Based on systematic analysis, an Integrated Plant Maintenance System (IPMS)is proposed in this paper to cope with challenges in plant maintenance. The characteristics of theIPMS are summarized and the necessity of its...Based on systematic analysis, an Integrated Plant Maintenance System (IPMS)is proposed in this paper to cope with challenges in plant maintenance. The characteristics of theIPMS are summarized and the necessity of its modeling is set forth. Based on the analysis andcomparison among structured, object-oriented and multi-agent modeling frameworks, a multi-agentmodeling framework is selected in this paper as a theoretical guidance and together with the Troposmethod for modeling, the system model of an integrated plant maintenance system is constructed. Thesystem model developed in this paper provides a guidance template for the Baling company in itsstepwise implementation of the IPMS.展开更多
AIM: To analyze the impact of steroid maintenance on the outcomes in kidney transplant recipients stratified by induction agent received.METHODS: Patients who underwent first-time deceased donor kidney transplantation...AIM: To analyze the impact of steroid maintenance on the outcomes in kidney transplant recipients stratified by induction agent received.METHODS: Patients who underwent first-time deceased donor kidney transplantation between 2000 and 2008 after receiving induction therapy with rabbitantithymocyte globulin(r-ATG), alemtuzumab or an interleukin-2 receptor blocker(IL-2B) and discharged on a calcineurin inhibitor(CNI)/mycophenolate mofetil(MMF)-regimen along with or without steroids were identified from the Organ Procurement and Transplant Network/United Network of Organ Sharing database.For each induction type, adjusted overall and deathcensored graft as well as patient survivals were compared between patients discharged on steroid vs no steroid. Among r-ATG induced patients, analysis was repeated after splitting the group into low and high immune risk groups.RESULTS: Among the 37217 patients included in the analysis, 17863 received r-ATG(steroid = 13001, nosteroid = 4862), 3028 alemtuzumab(steroid = 852, no-steroid = 2176) and 16326 IL-2B(steroid = 15008, no-steroid = 1318). Adjusted overall graft survival was inferior(HR = 1.16, 95%CI: 1.06-1.27, P = 0.002) with similar death-censored graft survival(HR = 0.99, 95%CI: 0.86-1.14, P = 0.86) for steroid vs no-steroid groups in r-ATG induced patients. Both adjusted overall and death-censored graft survivals for steroid vs nosteroid groups were similar in alemtuzumab(HR = 0.92, 95%CI: 0.73-1.15, P = 0.47 and HR = 0.87, 95%CI: 0.62-1.22, P = 0.43 respectively) and IL-2B(HR = 1.05, 95%CI: 0.91-1.21, P = 0.48 and HR = 0.94, 95%CI: 0.75-1.18, P = 0.60 respectively) induced groups. Adjusted patient survivals were inferior for steroid vs nosteroid groups in r-ATG induced(HR = 1.31, 95%CI: 1.15-1.49, P < 0.001) but similar in alemtuzumab(HR = 1.02, 95%CI: 0.75-1.38, P = 0.92) and IL-2B(HR = 1.17, 95%CI: 0.97-1.40, P = 0.10) induced patients. Among the r-ATG induced group there were 4346 patients in the low immune risk and 13517 patients in the high immune risk group. Adjusted overall graft survivals were inferior for steroid vs no steroid groups in both low immune(HR = 1.34, 95%CI: 1.09-1.64, P = 0.001) and high immune(HR = 1.18, 95%CI: 1.07-1.30, P = 0.005) risk groups. Adjusted death-censored graft survivals for steroid vs no steroid groups were similar in both low(HR = 1.06, 95%CI: 0.78-1.45, P = 0.70) and high(HR = 1.04, 95%CI: 0.98-1.20, P = 0.60) immune risk groups. Adjusted patient survivals were inferior for steroid vs no steroid groups in both low immune(HR =1.54, 95%CI: 1.18-2.02, P < 0.001) and high immune(HR = 1.32, 95%CI: 1.16-1.51, P = 0.002) risk groups. Overall, there were significantly higher deaths from infections and cardiovascular causes in patients maintained on steroids. CONCLUSION: Our study showed an association between steroid addition to a CNI/MMF-maintenance regimen and increased death with functioning graft in patients receiving r-ATG induction for first-time deceased donor kidney transplantation.展开更多
