BACKGROUND Rhinophyma,a late-stage subtype of rosacea,is characterized by excessive sebaceous glands and connective tissue proliferation.Patients may experience respiratory disturbances and psychological distress that...BACKGROUND Rhinophyma,a late-stage subtype of rosacea,is characterized by excessive sebaceous glands and connective tissue proliferation.Patients may experience respiratory disturbances and psychological distress that significantly affect their quality of life when excessive nasal hyperplasia obstructs the external nasal valves.Surgery is the treatment of choice for rhinophyma.However,excessive bleeding,scarring,pigmentation,and high recurrence rates frequently characterize current surgical methods.AIM To evaluate the clinical effectiveness and recurrence rates after treating severe rhinophyma with the five-blade scratcher.METHODS This study retrospectively analyzed the clinical records of 28 patients with severe rhinophyma rosacea.The Global Flushing Severity Score(GFSS),Clinician Erythema Assessment(CEA),Rhinophyma Severity Index(RHISI),Glasgow Benefit Inventory(GBI),and satisfaction scores were used to assess the recovery of patients at 6 months and 5 years,with the recurrence rate calculated at 5 years postoperatively.In addition,the levels of pro-inflammatory factors(TNF-α,IL-1β,and IL-6)in the serum of patients before and after surgery were detected by ELISA.RESULTS The GFSS,CEA,and RHISI scores at 6 months and 5 years postoperatively were significantly lower than those preoperatively(P<0.001 for both periods).Five-blade scratcher treatment greatly benefits patients as demonstrated by the GBI and patient satisfaction.A small number of patients(7/28,25%)reported recurrence after surgical treatment for rhinophyma in our department that was not more serious than before treatment.The expression of pro-inflammatory factors(TNF-α,IL-1β,and IL-6)in the patient's serum was significantly reduced after surgery of five-blade scratcher.CONCLUSION The five-blade scratcher treatment demonstrates notable advantages,including simplicity,safety,efficacy,and cost-effectiveness,coupled with reduced bleeding,minimized scarring,lower recurrence rates,reduced the level of pro-inflammatory factors and improved patient satisfaction.Consequently,this therapeutic modality exhibits a viable option for individuals afflicted with severe rhinophyma.展开更多
To design a propeller for ship power plant,the interaction between ship hull and propeller must be taken into account.The main concern is to apply the wake effect of ship stern on the propeller performance.In this pap...To design a propeller for ship power plant,the interaction between ship hull and propeller must be taken into account.The main concern is to apply the wake effect of ship stern on the propeller performance.In this paper,a coupled BEM(Boundary Element Method)/RANS(Renolds-Averaged Navier−Stokes)solver is used to simulate propeller behind the hull in the self-propulsion test.The motivation of this work is to develop a practical tool to design marine propulsion system without suffering long computational time.An unsteady boundary element method which is also known as panel method is chosen to estimate the propeller forces.Propeller wakes are treated using a time marching wake alignment method.Also,a RANS code coupled with VoF equation is developed to consider the ship motions and wake field effects in the problem.A coupling algorithm is developed to interchange ship wake field to the potential flow solver and propeller thrust to the RANS code.Based on the difference between hull resistance and the propeller thrust,a PI controller is developed to compute the propeller RPM in every time step.Verification of the solver is carried out using the towing tank test report of a 50 m oceanography research vessel.Wake factor and trust deduction coefficient are estimated numerically.Also,the wake rollup pattern of the propeller in open water is compared with the propeller in real wake field.展开更多
Regarding the scale effects on propeller＇s noncavitation hydrodynamics and hydroacoustics, three similar 7bladed highly-skewed propellers in the wake flow are addressed with diameters of 250, 500 and 1 000 mm, respec...Regarding the scale effects on propeller＇s noncavitation hydrodynamics and hydroacoustics, three similar 7bladed highly-skewed propellers in the wake flow are addressed with diameters of 250, 500 and 1 000 mm, respectively. The discrete line-spectrum noise and its standardized spectrum level scaling law, together with the total sound pressure level are analyzed. The non-cavitation noise predictions are completed by both the frequency domain method and the time domain method. As a fluctuated noise source, the time-dependent fluctuated pressure and normal velocity distribution on propeller blades are obtained by the unsteady Reynolds-averaged Navier-Stokes （ URANS ） simulation. Results show that the pressure coefficient distribution of three propellers on the 0.7R section is nearly superposed under the same advance ratio. The periodic thrust fluctuation of three propellers can exactly reflect the tonal components of the axial passing frequency （APF） and the blade passing frequency （BPF）, and the fluctuation enhancement from the small to the middle propeller at the BPF is greater than that from the middle to the big one. By the two noise prediction methods, the increment of the total sound pressure level from the small to the big propeller differs by 2.49 dB. Following the standardized scaling law, the spectrum curves of the middle and big propellers are nearly the same while significantly differing from the small one. The increment of both the line-spectrum level and the total sound pressure increases with the increase in diameter. It is suggested that the model scale of the propeller should be as large as possible in engineering to reduce the prediction error of the empirical scalin~ law and weaken the scale effects.展开更多
基金Shanghai Science and Technology Commission,No.21ZR1464000.
