Counterfeiting of modern banknotes poses a significant challenge,prompting the use of various preventive measures.One such measure is the magnetic anti-counterfeiting strip.However,due to its inherent weak magnetic pr...Counterfeiting of modern banknotes poses a significant challenge,prompting the use of various preventive measures.One such measure is the magnetic anti-counterfeiting strip.However,due to its inherent weak magnetic properties,visualizing its magnetic distribution has been a longstanding challenge.In this work,we introduce an innovative method by using a fiber optic diamond probe,a highly sensitive quantum sensor designed specifically for detecting extremely weak magnetic fields.We employ this probe to achieve high-resolution imaging of the magnetic fields associated with the RMB 50denomination anti-counterfeiting strip.Additionally,we conduct computer simulations by using COMSOL Multiphysics software to deduce the potential geometric characteristics and material composition of the magnetic region within the anti-counterfeiting strip.The findings and method presented in this study hold broader significance,extending the RMB 50 denomination to various denominations of the Chinese currency and other items that employ magnetic anti-counterfeiting strips.These advances have the potential to significantly improve and promote security measures in order to prevent the banknotes from being counterfeited.展开更多
Although 9.4 T magnetic resonance imaging(MRI) has been tested in healthy volunteers,its safety in diabetic patients is unclear.Furthermore,the effects of high static magnetic fields(SMFs),especially gradient vs.unifo...Although 9.4 T magnetic resonance imaging(MRI) has been tested in healthy volunteers,its safety in diabetic patients is unclear.Furthermore,the effects of high static magnetic fields(SMFs),especially gradient vs.uniform fields,have not been investigated in diabetics.Here,we investigated the consequences of exposure to 1.0-9.4 T high SMFs of different gradients(>10 T/m vs.0-10 T/m)on type 1 diabetic(T1D) and type 2 diabetic(T2D) mice.We found that 14 h of prolonged treatment of gradient(as high as 55.5 T/m) high SMFs(1.0-8.6 T) had negative effects on T1D and T2D mice,including spleen,hepatic,and renal tissue impairment and elevated glycosylated serum protein,blood glucose,inflammation,and anxiety,while 9.4 T quasi-uniform SMFs at 0-10 T/m did not induce the same effects.In regular T1D mice(blood glucose>16.7 mmol/L),the>10 T/m gradient high SMFs increased malondialdehyde(P<0.01) and decreased superoxide dismutase(P<0.05).However,in the severe T1D mice(blood glucose≥30.0 mmol/L),the>10 T/m gradient high SMFs significantly increased tissue damage and reduced survival rate.In vitro cellular studies showed that gradient high SMFs increased cellular reactive oxygen species and apoptosis and reduced MS-1 cell number and proliferation.Therefore,this study showed that prolonged exposure to high-field(1.0-8.6 T)>10 T/m gradient SMFs(35-1 380 times higher than that of current clinical MRI)can have negative effects on diabetic mice,especially mice with severe T1D,whereas 9.4 T high SMFs at 0-10T/m did not produce the same effects,providing important information for the future development and clinical application of SMFs,especially high-field MRI.展开更多
Light field 3D display technology is considered a revolutionary technology to address the critical visual fatigue issues in the existing 3D displays.Tabletop light field 3D display provides a brand-new display form th...Light field 3D display technology is considered a revolutionary technology to address the critical visual fatigue issues in the existing 3D displays.Tabletop light field 3D display provides a brand-new display form that satisfies multi-user shared viewing and collaborative works,and it is poised to become a potential alternative to the traditional wall and portable display forms.However,a large radial viewing angle and correct radial perspective and parallax are still out of reach for most current tabletop light field 3D displays due to the limited amount of spatial information.To address the viewing angle and perspective issues,a novel integral imaging-based tabletop light field 3D display with a simple flat-panel structure is proposed and developed by applying a compound lens array,two spliced 8K liquid crystal display panels,and a light shaping diffuser screen.The compound lens array is designed to be composed of multiple three-piece compound lens units by employing a reverse design scheme,which greatly extends the radial viewing angle in the case of a limited amount of spatial information and balances other important 3D display parameters.The proposed display has a radial viewing angle of 68.7°in a large display size of 43.5 inches,which is larger than the conventional tabletop light field 3D displays.The radial perspective and parallax are correct,and high-resolution 3D images can be reproduced in large radial viewing positions.We envision that this proposed display opens up possibility for redefining the display forms of consumer electronics.展开更多
