Cyclin-dependent kinase 5(Cdk5) is a member of the serine-threonine kinase family of cyclin-dependent kinases. Cdk5 is critical to normal mammalian nervous system development and plays important regulatory roles in ...Cyclin-dependent kinase 5(Cdk5) is a member of the serine-threonine kinase family of cyclin-dependent kinases. Cdk5 is critical to normal mammalian nervous system development and plays important regulatory roles in multiple cellular functions. Recent evidence indicates that Cdk5 is inappropriately activated in several neurodegenerative conditions, including Parkinson's disease(PD). PD is a chronic neurodegenerative disorder characterized by the loss of dopamine neurons in the substantia nigra, decreased striatal dopamine levels, and consequent extrapyramidal motor dysfunction. During neurotoxicity, p35 is cleaved to form p25. Binding of p25 with Cdk5 leads deregulation of Cdk5 resulting in number of neurodegenerative pathologies. To date, strategies to specifically inhibit Cdk5 hyperactivity have not been successful without affecting normal Cdk5 activity. Here we show that inhibition of p25/Cdk5 hyperactivation through TFP5/TP5, truncated 24-aa peptide derived from the Cdk5 activator p35 rescues nigrostriatal dopaminergic neurodegeneration induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP/MPP+) in a mouse model of PD. TP5 peptide treatment also blocked dopamine depletion in the striatum and improved gait dysfunction after MPTP administration. The neuroprotective effect of TFP5/TP5 peptide is also associated with marked reduction in neuroinflammation and apoptosis. Here we show inhibition of Cdk5/p25-hyperactivation by TFP5/TP5 peptide, which identifies Cdk5/p25 as a potential therapeutic target to reduce neurodegeneration in PD.展开更多
Most studies on environmental policy and total factor productivity(TFP)growth under the heterogeneity framework tend to ignore the distance to the technical frontier,while research that investigates TFP growth based o...Most studies on environmental policy and total factor productivity(TFP)growth under the heterogeneity framework tend to ignore the distance to the technical frontier,while research that investigates TFP growth based on technical distances does not tend to consider environmental policy.To fill this research gap,this study investigates the impact of environmental regulation on the total factor productivity of heterogeneous firms,based on technical distance.In addition to theoretical analysis,we apply a two-direction fixed effects model to test the impact using firm-level data selected from the CSMAR database and environmental regulation data of 287 Chinese cities between 2007 and 2015.We report two major findings from our analysis.First,environmental regulation increasingly enhances(or hinders)TFP growth,as firms get closer to(or further away from)the country-industry technology frontier,ceteris paribus.Second,grouped regression further highlights that environmental regulation affects TFP growth for heterogeneous firms.For proximal-type firms,environmental regulation promotes the growth of TFP through innovation and imitation mechanisms,while only the imitation mechanism works for middle-type firms.Neither mechanism,however,applies to distal-type firms,for whom environmental regulation hinders TFP growth.These conclusions provide a theoretical and practical basis for environmental policy,suggesting that the focus should be directed toward improving exit mechanisms for distal-type firms,creating a favorable market environment to accelerate the convergence of middle-type firms to the frontier,and encouraging proximal-type firms to innovate to catch up with or surpass the global frontier.展开更多
Aiming at the deficiency of exterminating measures of Chinese firm safety management, a simulation model of Chinese firm's safety management capability based on the organizational learning theory, in which the simula...Aiming at the deficiency of exterminating measures of Chinese firm safety management, a simulation model of Chinese firm's safety management capability based on the organizational learning theory, in which the simulation method of system dynamics is utilized. The level variable and rate variable are designed based on the practical situation and change situation of corresponding variables of firm's safety management ca- pability. Simulation firms are built with accident case groups of the oil industry, chemical industry, machine industry, coal mining industry, and weapon industry. Through analyzing the simulation result, the growth law of Chinese firm's safety management capability is obtained as follows: the accumulating and the coupling of safety knowledge should be emphasized at the same time; the balance of learning behavior of individual, group and organization should be considered together; different types of Chinese firm should take different safety policies according to their practical situations.展开更多
