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INTERNAL FLOW MECHANISM AND EXPERIMENTAL RESEARCH OF LOW PRESSURE AXIAL FAN WITH FORWARD-SKEWED BLADES 被引量:15
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作者 LI Yang LIU Jie +1 位作者 OUYANG Hua DU Zhao-Hui 《Journal of Hydrodynamics》 SCIE EI CSCD 2008年第3期299-305,共7页
This article presents the flow mechanism analysis and experimental study of a forward-skewed impeller and a radial impeller in low pressure axial fan. The forward-skewed blade was obtained by the optimization design o... This article presents the flow mechanism analysis and experimental study of a forward-skewed impeller and a radial impeller in low pressure axial fan. The forward-skewed blade was obtained by the optimization design of the radial blade and CFD technique. Measurement of the two blades was carried out in aerodynamic and aeroacoustic performance. Compared to the radial blade, the forward-skewed blade has demonstrated the improvements in efficiency, total pressure ratio, Stable Operating Range (SOR) and less aerodynamic noise. Detailed flow measurement and computation were performed for outlet flow field for investigating the responsible flow mechanisms. The results show the forward-skewed blade can cause a spanwise redistribution of flow toward the blade mid-span and reduce tip loading. This results in reduced significantly total pressure loss near hub and shroud endwall region, despite the slight increase of total pressure loss at mid-span. 展开更多
关键词 low pressure axial fan forward-skewed blade aerodynamic performance flow mechanism
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Numerical investigation of flow mechanisms of tandem impeller inside a centrifugal compressor 被引量:1
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作者 Ziliang LI Xin’gen LU +3 位作者 Shengfeng ZHAO Ge HAN Chengwu YANG Yanfeng ZHANG 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2019年第12期2627-2640,共14页
This study numerically investigated a single stage centrifugal compressor "Radiver" with a wedge diffuser and several tandem-designed impellers to explore the flow phenomena within the tandem impeller and th... This study numerically investigated a single stage centrifugal compressor "Radiver" with a wedge diffuser and several tandem-designed impellers to explore the flow phenomena within the tandem impeller and the potential to enhance compressor performance.The results demonstrate that tandem design and clocking fraction(ks)significantly affects the compressor performance.The compressor stage with tandem impellers of Series A of boundary layer growth interruption alone are observed to have a widely operating range but efficiency and total pressure ratio penalty compared with that of conventional impeller.The tandem impeller with at least the same impeller efficiency as the conventional design is considered as a critical design criteria so that further modification process based on the flow characteristic of tandem impeller is necessary.In order to restrain the inducer wake and exducer shock losses,parameters modification of blade angle and thickness distributions are necessary and the modified tandem impeller of Series B is obtained.The modified tandem impeller with 25%clocking arrangement shows an 8.45%stall margin increase and maintains the total pressure ratio and efficiency as the conventional design,which proves the potential of tandem impeller to improve compressor stage performance.It is noteworthy that the tandem impellers of Radiver have not shown obviously balanced exit flow field and the fundamental mechanism of stall margin extending of tandem impeller lies on the improved impeller/diffuser matching performance resulting from the incidence angle variation at diffuser inlet. 展开更多
关键词 Centrifugal compressor stage flow mechanism Impeller/diffuser matching Stall margin Tandem impeller
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Mechanism of Electromagnetic Flow Control Enhanced by Electro-Discharge in Water
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作者 纪延亮 周本谋 黄亚冬 《Chinese Physics Letters》 SCIE CAS CSCD 2018年第5期73-77,共5页
Pulsed discharge utilized to achieve large current density in the electromagnetic flow control is numerically studied. A mathematic discharge model is established to calculate the plasma channel, and an actuator is de... Pulsed discharge utilized to achieve large current density in the electromagnetic flow control is numerically studied. A mathematic discharge model is established to calculate the plasma channel, and an actuator is designed to generate the Lorentz force in the micro plasma channel. During the discharge process, the resistance in the channel decreases rapidly and a large current density appears between the discharge electrodes. After the actuator is applied in the leading edge of a flat plate, the separation region and downstream turbulent boundary layer on the plate disappear. Meanwhile, a skin-friction drag force reduction is achieved. 展开更多
关键词 mechanism of Electromagnetic flow Control Enhanced by Electro-Discharge in Water