In this work a complete approach for estimation of the spatial resolution for the gamma camera imaging based on the [1] is analyzed considering where the body distance is detected (close or far way). The organ of inte...In this work a complete approach for estimation of the spatial resolution for the gamma camera imaging based on the [1] is analyzed considering where the body distance is detected (close or far way). The organ of interest most of the times is not well defined, so in that case it is appropriate to use elliptical camera detection instead of circular. The image reconstruction is presented which allows spatially varying amounts of local smoothing. An inhomogeneous Markov random field (M.r.f.) model is described which allows spatially varying degrees of smoothing in the reconstructions and a re-parameterization is proposed which implicitly introduces a local correlation structure in the smoothing parameters using a modified maximum likelihood estimation (MLE) denoted as one step late (OSL) introduced by [2].展开更多
Single-cell volumetric imaging is essential for researching individual characteristics of cells.As a nonscanning imaging technique,lighteld microscopy(LFM)is a critical tool to achieve realtime three-dimensional imagi...Single-cell volumetric imaging is essential for researching individual characteristics of cells.As a nonscanning imaging technique,lighteld microscopy(LFM)is a critical tool to achieve realtime three-dimensional imaging with the advantage of single-shot.To address the inherent limits including nonuniform resolution and block-wise artifacts,various modied LFM strategies have been developed to provide new insights into the structural and functional information of cells.This review will introduce the principle and development of LFM,discuss the improved approaches based on hardware designs and 3D reconstruction algorithms,and present the applications in single-cell imaging.展开更多
Multiple single nucleotide polymorphisms may contribute to cognitive decline in Parkinson’s disease. However, the mechanism by which these single nucleotide polymorphisms modify brain imaging phenotype remains unclea...Multiple single nucleotide polymorphisms may contribute to cognitive decline in Parkinson’s disease. However, the mechanism by which these single nucleotide polymorphisms modify brain imaging phenotype remains unclear. The aim of this study was to investigate the potential effects of multiple single nucleotide polymorphisms on brain imaging phenotype in Parkinson’s disease. Forty-eight Parkinson’s disease patients and 39 matched healthy controls underwent genotyping and 7 T magnetic resonance imaging. A cognitive-weighted polygenic risk score model was designed, in which the effect sizes were determined individually for 36 single nucleotide polymorphisms. The correlations between polygenic risk score, neuroimaging features, and clinical data were analyzed. Furthermore, individual single nucleotide polymorphism analysis was performed to explore the main effects of genotypes and their interactive effects with Parkinson’s disease diagnosis. We found that, in Parkinson’s disease, the polygenic risk score was correlated with the neural activity of the hippocampus, parahippocampus, and fusiform gyrus, and with hippocampal-prefrontal and fusiform-temporal connectivity, as well as with gray matter alterations in the orbitofrontal cortex. In addition, we found that single nucleotide polymorphisms in α-synuclein(SNCA) were associated with white matter microstructural changes in the superior corona radiata, corpus callosum, and external capsule. A single nucleotide polymorphism in catechol-O-methyltransferase was associated with the neural activities of the lingual, fusiform, and occipital gyri, which are involved in visual cognitive dysfunction. Furthermore, DRD3 was associated with frontal and temporal lobe function and structure. In conclusion, imaging genetics is useful for providing a better understanding of the genetic pathways involved in the pathophysiologic processes underlying Parkinson’s disease. This study provides evidence of an association between genetic factors, cognitive functions, and multi-modality neuroimaging biomarkers in Parkinson’s disease.展开更多
