Effect of Auricular Piont Pressing Combined with Thunder-Fire Moxibustion on Abdominal Distension and Constipation After Thoracic Compression Fracture

Objective:To explore the effect of auricular point pressing combined with thunder-fire moxibustion in the treatment of abdominal distension and constipation after thoracic compression fracture.Methods:Totally 100 patients were randomly divided into 4 groups,the observation group 1(n=25)which were treated with conventional nursing combined with auricular piont pressing,observation group 2(n=25)treated with conventional nursing combined with thunder-fire moxibustion,observation group 3(n=25)treated with conventional nursing combined with auricular point pressing and thunder-fire moxibustion,and the control group(n=25)which adopted conventional nursing.First exhaust and defecation time after fracture in 4 groups were observed and compared.Results:The effect of observation group 3 was better than that of observation group 2,observation group 1 and control group(P<0.05).Conclusion:It is obvious that auricular point pressing combined with thunder-fire moxibustion has better result in treating abdominal distension and constipation after thoracic compression fracture.

Evaluating the clinical efficacy of Thunder-Fire moxibustion combined with ovulation monitoring in the treatment of adenomyosis combined with infertility

This study evaluated the clinical efficacy of Thunder-Fire moxibustion combined with ovulation monitoring for the treatment of adenomyosis-associated infertility.A series of 120 patients diagnosed with uterine adenomyosis and infertility and cold coagulation blood stasis syndrome in traditional Chinese medicine(with the clinical manifestations of premenstrual or menstrual lower abdomen cold pain,pain reduction with heat application,and cold extremities)were randomized equally to treatment group with Thunder-Fire moxibustion and ovulation monitoring as well as control group with ovulation monitoring only.Treatment continued for six menstrual cycles.The pregnancy rate of the treatment group was significantly increased with the control group(50.0%vs.23.3%,P=0.021).Dysmenorrhea and the traditional Chinese medicine syndrome in the treatment group improved significantly compared with the control group(3.87±2.03 vs.5.70±1.01,P=0.002 and 7.33±4.11 vs.10.52±2.33,P=0.006,respectively),and there was also significant between-group differences in serum cancer antigen 125(55.45±14.65 vs.63.34±11.41,P=0.031).However,the average uterus diameters in the treatment and control groups were not significantly different(67.13±7.59 vs.69.89±5.30,P=0.137).Thunder-Fire moxibustion with ovulation monitoring improved the pregnancy rate of patients diagnosed with adenomyosis-associated infertility.

Progress of improvement of pain and joint function of knee osteoarthritis treated with thunder-fire moxibustion in the last five years

Objective:To summarize the clinical research of improvement of pain and joint function of knee osteoarthritis treated with thunder-fire moxibustion in the last five years,in order to provide more objective and scientific theoretical basis for the clinical use of thunderfire moxibustion in the treatment of knee osteoarthritis.Methods:By using"thunder-fire moxibustion"and"knee osteoarthritis"as keywords,the clinical literature on the treatment of knee osteoarthritis mainly by thunder-fire moxibustion in the past 5 years in PubMed,CNKI,WF and VIP were analyzed.Results:Thunderfire moxibustion and its compound therapy,including internal use of traditional Chinese medicine,external use of traditional Chinese medicine,drug injection,physical therapy,acupuncture,heat sensitive moxibustion,pricking collaterals,acupoint application and ozone,could relieve pain,improve joint function,improve joint activity,improve patients daily life ability and have less adverse reactions.Conclusion:Thunder-fire moxibustion was a safe,non-invasive and effective treatment for knee osteoarthritis.However,further research is necessary due to the non-rigidity of the current clinical trial design.