This paper investigates whether environmental regulation affects firm's performance including productivity,wage and employment using firm-level data in 1996-2007.The identification uses Two Control Zones(TCZ)polic...This paper investigates whether environmental regulation affects firm's performance including productivity,wage and employment using firm-level data in 1996-2007.The identification uses Two Control Zones(TCZ)policy implemented by the Chinese government in 1998,in which tougher environmental regulations were imposed in TCZ cities but not others.By difference-indifferences estimation,we find that tougher environmental regulation leads to larger increase on both total factor productivity and wage,and firms tend to employ fewer workers under pressure of environmental protection.Heterogeneous tests show that the impacts are better for nonpollution intensive firms,non-exporters and SOEs.Finally,we find that R&D input and exiting firms among industry are the driving forces for enhancing TFP and increasing wage and unemployment.展开更多
Aiming to the deficiency of safety management measure,established simulation model about firm's safety management capability(FSMC) based on organizational learning theory.The system dynamics(SD) method was used,in...Aiming to the deficiency of safety management measure,established simulation model about firm's safety management capability(FSMC) based on organizational learning theory.The system dynamics(SD) method was used,in which level and rate system,vari- able equation and system structure flow diagram was concluded.Simulation model was verified from two aspects: first,model's sensitivity to variable was tested from the gross of safety investment and the proportion of safety investment;second,variables dependency was checked up from the correlative variable of FSMC and organizational learning.The feasibility of simulation model is verified though these processes.展开更多
The ’tri-gold program’ aiming at improving information exchange for China’s national economy has been put into practice. The ’Gold bridge’ project forms the infrastructure for the information exchange of the nati...The ’tri-gold program’ aiming at improving information exchange for China’s national economy has been put into practice. The ’Gold bridge’ project forms the infrastructure for the information exchange of the national economy. It makes great contributions to the control and decision-making of the country’s macro-economy, to the promotion of social productivity, and to relieving the bottleneck pressure on the parts of energy, communications and environment. The ’Gold Customs’ project aims at realizing paperless foreign trade. The ’Gold card’ project involves modern payment means, such as展开更多
This study examines the association between firm value and ownership structure, when board and controlling stockholders' voting rights deviate from obligations. The measurement of the corporate governance variables i...This study examines the association between firm value and ownership structure, when board and controlling stockholders' voting rights deviate from obligations. The measurement of the corporate governance variables is different from prior research. The author further investigates whether monitoring mechanisms can alleviate the agency problem due to percentage of outside directors. The empirical results show that the higher board voting rights-obligations is deviated, which means the weaker relation with the firm value. The author also finds the monitoring from outside directors can reduce the agency problems from board's deviation and thus can improve firm value. But the results of the controlling stockholders' deviation are mixed or insignificant. This research has implications for Taiwan's regulators who are striving to improve the information, transparency, and corporate governance of board and controlling shareholders' voting rights-obligations deviation.展开更多
Despite a surge of studies examining the impact of firm’s social capital on the innovation performance,empirical research shows controversial results.To resolve this problem,this paper conducted a meta-analysis to re...Despite a surge of studies examining the impact of firm’s social capital on the innovation performance,empirical research shows controversial results.To resolve this problem,this paper conducted a meta-analysis to restudy the relationship between firm’s social capital and innovation performance based on the empirical research results of 63 independent samples.This paper also identified some moderators affecting this relationship.The results indicated that the firm’s social capital-innovation performance link was positive and significant(r=0.363),and the age of the firm and the cultural context affected the impact of social capital on innovation performance to a large extent.Based on these findings,this paper developed recommendations for future research.展开更多