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Flow Loss Mechanism in a Supercritical Carbon Dioxide Centrifugal Compressor at Low Flow Rate Conditions
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作者 YANG Zimu JIANG Hongsheng +5 位作者 ZHUGE Weilin CAI Ruikai YANG Mingyang CHEN Haoxiang QIAN Yuping ZHANG Yangjun 《Journal of Thermal Science》 SCIE EI CSCD 2024年第1期114-125,共12页
With the advantages of high efficiency and compact structure,supercritical carbon dioxide(sC02)Brayton cycles have bright prospects for development in energy conversion field.As one of the core components of the power... With the advantages of high efficiency and compact structure,supercritical carbon dioxide(sC02)Brayton cycles have bright prospects for development in energy conversion field.As one of the core components of the power cycle,the centrifugal compressor tends to operate near the critical point(304.13 K,7.3773 MPa).Normally,the compressor efficiency increases as the inlet temperature decreases.When the inlet temperature is close to the critical point,the density increases sharply as the temperature decreases,which results in quickly decreasing of volume flow rate and efficiency reducing.The flow loss mechanism of the sCO_(2) compressor operating at low flow rate is studied in this paper.Computational fluid dynamics(CFD) simulations for sCO_(2)compressor were carried out at various inlet temperatures and various mass flow rates.When the sCO_(2)compressor operates at low volume flow rate,the flow loss is generated mainly on the suction side near the trailing edge of the blade.The flow loss is related to the counterclockwise vortexes generated on the suction side of the main blade.The vortexes are caused by the flow separation in the downstream region of the impeller passage,which is different from air compressors operating at low flow rates.The reason for this flow separation is that the effect of Coriolis force is especially severe for the sCO_(2) fluid,compared to the viscous force and inertial force.At lower flow rates,with the stronger effect of Coriolis force,the direction of relative flow velocity deviates from the direction of radius,resulting in its lower radial component.The lower radial relative flow velocity leads to severe flow separation on the suction side near the trailing edge of the main blade. 展开更多
关键词 supercritical CO_(2) centrifugal compressor flow loss mechanism Coriolis force
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A NUMERICAL STUDY OF BINGHAM TURBULENT FLOW IN SUDDEN-EXPANSION STRAIGHT CIRCULAR PIPE
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作者 胡春波 魏进家 +1 位作者 姜培正 苗永淼 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 1998年第11期0-0,0-0+0-0+0,共7页
The control equations for the turbulent flow of Bingham fluid are established according to Bingham fluid constitution equation. Pressure field and velocity field are correlted by pressure-correction equation. The nume... The control equations for the turbulent flow of Bingham fluid are established according to Bingham fluid constitution equation. Pressure field and velocity field are correlted by pressure-correction equation. The numerical computations are performed on Bingham fluid turbulent flow in sudden-expansion straight circular pipe, and the flow mechanisms are discussed. 展开更多
关键词 Bingham fluid TURBULENCE numerical study flow mechanisms
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Numerical simulation of gas transport mechanisms in tight shale gas reservoirs 被引量:21
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作者 Yao Jun Sun Hai +2 位作者 Fan Dong-yan Wang Chen-chen Sun Zhi-xue 《Petroleum Science》 SCIE CAS CSCD 2013年第4期528-537,共10页
Due to the nanometer scale pore size and extremely low permeability of a shale matrix,traditional Darcy's law can not exactly describe the combined gas transport mechanisms of viscous flow and Knudsen diffusion.Three... Due to the nanometer scale pore size and extremely low permeability of a shale matrix,traditional Darcy's law can not exactly describe the combined gas transport mechanisms of viscous flow and Knudsen diffusion.Three transport models modified by the Darcy equation with apparent permeability are used to describe the combined gas transport mechanisms in ultra-tight porous media,the result shows that Knudsen diffusion has a great impact on the gas transport and Darcy's law cannot be used in a shale matrix with a pore diameter less than 1 μm.A single porosity model and a double porosity model with consideration of the combined gas transport mechanisms are developed to evaluate the influence of gas transport mechanisms and fracture parameters respectively on shale gas production.The numerical results show that the gas production predicted by Darcy's law is lower than that predicted with consideration of Knudsen diffusion and the tighter the shale matrix,the greater difference of the gas production estimates.In addition,the numerical simulation results indicate that shale fractures have a great impact on shale gas production.Shale gas cannot be produced economically without fractures. 展开更多
关键词 Shale gas gas transport mechanisms viscous flow Knudsen diffusion fracture