Effect of moxibustion combined with five‑element music therapy on postoperative pain relief after mixed hemorrhoid operation

Objective:To investigate the effect of moxibustion combined with five‑element music therapy on the postoperative pain relief of patients undergoing surgical operation for mixed hemorrhoid with damp‑heat syndrome.Methods:Totally,159 patients meeting the inclusion criteria were assigned to the control group,study group 1,and study group 2,with 53 cases in each group.All patients received routine care after surgical treatment,including acupoint application and Chinese herbal fumigation.In addition,patients in the study group 1 received moxibustion,and those in the study group 2 were given moxibustion combined with five‑element music therapy.The degree of postoperative pain was evaluated using visual analog scale(VAS).Results:There was no significant difference in VAS score on pain during dressing changes among three groups(P>0.05).After 3,5,and 7 days of intervention,there was a significant difference in VAS score on pain at rest among three groups(P<0.001),and VAS score in the study group 2 was lower than that in the study group 1 and the control group after 3 and 5 days of intervention,respectively(P<0.05).Conclusion:Moxibustion combined with five‑element music therapy is effective to relieve the postoperative pain of patients undergoing a surgical operation for mixed hemorrhoids with damp‑heat syndrome.

Moxibustion eases chronic inflammatory visceral pain through regulating MEK, ERK and CREB in rats

AIM To investigate the effects of herb-partitioned moxibustion(HPM) on phosphorylation of mitogen-activated extracellular signal-regulated kinase(MEK)1, extracellular signal-regulated kinase(ERK)1/2 and c AMP response element binding protein(CREB) in spinal cord of rats with chronic inflammatory visceral pain(CIVP), and to explore the central mechanism of HPM in treating CIVP.METHODS Male Sprague-Dawley rats were randomized into normal, model, HPM, sham-HPM, MEK-inhibitor and dimethyl sulfoxide(DMSO) groups. The CIVP model was established using an enema mixture of trinitrobenzene sulfonic acid and ethanol. HPM was applied at bilateral Tianshu(ST25) and Qihai(CV6) acupoints in the HPM group, while in the sham-HPM group, moxa cones and herb cakes were only placed on the same points but not ignited. The MEK-inhibitor and DMSO groups received L5-L6 intrathecal injection of U0126 and 30% DMSO, respectively. Abdominal withdrawal reflex(AWR), mechanical withdrawal threshold(MWT) and thermal withdrawal latency(TWL) were applied for the assessment of pain behavior. The colonic tissue was observed under an optical microscope after hematoxylin-eosin staining. Expression of phosphor(p)MEK1, p ERK1/2 and p CREB in rat spinal cord was detected using Western blotting. The levels of MEK, ERK and CREB m RNA in rat spinal cord were detected using real-time polymerase chain reaction. RESULTS Compared with the normal group, the AWR scores were increased significantly(P < 0.01) and the MWT and TWL scores were decreased significantly(P < 0.05) in the model, sham-HPM and DMSO groups. Compared with the model group, the AWR scores were decreased significantly(P < 0.01) and the MWT and TWL scores were increased significantly in the HPM and MEK-inhibitor groups(P < 0.05). Compared with the sham-HPM and DMSO groups, the AWR scores were decreased significantly(P < 0.01) and the MWT and TWL scores were increased significantly(P < 0.05) in the HPM and MEK-inhibitor groups. Compared with the normal group, the expression of p MEK1, p ERK1/2 and p CREB proteins and the levels of MEK, ERK and CREB m RNA in rat spinal cord were increased significantly in the model, sham-HPM and DMSO groups(P < 0.01 or < 0.05). Compared with the model group, the expression of p MEK1, p ERK1/2 and p CREB proteins and the levels of MEK, ERK and CREB m RNA in rat spinal cord were reduced significantly in the HPM and MEK-inhibitor groups(P < 0.01 or < 0.05). Compared with the sham-HPM and DMSO groups, expression of p MEK1, p ERK1/2 and p CREB proteins and the levels of MEK, ERK and CREB m RNA in rat spinal cord were reduced significantly in the HPM and MEK-inhibitor groups(P < 0.01 or < 0.05). CONCLUSION HPM down-regulates protein phosphorylation of MEK1, ERK1/2 and CREB, and m RNA expression of MEK, ERK and CREB, inhibiting activation of the MEK/ERK/CREB signaling pathway in the spinal cord of CIVP rats, which is possibly a critical central mechanism of the analgesic effect of HPM.

