Biomonitoring using fish has been a popular method of assessing the toxic effects of cadmium concentrations of cadmium in water bodies and has led to bioaccumulation in fish contributing to various morphological alter...Biomonitoring using fish has been a popular method of assessing the toxic effects of cadmium concentrations of cadmium in water bodies and has led to bioaccumulation in fish contributing to various morphological alterations. Among the known effects of these alterations is developmental instability via fluctuating asymmetry (FA). The utilization of FA data is a simple yet effective method to evaluate the toxic effects of cadmium on the stability of development. This study used climbing perch (Anabas testudieneus) to assess the FA in the diameter of the eye because of low-level cadmium exposure. The left and right sides of the traits were measured once every four weeks for 16 weeks. The average measurements from both sides of the traits were used to calculate the FA value. Results found that the highest mean FA for the diameter of the eye was obtained in the highest treatment group, 0.015 mg/L. The results also indicate that increasing concentrations of cadmium exposure had a statistically significant effect on the FA of eye diameter. There was also a statistically significant interaction between the duration of exposure and treatment groups in FA of the diameter of the eye. The results from the study indicate that prolonged exposure to sub-lethal concentrations of cadmium can cause significant effects on the normal development of eyes in Anabas testudineus. This study can add to the body of research regarding fluctuating asymmetry as a tool to study developmental toxicants and assess other bilateral organs.展开更多
A popular dynamical model for the vortex induced vibration(VIV)of a suspended flexible cable consists of two coupled equations.The first equation is a partial differential equation governing the cable vibration.The se...A popular dynamical model for the vortex induced vibration(VIV)of a suspended flexible cable consists of two coupled equations.The first equation is a partial differential equation governing the cable vibration.The second equation is a wake oscillator that models the lift coefficient acting on the cable.The incoming wind acting on the cable is usually assumed as the uniform wind with a constant velocity,which makes the VIV model be a deterministic one.In the real world,however,the wind velocity is randomly fluctuant and makes the VIV of a suspended flexible cable be treated as a random vibration.In the present paper,the deterministic VIV model of a suspended flexible cable is modified to a random one by introducing the fluctuating wind.Using the normal mode approach,the random VIV system is transformed into an infinite-dimensional modal vibration system.Depending on whether a modal frequency is close to the aeolian frequency or not,the corresponding modal vibration is characterized as a resonant vibration or a non-resonant vibration.By applying the stochastic averaging method of quasi Hamiltonian systems,the response of modal vibrations in the case of resonance or non-resonance can be analytically predicted.Then,the random VIV response of the whole cable can be approximately calculated by superimposing the response of the most influential modal vibrations.Some numerical simulation results confirm the obtained analytical results.It is found that the intensity of the resonant modal vibration is much higher than that of the non-resonant modal vibration.Thus,the analytical results of the resonant modal vibration can be used as a rough estimation for the whole response of a cable.展开更多
BACKGROUND Stapes ankylosis is a rare cause of conductive hearing loss,and stapes suprastructure fixation is extremely rare with fewer than 30 reported cases.Patients usually visit the clinic with non-progressive cond...BACKGROUND Stapes ankylosis is a rare cause of conductive hearing loss,and stapes suprastructure fixation is extremely rare with fewer than 30 reported cases.Patients usually visit the clinic with non-progressive conductive hearing loss that typically began in the early years of life.CASE SUMMARY Herein,we report a case of a 37-year-old female with an isolated stapedial suprastructure fixation.The patient presented with unusual fluctuating auditory symptoms of tinnitus,ear fullness and mixed hearing loss.Pre-operative temporal bone computed tomography findings and operative findings revealed an isolated stapedial suprastructure fixation with monopod stapes caused by elongated pyramidal eminence.The hearing threshold recovered completely,and fluctuating auditory symptoms disappeared after the surgery.CONCLUSION This is the first report of stapedial suprastructure fixation with fluctuating auditory symptoms.Successful results are expected with surgical treatment.展开更多
