A phytochemical investigation on Isodon flavidus led to the isolation of flavidanolide A(1),a rearranged diterpenoid featuring a six/seven/five-membered tricyclic skeleton,together with flavidanolide B(2),an uncommon ...A phytochemical investigation on Isodon flavidus led to the isolation of flavidanolide A(1),a rearranged diterpenoid featuring a six/seven/five-membered tricyclic skeleton,together with flavidanolide B(2),an uncommon heterodimeric diterpenoid consisting of a norabietane and a seco-isopimarane monomeric units.Their structures were elucidated by extensive spectroscopic data and single-crystal X-ray diffraction analyses.Their plausible biosynthetic routes were also proposed.In the bioassay,flavidanolide B was found to exhibit good inhibitory effect against lipopolysaccharide(LPS)-induced nitric oxide(NO)production in RAW264.7 cells comparable to positive control pyrrolidinedithiocarbamate ammonium(PDTC),which provided evidence for the medicinal value of I.flavidus as a folk medicine for treating inflammatory diseases.展开更多
基金supported by the National Natural Science Foundation of China(No.82204605)the National Natural Science Foundation of China(No.81560709)+3 种基金the Technology Fund of Guizhou Administration of Traditional Chinese Medicine(No.QZYY-2022019)Science and Technology Tip-top Talent Foundation of Universities in Guizhou Province(No.Qian jiao he KY(2021)034)the Research Grant Council of the Hong Kong Special Administrative Region,China(No.HKBU 12102219)the University Grants Committee of the Hong Kong Special Administrative Region,China(UGC Research Matching Grant Scheme,No.RMG2019_1_19)。
文摘A phytochemical investigation on Isodon flavidus led to the isolation of flavidanolide A(1),a rearranged diterpenoid featuring a six/seven/five-membered tricyclic skeleton,together with flavidanolide B(2),an uncommon heterodimeric diterpenoid consisting of a norabietane and a seco-isopimarane monomeric units.Their structures were elucidated by extensive spectroscopic data and single-crystal X-ray diffraction analyses.Their plausible biosynthetic routes were also proposed.In the bioassay,flavidanolide B was found to exhibit good inhibitory effect against lipopolysaccharide(LPS)-induced nitric oxide(NO)production in RAW264.7 cells comparable to positive control pyrrolidinedithiocarbamate ammonium(PDTC),which provided evidence for the medicinal value of I.flavidus as a folk medicine for treating inflammatory diseases.
