3D‑Printed Carbon‑Based Conformal Electromagnetic Interference Shielding Module for Integrated Electronics

Electromagnetic interference shielding(EMI SE)modules are the core com-ponent of modern electronics.However,the tra-ditional metal-based SE modules always take up indispensable three-dimensional space inside electronics,posing a major obstacle to the integra-tion of electronics.The innovation of integrating 3D-printed conformal shielding(c-SE)modules with packaging materials onto core electronics offers infinite possibilities to satisfy ideal SE func-tion without occupying additional space.Herein,the 3D printable carbon-based inks with various proportions of graphene and carbon nanotube nanoparticles are well-formulated by manipulating their rheological peculiarity.Accordingly,the free-constructed architectures with arbitrarily-customized structure and multifunctionality are created via 3D printing.In particular,the SE performance of 3D-printed frame is up to 61.4 dB,simultaneously accompanied with an ultralight architecture of 0.076 g cm^(-3) and a superhigh specific shielding of 802.4 dB cm3 g^(-1).Moreover,as a proof-of-concept,the 3D-printed c-SE module is in situ integrated into core electronics,successfully replacing the traditional metal-based module to afford multiple functions for electromagnetic compatibility and thermal dissipa-tion.Thus,this scientific innovation completely makes up the blank for assembling carbon-based c-SE modules and sheds a brilliant light on developing the next generation of high-performance shielding materials with arbitrarily-customized structure for integrated electronics.

Optimal synthesis of heat-integrated distillation configurations using the two-column superstructure

In the realm of the synthesis of heat-integrated distillation configurations,the conventional approach for exploring more heat integration possibilities typically entails the splitting of a single column into a twocolumn configuration.However,this approach frequently necessitates tedious enumeration procedures,resulting in a considerable computational burden.To surmount this formidable challenge,the present study introduces an innovative remedy:The proposition of a superstructure that encompasses both single-column and multiple two-column configurations.Additionally,a simultaneous optimization algorithm is applied to optimize both the process parameters and heat integration structures of the twocolumn configurations.The effectiveness of this approach is demonstrated through a case study focusing on industrial organosilicon separation.The results underscore that the superstructure methodology not only substantially mitigates computational time compared to exhaustive enumeration but also furnishes solutions that exhibit comparable performance.

Pixelated non-volatile programmable photonic integrated circuits with 20-level intermediate states

Multi-level programmable photonic integrated circuits(PICs)and optical metasurfaces have gained widespread attention in many fields,such as neuromorphic photonics,opticalcommunications,and quantum information.In this paper,we propose pixelated programmable Si_(3)N_(4)PICs with record-high 20-level intermediate states at 785 nm wavelength.Such flexibility in phase or amplitude modulation is achieved by a programmable Sb_(2)S_(3)matrix,the footprint of whose elements can be as small as 1.2μm,limited only by the optical diffraction limit of anin-house developed pulsed laser writing system.We believe our work lays the foundation for laser-writing ultra-high-level(20 levels and even more)programmable photonic systems and metasurfaces based on phase change materials,which could catalyze diverse applications such as programmable neuromorphic photonics,biosensing,optical computing,photonic quantum computing,and reconfigurable metasurfaces.

High-chromium vanadium-titanium magnetite all-pellet integrated burden optimization and softening-melting behavior based on flux pellets

High-chromium vanadium-titanium magnetite(HVTM)is a crucial polymetallic-associated resource to be developed.The allpellet operation is a blast furnace trend that aims to reduce carbon dioxide emissions in the future.By referencing the production data of vanadium-titanium magnetite blast furnaces,this study explored the softening-melting behavior of high-chromium vanadium-titanium magnetite and obtained the optimal integrated burden based on flux pellets.The results show that the burden with a composition of 70wt%flux pellets and 30wt%acid pellets exhibits the best softening-melting properties.In comparison to that of the single burden,the softening-melting characteristic temperature of this burden composition was higher.The melting interval first increased from 307 to 362℃and then decreased to 282℃.The maximum pressure drop(ΔPmax)decreased from 26.76 to 19.01 kPa.The permeability index(S)dropped from 4643.5 to 2446.8 kPa·℃.The softening-melting properties of the integrated burden were apparently improved.The acid pellets played a role in withstanding load during the softening process.The flux pellets in the integrated burden exhibited a higher slag melting point,which increased the melting temperature during the melting process.The slag homogeneity and the TiC produced by over-reduction led to the gas permeability deterioration of the single burden.The segregation of the flux and acid pellets in the HVTM proportion and basicity mainly led to the better softening-melting properties of the integrated burden.