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MECHANICAL VIBRATIONAL POWER FLOW IN BEAM-PLATE ASSEMBLIES
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作者 Yi Chuijie Qinghua University Chen Tianning Li Wei Huang Xieqing Xi’an Jiaotong University 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 1995年第2期135-141,共7页
The vibrational power flow in the beam-plate assemblies and then with the isolators is investigated using analytical ' power flow' approach based on the some concepts of mechanical mo- bility and structural dy... The vibrational power flow in the beam-plate assemblies and then with the isolators is investigated using analytical ' power flow' approach based on the some concepts of mechanical mo- bility and structural dynamics. Theoretical expressions of the power flow in the structures are given and examined. The numerical results of the expressions are good agreements with the measuring re- sults obtained by the technique of vibration intensity. On the basis of these results, possible ways of reducing the vibrational power flow in the structures are suggested . 展开更多
关键词 Beam structure Plate structure Mechanical mobility Power flow
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Effects of relaxation time on start-up time for starting flow of Maxwell fluid in a pipe
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作者 Zhen Li Keqin Zhu 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2010年第2期209-215,共7页
Although the analytical solution of the starting flow of Maxwell fluid in a pipe has been derived for a long time, the effect of relaxation time λ on start-up time ts of this flow is still not well understood. Especi... Although the analytical solution of the starting flow of Maxwell fluid in a pipe has been derived for a long time, the effect of relaxation time λ on start-up time ts of this flow is still not well understood. Especially, there exist a series of jumps on the ts-λ. curve. In this paper we introduce a normalized mechanical energy by mode decomposition and mathematical analogy to describe the start-up process. An improved definition of start-up time is presented based on the normalized mechanical energy. It is proved that the ts-λ. curve contains a series of jumps if λ is larger than a critical value. The exact positions of the jumps are determined and the physical reason of the jumps is discussed. 展开更多
关键词 Maxwell fluid Starting flow·Relaxation time·Start-up time·Mechanical energy
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Research on the Aerodynamic Characteristics of Leading Edge and Bulge of Ram-Air Parafoil Based on CFD
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作者 Lei Ding Lingrui Chen +2 位作者 Yalei Bai Huimin Yao Chuanyu Gao 《World Journal of Engineering and Technology》 2023年第4期989-999,共11页
This study focuses on the aerodynamic characteristics and flow mechanism of three different configurations of ram-air parafoil with open/closed air inlet and bulges. Firstly, we designed a special parafoil configurati... This study focuses on the aerodynamic characteristics and flow mechanism of three different configurations of ram-air parafoil with open/closed air inlet and bulges. Firstly, we designed a special parafoil configuration for this study. Then we used numerical simulation to obtain the aerodynamic data of three parafoils at different angles of attack, and studied the influence of the bulge and the leading edge open/closed inlet on the aerodynamic performance of the ram-air parafoil. Finally, we study the flow mechanism of the ram-air parafoil through the pressure distribution and flow field. The results of the study show that compared with the aerodynamic parameters of the parafoil without bulges, the optimal angle of attack of the two parafoils with bulges is increased by 4?, the maximum lift to drag ratio of the parafoil with closed leading edge is reduced by about 4.3% and the optimal angle of attack is reduced by about 2?. The maximum lift to drag ratio of the parafoil with open leading edge is reduced by about 23.6% and the stalling angle of attack is reduced by about 4?. The pressure on the surface of a ram-air parafoil with open leading edge inlet is the highest. . 展开更多
关键词 Ram-Air Parafoil Numerical Simulation Aerodynamic Characteristics flow mechanism
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气-固密相流化床流型转变的机理模型 被引量:1
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作者 蔡平 金涌 +1 位作者 俞芷青 L.-S.Fan 《化学反应工程与工艺》 CAS CSCD 北大核心 1992年第3期297-301,共5页
以机理实验为依据,提出了一个描述气-固流化床中从鼓泡流态化向湍动流态化流型转变的物理模型。导出了当单位床层体积中气泡数目对气速的二阶导数为零时发生流型转变,该模型的计算机结果与实验数据吻合良好。
关键词 流型 流化床反应器
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Surrogate-based modeling and dimension reduction techniques for multi-scale mechanics problems 被引量:4
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作者 Wei Shyy Young-Chang Cho +3 位作者 Wenbo Du Amit Gupta Chien-Chou Tseng Ann Marie Sastry 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2011年第6期845-865,共21页
