While newer,more efficient Lithium-ion batteries(LIBs)and extinguishing agents have been developed to reduce the occurrence of thermal runaway accidents,there is still a scarcity of research focused on the application...While newer,more efficient Lithium-ion batteries(LIBs)and extinguishing agents have been developed to reduce the occurrence of thermal runaway accidents,there is still a scarcity of research focused on the application of surfactants in different LIBs extinguishing agents,particularly in terms of patented technologies.The aim of this review paper is to provide an overview of the technological progress of LIBs and LIBs extinguishing agents in terms of patents in Korea,Japan,Europe,the United States,China,etc.The initial part of this review paper is sort out LIBs technology development in different regions.In addition,to compare LIBs extinguishing agent progress and challenges of liquid,solid,combination of multiple,and microencapsulated.The subsequent section of this review focuses on an in-depth analysis dedicated to the efficiency and challenges faced by the surfactants corresponding design principles of LIBs extinguishing agents,such as nonionic and anionic surfactants.A total of 451,760 LIBs-related patent and 20 LIBs-fire-extinguishing agent-related patent were included in the analyses.The extinguishing effect,cooling performance,and anti-recombustion on different agents have been highlighted.After a comprehensive comparison of these agents,this review suggests that temperature-sensitive hydrogel extinguishing agent is ideal for the effective control of LIBs fire.The progress and challenges of surfactants have been extensively examined,focusing on key factors such as surface activity,thermal stability,foaming properties,environmental friendliness,and electrical conductivity.Moreover,it is crucial to emphasize that the selection of a suitable surfactant must align with the extinguishing strategy of the extinguishing agent for optimal firefighting effectiveness.展开更多
The laser-guided bomb(LGB)is an air-to-ground pre-cision-guided weapon that offers high hit rates,great power,and ease of use.LGBs are guided by semi-active laser ground-seek-ing technology,which means that atmospheri...The laser-guided bomb(LGB)is an air-to-ground pre-cision-guided weapon that offers high hit rates,great power,and ease of use.LGBs are guided by semi-active laser ground-seek-ing technology,which means that atmospheric conditions can affect their accuracy.The spatial release region(SRR)of LGBs is difficult to calculate precisely,especially when there is a poor field of view.This can result in a lower real hit probability.To increase the hit probability of LGBs in tough atmospheric situa-tions,a novel method for calculating the SRR has been pro-posed.This method is based on the transmittance model of the 1.06μm laser in atmospheric species and the laser diffuse reflection model of the target surface to determine the capture target time of the laser seeker.Then,it calculates the boundary ballistic space starting position by ballistic model and gets the spatial scope of the spatial release region.This method can determine the release region of LGBs based on flight test data such as instantaneous velocity,altitude,off-axis angle,and atmospheric visibility.By more effectively employing aircraft release conditions,atmospheric visibility and other factors,the SRR calculation method can improve LGB hit probabi-lity by 9.2%.展开更多
Safety issue of lithium-ion batteries(LIBs)such as fires and explosions is a significant challenge for their large scale applications.Considering the continuously increased battery energy density and wider large-scale...Safety issue of lithium-ion batteries(LIBs)such as fires and explosions is a significant challenge for their large scale applications.Considering the continuously increased battery energy density and wider large-scale battery pack applications,the possibility of LIBs fire significantly increases.Because of the fast burning and the easy re-ignition characteristics of LIBs,achieving an efficient and prompt LIBs fire suppression is critical for minimizing the fire hazards.Different from conventional fire hazards,the LIBs fire shows complicated and comprehensive characteristics,and an effective and suitable fire-extinguishing agent particularly designed for LIBs is highly desirable.Considerable efforts have been devoted to this topic,to the best of our knowledge,a comprehensive review on this regard is still rare.Moreover,in practice,a guidance for the design and selections of a proper fire-extinguishing