This study investigates the status of e-SCM and performance among Jordanian manufacturing sector. The objective of this study is to analyze the impact of trust and communication on the e-SCM usage. Moreover, the study...This study investigates the status of e-SCM and performance among Jordanian manufacturing sector. The objective of this study is to analyze the impact of trust and communication on the e-SCM usage. Moreover, the study investigates the effect of the trust and communication on the firm’s performance while the e-SCM usage is used as a mediating factor on firm’s performance. The proposed research model was validated by distributing 250 survey questionnaires to the manufacturing sector in Jordan. Structural equation modelling (SEM) technique was used to analyze the results. One of the main limitations of this study was that the results could not be universal since the study was limited to Jordan. We discussed the implications of our results for research and practice.展开更多
One day in April,our reporters visitedthis national super-large enterprise.Mr Huang Xiaoping,the generalmanager,briefed us on the company’s brilliantpast and bright future. The Yuejin Auto Group Company isfamed all o...One day in April,our reporters visitedthis national super-large enterprise.Mr Huang Xiaoping,the generalmanager,briefed us on the company’s brilliantpast and bright future. The Yuejin Auto Group Company isfamed all over the world for producing YuejinBrand automobiles.In 1958,the firstgeneration of Yuejin Brand automobiles cameout,and China has since had its first展开更多
Under the leadership of the Communist Party of China,the human rights cause in China has developed and progressed through the period of democratic revolution,the early founding of the People’s Republic of China,the n...Under the leadership of the Communist Party of China,the human rights cause in China has developed and progressed through the period of democratic revolution,the early founding of the People’s Republic of China,the new period of reform and openingup,and the new era of socialism with Chinese characteristics.all previous national Congresses of the Communist Party of China have made illustrations and arrangements on human rights issues,and the successive Party leaders have made important expositions on human rights issues.The Party and the state have enacted a series of policies,laws,and regulations to protect human rights in various periods.China has made historic and great achievements in human rights practice and created a human rights development path suited to China’s national conditions.China’s human rights development over the past century has fully proved that the CPC has always been,and it remains,the firm core of leadership for China’s human rights development and progress.展开更多
In November 2012, immediately after the close of the 18th National Congress of the Communist Party of China (CPC), CPC Central Committee General Secretary Xi Jinping proposed to "realize the Chinese dream of the gr...In November 2012, immediately after the close of the 18th National Congress of the Communist Party of China (CPC), CPC Central Committee General Secretary Xi Jinping proposed to "realize the Chinese dream of the great revival of the Chinese nation." He emphasized that the fulfillment of the Chinese dream regarding the great revival of the Chinese nation is simply the realization of the country's prosperity, the nation's revival and the people's happiness. All in all, the Chinese dream is the people's dream.展开更多
文摘Cyclin-dependent kinase 5(Cdk5) is a member of the serine-threonine kinase family of cyclin-dependent kinases. Cdk5 is critical to normal mammalian nervous system development and plays important regulatory roles in multiple cellular functions. Recent evidence indicates that Cdk5 is inappropriately activated in several neurodegenerative conditions, including Parkinson's disease(PD). PD is a chronic neurodegenerative disorder characterized by the loss of dopamine neurons in the substantia nigra, decreased striatal dopamine levels, and consequent extrapyramidal motor dysfunction. During neurotoxicity, p35 is cleaved to form p25. Binding of p25 with Cdk5 leads deregulation of Cdk5 resulting in number of neurodegenerative pathologies. To date, strategies to specifically inhibit Cdk5 hyperactivity have not been successful without affecting normal Cdk5 activity. Here we show that inhibition of p25/Cdk5 hyperactivation through TFP5/TP5, truncated 24-aa peptide derived from the Cdk5 activator p35 rescues nigrostriatal dopaminergic neurodegeneration induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP/MPP+) in a mouse model of PD. TP5 peptide treatment also blocked dopamine depletion in the striatum and improved gait dysfunction after MPTP administration. The neuroprotective effect of TFP5/TP5 peptide is also associated with marked reduction in neuroinflammation and apoptosis. Here we show inhibition of Cdk5/p25-hyperactivation by TFP5/TP5 peptide, which identifies Cdk5/p25 as a potential therapeutic target to reduce neurodegeneration in PD.
