Hepatic fibrosis is a common pathological process that occurs in the development of various chronic liver diseases into cirrhosis and liver cancer,characterized by excessive deposition of the extracellular matrix.In t...Hepatic fibrosis is a common pathological process that occurs in the development of various chronic liver diseases into cirrhosis and liver cancer,characterized by excessive deposition of the extracellular matrix.In the past,hepatic fibrosis was thought to be a static and irreversible pathological process.In recent years,with the rapid development of molecular biology and the continuous in-depth study of the liver at the microscopic level,more and more evidence has shown that hepatic fibrosis is a dynamic and reversible process.Therefore,it is particularly important to find an effective,simple,and inexpensive method for its prevention and treatment.Traditional Chinese medicine(TCM)occupies an important position in the treatment of hepatic fibrosis due to its advantages of low adverse reactions,low cost,and multi-target effectiveness.A large number of research results have shown that TCM monomers,single herbal extracts,and TCM formulas play important roles in the prevention and treatment of hepatic fibrosis.Oxidative stress(OS)is one of the key factors in the occurrence and development of hepatic fibrosis.Therefore,this article reviews the progress in the understanding of the mechanisms of TCM monomers,single herbal extracts,and TCM formulas in preventing and treating hepatic fibrosis by inhibiting OS in recent years,in order to provide a reference and basis for drug therapy of hepatic fibrosis.展开更多
Chinese herbal flavonoids play a role in improving the health of aquatic animals and optimizing the quality of aquatic products.The efficient extraction of flavonoids is beneficial to deepening the application of flav...Chinese herbal flavonoids play a role in improving the health of aquatic animals and optimizing the quality of aquatic products.The efficient extraction of flavonoids is beneficial to deepening the application of flavonoids in aquatic products.To explore the optimal way of flavonoid extraction has become a hot research topic.In this study,based on temperature,ultrasonic power and extraction time,the best ways to extract flavonoids from four Chinese herbal medicines,purslane,Verbena,Fructus Amomi and Alpinia oxyphylla,were explored.Through single-factor and multi-factor optimization extraction,the most appropriate conditions for flavonoid extraction were obtained.The results showed that the best way of ultrasonic assisted extraction of flavonoids was purslane at 40℃,300 W(400 W),Verbena at 70℃,400W,Fructus Amomi at 50℃,200 W,and A.oxyphylla at 40℃,400W,and 40 min.The results of orthogonal design showed that purslane could get 13.20 mg/g at 40℃,400 W and 50 min,Verbena could get 10.23 mg/g at 60℃,300 W and 30 min,Fructus Amomi could get 8.18 mg/g at 50℃,300 W and 60 min,and A.oxyphylla could get 7.31 mg/g at 30℃,300 W and 50 min.展开更多
Hyperlipidemia （HLP） is the No.1 risk factor for patients with atherosclerosis （AS） and is directly related to the occurrence of coronary artery disease （CAD） and cerebrovascular disease. Therefore, prevention a...Hyperlipidemia （HLP） is the No.1 risk factor for patients with atherosclerosis （AS） and is directly related to the occurrence of coronary artery disease （CAD） and cerebrovascular disease. Therefore, prevention and treatment of AS is of great importance and of practical significance in controlling the incidence and mortality of CAD. With its peculiar syndrome-dependent therapy, traditional Chinese medicine （TCM） has accumulated abundant practical experiences in this field and good clinical effects have been achieved. Chinese herbal medicine, with its particularly unique advantages and high potentials yet to be tapped, displays its huge strength in HLP prevention and treatment. The progress of studies concerning prevention and treatment of HLP by Chinese herbal medicines, in the form of monomers or compound recipes, is reviewed in this paper.展开更多
文摘Hepatic fibrosis is a common pathological process that occurs in the development of various chronic liver diseases into cirrhosis and liver cancer,characterized by excessive deposition of the extracellular matrix.In the past,hepatic fibrosis was thought to be a static and irreversible pathological process.In recent years,with the rapid development of molecular biology and the continuous in-depth study of the liver at the microscopic level,more and more evidence has shown that hepatic fibrosis is a dynamic and reversible process.Therefore,it is particularly important to find an effective,simple,and inexpensive method for its prevention and treatment.Traditional Chinese medicine(TCM)occupies an important position in the treatment of hepatic fibrosis due to its advantages of low adverse reactions,low cost,and multi-target effectiveness.A large number of research results have shown that TCM monomers,single herbal extracts,and TCM formulas play important roles in the prevention and treatment of hepatic fibrosis.Oxidative stress(OS)is one of the key factors in the occurrence and development of hepatic fibrosis.Therefore,this article reviews the progress in the understanding of the mechanisms of TCM monomers,single herbal extracts,and TCM formulas in preventing and treating hepatic fibrosis by inhibiting OS in recent years,in order to provide a reference and basis for drug therapy of hepatic fibrosis.
基金Supported by High-level Talents Project of Hainan Province(No.2019RC246)the Natural Science Foundation of Hainan Province(No.20163074,No.20163071)"Ichthyology"First-Class Undergraduate Course Construction Project of Hainan Province.
文摘Chinese herbal flavonoids play a role in improving the health of aquatic animals and optimizing the quality of aquatic products.The efficient extraction of flavonoids is beneficial to deepening the application of flavonoids in aquatic products.To explore the optimal way of flavonoid extraction has become a hot research topic.In this study,based on temperature,ultrasonic power and extraction time,the best ways to extract flavonoids from four Chinese herbal medicines,purslane,Verbena,Fructus Amomi and Alpinia oxyphylla,were explored.Through single-factor and multi-factor optimization extraction,the most appropriate conditions for flavonoid extraction were obtained.The results showed that the best way of ultrasonic assisted extraction of flavonoids was purslane at 40℃,300 W(400 W),Verbena at 70℃,400W,Fructus Amomi at 50℃,200 W,and A.oxyphylla at 40℃,400W,and 40 min.The results of orthogonal design showed that purslane could get 13.20 mg/g at 40℃,400 W and 50 min,Verbena could get 10.23 mg/g at 60℃,300 W and 30 min,Fructus Amomi could get 8.18 mg/g at 50℃,300 W and 60 min,and A.oxyphylla could get 7.31 mg/g at 30℃,300 W and 50 min.
基金Supported by the Natural Science Foundation of Zhejiang Province(No. Y204269)Chinese Medicine Foundation of Zhejiang Province(No.2005C004)
文摘Hyperlipidemia （HLP） is the No.1 risk factor for patients with atherosclerosis （AS） and is directly related to the occurrence of coronary artery disease （CAD） and cerebrovascular disease. Therefore, prevention and treatment of AS is of great importance and of practical significance in controlling the incidence and mortality of CAD. With its peculiar syndrome-dependent therapy, traditional Chinese medicine （TCM） has accumulated abundant practical experiences in this field and good clinical effects have been achieved. Chinese herbal medicine, with its particularly unique advantages and high potentials yet to be tapped, displays its huge strength in HLP prevention and treatment. The progress of studies concerning prevention and treatment of HLP by Chinese herbal medicines, in the form of monomers or compound recipes, is reviewed in this paper.