agent for LIBs is urgently needed.Herein,the special mechanisms and characteristics for LIBs fire and the corresponding design principles for LIBs fire-extinguishing agent were introduced.It is revealed that a fire-extinguishing agent developed for LIBs fire will most likely need a high heat capacity,high wetting,low viscosity and low electrical conductivity.After a comprehensive comparison of these agents in terms of these performances,water-based fire-extinguishing agents show best.Several typical fire-extinguishing agents such as gaseous agents,dry powders,water-based and aerosol fire-extinguishing agents were then introduced,and their fire extinguishment mechanisms were presented.Finally,their effectiveness in suppressing the fire were summarized.Water-based fire-extinguishing agents possess high cooling capacity and excellent anti-reflash performance for the fire.We believe this review could shed light on developing an efficient fire-extinguishing agent particularly designed for LIBs.展开更多
Based on the testing restult of character of forest fire, with the aid mold of flameextinguishing and mathematical method, the combustion of the forest fuels and the energy transtfer under the convention condition wer...Based on the testing restult of character of forest fire, with the aid mold of flameextinguishing and mathematical method, the combustion of the forest fuels and the energy transtfer under the convention condition were studied and the mechanism and interrelated elements of flameextinguishing with high velocity airflow were given. The energy formulae is given:Nz =Ka0 L0 (15)GH/102η through combustion calculation and test revision This formula was checked through simulated testing for extinguishing low, medial and high intensity fires with high velocity airflow.展开更多
The buried village is Vinh Moc where more than 1200 Vietnamese, including soldiers, who lived underground during the Vietnam War (1965 to 1972) were hand dug into red basalt bedrock. The Vinh Moc Village was strategic...The buried village is Vinh Moc where more than 1200 Vietnamese, including soldiers, who lived underground during the Vietnam War (1965 to 1972) were hand dug into red basalt bedrock. The Vinh Moc Village was strategically located on the border of North Vietnam and South Vietnam approximately 14 km north of the DMZ and along the shoreline of the South China Sea. During the Vietnam War, the US Air Force heavily bombed Vinh Moc. The North Vietnamese Army (NVA) had an important military base on nearby Con Co Island. Brave civil volunteers from Vinh Moc would make the 28 km dangerous journey to the island, disguised as fishermen, to deliver supplies to the soldiers stationed there. The people who remained at Vinh Moc dug tunnels into red basalt hills in order to survive this onslaught. The American forces assessed the villagers of Vinh Moc were supplying food and armaments to the NVA garrison on the island of Con Co, which was in turn hindering the American bombers on their way to bomb Hanoi. The US military objective was to force the villagers of Vinh Moc to leave the area. The villagers initially dug the tunnels to a 10 m depth but the American forces designed bombs that burrowed down 10 m before exploding. The soil tunnels were then deepened to 30 m to provide safety for the soldiers and civilians working there during the intense US Air Force bombing. The primary objective of the research study was to determine how the soils and parent material of Vinh Moc Village, protected their villagers from the United States Air Force bombardment during the Vietnam War. In addition, the natural parent material at both the Vinh Moc and Cu Chi were assessed to determine why the tunnels were so resilient. The Cu Chi and Iron Triangle soil tunnels were dug by hand in the Old Alluvium soils and parent material where iron in solution precipitated and became the soil binding material. The Vinh Moc tunnels were hand dug in porous, red basalt (bedrock) hills where the consolidated rock structure itself provided the required binding material. Neither site needed support beams to hold up the ceilings.展开更多