Microwave-induced thermoacoustic imaging(MTAI)has advantages including the large imaging depth,high imaging resolution,high imaging contrast,and fast imaging speed.The thermoacoustic(TA)group of South China Normal Uni...Microwave-induced thermoacoustic imaging(MTAI)has advantages including the large imaging depth,high imaging resolution,high imaging contrast,and fast imaging speed.The thermoacoustic(TA)group of South China Normal University has dedicated to developing TA imaging for more than a decade and has made many breakthroughs.This review introduces these breakthroughs from two aspects including the improvement in techniques and the exploration of applications.On the technological level,there are ultrashort microwave pulse(USMP)-inducedTA imaging that can improve the imaging resolution,nonlinear thermoacoustic imaging(NTAI)that can improve the imaging contrast,polarized microwave-inducedthermoacoustic imaging(P-MTAI)that can obtain cellular-level alignment information,and more convenient and accurate handheld and multimodal probes.On the application side,the optimization and expansion have been carried out,mainly concentrating on breast and myocardial imaging.Finally,several current research directions are introduced,including the application of P-MTAI on joint imaging and research on whole-body imaging of small animals.展开更多
Pedo-spectroscopy has the potential to provide valuable information about soil physical,chemical,and biological properties.Nowadays,wemay predict soil properties usingVNIRfield imaging spectra(IS)such as Prisma satell...Pedo-spectroscopy has the potential to provide valuable information about soil physical,chemical,and biological properties.Nowadays,wemay predict soil properties usingVNIRfield imaging spectra(IS)such as Prisma satellite data or laboratory spectra(LS).The primary goal of this study is to investigate machine learning models namely Partial Least Squares Regression(PLSR)and Support Vector Regression(SVR)for the prediction of several soil properties,including clay,sand,silt,organic matter,nitrate NO3-,and calcium carbonate CaCO_(3),using five VNIR spectra dataset combinations(%IS,%LS)as follows:C1(0%IS,100%LS),C2(20%IS,80%LS),C3(50%IS,50%LS),C4(80%IS,20%LS)and C5(100%IS,0%LS).Soil samples were collected at bare soils and at the upper(0–30 cm)layer.The data set has been split into a training dataset 80%of the collected data(n=248)and a validation dataset 20%of the collected data(n=61).The proposed PLSR and SVR models were trained then tested for each dataset combination.According to our results,SVR outperforms PLSR for both:C1(0%IS,100%LS)and C5(100%IS,0%LS).For Soil Organic Matter(SOM)prediction,it achieves(R^(2)=0.79%,RMSE=1.42%)and(R^(2)=0.76%,RMSE=1.3%),respectively.The data fusion has improved the soil property prediction.The highest improvement was obtained for the SOM property(R^(2)=0.80%,RMSE=1.39)when using the SVR model and applying the second Combination C2(20% of IS and 80%LS).展开更多
大豆含油率的高低直接影响榨油与育种结果。为探究大豆含油率的最佳检测方法与构建含油率高低判别模型,该研究基于不同维度低场核磁共振(low field nuclear magnetic resonance,LF-NMR)技术,以国标法为对照,利用LF-NMR波谱和LF-NMR含油...大豆含油率的高低直接影响榨油与育种结果。为探究大豆含油率的最佳检测方法与构建含油率高低判别模型,该研究基于不同维度低场核磁共振(low field nuclear magnetic resonance,LF-NMR)技术,以国标法为对照,利用LF-NMR波谱和LF-NMR含油含水率软件检测大豆含油率;核磁共振成像(magnetic resonance imaging,MRI)结合深度学习,建立大豆含油率高低判别模型。引入低场二维核磁共振(low field two-dimensional nuclear magnetic resonance,LF-2D-NMR)技术,定性分析一维波谱中信号重叠无法区分组分的问题。试验结果表明,LF-NMR含油含水率软件能快速准确检测大豆含油率,T1-T2二维核磁图谱成功解决了自由水和油信号重叠问题。利用U-net++深度学习模型对MRI成像的矢状面、冠状面、横截面以及三面混合数据集进行训练,其中横截面评价指标与其他数据集相比更优,语义分割部分中平均交并比(mean intersection over union,mIoU)约0.9058,全局准确率0.9980,训练后的模型能够将MRI图像识别并分割,快速判别大豆含油率高低。试验证明,LF-NMR及MRI能够快速无损掌握大豆含油率信息,为大豆的高油育种提供了新思路和技术支持。展开更多
基金Project supported by the National Key Research and Development Program of China (Grant No.2021YFB2012600)the Shanghai Aerospace Science and Technology Innovation Fund,China (Grant No.SAST-2022-102)。
文摘Counterfeiting of modern banknotes poses a significant challenge,prompting the use of various preventive measures.One such measure is the magnetic anti-counterfeiting strip.However,due to its inherent weak magnetic properties,visualizing its magnetic distribution has been a longstanding challenge.In this work,we introduce an innovative method by using a fiber optic diamond probe,a highly sensitive quantum sensor designed specifically for detecting extremely weak magnetic fields.We employ this probe to achieve high-resolution imaging of the magnetic fields associated with the RMB 50denomination anti-counterfeiting strip.Additionally,we conduct computer simulations by using COMSOL Multiphysics software to deduce the potential geometric characteristics and material composition of the magnetic region within the anti-counterfeiting strip.The findings and method presented in this study hold broader significance,extending the RMB 50 denomination to various denominations of the Chinese currency and other items that employ magnetic anti-counterfeiting strips.These advances have the potential to significantly improve and promote security measures in order to prevent the banknotes from being counterfeited.