Astrocytes integrate time and space

Astrocytes read and react to synaptic transmission through tripartite synapses,where the binding of neurotransmitters onto astrocytic receptors triggers an increase in intracellular calcium.Recent investigations have revealed that astrocytes exhibit two distinct states of intracellular calcium activity:(1)graded subcellular localized clusters with independently active microdomains,likely influenced by nearby synaptic events,and(2)whole-cell astrocyte calcium surges,believed to result from the coordinated activation of multiple synapses.Notably,astrocyte calcium responses are not solely graded;instead,a spatial threshold of intracellular calcium activity can be overcome to elicit an astrocyte calcium surge.Together these calcium responses,in turn,initiate downstream signaling pathways capable of modifying synaptic communication and overall network activity.In summary,astrocytes can function as integrators of local synaptic events,actively contributing to information processing within the brain.

Development and Validation of Integrated Nutrient Management Practices of Industrial Processing Varieties: Asterix and Courage in Bangladesh

An experiment was meticulously conducted at the research field of Bangabandhu Sheikh Mujibur Rahman Agricultural University (BSMRAU), Gazipur, Bangladesh, during the 2011-2012 potato growing season to develop integrated crop management practices for the potato seed production of industrial processing varieties Asterix and Courage. Significantly, higher growth and yield parameters were found in the BADC-recommended practice. Later, another experiment was conducted to validate the BADC practice during the 2013-2014 potato growing season in two locations in Bangladesh. Results showed that the production of tuber per hill, tuber weight per hill as well as gross tuber yield per plot, higher proportion of storable seed tubers, and more quality seed potatoes (A-grade and B-grade) seed tubers were found significantly higher in the “BADC developed practice” compared to other treatments. Viral diseases (PLRV and PVY) prevalence was lower in “BADC developed practice”. Moreover, “BADC developed practice” contributed more economic yield by minimizing input cost compared to “Munshiganj advanced farmers’ practice”. Therefore, the “BADC developed practice” was found “superior” regarding yield, quality, and profitability in seed potato production of industrial varieties—Asterix and Courage in Bangladesh.

Impacts of Integrated Multi-Trophic Aquaculture on Phytoplankton in Sanggou Bay

Integrated multi-trophic aquaculture(IMTA)has been considered as an ecofriendly culture system providing a potential solution to environmental risks caused by intensive monoculture system.However,the impact of IMTA on phytoplankton remains unclear.In this study,the spatial and temporal variations of phytoplankton in Sanggou Bay were investigated seasonally based on 21 sampling sites covering three cultivation zones(bivalve zone,IMTA zone,and kelp zone)and one control zone(without aquatic cultivation).In total,128 phytoplankton species,with diatoms and dinoflagellates as the dominant groups,were obtained across the whole year,and the mean Shannon diversity index(H')and species richness(SR)were determined as 1.39 and 9.39,respectively.The maximum chlorophyll a(Chl-a)(6.32μg L^(-1))and plankton diversity(H'of 1.97)occurred in summer and autumn,respectively.Compared to other zones,the bivalve zone displayed significantly higher Chl-a and lower H'in majority of time.Pairwise PERMANOVA analysis indicated that the phytoplankton assemblage in the bivalve zone was significantly different with the control and kelp zones,while the IMTA zone maintained close to other three zones.Based on generalized additive models,temperature,NO_(2)^(-)-N,N/P ratio,SiO_(3)^(2-)-Si,and salinity were determined as the key factors underlying Chl-a and phytoplankton diversity.Addi-tionally,the results of redundancy analysis further indicated that the phytoplankton assemblage in the bivalve zone is positively re-lated with nutrients such as NO_(3)^(-)-N and NH_(4)^(+)-N as well as water depth,while the phytoplankton assemblages in the kelp,control,and IMTA zones are associated with NO_(2)^(-)-N,SiO_(3)^(2-)-Si,and salinity.Taken all observations into consideration together,it can be inferred that IMTA can effectively reduce Chl-a level compared to bivalve monoculture by reducing the nutrients.However,the SR,H’,and species composition of phytoplankton are primarily determined by local environment factors such as temperature,water depth,salinity and SiO_(3)^(2-)-Si.