Maintenance plays an important role in acquiring cost and service advantage for an enterprise. A supply chain-oriented e-maintenance management mode is presented as a new thought on equipment maintenance on the basis ...Maintenance plays an important role in acquiring cost and service advantage for an enterprise. A supply chain-oriented e-maintenance management mode is presented as a new thought on equipment maintenance on the basis of analyzing the importance of maintenance and the characteristics of current maintenance modes. The mode allies personnel and organizations related to plant in order to construct the dynamic alliance of failure diagnosis and maintenance; through optimized deployment of maintenance resources and management of maintenance flow, the maximization of maintenance profit is realized. This paper analyzes the current multi-agent technology, and multi- agent technology is adopted to construct resource negotiation and a problem-resolving negotiation mechanism in an e-maintenance supply chain. At the same time, an agent negotiation process of resource deployment and harmony is analyzed. Finally, the key technologies realizing e-maintenance based on a supply chain environment are analyzed, which can realize the coordination, effectiveness and agility of an e-maintenance supply chain.展开更多
The behavior decision of agent in multi-agent system is dependent on the task of individual agent ,the cooperation with other agents,and the multi-agent system' constraints. The paper presents three abstract conce...The behavior decision of agent in multi-agent system is dependent on the task of individual agent ,the cooperation with other agents,and the multi-agent system' constraints. The paper presents three abstract concept models of achievement intention,joint intention and maintenance intention representing the factors that affect agent's behaviors respectively,to investigate autonomous agent's behaviors decision in support of agent-oriented software development. The paper discusses and analyzes how they will affect agent's behavior decision and the relationship among them,defines their formal and rigorous semantics,finally specifies and proves a number of important properties.展开更多
提出了一种基于M u lti-A gen t的虚拟维修训练系统(VM TS)结构框架,整个系统分别由主控A gen t、仿真A gen t、和接口A gen t3个具有交互作用的A gen t组成,从而将虚拟维修训练系统的开发转化为一个多A gen t系统的设计与开发。基于多A...提出了一种基于M u lti-A gen t的虚拟维修训练系统(VM TS)结构框架,整个系统分别由主控A gen t、仿真A gen t、和接口A gen t3个具有交互作用的A gen t组成,从而将虚拟维修训练系统的开发转化为一个多A gen t系统的设计与开发。基于多A gen t的框架结构可实现受训者的智能模型及虚拟训练场景中虚拟物体的行为模型,从而可以提高VM TS的健壮性和可重用性。基于A gen t的概念模型实现了A gen t之间的交互和协作,并介绍了主控A gen t和仿真A gen t的具体实现方法。展开更多
基金theHunanProvince(China)DemonstrationProgramforInformatizationinManufactureun derGrantNo. Hnmie A 070,andHunanProvinceScienceandTechnologyDepartmentPlanProjectunderGrantNo.03GKY3057
文摘Based on systematic analysis, an Integrated Plant Maintenance System (IPMS)is proposed in this paper to cope with challenges in plant maintenance. The characteristics of theIPMS are summarized and the necessity of its modeling is set forth. Based on the analysis andcomparison among structured, object-oriented and multi-agent modeling frameworks, a multi-agentmodeling framework is selected in this paper as a theoretical guidance and together with the Troposmethod for modeling, the system model of an integrated plant maintenance system is constructed. Thesystem model developed in this paper provides a guidance template for the Baling company in itsstepwise implementation of the IPMS.