基金supported by Humanities and Social Science project of Ministry of Education of China“Study on the impact of environmental regulation on firm's TFP growth”[Grant number:17YJC790196].
文摘Most studies on environmental policy and total factor productivity(TFP)growth under the heterogeneity framework tend to ignore the distance to the technical frontier,while research that investigates TFP growth based on technical distances does not tend to consider environmental policy.To fill this research gap,this study investigates the impact of environmental regulation on the total factor productivity of heterogeneous firms,based on technical distance.In addition to theoretical analysis,we apply a two-direction fixed effects model to test the impact using firm-level data selected from the CSMAR database and environmental regulation data of 287 Chinese cities between 2007 and 2015.We report two major findings from our analysis.First,environmental regulation increasingly enhances(or hinders)TFP growth,as firms get closer to(or further away from)the country-industry technology frontier,ceteris paribus.Second,grouped regression further highlights that environmental regulation affects TFP growth for heterogeneous firms.For proximal-type firms,environmental regulation promotes the growth of TFP through innovation and imitation mechanisms,while only the imitation mechanism works for middle-type firms.Neither mechanism,however,applies to distal-type firms,for whom environmental regulation hinders TFP growth.These conclusions provide a theoretical and practical basis for environmental policy,suggesting that the focus should be directed toward improving exit mechanisms for distal-type firms,creating a favorable market environment to accelerate the convergence of middle-type firms to the frontier,and encouraging proximal-type firms to innovate to catch up with or surpass the global frontier.
基金the National Social Science Foundation of China (07BJY080)
文摘Aiming at the deficiency of exterminating measures of Chinese firm safety management, a simulation model of Chinese firm's safety management capability based on the organizational learning theory, in which the simulation method of system dynamics is utilized. The level variable and rate variable are designed based on the practical situation and change situation of corresponding variables of firm's safety management ca- pability. Simulation firms are built with accident case groups of the oil industry, chemical industry, machine industry, coal mining industry, and weapon industry. Through analyzing the simulation result, the growth law of Chinese firm's safety management capability is obtained as follows: the accumulating and the coupling of safety knowledge should be emphasized at the same time; the balance of learning behavior of individual, group and organization should be considered together; different types of Chinese firm should take different safety policies according to their practical situations.
基金The authors are supported financially by the National Natural Science Foundation of China[Grant Number.71403216,71703128,71832012]MOE(Ministry of Education of China)of Humanities and Social Sciences Project[Grant Number.19YJC790062].
文摘This paper investigates whether environmental regulation affects firm's performance including productivity,wage and employment using firm-level data in 1996-2007.The identification uses Two Control Zones(TCZ)policy implemented by the Chinese government in 1998,in which tougher environmental regulations were imposed in TCZ cities but not others.By difference-indifferences estimation,we find that tougher environmental regulation leads to larger increase on both total factor productivity and wage,and firms tend to employ fewer workers under pressure of environmental protection.Heterogeneous tests show that the impacts are better for nonpollution intensive firms,non-exporters and SOEs.Finally,we find that R&D input and exiting firms among industry are the driving forces for enhancing TFP and increasing wage and unemployment.
基金the State Social Science Fund of China(07BJY080)
文摘Aiming to the deficiency of safety management measure,established simulation model about firm's safety management capability(FSMC) based on organizational learning theory.The system dynamics(SD) method was used,in which level and rate system,vari- able equation and system structure flow diagram was concluded.Simulation model was verified from two aspects: first,model's sensitivity to variable was tested from the gross of safety investment and the proportion of safety investment;second,variables dependency was checked up from the correlative variable of FSMC and organizational learning.The feasibility of simulation model is verified though these processes.