Relativistic isobar^(96)_(44)Ru+^(96)_(44)Ru and^(96)_(40)Zr+^(96)_(40)Zrcollisions have revealed intricate differences in their nuclear size and shape,inspiring unconventional studies of nuclear structure using relat...Relativistic isobar^(96)_(44)Ru+^(96)_(44)Ru and^(96)_(40)Zr+^(96)_(40)Zrcollisions have revealed intricate differences in their nuclear size and shape,inspiring unconventional studies of nuclear structure using relativistic heavy ion collisions.In this study,we investigate the relative differences in the mean multiplicityR_(<Nch>)and the secondR_(ε2)and third-order eccentricityR_(ε3)between isobar collisions using initial state Glauber models.It is found that initial fluctuations and nuclear deformations have negligible effects on R_(<Nch>)in most central collisions,while both are important for the R_(ε2)and R_(ε3),the degree of which is sensitive to the underlying nucleonic or sub-nucleonic degree of freedom.These features,compared to real data,may probe the particle production mechanism and the physics underlying nuclear structure.展开更多
As an important source of low-carbon,clean fossil energy,natural gas hydrate plays an important role in improving the global energy consumption structure.Developing the hydrate industry in the South China Sea is impor...As an important source of low-carbon,clean fossil energy,natural gas hydrate plays an important role in improving the global energy consumption structure.Developing the hydrate industry in the South China Sea is important to achieving‘carbon peak and carbon neutrality’goals as soon as possible.Deep-water areas subjected to the action of long-term stress and tectonic movement have developed complex and volatile terrains,and as such,the morphologies of hydrate-bearing sediments(HBSs)fluctuate correspondingly.The key to numerically simulating HBS morphologies is the establishment of the conceptual model,which represents the objective and real description of the actual geological body.However,current numerical simulation models have characterized HBSs into horizontal strata without considering the fluctuation characteristics.Simply representing the HBS as a horizontal element reduces simulation accuracy.Therefore,the commonly used horizontal HBS model and a model considering the HBS’s fluctuation characteristics with the data of the SH2 site in the Shenhu Sea area were first constructed in this paper.Then,their production behaviors were compared,and the huge impact of the fluctuation characteristics on HBS production was determined.On this basis,the key parameters affecting the depressurization production of the fluctuating HBSs were studied and optimized.The research results show that the fluctuation characteristics have an obvious influence on the hydrate production of HBSs by affecting their temperatures and pressure distributions,as well as the transmission of the pressure drop and methane gas discharge.Furthermore,the results show that the gas productivity of fluctuating HBSs was about 5%less than that of horizontal HBSs.By optimizing the depressurization amplitude,well length,and layout location of vertical wells,the productivity of fluctuating HBSs increased by about 56.6%.展开更多
In nuclear reactors,temperature fluctuations of fluids may cause fatigue damage to adjacent structures;this is referred to as thermal striping.Research on thermal striping in the upper plenum has mainly focused on flu...In nuclear reactors,temperature fluctuations of fluids may cause fatigue damage to adjacent structures;this is referred to as thermal striping.Research on thermal striping in the upper plenum has mainly focused on fluid fields.Few experimental studies have been reported on solid structures in a fluid field with a coaxial jet.This study entailed an experimental study of the temperature fluctuations in the fluid and on a plate surface caused by a coaxial jet.The temperature fluctuations of the fluid and plate surfaces located at different heights were analyzed.The cause of the temperature fluctuation was analyzed using a transient temperature distribution.The results show that the mixing of the hot and cold fluids gradually becomes uniform in the positive axial direction.The average surface temperatures tended to be consistent.When the jet reaches the plate surface,the swing of the jet center,contraction and expansion of the cold jet,and changes in the jet shape result in temperature fluctuations.The intensity of the temperature fluctuation was affected by the position.More attention should be paid when the plate is located at a lower height,and between the hot and cold-fluid nozzles.展开更多