基金Supported by Health Resources and Services Administration Contract 231-00-0115
文摘AIM: To analyze the impact of steroid maintenance on the outcomes in kidney transplant recipients stratified by induction agent received.METHODS: Patients who underwent first-time deceased donor kidney transplantation between 2000 and 2008 after receiving induction therapy with rabbitantithymocyte globulin(r-ATG), alemtuzumab or an interleukin-2 receptor blocker(IL-2B) and discharged on a calcineurin inhibitor(CNI)/mycophenolate mofetil(MMF)-regimen along with or without steroids were identified from the Organ Procurement and Transplant Network/United Network of Organ Sharing database.For each induction type, adjusted overall and deathcensored graft as well as patient survivals were compared between patients discharged on steroid vs no steroid. Among r-ATG induced patients, analysis was repeated after splitting the group into low and high immune risk groups.RESULTS: Among the 37217 patients included in the analysis, 17863 received r-ATG(steroid = 13001, nosteroid = 4862), 3028 alemtuzumab(steroid = 852, no-steroid = 2176) and 16326 IL-2B(steroid = 15008, no-steroid = 1318). Adjusted overall graft survival was inferior(HR = 1.16, 95%CI: 1.06-1.27, P = 0.002) with similar death-censored graft survival(HR = 0.99, 95%CI: 0.86-1.14, P = 0.86) for steroid vs no-steroid groups in r-ATG induced patients. Both adjusted overall and death-censored graft survivals for steroid vs nosteroid groups were similar in alemtuzumab(HR = 0.92, 95%CI: 0.73-1.15, P = 0.47 and HR = 0.87, 95%CI: 0.62-1.22, P = 0.43 respectively) and IL-2B(HR = 1.05, 95%CI: 0.91-1.21, P = 0.48 and HR = 0.94, 95%CI: 0.75-1.18, P = 0.60 respectively) induced groups. Adjusted patient survivals were inferior for steroid vs nosteroid groups in r-ATG induced(HR = 1.31, 95%CI: 1.15-1.49, P < 0.001) but similar in alemtuzumab(HR = 1.02, 95%CI: 0.75-1.38, P = 0.92) and IL-2B(HR = 1.17, 95%CI: 0.97-1.40, P = 0.10) induced patients. Among the r-ATG induced group there were 4346 patients in the low immune risk and 13517 patients in the high immune risk group. Adjusted overall graft survivals were inferior for steroid vs no steroid groups in both low immune(HR = 1.34, 95%CI: 1.09-1.64, P = 0.001) and high immune(HR = 1.18, 95%CI: 1.07-1.30, P = 0.005) risk groups. Adjusted death-censored graft survivals for steroid vs no steroid groups were similar in both low(HR = 1.06, 95%CI: 0.78-1.45, P = 0.70) and high(HR = 1.04, 95%CI: 0.98-1.20, P = 0.60) immune risk groups. Adjusted patient survivals were inferior for steroid vs no steroid groups in both low immune(HR =1.54, 95%CI: 1.18-2.02, P < 0.001) and high immune(HR = 1.32, 95%CI: 1.16-1.51, P = 0.002) risk groups. Overall, there were significantly higher deaths from infections and cardiovascular causes in patients maintained on steroids. CONCLUSION: Our study showed an association between steroid addition to a CNI/MMF-maintenance regimen and increased death with functioning graft in patients receiving r-ATG induction for first-time deceased donor kidney transplantation.
文摘Maintenance plays an important role in acquiring cost and service advantage for an enterprise. A supply chain-oriented e-maintenance management mode is presented as a new thought on equipment maintenance on the basis of analyzing the importance of maintenance and the characteristics of current maintenance modes. The mode allies personnel and organizations related to plant in order to construct the dynamic alliance of failure diagnosis and maintenance; through optimized deployment of maintenance resources and management of maintenance flow, the maximization of maintenance profit is realized. This paper analyzes the current multi-agent technology, and multi- agent technology is adopted to construct resource negotiation and a problem-resolving negotiation mechanism in an e-maintenance supply chain. At the same time, an agent negotiation process of resource deployment and harmony is analyzed. Finally, the key technologies realizing e-maintenance based on a supply chain environment are analyzed, which can realize the coordination, effectiveness and agility of an e-maintenance supply chain.
文摘The behavior decision of agent in multi-agent system is dependent on the task of individual agent ,the cooperation with other agents,and the multi-agent system' constraints. The paper presents three abstract concept models of achievement intention,joint intention and maintenance intention representing the factors that affect agent's behaviors respectively,to investigate autonomous agent's behaviors decision in support of agent-oriented software development. The paper discusses and analyzes how they will affect agent's behavior decision and the relationship among them,defines their formal and rigorous semantics,finally specifies and proves a number of important properties.
文摘提出了一种基于M u lti-A gen t的虚拟维修训练系统(VM TS)结构框架,整个系统分别由主控A gen t、仿真A gen t、和接口A gen t3个具有交互作用的A gen t组成,从而将虚拟维修训练系统的开发转化为一个多A gen t系统的设计与开发。基于多A gen t的框架结构可实现受训者的智能模型及虚拟训练场景中虚拟物体的行为模型,从而可以提高VM TS的健壮性和可重用性。基于A gen t的概念模型实现了A gen t之间的交互和协作,并介绍了主控A gen t和仿真A gen t的具体实现方法。