文摘BACKGROUND Rhinophyma,a late-stage subtype of rosacea,is characterized by excessive sebaceous glands and connective tissue proliferation.Patients may experience respiratory disturbances and psychological distress that significantly affect their quality of life when excessive nasal hyperplasia obstructs the external nasal valves.Surgery is the treatment of choice for rhinophyma.However,excessive bleeding,scarring,pigmentation,and high recurrence rates frequently characterize current surgical methods.AIM To evaluate the clinical effectiveness and recurrence rates after treating severe rhinophyma with the five-blade scratcher.METHODS This study retrospectively analyzed the clinical records of 28 patients with severe rhinophyma rosacea.The Global Flushing Severity Score(GFSS),Clinician Erythema Assessment(CEA),Rhinophyma Severity Index(RHISI),Glasgow Benefit Inventory(GBI),and satisfaction scores were used to assess the recovery of patients at 6 months and 5 years,with the recurrence rate calculated at 5 years postoperatively.In addition,the levels of pro-inflammatory factors(TNF-α,IL-1β,and IL-6)in the serum of patients before and after surgery were detected by ELISA.RESULTS The GFSS,CEA,and RHISI scores at 6 months and 5 years postoperatively were significantly lower than those preoperatively(P<0.001 for both periods).Five-blade scratcher treatment greatly benefits patients as demonstrated by the GBI and patient satisfaction.A small number of patients(7/28,25%)reported recurrence after surgical treatment for rhinophyma in our department that was not more serious than before treatment.The expression of pro-inflammatory factors(TNF-α,IL-1β,and IL-6)in the patient's serum was significantly reduced after surgery of five-blade scratcher.CONCLUSION The five-blade scratcher treatment demonstrates notable advantages,including simplicity,safety,efficacy,and cost-effectiveness,coupled with reduced bleeding,minimized scarring,lower recurrence rates,reduced the level of pro-inflammatory factors and improved patient satisfaction.Consequently,this therapeutic modality exhibits a viable option for individuals afflicted with severe rhinophyma.
文摘To design a propeller for ship power plant,the interaction between ship hull and propeller must be taken into account.The main concern is to apply the wake effect of ship stern on the propeller performance.In this paper,a coupled BEM(Boundary Element Method)/RANS(Renolds-Averaged Navier−Stokes)solver is used to simulate propeller behind the hull in the self-propulsion test.The motivation of this work is to develop a practical tool to design marine propulsion system without suffering long computational time.An unsteady boundary element method which is also known as panel method is chosen to estimate the propeller forces.Propeller wakes are treated using a time marching wake alignment method.Also,a RANS code coupled with VoF equation is developed to consider the ship motions and wake field effects in the problem.A coupling algorithm is developed to interchange ship wake field to the potential flow solver and propeller thrust to the RANS code.Based on the difference between hull resistance and the propeller thrust,a PI controller is developed to compute the propeller RPM in every time step.Verification of the solver is carried out using the towing tank test report of a 50 m oceanography research vessel.Wake factor and trust deduction coefficient are estimated numerically.Also,the wake rollup pattern of the propeller in open water is compared with the propeller in real wake field.
基金The National Natural Science Foundation of China(No.51009144)
文摘Regarding the scale effects on propeller＇s noncavitation hydrodynamics and hydroacoustics, three similar 7bladed highly-skewed propellers in the wake flow are addressed with diameters of 250, 500 and 1 000 mm, respectively. The discrete line-spectrum noise and its standardized spectrum level scaling law, together with the total sound pressure level are analyzed. The non-cavitation noise predictions are completed by both the frequency domain method and the time domain method. As a fluctuated noise source, the time-dependent fluctuated pressure and normal velocity distribution on propeller blades are obtained by the unsteady Reynolds-averaged Navier-Stokes （ URANS ） simulation. Results show that the pressure coefficient distribution of three propellers on the 0.7R section is nearly superposed under the same advance ratio. The periodic thrust fluctuation of three propellers can exactly reflect the tonal components of the axial passing frequency （APF） and the blade passing frequency （BPF）, and the fluctuation enhancement from the small to the middle propeller at the BPF is greater than that from the middle to the big one. By the two noise prediction methods, the increment of the total sound pressure level from the small to the big propeller differs by 2.49 dB. Following the standardized scaling law, the spectrum curves of the middle and big propellers are nearly the same while significantly differing from the small one. The increment of both the line-spectrum level and the total sound pressure increases with the increase in diameter. It is suggested that the model scale of the propeller should be as large as possible in engineering to reduce the prediction error of the empirical scalin~ law and weaken the scale effects.