文摘The ’tri-gold program’ aiming at improving information exchange for China’s national economy has been put into practice. The ’Gold bridge’ project forms the infrastructure for the information exchange of the national economy. It makes great contributions to the control and decision-making of the country’s macro-economy, to the promotion of social productivity, and to relieving the bottleneck pressure on the parts of energy, communications and environment. The ’Gold Customs’ project aims at realizing paperless foreign trade. The ’Gold card’ project involves modern payment means, such as
文摘This study examines the association between firm value and ownership structure, when board and controlling stockholders' voting rights deviate from obligations. The measurement of the corporate governance variables is different from prior research. The author further investigates whether monitoring mechanisms can alleviate the agency problem due to percentage of outside directors. The empirical results show that the higher board voting rights-obligations is deviated, which means the weaker relation with the firm value. The author also finds the monitoring from outside directors can reduce the agency problems from board's deviation and thus can improve firm value. But the results of the controlling stockholders' deviation are mixed or insignificant. This research has implications for Taiwan's regulators who are striving to improve the information, transparency, and corporate governance of board and controlling shareholders' voting rights-obligations deviation.
基金This work was supported by MOE(Ministry of Education in China)Project of Humanities and Social Sciences(No.20YJC630022)Shandong Province Natural Science Foundation(No.ZR2017MG033)Fundamental Research Funds for the Central Universities(No.HIT.HSS.201875).
文摘Despite a surge of studies examining the impact of firm’s social capital on the innovation performance,empirical research shows controversial results.To resolve this problem,this paper conducted a meta-analysis to restudy the relationship between firm’s social capital and innovation performance based on the empirical research results of 63 independent samples.This paper also identified some moderators affecting this relationship.The results indicated that the firm’s social capital-innovation performance link was positive and significant(r=0.363),and the age of the firm and the cultural context affected the impact of social capital on innovation performance to a large extent.Based on these findings,this paper developed recommendations for future research.
文摘This study investigates the status of e-SCM and performance among Jordanian manufacturing sector. The objective of this study is to analyze the impact of trust and communication on the e-SCM usage. Moreover, the study investigates the effect of the trust and communication on the firm’s performance while the e-SCM usage is used as a mediating factor on firm’s performance. The proposed research model was validated by distributing 250 survey questionnaires to the manufacturing sector in Jordan. Structural equation modelling (SEM) technique was used to analyze the results. One of the main limitations of this study was that the results could not be universal since the study was limited to Jordan. We discussed the implications of our results for research and practice.
文摘One day in April,our reporters visitedthis national super-large enterprise.Mr Huang Xiaoping,the generalmanager,briefed us on the company’s brilliantpast and bright future. The Yuejin Auto Group Company isfamed all over the world for producing YuejinBrand automobiles.In 1958,the firstgeneration of Yuejin Brand automobiles cameout,and China has since had its first
文摘Under the leadership of the Communist Party of China,the human rights cause in China has developed and progressed through the period of democratic revolution,the early founding of the People’s Republic of China,the new period of reform and openingup,and the new era of socialism with Chinese characteristics.all previous national Congresses of the Communist Party of China have made illustrations and arrangements on human rights issues,and the successive Party leaders have made important expositions on human rights issues.The Party and the state have enacted a series of policies,laws,and regulations to protect human rights in various periods.China has made historic and great achievements in human rights practice and created a human rights development path suited to China’s national conditions.China’s human rights development over the past century has fully proved that the CPC has always been,and it remains,the firm core of leadership for China’s human rights development and progress.
文摘In November 2012, immediately after the close of the 18th National Congress of the Communist Party of China (CPC), CPC Central Committee General Secretary Xi Jinping proposed to "realize the Chinese dream of the great revival of the Chinese nation." He emphasized that the fulfillment of the Chinese dream regarding the great revival of the Chinese nation is simply the realization of the country's prosperity, the nation's revival and the people's happiness. All in all, the Chinese dream is the people's dream.