BACKGROUND The carcinogenesis of stomach adenocarcinoma(STAD)involves many different molecules and multiple pathways,including the NOTCH signaling pathway.As a key factor that functions as a critical link in the NOTCH...BACKGROUND The carcinogenesis of stomach adenocarcinoma(STAD)involves many different molecules and multiple pathways,including the NOTCH signaling pathway.As a key factor that functions as a critical link in the NOTCH pathway,mind bomb 1(MIB1)is upregulated in various tumors and has been reported to promote cell metastasis and invasion.However,studies on the role of MIB1 in STAD are limited.Here,we evaluated the prognostic value of MIB1 in STAD and its association with immune infiltration and copy number variation.AIM To elucidate the relationship between MIB1 gene and gastric cancer(GC)and provide a new idea for the treatment of GC.METHODS We identified mutations in the MIB1 gene by searching the cBioPortal database and then analyzed their relationship with the overall survival rate and diseasefree survival rate using the Kaplan-Meier method.The Cancer Genome Atlas(TCGA)database provided transcript levels for MIB1 in STADs and normal tissues.As a method of distinguishing the STAD tissues from adjacent normal tissues,a receiver operating characteristic(ROC)curve was generated.Kaplan-Meier plotter was used to determine the effect of MIB1 expression on survival.Based on the LinkedOmics database,we were able to identify the coexpressed genes of the MIB1 gene,the top 50 positively correlated genes,and the top 50 negatively correlated genes.STRING was used to construct protein-protein interaction networks related to the MIB1 gene.An analysis of functional enrichment was carried out using the R package“Cluster Profiler”.The relationships between mRNA expression of MIB1 and immune infiltrates were assessed by Tumor IMmune Estimation Resource(TIMER)and the“GSVA package”in R.RESULTS According to the cBioPortal database,the MIB1 mutation rate in 287 patients in the TCGA dataset was approximately 6%.Kaplan-Meier survival analysis showed that patients with STAD in the mutated group had a worse prognosis than those in the unmutated group(P=0.0156).There was a significant upregulation of MIB1 expression in STAD tissues compared to adjacent normal tissues.A high T stage was associated with increased MIB1 mRNA expression.The ROC curve analysis revealed 59.4%sensitivity and 85.6%specificity of MIB1 for differentiating STAD tissues from adjacent normal tissues at a truncation level of 2.248.Kaplan-Meier plotter indicated that patients with higher MIB1 levels had a worse prognosis than those with lower levels(26.4 mo vs 56.2 mo,P=0.0330).A correlation analysis demonstrated an association between immune infiltrates and MIB1 mRNA expression.CONCLUSION Upregulation of MIB1 expression is significantly associated with poor survival rate and immune infiltration in gastric adenocarcinoma.MIB1 may be a biomarker for the poor prognosis of STAD patients and a potential immunotherapeutic target.展开更多
基金supported by the National Key Research and Development Program of China (No.2017YFC0804700)the Opening Project of State Key Laboratory of Explosion Science and Technology,Beijing Institute of Technology (No.KFJJ23-23M)。
文摘While newer,more efficient Lithium-ion batteries(LIBs)and extinguishing agents have been developed to reduce the occurrence of thermal runaway accidents,there is still a scarcity of research focused on the application of surfactants in different LIBs extinguishing agents,particularly in terms of patented technologies.The aim of this review paper is to provide an overview of the technological progress of LIBs and LIBs extinguishing agents in terms of patents in Korea,Japan,Europe,the United States,China,etc.The initial part of this review paper is sort out LIBs technology development in different regions.In addition,to compare LIBs extinguishing agent progress and challenges of liquid,solid,combination of multiple,and microencapsulated.The subsequent section of this review focuses on an in-depth analysis dedicated to the efficiency and challenges faced by the surfactants corresponding design principles of LIBs extinguishing agents,such as nonionic and anionic surfactants.A total of 451,760 LIBs-related patent and 20 LIBs-fire-extinguishing agent-related patent were included in the analyses.The extinguishing effect,cooling performance,and anti-recombustion on different agents have been highlighted.After a comprehensive comparison of these agents,this review suggests that temperature-sensitive hydrogel extinguishing agent is ideal for the effective control of LIBs fire.The progress and challenges of surfactants have been extensively examined,focusing on key factors such as surface activity,thermal stability,foaming properties,environmental friendliness,and electrical conductivity.Moreover,it is crucial to emphasize that the selection of a suitable surfactant must align with the extinguishing strategy of the extinguishing agent for optimal firefighting effectiveness.