Carbon nanotube integrated circuit technology:purification,assembly and integration

As the manufacturing process of silicon-based integrated circuits(ICs)approaches its physical limit,the quantum effect of silicon-based field-effect transistors(FETs)has become increasingly evident.And the burgeoning carbon-based semiconductor technology has become one of the most disruptive technologies in the post-Moore era.As one-dimensional nanomaterials,carbon nanotubes(CNTs)are far superior to silicon at the same technology nodes of FETs because of their excellent electrical transport and scaling properties,rendering them the most competitive material in the next-generation ICs technology.However,certain challenges impede the industrialization of CNTs,particularly in terms of material preparation,which significantly hinders the development of CNT-based ICs.Focusing on CNT-based ICs technology,this review summarizes its main technical status,development trends,existing challenges,and future development directions.

Command filtered integrated estimation guidance and control for strapdown missiles with circular field of view

In this paper,an integrated estimation guidance and control(IEGC)system is designed based on the command filtered backstepping approach for circular field-of-view(FOV)strapdown missiles.The threedimensional integrated estimation guidance and control nonlinear model with limited actuator deflection angle is established considering the seeker's FOV constraint.The boundary time-varying integral barrier Lyapunov function(IBLF)is employed in backstepping design to constrain the body line-of-sight(BLOS)in IEGC system to fit a circular FOV.Then,the nonlinear adaptive controller is designed to estimate the changing aerodynamic parameters.The generalized extended state observer(GESO)is designed to estimate the acceleration of the maneuvering targets and the unmatched time-varying disturbances for improving tracking accuracy.Furthermore,the command filters are used to solve the"differential expansion"problem during the backstepping design.The Lyapunov theory is used to prove the stability of the overall closed-loop IEGC system.Finally,the simulation results validate the integrated system's effectiveness,achieving high accuracy strikes against maneuvering targets.

Integrated analysis of plasma rotation effect on HL-3 hybrid scenario

The hybrid scenario,which has good confinement and moderate MHD instabilities,is a proposed operation scenario for international thermonuclear experimental reactor(ITER).In this work,the effect of plasma rotation on the HL-3 hybrid scenario is analyzed with the integrated modeling framework OMFIT.The results show that toroidal rotation has no obvious effect on confinement with a high line averaged density of n_(bar)~(7)×10^(19)m^(-3).In this case,the ion temperature only changes from 4.7 keV to 4.4 keV with the rotation decreasing from 10^(5) rad/s to 10^(3) rad/s,which means that the turbulent heat transport is not dominant.While in the scenarios characterized by lower densities,such as n_(bar)~4×10^(19)m^(-3),turbulent transport becomes dominant in determining heat transport.The ion temperature rises from 3.8 keV to 6.1 keV in the core as the rotation velocity increases from 10^(3) rad/s to 10^(5) rad/s.Despite the ion temperature rising,the rotation velocity does not obviously affect electron temperature or density.Additionally,it is noteworthy that the variation in rotation velocity does not significantly affect the global confinement of plasma in scenarios with low density or with high density.

An inversely designed integrated spectrometer with reconfigurable performance and ultra-low power consumption

Despite the pressing demand for integrated spectrometers,a solution that deliver high-performance while being practically operated is still missing.Furthermore,current integrated spectrometers lack reconfigurability in their performance,which is highly desirable for dynamic working scenarios.This study presents a viable solution by demonstrating a userfriendly,reconfigurable spectrometer on silicon.At the core of this innovative spectrometer is a programmable photonic circuit capable of exhibiting diverse spectral responses,which can be significantly adjusted using on-chip phase shifters.The distinguishing feature of our spectrometer lies in its inverse design approach,facilitating effortless control and efficient manipulation of the programmable circuit.By eliminating the need for intricate configuration,our design reduces power consumption and mitigates control complexity.Additionally,our reconfigurable spectrometer offers two distinct operating conditions.In the Ultra-High-Performance mode,it is activated by multiple phase-shifters and achieves exceptional spectral resolution in the picometer scale while maintaining broad bandwidth.On the other hand,the Ease-of-Use mode further simplifies the control logic and reduces power consumption by actuating a single-phase shifter.Although this mode provides a slightly degraded spectral resolution of approximately 0.3 nm,it prioritizes ease of use and is wellsuited for applications where ultra-fine spectral reconstruction is not a primary requirement.