基金supported by the National Natural Science Foundation of China (U21A20148, 31900506, 52007185)International Partnership Program of the Chinese Academy of Sciences(116134KYSB20210052)+2 种基金Heye Health Technology Chong Ming Project(HYCMP2021010)CAS President’s International Fellowship Initiative Grant(2022VMA0009)CASHIPS Director’s Fund (BJPY2021A06,2021YZGH04, YZJJ2020QN26, YZJJZX202014, YZJJ2021QN32,YZJJ2023QN43)。
文摘Although 9.4 T magnetic resonance imaging(MRI) has been tested in healthy volunteers,its safety in diabetic patients is unclear.Furthermore,the effects of high static magnetic fields(SMFs),especially gradient vs.uniform fields,have not been investigated in diabetics.Here,we investigated the consequences of exposure to 1.0-9.4 T high SMFs of different gradients(>10 T/m vs.0-10 T/m)on type 1 diabetic(T1D) and type 2 diabetic(T2D) mice.We found that 14 h of prolonged treatment of gradient(as high as 55.5 T/m) high SMFs(1.0-8.6 T) had negative effects on T1D and T2D mice,including spleen,hepatic,and renal tissue impairment and elevated glycosylated serum protein,blood glucose,inflammation,and anxiety,while 9.4 T quasi-uniform SMFs at 0-10 T/m did not induce the same effects.In regular T1D mice(blood glucose>16.7 mmol/L),the>10 T/m gradient high SMFs increased malondialdehyde(P<0.01) and decreased superoxide dismutase(P<0.05).However,in the severe T1D mice(blood glucose≥30.0 mmol/L),the>10 T/m gradient high SMFs significantly increased tissue damage and reduced survival rate.In vitro cellular studies showed that gradient high SMFs increased cellular reactive oxygen species and apoptosis and reduced MS-1 cell number and proliferation.Therefore,this study showed that prolonged exposure to high-field(1.0-8.6 T)>10 T/m gradient SMFs(35-1 380 times higher than that of current clinical MRI)can have negative effects on diabetic mice,especially mice with severe T1D,whereas 9.4 T high SMFs at 0-10T/m did not produce the same effects,providing important information for the future development and clinical application of SMFs,especially high-field MRI.
基金We are grateful for financial supports from National Key R&D Program of China(Grant No.2021YFB2802300)the National Natural Science Foundation of China(Grant Nos.62105014,62105016,and 62020106010)。
文摘Light field 3D display technology is considered a revolutionary technology to address the critical visual fatigue issues in the existing 3D displays.Tabletop light field 3D display provides a brand-new display form that satisfies multi-user shared viewing and collaborative works,and it is poised to become a potential alternative to the traditional wall and portable display forms.However,a large radial viewing angle and correct radial perspective and parallax are still out of reach for most current tabletop light field 3D displays due to the limited amount of spatial information.To address the viewing angle and perspective issues,a novel integral imaging-based tabletop light field 3D display with a simple flat-panel structure is proposed and developed by applying a compound lens array,two spliced 8K liquid crystal display panels,and a light shaping diffuser screen.The compound lens array is designed to be composed of multiple three-piece compound lens units by employing a reverse design scheme,which greatly extends the radial viewing angle in the case of a limited amount of spatial information and balances other important 3D display parameters.The proposed display has a radial viewing angle of 68.7°in a large display size of 43.5 inches,which is larger than the conventional tabletop light field 3D displays.The radial perspective and parallax are correct,and high-resolution 3D images can be reproduced in large radial viewing positions.We envision that this proposed display opens up possibility for redefining the display forms of consumer electronics.