基金This work was supported by the major research projects within the military-international class(JY2021B077).
文摘The laser-guided bomb(LGB)is an air-to-ground pre-cision-guided weapon that offers high hit rates,great power,and ease of use.LGBs are guided by semi-active laser ground-seek-ing technology,which means that atmospheric conditions can affect their accuracy.The spatial release region(SRR)of LGBs is difficult to calculate precisely,especially when there is a poor field of view.This can result in a lower real hit probability.To increase the hit probability of LGBs in tough atmospheric situa-tions,a novel method for calculating the SRR has been pro-posed.This method is based on the transmittance model of the 1.06μm laser in atmospheric species and the laser diffuse reflection model of the target surface to determine the capture target time of the laser seeker.Then,it calculates the boundary ballistic space starting position by ballistic model and gets the spatial scope of the spatial release region.This method can determine the release region of LGBs based on flight test data such as instantaneous velocity,altitude,off-axis angle,and atmospheric visibility.By more effectively employing aircraft release conditions,atmospheric visibility and other factors,the SRR calculation method can improve LGB hit probabi-lity by 9.2%.
基金This work was supported by the National Key Research and Development Program of China(grant number 2017YFC0804700)the National Key Research and Development Program(2019YFC0810703)the National Natural Science Foundation of China(grant number 51874041).
文摘Safety issue of lithium-ion batteries(LIBs)such as fires and explosions is a significant challenge for their large scale applications.Considering the continuously increased battery energy density and wider large-scale battery pack applications,the possibility of LIBs fire significantly increases.Because of the fast burning and the easy re-ignition characteristics of LIBs,achieving an efficient and prompt LIBs fire suppression is critical for minimizing the fire hazards.Different from conventional fire hazards,the LIBs fire shows complicated and comprehensive characteristics,and an effective and suitable fire-extinguishing agent particularly designed for LIBs is highly desirable.Considerable efforts have been devoted to this topic,to the best of our knowledge,a comprehensive review on this regard is still rare.Moreover,in practice,a guidance for the design and selections of a proper fire-extinguishing agent for LIBs is urgently needed.Herein,the special mechanisms and characteristics for LIBs fire and the corresponding design principles for LIBs fire-extinguishing agent were introduced.It is revealed that a fire-extinguishing agent developed for LIBs fire will most likely need a high heat capacity,high wetting,low viscosity and low electrical conductivity.After a comprehensive comparison of these agents in terms of these performances,water-based fire-extinguishing agents show best.Several typical fire-extinguishing agents such as gaseous agents,dry powders,water-based and aerosol fire-extinguishing agents were then introduced,and their fire extinguishment mechanisms were presented.Finally,their effectiveness in suppressing the fire were summarized.Water-based fire-extinguishing agents possess high cooling capacity and excellent anti-reflash performance for the fire.We believe this review could shed light on developing an efficient fire-extinguishing agent particularly designed for LIBs.
文摘Based on the testing restult of character of forest fire, with the aid mold of flameextinguishing and mathematical method, the combustion of the forest fuels and the energy transtfer under the convention condition were studied and the mechanism and interrelated elements of flameextinguishing with high velocity airflow were given. The energy formulae is given:Nz =Ka0 L0 (15)GH/102η through combustion calculation and test revision This formula was checked through simulated testing for extinguishing low, medial and high intensity fires with high velocity airflow.