Design of compact integrated diamond nitrogen-vacancy center quantum probe

An integrated quantum probe for magnetic field imaging is proposed,where the nitrogen–vacancy(NV)center fixed at the fiber tip is located on the periphery of flexible ring resonator.Using flexible polyimide(PI)as the substrate medium,we design a circular microstrip antenna,which can achieve a bandwidth of 140 MHz at Zeeman splitting frequency of 2.87 GHz,specifically suitable for NV center experiments.Subsequently,this antenna is seamlessly fixed at a three-dimensional-printed cylindrical support,allowing the optical fiber tip to extend out of a dedicated aperture.To mitigate errors originating from processing,precise tuning within a narrow range can be achieved by adjusting the conformal amplitude.Finally,we image the microwave magnetic field around the integrated probe with high resolution,and determine the suitable area for placing the fiber tip(SAP).

Advances and outlook of integrated reservoir-wellbore-pipe network simulation technology

The integrated simulation and optimization technology of reservoir-wellbore-pipe network is developed to reflect the mutual influence and restriction among reservoir engineering,oil production engineering and surface engineering,and to obtain the scheme with minimum conflict and optimal benefit in each step.This technology is based on the concept of global optimization to maximize production and profit,reduce costs and increase benefit.This paper elaborates the current situation of integrated simulation technology of reservoir-wellbore-pipe network both at home and abroad,discusses its correlation with the primary business of Sinopec and its development from three aspects of modeling,cloud platform and intellectualization.Suggestions on its future development are put forward from underlying data,software platform,popularization and application,and cross-border integration to provide means and guidance for the construction of intelligent oil and gas fields.The results show that the integrated simulation of reservoir-wellbore-pipe network can better reflect the optimization requirements of each step,avoid the ineffective operation of field equipment,and effectively improve the efficiency of research and management.Coupling solution,global optimization method and pressure fitting,which can make the simulation results reflect the real situation,are the key technologies for the network.The theoretical technology and main function research of integrated simulation technology have been mature,but the large-scale application and local function improvement of oil and gas fields are yet to be promoted.In the future,the integrated simulation of reservoir-wellbore-pipe network will develop from digitalization to modeling and intellectualization,from local simulation to cloud computing,and from manual intervention to intelligent decision-making.We suggest speeding up the construction of the unified database and model base of the whole underlying platform,strengthening the construction of software integration and integration platform with independent intellectual property rights,speeding up the popularization and application of intelligent oil and gas field demonstration projects,and strengthening the integration of oil and gas industry with artificial intelligence(AI),big data and block chain for its development.

Obstacles to the Integrated Care of Children Aged 6 to 59 Months Suffering from Acute and Severe Malnutrition at the Chu-Me and HATC of N’Djamena/Chad

Introduction: the problem of Severe Acute Malnutrition (SAM) and its consequences concern and challenge all social actors worldwide. The objective of the study was to identify the real obstacles that actors face in the integrated management of children aged 6 - 59 months suffering from SAM at the University Hospital of Mother and Child (CHUME) and the Chad-China Friendship Hospital (HATC) of N’Djamena. Methodology: this is a cross-sectional descriptive and interpretative study conducted from January to October 2023 at the CHUME and HATC of N’Djamena. It is based on questionnaires and direct observation of two hundred and thirty-six (236) parents or guardians of malnourished children admitted to these health facilities. All 236 agreed to participate freely in this study. Results: it appears from this study that the obstacles to the integrated management of malnourished children were: poor care-care relationship (26.7%) permanent product breaks (22.9%), the direct costs of services ranged from 30,000 to 60,000 FCFA (41.53%), drugs used for the treatment of patients came from the street (66.10%), malaria and anemia occupy an important place (27.5%), 57.2% respondents had monthly income below 60,000 CFAF. Conclusion: the present study carried out has identified the real bottlenecks to the integrated management of children suffering from SAM in the therapeutic nutritional units of the city of N’Djamena. .

A Hybrid Integrated and Low-Cost Multi-Chip Broadband Doherty Power Amplifier Module for 5G Massive MIMO Application

In this paper,a hybrid integrated broadband Doherty power amplifier(DPA)based on a multi-chip module(MCM),whose active devices are fabricated using the gallium nitride(GaN)process and whose passive circuits are fabricated using the gallium arsenide(GaAs)integrated passive device(IPD)process,is proposed for 5G massive multiple-input multiple-output(MIMO)application.An inverted DPA structure with a low-Q output network is proposed to achieve better bandwidth performance,and a single-driver architecture is adopted for a chip with high gain and small area.The proposed DPA has a bandwidth of 4.4-5.0 GHz that can achieve a saturation of more than 45.0 dBm.The gain compression from 37 dBm to saturation power is less than 4 dB,and the average power-added efficiency(PAE)is 36.3%with an 8.5 dB peak-to-average power ratio(PAPR)in 4.5-5.0 GHz.The measured adjacent channel power ratio(ACPR)is better than50 dBc after digital predistortion(DPD),exhibiting satisfactory linearity.

