Frequency is one of the fundamental parameters of sound.The frequency of an acoustic stimulus can be represented by a neural response such as spike rate,and/or first spike latency(FSL)of a given neuron.The spike rates...Frequency is one of the fundamental parameters of sound.The frequency of an acoustic stimulus can be represented by a neural response such as spike rate,and/or first spike latency(FSL)of a given neuron.The spike rates/frequency function of most neurons changes with different acoustic ampli-tudes,whereas FSL/frequency function is highly stable.This implies that FSL might represent the fre-quency of a sound stimulus more efficiently than spike rate.This study involved representations of acoustic frequency by spike rate and FSL of central inferior colliculus(IC)neurons responding to free-field pure-tone stimuli.We found that the FSLs of neurons responding to characteristic frequency(CF)of sound stimulus were usually the shortest,regardless of sound intensity,and that spike rates of most neurons showed a variety of function according to sound frequency,especially at high intensities.These results strongly suggest that FSL of auditory IC neurons can represent sound frequency more precisely than spike rate.展开更多
For the design and development of advanced prosthetic limbs, many attempts have been made to restore the function of mechanoreceptors using artificial tactile sensors. Mechanoreceptors in human skin, which make dexter...For the design and development of advanced prosthetic limbs, many attempts have been made to restore the function of mechanoreceptors using artificial tactile sensors. Mechanoreceptors in human skin, which make dexterous manipulation pos- sible, respond to the mechanical stimuli in the form of spike trains. In this paper, a bin-inspired approach to replicate the Fast Adapting type I （FA-I） mechanoreceptor is developed, where piezoelectric materials, such as polyvinylidene difluoride （PVDF） films, are used to generate continuous analog electrical signals; then the analog signals are successfully converted into spike trains using the spiking neuron model. By comparing with spike trains measured from the glabrous skin of macaque monkeys, it was found that this approach can mimic FA-I afferent spiking activities in terms of both the average inter-spike interval and the first spike latency. Spike features of the FA-I mechanoreceptors, such as the variability, frequency dependent responses, and population activity, were also explored, which may play a vital role in the understanding of the functionality of FA-I mech- anoreceptors and the development of advanced prosthetic limbs.展开更多
基金the National Natural Science Foundation of China(Grant Nos.30170250,90208012,and 30270440)the Innovation Program of the Chinese Academy of Sciences(Grant No.KGCX2-SW-602-2)Natural Science Founda-tion of Guangdong Province(Grant No.32870)
文摘Frequency is one of the fundamental parameters of sound.The frequency of an acoustic stimulus can be represented by a neural response such as spike rate,and/or first spike latency(FSL)of a given neuron.The spike rates/frequency function of most neurons changes with different acoustic ampli-tudes,whereas FSL/frequency function is highly stable.This implies that FSL might represent the fre-quency of a sound stimulus more efficiently than spike rate.This study involved representations of acoustic frequency by spike rate and FSL of central inferior colliculus(IC)neurons responding to free-field pure-tone stimuli.We found that the FSLs of neurons responding to characteristic frequency(CF)of sound stimulus were usually the shortest,regardless of sound intensity,and that spike rates of most neurons showed a variety of function according to sound frequency,especially at high intensities.These results strongly suggest that FSL of auditory IC neurons can represent sound frequency more precisely than spike rate.
文摘For the design and development of advanced prosthetic limbs, many attempts have been made to restore the function of mechanoreceptors using artificial tactile sensors. Mechanoreceptors in human skin, which make dexterous manipulation pos- sible, respond to the mechanical stimuli in the form of spike trains. In this paper, a bin-inspired approach to replicate the Fast Adapting type I （FA-I） mechanoreceptor is developed, where piezoelectric materials, such as polyvinylidene difluoride （PVDF） films, are used to generate continuous analog electrical signals; then the analog signals are successfully converted into spike trains using the spiking neuron model. By comparing with spike trains measured from the glabrous skin of macaque monkeys, it was found that this approach can mimic FA-I afferent spiking activities in terms of both the average inter-spike interval and the first spike latency. Spike features of the FA-I mechanoreceptors, such as the variability, frequency dependent responses, and population activity, were also explored, which may play a vital role in the understanding of the functionality of FA-I mech- anoreceptors and the development of advanced prosthetic limbs.