AIM:To study functional brain abnormalities in patients with hypertensive retinopathy(HR)and to discuss the pathophysiological mechanisms of HR by fractional amplitude of low-frequency fluctuations(fALFFs)method.METHO...AIM:To study functional brain abnormalities in patients with hypertensive retinopathy(HR)and to discuss the pathophysiological mechanisms of HR by fractional amplitude of low-frequency fluctuations(fALFFs)method.METHODS:Twenty HR patients and 20 healthy controls(HCs)were respectively recruited.The age,gender,and educational background characteristics of the two groups were similar.After functional magnetic resonance imaging(fMRI)scanning,the subjects’spontaneous brain activity was evaluated with the fALFF method.Receiver operating characteristic(ROC)curve analysis was used to classify the data.Further,we used Pearson’s correlation analysis to explore the relationship between fALFF values in specific brain regions and clinical behaviors in patients with HR.RESULTS:The brain areas of the HR group with lower fALFF values than HCs were the right orbital part of the middle frontal gyrus(RO-MFG)and right lingual gyrus.In contrast,the values of fALFFs in the left middle temporal gyrus(MTG),left superior temporal pole(STP),left middle frontal gyrus(MFG),left superior marginal gyrus(SMG),left superior parietal lobule(SPL),and right supplementary motor area(SMA)were higher in the HR group.The results of a t-test showed that the average values of fALFFs were statistically significantly different in the HR group and HC group(P<0.001).The fALFF values of the left middle frontal gyrus in HR patients were positively correlated with anxiety scores(r=0.9232;P<0.0001)and depression scores(r=0.9682;P<0.0001).CONCLUSION:fALFF values in multiple brain regions of HR patients are abnormal,suggesting that these brain regions in HR patients may be dysfunctional,which may help to reveal the pathophysiological mechanisms of HR.展开更多
To evaluate the regularity of resilient modulus for hot-mix asphalt(HMA)under large temperature fluctuations,back propagation(BP)neural network technology was used to analyze the continuous change of HMA resilient mod...To evaluate the regularity of resilient modulus for hot-mix asphalt(HMA)under large temperature fluctuations,back propagation(BP)neural network technology was used to analyze the continuous change of HMA resilient modulus.Firstly,based on the abundant data,the training model of HMA resilient modulus was established by using BP neural network technology.Subsequently,BP neural network prediction and regression analysis were performed,and the prediction model of HMA resilient modulus at different temperatures(50C to 60C)was obtained,which fully considered multi-factor and nonlinearity.Finally,the fitted theoretical model can be used to evaluate the HMA performance under the condition of large temperature fluctuations,and the rationality of theoretical model was verified by taking Harbin region as an example.It was found that the relationship between HMA resilient modulus and temperatures can be described by inverse tangent function.And the key parameters of theoretical model can be used to evaluate the continuous change characteristics of HMA resilient modulus with large temperature fluctuations.The results can further improve the HMA performance evaluation system and have certain theoretical value.展开更多
In the fiber winding process,strong disturbance,uncertainty,strong coupling,and fiber friction complicate the winding constant tension control.In order to effectively reduce the influence of these problems on the tens...In the fiber winding process,strong disturbance,uncertainty,strong coupling,and fiber friction complicate the winding constant tension control.In order to effectively reduce the influence of these problems on the tension output,this paper proposed a tension fluctuation rejection strategy based on feedforward compensation.In addition to the bias harmonic curve of the unknown state,the tension fluctuation also contains the influence of bounded noise.A tension fluctuation observer(TFO)is designed to cancel the uncertain periodic signal,in which the frequency generator is used to estimate the critical parameter information.Then,the fluctuation signal is reconstructed by a third-order auxiliary filter.The estimated signal feedforward compensates for the actual tension fluctuation.Furthermore,a time-varying parameters fractional-order PID controller(TPFOPID)is realized to attenuate the bounded noise in the fluctuation.Finally,TPFOPID is enhanced by TFO and applied to control a tension control system considering multi-source disturbances.The stability of the method is analyzed by using the Lyapunov theorem.Finally,numerical simulations verify that the proposed scheme improves the tracking ability and robustness of the system in response to tension fluctuations.展开更多