Development of an Integrated Disposable Device for SARSCoV-2 Nucleic Acid Extraction and Detection

Objective To develop a highly sensitive and rapid nucleic acid detection method for the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Methods We designed,developed,and manufactured an integrated disposable device for SARS-CoV-2 nucleic acid extraction and detection.The precision of the liquid transfer and temperature control was tested.A comparison between our device and a commercial kit for SARS-Cov-2 nucleic acid extraction was performed using real-time fluorescence reverse transcription polymerase chain reaction(RT-PCR).The entire process,from SARS-CoV-2 nucleic acid extraction to amplification,was evaluated.Results The precision of the syringe transfer volume was 19.2±1.9μL(set value was 20),32.2±1.6(set value was 30),and 57.2±3.5(set value was 60).Temperature control in the amplification tube was measured at 60.0±0.0℃(set value was 60)and 95.1±0.2℃(set value was 95)respectively.SARS-Cov-2 nucleic acid extraction yield through the device was 7.10×10^(6) copies/mL,while a commercial kit yielded 2.98×10^(6) copies/mL.The mean time to complete the entire assay,from SARS-CoV-2 nucleic acid extraction to amplification detection,was 36 min and 45 s.The detection limit for SARS-CoV-2 nucleic acid was 250 copies/mL.Conclusion The integrated disposable devices may be used for SARS-CoV-2 Point-of-Care test(POCT).

Robust optimal dispatch strategy of integrated energy system considering CHP-P2G-CCS

Integrated energy systems(IESs)can improve energy efficiency and reduce carbon emissions,essential for achieving peak carbon emissions and carbon neutrality.This study investigated the characteristics of the CHP model considering P2G and carbon capture systems,and a two-stage robust optimization model of the electricity-heat-gascold integrated energy system was developed.First,a CHP model considering the P2G and carbon capture system was established,and the electric-thermal coupling characteristics and P2G capacity constraints of the model were derived,which proved that the model could weaken the electric-thermal coupling characteristics,increase the electric power regulation range,and reduce carbon emissions.Subsequently,a two-stage robust optimal scheduling model of an IES was constructed,in which the objective function in the day-ahead scheduling stage was to minimize the start-up and shutdown costs.The objective function in the real-time scheduling stage was to minimize the equipment operating costs,carbon emission costs,wind curtailment,and solar curtailment costs,considering multiple uncertainties.Finally,after the objective function is linearized with a ψ-piecewise method,the model is solved based on the C&CG algorithm.Simulation results show that the proposed model can effectively absorb renewable energy and reduce the total cost of the system.

Analysis of Spatiotemporal Changes in Integrated Land Productivity in Chongqing from 1997 to 2023

[Objectives]Integrated land productivity can reflect the comprehensive utilization of land and the overall output level,which is the most basic and commonly used indicator in assessing land use efficiency.This thesis aims to analyze the spatial and temporal changes of integrated land productivity in Chongqing from 1997 to 2023 in order to assess its land use efficiency.[Methods]This study measured the integrated land productivity of Chongqing Municipality,the only municipality directly under the central government in the western part of China,over the past 26 years(1997-2023)through relevant surveys and statistical data,and analyzed in depth the integrated land productivity of the 38 districts and counties under the jurisdiction of Chongqing,as well as the functional sub-districts of the"one district and two clusters"and the"one district and two clusters"in Chongqing.It also analyzes the characteristics of spatial and temporal differences in land productivity in 38 districts and counties under the jurisdiction of Chongqing and"one district and two clusters".[Results]The results of the study show that over the past 26 years,the integrated land productivity of Chongqing has shown an annual growth trend,and the integrated land productivity of the 38 districts and counties and the functional subregions of"one district and two clusters"has also increased significantly,but the average annual growth rate of the integrated land productivity varies among different regions.From the perspective of spatial differences,there are significant differences in land productivity among the 38 districts and counties of Chongqing and the functional subregions of"one district and two clusters",which are mainly due to the different natural conditions,economic development levels and functional positioning of each region.[Conclusions]Based on the results of the study and the actual situation of Chongqing,this paper puts forward the leading measures to improve the integrated land productivity,with a view to providing a reference basis for Chongqing to improve the efficiency of land use and promote the sustainable use of land resources.