Twenty cases of globus hystericus treated by bloodletting combined with thunder-fire moxibustion

Objective To observe the clinical effect in treatment of globus hystericus with acupoint bloodletting and thunder-fire moxibust-ion therapy. Methods Twenty patients were subject to bloodletting at Ganshu （肝俞 BL 18） in both sides and to thunder-fire moxibustion at Danzhong （膻中 CV 17） and Zhongwan （中脘 CV 12）. Once a day, twenty treatments were given. Results Sixteen cases were cured and 4 cases effective; cured rate was 80% and effective rate 100%. Conclusion Bloodletting comb for globus hystericus is better ined with thunder-fire moxibustion therapy n clinical efficacy, significantly improving the patients＇ clinical symptoms.

Observation on therapeutic efficacy of thunder-fire moxibustion for hypomenorrhea after induced abortion

Objective:To observe the clinical efficacy of thunder-fire moxibustion for hypomenorrhea after induced abortion.Methods:A total of 74 patients with hypomenorrhea after induced abortion were randomized into two groups,with 37 cases in each group.The control group was treated with conventional hormone sequential therapy,and the observation group was treated with thunder-fire moxibustion.The course of treatment was 3 menstrual cycles.The traditional Chinese medicine(TCM)symptom scores,menstrual volume,endometrial thickness and the sex hormone levels were observed before and after treatment.The clinical efficacy was compared after treatment.Results:The total effective rate in the observation group and the control group was 91.4%and 73.5%,respectively,and the difference between the two groups was statistically significant(P<0.05).After treatment,the TCM symptom scores in both groups decreased significantly(all P<0.05),and the scores in the observation group were lower than those in the control group(P<0.05).The menstrual volume,endometrial thickness and each sex hormone level of the patients in both groups were significantly improved after treatment(all P<0.05),and the improvements in the observation group were more significant than those in the control group(all P<0.05).Conclusion:Thunder-fire moxibustion can significantly improve the clinical symptoms of patients with hypomenorrhea after induced abortion;it can increase menstrual volume and endometrial thickness,and regulate the sex hormone levels,producing a better curative effect than the conventional hormone sequential therapy.

Effect of acupuncture plus thunder-fire moxibustion on MMP-3, TIMP-1 and TGF-β1 in rats with knee osteoarthritis

Objective： To observe the effect of acupuncture plus thunder-fire moxibustion on the expressions of matrix metalloproteinase-3 （MMP-3）, tissue inhibitor of metalloproteinase-1 （TIMP-1） and transforming growth factor-β1 （TGF-β1） in cartilage of knee osteoarthritis （KOA） rats, and to explore the mechanism of acupuncture plus thunder-fire moxibustion in the treatment of KOA. Methods： Thirty Sprague-Dawley （SD） rats were randomly divided into a blank control group, a model group and an acupuncture-moxibustion group by random digits table, 10 rats in each group. Rats in the model group and the acupuncture-moxibustion group were injected with papain in the right posterior knee joint to prepare the models. The levels of MMP-3 and TIMP-1 in rat synovium of each group were measured by enzyme-linked immunosorbent assay （ELBA） after 2 weeks of treatment. The level of TGF-β1 was determined by Motic B5 Micro-camera system. Results： The levels of MMP-3 and TIMP-1 in the cartilage of the model group were significantly higher than those in the blank control group （all P〈0.01）; the levels of MMP-3 and TIMP-1 in the acupuncture-moxibustion group were lower than those in the model group, and the between-group differences were statistically significant （all P〈0.05）. The levels of MMP-3 and TIMP-1 in the acupuncture-moxibustion group were higher than those in the blank control group, and the differences were statistically significant （all P〈0.05）. The level of TGF-β1 in cartilage tissues of the model group was significantly lower than that in the blank control group （P〈0.01）; the level of TGF-β1 in the acupuncture-moxibustion group was higher than that in the model group （P〈0.05）, but it was lower than that in the blank control group, and the between-group difference was statistically significant （P〈0.05）. Conclusion： Acupuncture plus thunder-fire moxibustion can effectively recover the abnormal expressions of MMP-3 and TIMP-1 in KOA model rats and somewhat up-regulate TGF-β1, which may be one of its mechanisms of acupuncture plus thunder-fire for KOA.