Successful modeling and/or design of engineering systems often requires one to address the impact of multiple "design variables" on the prescribed outcome.There are often multiple,competing objectives based on which... Successful modeling and/or design of engineering systems often requires one to address the impact of multiple "design variables" on the prescribed outcome.There are often multiple,competing objectives based on which we assess the outcome of optimization.Since accurate,high fidelity models are typically time consuming and computationally expensive,comprehensive evaluations can be conducted only if an efficient framework is available.Furthermore,informed decisions of the model/hardware's overall performance rely on an adequate understanding of the global,not local,sensitivity of the individual design variables on the objectives.The surrogate-based approach,which involves approximating the objectives as continuous functions of design variables from limited data,offers a rational framework to reduce the number of important input variables,i.e.,the dimension of a design or modeling space.In this paper,we review the fundamental issues that arise in surrogate-based analysis and optimization,highlighting concepts,methods,techniques,as well as modeling implications for mechanics problems.To aid the discussions of the issues involved,we summarize recent efforts in investigating cryogenic cavitating flows,active flow control based on dielectric barrier discharge concepts,and lithium(Li)-ion batteries.It is also stressed that many multi-scale mechanics problems can naturally benefit from the surrogate approach for "scale bridging." 展开更多
关键词 Multi-scale mechanics ~ Cryogenic cavitating flow Surrogate-based modeling Active flow control Engineering system
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SIMULATION AND APPLICATION OF THREE_DIMENSIONAL MIGRATION_ACCUMULATION OF OIL RESOURCES 被引量:3
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作者 袁益让 赵卫东 +1 位作者 程爱杰 韩玉笈 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 1999年第9期999-1009,共11页
Numerical simulation of oil migration and accumulation is to describe the history of oil migration and accumulation in basin evolution. It is of great value in the exploration of oil resources and their rational evalu... Numerical simulation of oil migration and accumulation is to describe the history of oil migration and accumulation in basin evolution. It is of great value in the exploration of oil resources and their rational evaluation. In this paper, from such actual conditions as the effects of mechanics of fluids in porous media and 3-dimensional geology characteristics, a kind of modified method of second order splitting-up implicit interactive scheme is pur forward. For the famous hydraulic experiment of secondary migration-accumulation, the numerical simulation test has been done, and both the computational and experimental results are basically identical. For the actual problem of Dongying hollow of Shengli Petroleum Oil Field, the numerical simulation test and the actual conditions are basically coincident. Thus the well-known problem has been solved. 展开更多
关键词 mechanics of immiscible flow 3-dimensional migration-accumulation of oil resources splitting-up numerical simulation Dongying hollow
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A growth kinetics model of rate decomposition for Si_(1-x)Ge_x alloy based on dimer theory 被引量:1
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作者 戴显英 吉瑶 郝跃 《Chinese Physics B》 SCIE EI CAS CSCD 2014年第1期284-288,共5页
According to the dimer theory on semiconductor surface and chemical vapor deposition(CVD) growth characteristics of Sil_xGex, two mechanisms of rate decomposition and discrete flow density are proposed. Based on the... According to the dimer theory on semiconductor surface and chemical vapor deposition(CVD) growth characteristics of Sil_xGex, two mechanisms of rate decomposition and discrete flow density are proposed. Based on these two mech- anisms, the Grove theory and Fick's first law, a CVD growth kinetics model of Sil-xGex alloy is established. In order to make the model more accurate, two growth control mechanisms of vapor transport and surface reaction are taken into account. The paper also considers the influence of the dimer structure on the growth rate. The results show that the model calcuated valne is consistent with the experimental vahles at different ternnerntllres. 展开更多
关键词 dimer theory rate decomposition discrete flow density mechanisms growth kinetics
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AMT-Fault-Diagnosis Device Based on ISO 15765 被引量:1
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作者 席军强 肖宽 杨爱均 《Journal of Beijing Institute of Technology》 EI CAS 2010年第4期405-410,共6页
To debug automatic mechanical transmission(AMT) more quickly and accurately,an AMT-fault-diagnosis device is designed based on the ISO 15765 protocol,which adopts the flow control mechanism and has off-line diagnost... To debug automatic mechanical transmission(AMT) more quickly and accurately,an AMT-fault-diagnosis device is designed based on the ISO 15765 protocol,which adopts the flow control mechanism and has off-line diagnostics function.Requirements for the device are analyzed and diagnostic trouble code(DTC) is defined.Electrically controlled hardware with graphics display function and fault diagnostic software flowchart are designed based on the electronic control hydraulic AMT system.Bench and vehicle driving tests showethat the AMT-fault-diagnosis device can read and delete the fault message successfully with a stable performance. 展开更多