Amend:An integrated platform of retracted papers and concerned papers

Purpose:The notable increase in retraction papers has attracted considerable attention from diverse stakeholders.Various sources are now offering information related to research integrity,including concerns voiced on social media,disclosed lists of paper mills,and retraction notices accessible through journal websites.However,despite the availability of such resources,there remains a lack of a unified platform to consolidate this information,thereby hindering efficient searching and cross-referencing.Thus,it is imperative to develop a comprehensive platform for retracted papers and related concerns.This article aims to introduce“Amend,”a platform designed to integrate information on research integrity from diverse sources.Design/methodology/approach:The Amend platform consolidates concerns and lists of problematic articles sourced from social media platforms(e.g.,PubPeer,For Better Science),retraction notices from journal websites,and citation databases(e.g.,Web of Science,CrossRef).Moreover,Amend includes investigation and punishment announcements released by administrative agencies(e.g.,NSFC,MOE,MOST,CAS).Each related paper is marked and can be traced back to its information source via a provided link.Furthermore,the Amend database incorporates various attributes of retracted articles,including citation topics,funding details,open access status,and more.The reasons for retraction are identified and classified as either academic misconduct or honest errors,with detailed subcategories provided for further clarity.Findings:Within the Amend platform,a total of 32,515 retracted papers indexed in SCI,SSCI,and ESCI between 1980 and 2023 were identified.Of these,26,620(81.87%)were associated with academic misconduct.The retraction rate stands at 6.64 per 10,000 articles.Notably,the retraction rate for non-gold open access articles significantly differs from that for gold open access articles,with this disparity progressively widening over the years.Furthermore,the reasons for retractions have shifted from traditional individual behaviors like falsification,fabrication,plagiarism,and duplication to more organized large-scale fraudulent practices,including Paper Mills,Fake Peer-review,and Artificial Intelligence Generated Content(AIGC).Research limitations:The Amend platform may not fully capture all retracted and concerning papers,thereby impacting its comprehensiveness.Additionally,inaccuracies in retraction notices may lead to errors in tagged reasons.Practical implications:Amend provides an integrated platform for stakeholders to enhance monitoring,analysis,and research on academic misconduct issues.Ultimately,the Amend database can contribute to upholding scientific integrity.Originality/value:This study introduces a globally integrated platform for retracted and concerning papers,along with a preliminary analysis of the evolutionary trends in retracted papers.

Positive health:An integrated quantitative approach in patients with chronic gastrointestinal and hepato-pancreatico-biliary disorders

BACKGROUND The concept of positive health(PH)supports an integrated approach for patients by taking into account six dimensions of health.This approach is especially relevant for patients with chronic disorders.Chronic gastrointestinal and hepatopancreatico-biliary(GI-HPB)disorders are among the top-6 of the most prevalent chronically affected organ systems.The impact of chronic GI-HPB disorders on individuals may be disproportionally high because:(1)The affected organ system frequently contributes to a malnourished state;and(2)persons with chronic GIHPB disorders are often younger than persons with chronic diseases in other organ systems.AIM To describe and quantify the dimensions of PH in patients with chronic GI-HPB disorders.METHODS Prospective,observational questionnaire study performed between 2019 and 2021 in 235 patients with a chronic GIHPB disorder attending the Outpatient Department of the Maastricht University Medical Center.Validated questionnaires and data from patient files were used to quantify the six dimensions of PH.Internal consistency was tested with McDonald’s Omega.Zero-order Pearson correlations and t-tests were used to assess associations and differences.A P value<0.05 was considered significant.RESULTS The GI-HPB patients scored significantly worse in all dimensions of PH compared to control data or norm scores from the general population.Regarding quality of life,participation and daily functioning,GI-HPB patients scored in the same range as patients with chronic disorders in other organ systems,but depressive symptoms(in 35%)and malnutrition(in 45%)were more frequent in patients with chronic GI-HPB disorders.Intercorrelation scores between the six dimensions were only very weak to weak,forcing us to quantify each domain separately.CONCLUSION All six dimensions of PH are impaired in the GI-HPB patients.Malnutrition and depressive symptoms are more prevalent compared to patients with chronic disorders in other organ systems.