Electroacupuncture combined with thunder-fire moxibustion for knee osteoarthritis of cold-damp type:A randomized controlled trial

Objective:To observe the clinical effect differences of knee osteoarthritis(KOA)with cold-damp type between electroacupuncture(EA)combined with thunder-fire moxibustion and medication.Methods:A total of 72 cases of KOA patients with cold-damp type were randomly divided into a combined treatment group of EA and thunder-fire moxibustion(combined treatment group)and a medication group,36 cases in each group.In the combined treatment group,the acupoints for EA were Dubi(犊鼻ST35),Neixiyan(内膝眼EX-LE4),Zusanli(足三里ST36),Yanglingquan(阳陵泉GB34),Yinlingquan(阴陵泉SP9),Xuehai(血海SP10),Liangqiu(梁丘ST34)and Heding(鹤顶EX-LE2).During the period of EA,the suspending thunder-fire moxibustion was applied to Shenque CV8)and Guanyuan(关元CV4).In the medication group,diclofenac sodium double release intestine-sol capsule and Fugui gutong capsules were prescribed for oral administration.The treatment for 14 days was taken as one course and the consecutive 2 courses of treatment were required in each group.Before and after treatment,as well as in the follow-up visit,the pain score(visual analogue scale,VAS),the knee function score(Western Ontario and McMaster University,WOMAC,the expressions of interleukin 6(IL-6)and transforming growth factorβ1(TGF-β1)in the joint fluid as well as the difference in the clinical therapeutic effect were observed in the two groups separately.Results:(1)The pain score:compared with those before treatment,the VAS scores were all reduced after treatment and in the follow-up in the two groups(all P<0.05).After treatment and in the follow-up,VAS scores in the combined treatment group were lower than those in the medication group(both P<0.05).(2)The knee function score:WOMAC score of each item,i.e.pain,stiffness and function,as well as the total score after treatment and the follow-up were all lower than those before treatment in the patients of the two groups(all P<0.05).The score of each item,i.e.pain and function,as well as the total score in the combined treatment group were all lower than those in the medication group after treatment and the follow-up respectively(all P<0.05).(3)The expressions of IL-6 and TGF-β1:the level of IL-6 in the joint fluid was reduced after treatment as compared with that before treatment in either group and the level of TGF-β1 was increased,indicating the statistical differences(all P<0.05).After treatment,the level of IL-6 in the combined treatment group was lower than that in the medication group and the level of TGF-β1 was higher than that of the medicating group,indicating the statistical significance(both P<0.05).(4)The total effective rate in the combined treatment group was 97.1%,higher than 78.8%in the medication group,indicating the statistical significance(P<0.05).Conclusion:The clinical effect of the combined treatment of electroacupuncture and the thunder-fire moxibustion is remarkable on knee osteoarthritis of cold-damp type.The combined treatment presents a more advantageous at the sustainability of the therapeutic effect as compared with medication.

Acupotomy combined with thunder-fire wonder moxibustion for 165 cases of calcaneodynia

Objective： To observe the clinical efficacy of acupotomy combined with thunder-fire wonder moxibustion for calcaneodynia. Methods： Acupotomy combined with thunder-fire wonder moxibustion was applied in 165 cases of calcaneodynia on single foot. Acupotomy was used to the releasing and stripping at the local tender point of the affected heel. Thunder-fire wonder moxibustion was carried out around the incision after the acupotomy. After treatment for once, the patients were asked to visit to hospital again after 1 week to observe the curative effect. If the symptom disappeared, the treatment can be terminated. If not, the treatment for another time was conducted. Treatment should not be performed for more than 3 times. Results： A total of 25 patients were cured after treatment for once, accounting for 15.2%（25/165） of the whole. A total of 105 patients were cured after treatment for 2 times, accounting for 63.6%（105/165） of the whole. A total of 20 patients were cured after treatment for 3 times, accounting for 12.1%（20/165） of the whole. A total of 15 patients were ineffective after treatment for 3 times, accounting for 9.1%（15/165） of the whole. The total cure rate was 90.9%. Conclusion： Acupotomy combined with thunder-fire wonder moxibustion for calcaneodynia has definite effect, which is worthy of clinical popularization and application.

