。PFEs在经胸超声心动图检查、心脏手术和尸检中偶... 心脏乳头状弹力纤维瘤(PFEs)是一种罕见的良性心脏肿瘤,通常位于左心瓣膜上。PFEs对心脏血流动力学和瓣膜功能影响微弱,所以大多数患者无临床症状,但也可能会出现危及生命的并发症。PFEs在经胸超声心动图检查、心脏手术和尸检中偶有发现。PFEs的治疗方法目前还存在争议。该病的发病率及危险因素尚无确切报道。随着超声心动检查技术的发展和普及,该病的检出率不断提高。 展开更多
关键词 心脏乳头状弹力纤维瘤 超声心动描记术 治疗
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肺动脉瓣乳头状弹力纤维瘤2例并文献复习
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作者 陆国梁 孙婷 +2 位作者 马伦超 黄杰周 谢少波 《临床医药实践》 2021年第10期761-763,共3页
目的:探讨心脏特殊位置乳头状弹力纤维瘤(PFE)的诊断、鉴别诊断要点及治疗方案。方法:回顾性分析2016年—2019年接受肺动脉瓣肿物切除并经术后病理证实为PFE的2例患者的临床表现、术前影像学检查特点及手术方式,并复习相关文献。结果:2... 目的:探讨心脏特殊位置乳头状弹力纤维瘤(PFE)的诊断、鉴别诊断要点及治疗方案。方法:回顾性分析2016年—2019年接受肺动脉瓣肿物切除并经术后病理证实为PFE的2例患者的临床表现、术前影像学检查特点及手术方式,并复习相关文献。结果:2例患者均合并其他心内畸形,临床表现无特异性,术前影像学检查未能正确诊断。2例均行肿物切除、肺动脉瓣成形术及同期心内畸形矫正,预后良好。结论:累及肺动脉瓣的PFE罕见,术前易误诊,一经诊断,建议手术切除。 展开更多
关键词 肺动脉瓣 乳头状弹力纤维瘤 心脏肿瘤
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主动脉瓣乳头状弹力纤维瘤1例报道并文献复习 被引量:7
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作者 于小华 吴波 +5 位作者 石群立 周晓军 孙桂勤 孟奎 马恒辉 盛春宁 《诊断病理学杂志》 CSCD 2004年第6期395-396,I103,共3页
目的 探讨发生于心脏瓣膜的乳头状弹力纤维瘤的临床和病理学特征 ,为临床治疗提供依据。方法 应用光镜、组织化学、免疫组化方法对 1例发生于主动脉瓣的乳头状弹力纤维瘤进行形态学研究并复习文献。结果 心脏的乳头状弹力纤维瘤临床... 目的 探讨发生于心脏瓣膜的乳头状弹力纤维瘤的临床和病理学特征 ,为临床治疗提供依据。方法 应用光镜、组织化学、免疫组化方法对 1例发生于主动脉瓣的乳头状弹力纤维瘤进行形态学研究并复习文献。结果 心脏的乳头状弹力纤维瘤临床上缺乏特征性的症状和体征。心动超声提示主动脉瓣异常回声。组织学 :瘤组织呈乳头状生长 ,乳头中央为红染均质物 ,表面衬覆单层立方或扁平上皮。免疫组化 :乳头状表面衬覆的上皮CD31和CD34(+) ,乳头轴心则CD117和S 10 0蛋白 (+) ,弹力纤维染色 (+)。结论 发生于心脏的乳头状弹力纤维瘤十分罕见 ,主要发生于瓣膜表面。尽管在病理学方面根据此肿瘤的发生部位及组织学形态不难做出诊断 ,但因其临床症状不典型 。 展开更多
关键词 乳头状 弹力纤维 主动脉瓣 上皮 文献复习 临床 心脏 回声 组织化学 缺乏
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心脏乳头状纤维弹力瘤临床特征及手术切除效果的初步分析 被引量:3
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作者 周晓辉 段雪晶 +4 位作者 刘睿 关强 张昌伟 王跃堂 王立清 《中国循环杂志》 CSCD 北大核心 2021年第6期601-605,共5页
目的:分析心脏乳头状纤维弹力瘤(CPF)的临床特征和手术切除效果。方法:回顾性分析中国医学科学院阜外医院2002年1月至2020年5月间33例外科手术切除的CPF患者的临床资料,探讨该肿瘤的临床特征和手术切除效果。结果:本组33例患者外科术后... 目的:分析心脏乳头状纤维弹力瘤(CPF)的临床特征和手术切除效果。方法:回顾性分析中国医学科学院阜外医院2002年1月至2020年5月间33例外科手术切除的CPF患者的临床资料,探讨该肿瘤的临床特征和手术切除效果。结果:本组33例患者外科术后均顺利出院。术后失访3例(9.10%),其余30例(90.90%)患者随访1~216个月,平均74.84个月,患者全部存活,无肿瘤复发。33例患者共有36处CPF起源,其中起源于瓣膜的CPF有26处(72.22%);起源于瓣膜的CPF中以二尖瓣为主(38.46%,10/26),其次为主动脉瓣和三尖瓣(均为26.92%,7/26),再次为肺动脉瓣(7.69%,2/26);2例患者为多处起源。结论:国人CPF多数起源于瓣膜表面,其中以二尖瓣为主。外科手术切除是CPF的有效治疗手段,中远期无复发。 展开更多
关键词 乳头状纤维弹力瘤 心脏肿瘤 临床特征 手术
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心脏乳头状纤维弹力瘤的临床病理分析 被引量:4
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作者 刘坦坦 王映梅 +1 位作者 王哲 李擒龙 《临床与病理杂志》 2018年第2期307-311,共5页
目的:探讨心脏乳头状纤维弹力瘤(papillary fibroelastoma,PFE)的临床病理特征、免疫表型、诊断与鉴别诊断、治疗及预后特点,以提高对其临床及病理改变的认识。方法:对中国人民解放军空军军医大学第一附属医院收治的5例心脏PFE患者的临... 目的:探讨心脏乳头状纤维弹力瘤(papillary fibroelastoma,PFE)的临床病理特征、免疫表型、诊断与鉴别诊断、治疗及预后特点,以提高对其临床及病理改变的认识。方法:对中国人民解放军空军军医大学第一附属医院收治的5例心脏PFE患者的临床资料及病理学特征进行回顾性分析与讨论;对石蜡包埋组织切片进行HE染色、免疫组织化学染色和特殊染色。结果:在镜下观察到肿瘤形成具有分支的复杂乳头状结构,表面衬覆单层扁平或立方上皮,乳头结构中央为致密的纤维结缔组织,中央外围含有不等量的黏液样物质;乳头表面上皮表达CD31,CD34及ERG,乳头轴心局灶表达S-100;乳头轴心弹力纤维染色(+),黏液样区域PAS(+),D-PAS(+)及AB(+)。结论:尽管心脏PFE具备特征性的形态学特征,但由于缺乏特异性临床症状和体征,故临床诊断困难。因此,该肿瘤的诊断依赖于组织病理学特点、免疫组织化学标志及特殊染色。 展开更多
关键词 心脏乳头状纤维弹力瘤 诊断 鉴别诊断
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