关键词 automatic mechanical transmission(AMT) fault diagnosis ISO 15765 flow control mechanism
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Fast determination of meso-level mechanical parameters of PFC models 被引量:4
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作者 Guo Jianwei Xu Guoan +1 位作者 Jing Hongwen Kuang Tiejun 《International Journal of Mining Science and Technology》 SCIE EI 2013年第1期157-162,共6页
To solve the problems of blindness and inefficiency existing in the determination of meso-level mechanical parameters of particle flow code (PFC) models, we firstly designed and numerically carried out orthogonal test... To solve the problems of blindness and inefficiency existing in the determination of meso-level mechanical parameters of particle flow code (PFC) models, we firstly designed and numerically carried out orthogonal tests on rock samples to investigate the correlations between macro-and meso-level mechanical parameters of rock-like bonded granular materials. Then based on the artificial intelligent technology, the intelligent prediction systems for nine meso-level mechanical parameters of PFC models were obtained by creating, training and testing the prediction models with the set of data got from the orthogonal tests. Lastly the prediction systems were used to predict the meso-level mechanical parameters of one kind of sandy mudstone, and according to the predicted results the macroscopic properties of the rock were obtained by numerical tests. The maximum relative error between the numerical test results and real rock properties is 3.28% which satisfies the precision requirement in engineering. It shows that this paper provides a fast and accurate method for the determination of meso-level mechanical parameters of PFC models. 展开更多
关键词 Particle flow code Meso-level mechanical parameter Macroscopic property Orthogonal test Intelligent prediction
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DYNAMIC RECOVERY AND DYNAMIC RECRYSTALLIZATION OF 7005 ALUMINIUM ALLOY DURING HOT COMPRESSION 被引量:33
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作者 J. Shen S. S. Xie and J. H. tang (General Research Institute for Non - ferrous Metals,Beijing 100088, China) 《Acta Metallurgica Sinica(English Letters)》 SCIE EI CAS CSCD 2000年第1期379-386,共8页
Dynamic recovery and dynamic recrystallizatin behaviors of AA7005 aluminium alloy (Al - Zn - Mg) during hot compression are investigated by isothermal compression testing.The interdependence of flow stress,stress, s... Dynamic recovery and dynamic recrystallizatin behaviors of AA7005 aluminium alloy (Al - Zn - Mg) during hot compression are investigated by isothermal compression testing.The interdependence of flow stress,stress, strain rate,true strain and deformation temperature for the alloy is analyzed by introduc- ing Zener-Hollomon parameter. A steady - state flow of the 7005 alloy is confirmed to be a thermal- ly activated process.which is governed by rate-controlling mechanisms of dislocations.A hyperbolic sine relationship can satisfactorily correlate temperature, strain rate with flow stress through an Arrhe- nius term that involves thermal activation parameters. The dynamic recovery mechanisms of the alloy are discussed.Cross- slip of jogged screw dislocations is the main dynamic recovery mechanism over the deformation temperatures and strain rates.Subgrains are highly developed in the originally elongat- ed grains.The size of the subgrain increases with decrease of the natural logarithm of Zener- Hol - lomon parameter.Local dynamic recrystallization is operative when the alloy is deformed at temperature of 500℃ and strain rate of 0. 001s - 1. 展开更多
关键词 compression flow stress dynamic recovery dynamic recrystallization restoration mechanism
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MECHANISM OF WALL PRESSURE FLUCTUATIONS BENEATH THE OPEN CHANNEL FLOW 被引量:1
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作者 ZHAO YAONAN, Tianjin University 《Journal of Hydrodynamics》 SCIE EI CSCD 1989年第1期52-60,共9页
Based on the measured results that wall pressure fluctuations are mainly de- cided by coherent structures of turbulence, the relationship between root-mean- square wall pressure and wall shear stress in turbulent shea... Based on the measured results that wall pressure fluctuations are mainly de- cided by coherent structures of turbulence, the relationship between root-mean- square wall pressure and wall shear stress in turbulent shear flow and that between the intensities of pressure and fluctuating velocity in homogeneous and isotropic turbulence are established in this paper. These relationships are consistent with former works, and have good agreement with experimental data. The paper also dis- cusses the concept of 'apparent pressure' on the wall in mean flow. 展开更多
