Utilization of biodiesel waste in the development of botanical-based floating tablet formulation against early stages of mosquitoes

The current paper has elaborated the efficient utilization of liquid biodiesel waste in combination with dillapiole and citronella essential oil as active ingredients.Sawdust,cellulose and hydrophobic silica were used as inert ingredients,which make the tablet to float over the water surface.ATR-FTIR analysis of tablet confirmed the compatibility with citronella oil,dillapiole,liquid biodiesel waste in tablet composition after compression.Physico-chemical analysis studies show that tablet parameters are in standard limits.SEM analysis shows some porous structures in tablet composition which confirms the floating nature of the tablets.The specific ratio(2:2:1)of citronella oil,dillapiole and liquid biodiesel waste showed maximum mortality,i.e.95%after 24 h.After application,the tablet is nontoxic towards the aquatic organisms and water quality remains unaf-fected.The better performance of the tablets has been evaluated in terms of characterization studies,viz.ATR-FTIR and SEM studies and bioefficacy trials which confirmed the presence of active ingredients responsible for insecticidal activity.

Statistical design and evaluation of a propranolol HCl gastric floating tablet

The purpose of this research was to apply statistical design for the preparation of a gastric floating tablet(GFT)of propranolol HCl and to investigate the effect of formulation variables on drug release and the buoyancy properties of the delivery system.The contents of polyethylene oxide(PEO)WSR coagulant and sodium bicarbonate were used as independent variables in central composite design of the best formulation.Main effects and interaction terms of the formulation variables were evaluated quantitatively using a mathematical model approach showing that both independent variables have significant effects on floating lag time,%drug release at 1 h(D_(1h))and time required to release 90%of the drug(t_(90)).The desired function was used to optimize the response variables,each with a different target,and the observed responses were in good agreement with the experimental values.FTIR and DSC studies of the statistically optimized formulation revealed there was no chemical interaction between drug and polymer.The statistically optimized formulation released drug according to first order kinetics with a non-Fickian diffusion mechanism.Evaluation of the optimized formulation in vivo in human volunteers showed that the GFT was buoyant in gastric fluid and that its gastric residence time was enhanced in the fed but not the fasted state.