Efficacy observation on degenerative gonitis treated with triple needling combined with thunder-fire moxibustion

Objective To evaluate the clinical efficacy of degenerative gonitis treated with triple needling combined with thunder-fire moxibustion for better promotion and clinical application. Methods Ninety-eight patients with degenerative gonitis were randomly divided into a thunder-fire moxibustion group （group A） and an acupuncture group （group B） according to randon number table, with forty-nine cases in each group. In group A, Neixiyan （内膝眼 EX-LE 4）, Dubi （犊鼻 ST 35）, Yanglingquan （阳陵泉 GB 34）, Xuehai （血海 SP 10）, Liangqiu （梁丘 ST 34）, Zusanli （足三里 ST 36）, Yinlingquan （阳陵泉 SP 9） and Xiyangguan （膝阳关 GB 33） were selected to accept triple and needling thunder-fire moxibustion for 20 min after the needles were retained for 40 min. The patients in group B were only treated with acupuncture. Thunder-fire moxibustion was not applied in the group B. The treatment was given once a day for four weeks. Knee function score and knee stiffness score in both groups were recorded before and after treatment, and the therapeutic effect was assessed. Results After four weeks＇ treatment, the total effective rate of group A was 93.9% （46/49）, which was superior to 71.4% （35/49） in group B （P〈0.05）. Improvement in knee stiffness in group A was superior to that in group B （P〈0.01）. Conclusion Triple needling combined with thunder-fire moxibustion had clinical efficacy on degenerative gonitis, which is a better treatment option with the total efficacy significantly superior to that of acupuncture only.

针灸治疗中风病的病例注册登记研究——数据元及定义

中风病防治一直是全球医学界关注的焦点,针灸治疗中风病的独特优势日益突出,《中国急性缺血性脑卒中指南2018》推荐急性脑梗死患者进行针刺治疗(Ⅱ级推荐,B级证据)。标准化、规范化临床研究数据可以保证临床研究的数据质量,为数据的整理和挖掘提供保障,病例注册登记属于真实世界研究,数据元素的一致性是保证计划实施、数据质量高效、临床研究证据可信的必备要素之一。因此,课题组基于国家重点研发计划课题“针灸治疗中风病的病例注册登记研究”制订了本课题的数据元及定义,以期优化针灸防治中风病临床研究范式。

基于“益火补土”理论运用五行雷火灸治疗脾气亏虚证泄泻的临床研究

目的 观察在“益火补土”理论指导下运用五行雷火灸治疗脾气亏虚证泄泻的临床效果。方法 选取2019年1月至2021年12月河南中医药大学第一附属医院脾胃肝胆病科住院治疗的66例脾气亏虚证泄泻患者为研究对象,按照随机数表法将其分为对照组与治疗组,各33例。对照组实施常规治疗,治疗组在常规治疗基础上实施五行雷火灸治疗。比较两组的治疗效果。结果 治疗后、随访后,治疗组的主要单项症状积分低于对照组(P<0.05);治疗组的疗效指数高于对照组(P<0.05)。治疗组的主要单项症状治疗总显效率高于对照组(P<0.05)。治疗组的疾病治疗总显效率高于对照组(P<0.05)。结论 基于“益火补土”理论运用五行雷火灸治疗脾气亏虚证泄泻能显著改善患者的临床症状,可获得较佳治疗效果。

雷火灸联合五行音乐疗法治疗气滞血瘀型盆腔炎性疾病后遗症患者的临床效果

目的探讨雷火灸联合五行音乐疗法治疗气滞血瘀型盆腔炎性疾病后遗症(SPID)患者的临床效果。方法将65例气滞血瘀型SPID患者随机分为观察组(n=33)和对照组(n=32)。观察组采用雷火灸联合五行音乐疗法治疗,对照组采用单纯雷火灸治疗,两组均治疗2个疗程。比较两组患者治疗前、治疗第1个疗程后、治疗第2个疗程后的中医证候量表评分和医院焦虑抑郁量表(HADS)评分,统计治疗第2个疗程后两组患者不良反应发生情况。结果治疗第1个疗程后及治疗第2个疗程后,两组患者的中医证候量表总分、主症总分、次症总分低于治疗前,且两组患者治疗第2个疗程后的上述指标低于治疗第1个疗程后(P<0.05);治疗第1个疗程后、治疗第2个疗程后,观察组的中医证候量表总分、主症总分低于对照组(P<0.05)。治疗第2个疗程后,观察组的焦虑评分、抑郁评分低于治疗前及治疗第1个疗程后,且低于对照组(P<0.05),而两组患者均未出现不良反应。结论采用雷火灸联合五行音乐疗法治疗可有效改善气滞血瘀型SPID患者的中医证候,改善患者焦虑、抑郁情绪效果优于单纯雷火灸治疗,且安全性良好。

