Numerical Simulation of TWo Different Flexible Bodies Immersed in Moving Flow

The coupled motion of two flexible bodies with different lengths immersed in moving fluid is studied numerically. The flapping frequency, flapping amplitude and average drag coefficient of each body are calculated and the influences of the arranging manner and separation distance are analyzed. In our simulation, when placed in the flow individually, the flexible body with a longer length will flap in period and the shorter one will maintain still straightly in the flow direction. The numerical results show that, two different flexible structures near placed in moving flow would strongly interact. When they are placed side by side, the existence of the stable shorter flexible body will restrain the flapping of the longer one while the existence of the longer flexible body may also induce the shorter one to flap synchronously. When placed in tandem with the shorter flexible body in upstream, the flapping of the longer one in downstream will be obviously enhanced. In the situation for the longer flexible body placed in upstream of the shorter one, the coupled flapping amplitude and average drag coefficients increase and decrease periodically with increasing the arranging space, and peak values appear as a result of the mediate of the tail wakes.

Development of a Flexible Multibody Model to Simulate Nonlinear Effects in Printing Process

Modern high speed printing machines are able to print up to 700 m/min. At this rate, little excita-tions lead to vibrations, which may lead to loss of contact between the rollers (bouncing). This bouncing results in white stripes, being visible on the printed image. To enable the simulation of the whole printing process, including effects like bouncing, a discrete multibody model is developed. The rollers are modeled by several rigid bodies. These bodies are connected to each other by rotational springs, which allow simulation of the first bending eigenmodes of each roller. The contact area between the rollers is modeled by several nonlinear translational springs and damping elements. These elements change their stiffness and damping values depending on the distance between the rollers. If a defined distance is exceeded, the values become zero, which represents the loss of contact (bouncing). The unknown spring and damping elements of this model are parametrized with help of an experimental modal analysis. This paper presents the development of a flexible multibody model to simulate nonlinear effects in printing process.

Structural modeling of proteins by integrating small-angle x-ray scattering data

Elucidating the structure of large biomolecules such as multi-domain proteins or protein complexes is challenging due to their high flexibility in solution. Recently, an ＂integrative structural biology＂ approach has been proposed, which aims to determine the protein structure and characterize protein flexibility by combining complementary high- and lowresolution experimental data using computer simulations. Small-angle x-ray scattering（SAXS） is an efficient technique that can yield low-resolution structural information, including protein size and shape. Here, we review computational methods that integrate SAXS with other experimental datasets for structural modeling. Finally, we provide a case study of determination of the structure of a protein complex formed between the tandem SH3 domains in c-Cb1-associated protein and the proline-rich loop in human vinculin.

Proficiency of virtual reality simulator training in flexible retrograde ureteroscopy renal stone management

Background Minimally invasive flexible ureteroscopy techniques have widely adopted in the management of patients with renal stones. We performed this study to investigate the value of virtual reality simulator training in retrograde flexible ureteroscopy renal stone treatment for catechumen.