关键词 mechanism OF WALL PRESSURE FLUCTUATIONS BENEATH THE OPEN CHANNEL flow
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ON THE STRUCTURE AND MOVEMENT MECHANISM OF FLOW WITH HYPERCONCENTRATION OF SEDIMENT
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作者 王明甫 段文忠 +1 位作者 谈广鸣 詹义正 《Science China Mathematics》 SCIE 1988年第1期114-128,共15页
This paper, based on the information obtained from flume experiments and field observations, concerns with the analyses of the flow with hyperconcentration of sediment containing a certain amount of fine particles. At... This paper, based on the information obtained from flume experiments and field observations, concerns with the analyses of the flow with hyperconcentration of sediment containing a certain amount of fine particles. Attention is focused on the classification of flow with hyperconcentration of sediment, the properties of the Bingham shear stress τB and rigidity coefficient η, the movement mechanism of fluid within flow-core and non-flow-core regions, the shear stress distribution and so on. Several formulae have been proposed to indicate vertical velocity distribution of 2-dimensional steady and uniform turbulent flow with hyperconcentration of fluid. The formulae can be applied either to the flow of the Bingham fluid or to that of the Newtonian fluid. 展开更多
关键词 ON THE STRUCTURE AND MOVEMENT mechanism OF flow WITH HYPERCONCENTRATION OF SEDIMENT
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纳米多孔介质中的流体流动
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作者 Weiyao Zhu Bin Pan +4 位作者 Zhen Chen Wengang Bu Qipeng Ma Kai Liu Ming Yue 《Engineering》 SCIE EI CAS 2024年第1期138-151,共14页
Fluid flow at nanoscale is closely related to many areas in nature and technology(e.g.,unconventional hydrocarbon recovery,carbon dioxide geo-storage,underground hydrocarbon storage,fuel cells,ocean desalination,and b... Fluid flow at nanoscale is closely related to many areas in nature and technology(e.g.,unconventional hydrocarbon recovery,carbon dioxide geo-storage,underground hydrocarbon storage,fuel cells,ocean desalination,and biomedicine).At nanoscale,interfacial forces dominate over bulk forces,and nonlinear effects are important,which significantly deviate from conventional theory.During the past decades,a series of experiments,theories,and simulations have been performed to investigate fluid flow at nanoscale,which has advanced our fundamental knowledge of this topic.However,a critical review is still lacking,which has seriously limited the basic understanding of this area.Therefore herein,we systematically review experimental,theoretical,and simulation works on single-and multi-phases fluid flow at nanoscale.We also clearly point out the current research gaps and future outlook.These insights will promote the significant development of nonlinear flow physics at nanoscale and will provide crucial guidance on the relevant areas. 展开更多
关键词 Transport in nanoporous media Multi-phase fluid dynamics Nonlinear flow mechanisms Nonlinear flow conservation equations Interfacial forces Molecular dynamics simulation
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Flow behavior and deposition study of pollen-shape carrier particles in an idealized inhalation path model 被引量:2
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作者 Meer Saiful Hassan Raymond Lau 《Particuology》 SCIE EI CAS CSCD 2010年第1期51-59,共9页
Pollen-shape (spiked sphere) hydroxyapatite (HA) particles for drug carrier application are studied. The particle shape and size effect on flow characteristics and deposition are assessed. The pollen-shape HA part... Pollen-shape (spiked sphere) hydroxyapatite (HA) particles for drug carrier application are studied. The particle shape and size effect on flow characteristics and deposition are assessed. The pollen-shape HA particles are synthesized to have comparable size as typical carrier particles with mean diameter of 30-50 μm and effective density less than 0.3 g/cm^3. The flow behaviors of HA and commonly used lactose (LA) carrier particles are characterized by the Carr's compressibility index (CI). The HA particles have lower CI than the LA particles for the same size range. The flow fields of HA and LA carrier particles are measured in an idealized inhalation path model using particle image velocimetry (PLY) technique. The particle streamlines indicate that a large portion of particles may deposit at the bending section due to inertial impaction and gravitational deposition. The flow field result shows that HA particles give smaller separation regions than the LA particles for the same size range. The pollen-shape HA particles are found to be able to follow the gas flow in the model and minimize undesired deposition. Deposition result confirms the bending section to have the most deposition. Deposition is found to be a function of particle properties. An empirical correlation is derived for the deposition efficiency of the pollen-shape particles as a function of particles Stokes number. 展开更多
关键词 Aerosol Fluid mechanics Multiphase flow Particle Powder technology Pulmonary drug delivery
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