文摘The buried village is Vinh Moc where more than 1200 Vietnamese, including soldiers, who lived underground during the Vietnam War (1965 to 1972) were hand dug into red basalt bedrock. The Vinh Moc Village was strategically located on the border of North Vietnam and South Vietnam approximately 14 km north of the DMZ and along the shoreline of the South China Sea. During the Vietnam War, the US Air Force heavily bombed Vinh Moc. The North Vietnamese Army (NVA) had an important military base on nearby Con Co Island. Brave civil volunteers from Vinh Moc would make the 28 km dangerous journey to the island, disguised as fishermen, to deliver supplies to the soldiers stationed there. The people who remained at Vinh Moc dug tunnels into red basalt hills in order to survive this onslaught. The American forces assessed the villagers of Vinh Moc were supplying food and armaments to the NVA garrison on the island of Con Co, which was in turn hindering the American bombers on their way to bomb Hanoi. The US military objective was to force the villagers of Vinh Moc to leave the area. The villagers initially dug the tunnels to a 10 m depth but the American forces designed bombs that burrowed down 10 m before exploding. The soil tunnels were then deepened to 30 m to provide safety for the soldiers and civilians working there during the intense US Air Force bombing. The primary objective of the research study was to determine how the soils and parent material of Vinh Moc Village, protected their villagers from the United States Air Force bombardment during the Vietnam War. In addition, the natural parent material at both the Vinh Moc and Cu Chi were assessed to determine why the tunnels were so resilient. The Cu Chi and Iron Triangle soil tunnels were dug by hand in the Old Alluvium soils and parent material where iron in solution precipitated and became the soil binding material. The Vinh Moc tunnels were hand dug in porous, red basalt (bedrock) hills where the consolidated rock structure itself provided the required binding material. Neither site needed support beams to hold up the ceilings.
基金Supported by the Science and Technology Program of Liaoning Province,No.2021-MS-040.
文摘BACKGROUND The carcinogenesis of stomach adenocarcinoma(STAD)involves many different molecules and multiple pathways,including the NOTCH signaling pathway.As a key factor that functions as a critical link in the NOTCH pathway,mind bomb 1(MIB1)is upregulated in various tumors and has been reported to promote cell metastasis and invasion.However,studies on the role of MIB1 in STAD are limited.Here,we evaluated the prognostic value of MIB1 in STAD and its association with immune infiltration and copy number variation.AIM To elucidate the relationship between MIB1 gene and gastric cancer(GC)and provide a new idea for the treatment of GC.METHODS We identified mutations in the MIB1 gene by searching the cBioPortal database and then analyzed their relationship with the overall survival rate and diseasefree survival rate using the Kaplan-Meier method.The Cancer Genome Atlas(TCGA)database provided transcript levels for MIB1 in STADs and normal tissues.As a method of distinguishing the STAD tissues from adjacent normal tissues,a receiver operating characteristic(ROC)curve was generated.Kaplan-Meier plotter was used to determine the effect of MIB1 expression on survival.Based on the LinkedOmics database,we were able to identify the coexpressed genes of the MIB1 gene,the top 50 positively correlated genes,and the top 50 negatively correlated genes.STRING was used to construct protein-protein interaction networks related to the MIB1 gene.An analysis of functional enrichment was carried out using the R package“Cluster Profiler”.The relationships between mRNA expression of MIB1 and immune infiltrates were assessed by Tumor IMmune Estimation Resource(TIMER)and the“GSVA package”in R.RESULTS According to the cBioPortal database,the MIB1 mutation rate in 287 patients in the TCGA dataset was approximately 6%.Kaplan-Meier survival analysis showed that patients with STAD in the mutated group had a worse prognosis than those in the unmutated group(P=0.0156).There was a significant upregulation of MIB1 expression in STAD tissues compared to adjacent normal tissues.A high T stage was associated with increased MIB1 mRNA expression.The ROC curve analysis revealed 59.4%sensitivity and 85.6%specificity of MIB1 for differentiating STAD tissues from adjacent normal tissues at a truncation level of 2.248.Kaplan-Meier plotter indicated that patients with higher MIB1 levels had a worse prognosis than those with lower levels(26.4 mo vs 56.2 mo,P=0.0330).A correlation analysis demonstrated an association between immune infiltrates and MIB1 mRNA expression.CONCLUSION Upregulation of MIB1 expression is significantly associated with poor survival rate and immune infiltration in gastric adenocarcinoma.MIB1 may be a biomarker for the poor prognosis of STAD patients and a potential immunotherapeutic target.