文摘In this work a complete approach for estimation of the spatial resolution for the gamma camera imaging based on the [1] is analyzed considering where the body distance is detected (close or far way). The organ of interest most of the times is not well defined, so in that case it is appropriate to use elliptical camera detection instead of circular. The image reconstruction is presented which allows spatially varying amounts of local smoothing. An inhomogeneous Markov random field (M.r.f.) model is described which allows spatially varying degrees of smoothing in the reconstructions and a re-parameterization is proposed which implicitly introduces a local correlation structure in the smoothing parameters using a modified maximum likelihood estimation (MLE) denoted as one step late (OSL) introduced by [2].
基金This paper was supported by Shenzhen Science and Technology Innovation grants(JCYJ20200109115633343,JCYJ20210324123610030).
文摘Single-cell volumetric imaging is essential for researching individual characteristics of cells.As a nonscanning imaging technique,lighteld microscopy(LFM)is a critical tool to achieve realtime three-dimensional imaging with the advantage of single-shot.To address the inherent limits including nonuniform resolution and block-wise artifacts,various modied LFM strategies have been developed to provide new insights into the structural and functional information of cells.This review will introduce the principle and development of LFM,discuss the improved approaches based on hardware designs and 3D reconstruction algorithms,and present the applications in single-cell imaging.
基金supported by grants from the National Natural Science Foundation of China,Nos. 81771216 (to JLP), 81520108010 (to BRZ),and 82101323 (to TS)the National Key R&D Program of China,No. 2018YFA0701400 (to HYL)+3 种基金the Primary Research and Development Plan of Zhejiang Province,No. 2020C03020 (to BRZ)the Key Project of Zhejiang Laboratory,No. 2018EB0ZX01 (to HYL)the Fundamental Research Funds for the Central Universities,No. 2019XZZX001-01-21 (to HYL)Preferred Foundation of Zhejiang Postdoctors,No. ZJ2021152 (to TS)。
文摘Multiple single nucleotide polymorphisms may contribute to cognitive decline in Parkinson’s disease. However, the mechanism by which these single nucleotide polymorphisms modify brain imaging phenotype remains unclear. The aim of this study was to investigate the potential effects of multiple single nucleotide polymorphisms on brain imaging phenotype in Parkinson’s disease. Forty-eight Parkinson’s disease patients and 39 matched healthy controls underwent genotyping and 7 T magnetic resonance imaging. A cognitive-weighted polygenic risk score model was designed, in which the effect sizes were determined individually for 36 single nucleotide polymorphisms. The correlations between polygenic risk score, neuroimaging features, and clinical data were analyzed. Furthermore, individual single nucleotide polymorphism analysis was performed to explore the main effects of genotypes and their interactive effects with Parkinson’s disease diagnosis. We found that, in Parkinson’s disease, the polygenic risk score was correlated with the neural activity of the hippocampus, parahippocampus, and fusiform gyrus, and with hippocampal-prefrontal and fusiform-temporal connectivity, as well as with gray matter alterations in the orbitofrontal cortex. In addition, we found that single nucleotide polymorphisms in α-synuclein(SNCA) were associated with white matter microstructural changes in the superior corona radiata, corpus callosum, and external capsule. A single nucleotide polymorphism in catechol-O-methyltransferase was associated with the neural activities of the lingual, fusiform, and occipital gyri, which are involved in visual cognitive dysfunction. Furthermore, DRD3 was associated with frontal and temporal lobe function and structure. In conclusion, imaging genetics is useful for providing a better understanding of the genetic pathways involved in the pathophysiologic processes underlying Parkinson’s disease. This study provides evidence of an association between genetic factors, cognitive functions, and multi-modality neuroimaging biomarkers in Parkinson’s disease.