一种艾灸装置的结构设计及支撑座的优化设计

为了提高艾灸的质量和效率,设计了一种艾灸装置,整个艾灸装置既能实现自动清灰,且艾灸温度能精准控制。为了艾灸装置的使用方便和成本低减,对艾灸装置的关键部件艾灸支撑座进行了优化设计,以艾灸支撑座的三个结构尺寸为设计变量,利用OSF方法选取了设计变量的试验点,建立了径向基神经网络代理模型,并检验了该模型的精度。以艾灸支撑座的质量和最大变形量为多目标优化函数,以最大变形量和最大应力为约束条件,利用多岛遗传算法得到Pareto最优解集。在保证艾灸支撑座力学性能不降低的前提下,质量减轻了15.01%。结果表明,该方法具有较高的精度和较强的工程实用性。

隔药灸联合中医五行手指操治疗寒湿痹阻型类风湿关节炎的疗效观察

目的探讨隔药灸联合中医五行手指操改善寒湿痹阻型类风湿关节炎(rheumatoid arthritis,RA)的临床疗效。方法将90例寒湿痹阻型RA患者随机分为对照组和观察组,每组45例。对照组予以来氟米特片、艾拉莫德片、塞来昔布胶囊口服;观察组在对照组基础上行隔药灸联合中医五行手指操,其中隔药灸选取脾俞、阳陵泉、腰阳关、命门及手阳明大肠经、手少阳三焦经、手太阳小肠经上的阿是穴,每日1次,每次30 min。两组均治疗10 d。分别于治疗前后观察两组患者的疼痛视觉模拟评分(visual analogue scale,VAS)、炎症指标红细胞沉降率(erythrocyte sedimentation rate,ESR)、C反应蛋白(C-reactive protein,CRP)、焦虑自评量表(self-rating anxiety scale,SAS)、健康评估问卷(health assessment questionnaire,HAQ)、中医证候积分,并于治疗后评定两组患者的临床疗效。结果治疗后,两组患者的VAS、ESR、CRP、SAS、HAQ及中医证候积分均较治疗前降低(P<0.05,P<0.01),且观察组上述指标均低于对照组(P<0.05,P<0.01)。观察组总有效率为80.00%,高于对照组的55.56%(P<0.01)。结论隔药灸联合中医五行手指操能改善寒湿痹阻型RA患者临床症状,提高患者生存质量。

温通穴位灸刮疗法结合五行音乐护理对脑卒中后康复期患者积极情绪及疾病自我感受负担的影响

目的探究温通穴位灸刮疗法结合五行音乐护理对脑卒中后康复期患者积极情绪及疾病自我感受负担的影响。方法选取2020年2月至2022年1月收治的90例脑卒中后康复期患者为研究对象,采用随机数字表法将其分为对照组与观察组,各45例。对照组采用常规护理干预,观察组在对照组基础上加温通穴位灸刮疗法结合五行音乐护理进行干预。比较两组的干预效果。结果干预后,观察组的积极情绪评分高于对照组,消极情绪评分低于对照组(P<0.05)。干预后,观察组的自我感受负担量表(SPBS)各维度评分低于对照组(P<0.05)。干预后,观察组的简易Fugl-Meyer运动功能量表(FMA)、Barthel指数(BI)评分高于对照组(P<0.05)。结论温通穴位灸刮疗法结合五行音乐护理不仅能够提高脑卒中后康复期患者的积极情绪,并减轻疾病自我感受负担,使其能够积极主动配合康复训练,最终促进肢体、生活能力恢复,值得推广。

保健灸对老年人头发锰锌铜铁钙含量的影响

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