Flos Abelmoschus manihot has a long history of application.Recent studies show that total flavone of A.manihot(L.)Medic(TFA)has a wide range of pharmacological activity.This article is a review mainly on chemical comp...Flos Abelmoschus manihot has a long history of application.Recent studies show that total flavone of A.manihot(L.)Medic(TFA)has a wide range of pharmacological activity.This article is a review mainly on chemical composition,method of determination and pharmacologic action of TFA,and it raises research and development direction.展开更多
Objective To explore the molecular mechanisms of the total flavonoids extracted from the flowers of Abelmoschus manihot(TFA) against α-naphthylisothiocyanate(ANIT)-induced cholestasis. Methods The hepatoprotectiv...Objective To explore the molecular mechanisms of the total flavonoids extracted from the flowers of Abelmoschus manihot(TFA) against α-naphthylisothiocyanate(ANIT)-induced cholestasis. Methods The hepatoprotective activities of TFA(125, 250 and 500 mg/kg) were investigated on ANIT-induced cholestatic liver injury in rats. Serum levels of alanine aminotransferase(ALT), aspartate aminotransferase(AST), total bilirubin(TBIL), total bile acid(TBA), and bile flow were measured to evaluate the protective effect of TFA. Furthermore, the hepatic m RNA and protein levels of transports, multidrug resistance-associated protein 2(MRP2), bile salt export pump(BSEP), and Na+-taurocholate cotransporting polypeptide(NTCP) were investigated to elucidate the protective mechanisms of TFA against ANIT-induced cholestasis. Results Pretreatment of TFA significantly and dose-dependently decreased the ANIT-induced elevation of serum ALT, AST, TBIL, and TBA levels and increased the ANIT-induced suppression of bile flow. Moreover, TFA was found to increase the expression of liver MRP2, BSEP, and NTCP in both protein and m RNA levels in ANIT-induced liver injury in rats with cholestasis. Conclusion TFA exerts a therapeutic effect on ANIT-induced liver injury in rats with cholestasis, possibly through regulating the expressions of hepatic transporters.展开更多
Abelmoschus manihot(L.)Medik.(A.manihot)is a traditional Chinese herbal medicine with a variety of pharmacological properties.It was first recorded in Jiayou Materia Medica dating back to the Song dynasty to eliminate...Abelmoschus manihot(L.)Medik.(A.manihot)is a traditional Chinese herbal medicine with a variety of pharmacological properties.It was first recorded in Jiayou Materia Medica dating back to the Song dynasty to eliminate urinary tract irritation by clearing away heat and diuretic effect.However,its pharmacological action on urinary tract infections has not been investigated.The present study aims to evaluate the anti-inflammatory activity of A.manihot on a mouse model of lipopolysaccharide(LPS)-induced cystitis.The results showed that A.manihot decreased white blood cell(WBC)count in urine sediments of the cystitis mice,alleviated bladder congestion,edema,as well as histopathological damage,reduced the expression levels of tumor necrosis factor-α,interleukin-6,and interleukin-1βsimultaneously.Moreover,A.manihot administration significantly downregulated the expression levels of TLR4,MYD88,IκBα,p-IκBα,NF-κB p65,and p-NF-κB p65 in LPS-induced cystitis mice.These findings demonstrated the protective effect of A.manihot against LPS-induced cystitis,which is attributed to its anti-inflammatory profile by suppressing TLR4/MYD88/NF-κB pathways.Our results suggest that A.manihot could be a potential candidate for cystitis treatment.展开更多
基金Jiangsu Natural Science Foundation Project(BK2008490).
文摘Flos Abelmoschus manihot has a long history of application.Recent studies show that total flavone of A.manihot(L.)Medic(TFA)has a wide range of pharmacological activity.This article is a review mainly on chemical composition,method of determination and pharmacologic action of TFA,and it raises research and development direction.
基金National Nature Science Foundation of China(No.30572350)New Drug Foundation of State Administration of Traditional Chinese Medicine(DIX005A)
文摘Objective To explore the molecular mechanisms of the total flavonoids extracted from the flowers of Abelmoschus manihot(TFA) against α-naphthylisothiocyanate(ANIT)-induced cholestasis. Methods The hepatoprotective activities of TFA(125, 250 and 500 mg/kg) were investigated on ANIT-induced cholestatic liver injury in rats. Serum levels of alanine aminotransferase(ALT), aspartate aminotransferase(AST), total bilirubin(TBIL), total bile acid(TBA), and bile flow were measured to evaluate the protective effect of TFA. Furthermore, the hepatic m RNA and protein levels of transports, multidrug resistance-associated protein 2(MRP2), bile salt export pump(BSEP), and Na+-taurocholate cotransporting polypeptide(NTCP) were investigated to elucidate the protective mechanisms of TFA against ANIT-induced cholestasis. Results Pretreatment of TFA significantly and dose-dependently decreased the ANIT-induced elevation of serum ALT, AST, TBIL, and TBA levels and increased the ANIT-induced suppression of bile flow. Moreover, TFA was found to increase the expression of liver MRP2, BSEP, and NTCP in both protein and m RNA levels in ANIT-induced liver injury in rats with cholestasis. Conclusion TFA exerts a therapeutic effect on ANIT-induced liver injury in rats with cholestasis, possibly through regulating the expressions of hepatic transporters.
基金supported by the“Double First-Class”University project(CPU2018GF06).
文摘Abelmoschus manihot(L.)Medik.(A.manihot)is a traditional Chinese herbal medicine with a variety of pharmacological properties.It was first recorded in Jiayou Materia Medica dating back to the Song dynasty to eliminate urinary tract irritation by clearing away heat and diuretic effect.However,its pharmacological action on urinary tract infections has not been investigated.The present study aims to evaluate the anti-inflammatory activity of A.manihot on a mouse model of lipopolysaccharide(LPS)-induced cystitis.The results showed that A.manihot decreased white blood cell(WBC)count in urine sediments of the cystitis mice,alleviated bladder congestion,edema,as well as histopathological damage,reduced the expression levels of tumor necrosis factor-α,interleukin-6,and interleukin-1βsimultaneously.Moreover,A.manihot administration significantly downregulated the expression levels of TLR4,MYD88,IκBα,p-IκBα,NF-κB p65,and p-NF-κB p65 in LPS-induced cystitis mice.These findings demonstrated the protective effect of A.manihot against LPS-induced cystitis,which is attributed to its anti-inflammatory profile by suppressing TLR4/MYD88/NF-κB pathways.Our results suggest that A.manihot could be a potential candidate for cystitis treatment.