文摘Microwave-induced thermoacoustic imaging(MTAI)has advantages including the large imaging depth,high imaging resolution,high imaging contrast,and fast imaging speed.The thermoacoustic(TA)group of South China Normal University has dedicated to developing TA imaging for more than a decade and has made many breakthroughs.This review introduces these breakthroughs from two aspects including the improvement in techniques and the exploration of applications.On the technological level,there are ultrashort microwave pulse(USMP)-inducedTA imaging that can improve the imaging resolution,nonlinear thermoacoustic imaging(NTAI)that can improve the imaging contrast,polarized microwave-inducedthermoacoustic imaging(P-MTAI)that can obtain cellular-level alignment information,and more convenient and accurate handheld and multimodal probes.On the application side,the optimization and expansion have been carried out,mainly concentrating on breast and myocardial imaging.Finally,several current research directions are introduced,including the application of P-MTAI on joint imaging and research on whole-body imaging of small animals.
基金supported by Princess Nourah bint Abdulrahman University Researchers Supporting Project number (PNURSP2023R196),Princess Nourah bint Abdulrahman University,Riyadh,Saudi Arabia.
文摘Pedo-spectroscopy has the potential to provide valuable information about soil physical,chemical,and biological properties.Nowadays,wemay predict soil properties usingVNIRfield imaging spectra(IS)such as Prisma satellite data or laboratory spectra(LS).The primary goal of this study is to investigate machine learning models namely Partial Least Squares Regression(PLSR)and Support Vector Regression(SVR)for the prediction of several soil properties,including clay,sand,silt,organic matter,nitrate NO3-,and calcium carbonate CaCO_(3),using five VNIR spectra dataset combinations(%IS,%LS)as follows:C1(0%IS,100%LS),C2(20%IS,80%LS),C3(50%IS,50%LS),C4(80%IS,20%LS)and C5(100%IS,0%LS).Soil samples were collected at bare soils and at the upper(0–30 cm)layer.The data set has been split into a training dataset 80%of the collected data(n=248)and a validation dataset 20%of the collected data(n=61).The proposed PLSR and SVR models were trained then tested for each dataset combination.According to our results,SVR outperforms PLSR for both:C1(0%IS,100%LS)and C5(100%IS,0%LS).For Soil Organic Matter(SOM)prediction,it achieves(R^(2)=0.79%,RMSE=1.42%)and(R^(2)=0.76%,RMSE=1.3%),respectively.The data fusion has improved the soil property prediction.The highest improvement was obtained for the SOM property(R^(2)=0.80%,RMSE=1.39)when using the SVR model and applying the second Combination C2(20% of IS and 80%LS).
文摘大豆含油率的高低直接影响榨油与育种结果。为探究大豆含油率的最佳检测方法与构建含油率高低判别模型,该研究基于不同维度低场核磁共振(low field nuclear magnetic resonance,LF-NMR)技术,以国标法为对照,利用LF-NMR波谱和LF-NMR含油含水率软件检测大豆含油率;核磁共振成像(magnetic resonance imaging,MRI)结合深度学习,建立大豆含油率高低判别模型。引入低场二维核磁共振(low field two-dimensional nuclear magnetic resonance,LF-2D-NMR)技术,定性分析一维波谱中信号重叠无法区分组分的问题。试验结果表明,LF-NMR含油含水率软件能快速准确检测大豆含油率,T1-T2二维核磁图谱成功解决了自由水和油信号重叠问题。利用U-net++深度学习模型对MRI成像的矢状面、冠状面、横截面以及三面混合数据集进行训练,其中横截面评价指标与其他数据集相比更优,语义分割部分中平均交并比(mean intersection over union,mIoU)约0.9058,全局准确率0.9980,训练后的模型能够将MRI图像识别并分割,快速判别大豆含油率高低。试验证明,LF-NMR及MRI能够快速无损掌握大豆含油率信息,为大豆的高油育种提供了新思路和技术支持。