BACKGROUND Patients with type 2 diabetes mellitus(T2DM)have large fluctuations in blood glucose(BG),abnormal metabolic function and low immunity to varying degrees,which increases the risk of malignant tumor diseases ...BACKGROUND Patients with type 2 diabetes mellitus(T2DM)have large fluctuations in blood glucose(BG),abnormal metabolic function and low immunity to varying degrees,which increases the risk of malignant tumor diseases and affects the efficacy of tumor chemotherapy.Controlling hyperglycemia may have important therapeutic implications for cancer patients.AIM To clarify the influence of BG fluctuations on chemotherapy efficacy and safety in T2DM patients complicated with lung carcinoma(LC).METHODS The clinical data of 60 T2DM+LC patients who presented to the First Affiliated Hospital of Ningbo University between January 2019 and January 2021 were retrospectively analyzed.All patients underwent chemotherapy and were grouped as a control group(CG;normal BG fluctuation with a mean fluctuation<3.9 mmol/L)and an observation group(OG;high BG fluctuation with a mean fluctuation≥3.9 mmol/L)based on their BG fluctuations,with 30 cases each.BGrelated indices,tumor markers,serum inflammatory cytokines and adverse reactions were comparatively analyzed.Pearson correlation analysis was performed to analyze the correlation between BG fluctuations and tumor markers.RESULTS The fasting blood glucose and 2-hour postprandial blood glucose levels in the OG were notably elevated compared with those in the CG,together with markedly higher mean amplitude of glycemic excursions(MAGE),mean of daily differences,largest amplitude of glycemic excursions and standard deviation of blood glucose(P<0.05).In addition,the OG exhibited evidently higher levels of carbohydrate antigen 19-9,carbohydrate antigen 125,carcinoembryonic antigen,neuron-specific enolase,cytokeratin 19,tumor necrosis factor-α,interleukin-6,and highsensitivity C-reactive protein than the CG(P<0.05).Pearson analysis revealed a positive association of MAGE with serum tumor markers.The incidence of adverse reactions was significantly higher in the OG than in the CG(P<0.05).CONCLUSION The greater the BG fluctuation in LC patients after chemotherapy,the more unfavorable the therapeutic effect of chemotherapy;the higher the level of tumor markers and inflammatory cytokines,the more adverse reactions the patient experiences.展开更多
A new averaged general dynamic equation (GDE) for nanoparticles in the turbulent flow is derived by considering the combined effect of convection, Brownian diffusion, turbulent diffusion, turbulent coagulation, and ...A new averaged general dynamic equation (GDE) for nanoparticles in the turbulent flow is derived by considering the combined effect of convection, Brownian diffusion, turbulent diffusion, turbulent coagulation, and fluctuating coagulation. The equation is solved with the Taylor-series expansion moment method in a turbulent pipe flow. The experiments are performed. The numerical results of particle size distribu- tion correlate well with the experimental data. The results show that, for a turbulent nanoparticulate flow, a fluctuating coagulation term should be included in the averaged particle GDE. The larger the Schmidt number is and the lower the Reynolds number is, the smaller the value of ratio of particle diameter at the outlet to that at the inlet is. At the outlet, the particle number concentration increases from the near-wall region to the near-center region. The larger the Schmidt number is and the higher the Reynolds num- ber is, the larger the difference in particle number concentration between the near-wall region and near-center region is. Particle polydispersity increases from the near-center region to the near-wall region. The particles with a smaller Schmidt number and the flow with a higher Reynolds number show a higher polydispersity. The degree of particle polydispersity is higher considering fluctuating coagulation than that without considering fluctuating coagulation.展开更多
This paper examines the hypothesis that non-native plant invasions are related to fluctuating resource availability as proposed by Davis et al. (2000). I measured relative functional responses of both invasive and n...This paper examines the hypothesis that non-native plant invasions are related to fluctuating resource availability as proposed by Davis et al. (2000). I measured relative functional responses of both invasive and native plants to changed resource availability due to nutrient enrichment and rainfall, and to increased disturbance. Data are presented from studies in two contrasting ecosystems. First is a series of glasshouse and field experiments on the invader Hieracium lepidulum and associated invasive and native species in subalpine temperate New Zealand. Second is a field study of invasive and native plant responses to altered disturbance regimes and rainfall from tropical savannas of north eastern Australia. Invaders responded differently from native species to changes in resource availability in both subalpine and tropical studies. However, invaders differed among themselves showing that different species exploit different functional niches to invade their respective habitats. These findings contribute to the contention that the fluctuating resource hypothesis does not provide a universal explanation for plant invasions. The diverse functional responses to increased resource availability among invaders in this and previous studies suggest that the cause of invasion depends on unique combinations of habitat and functional attributes of invaders and native assemblages. Such findings imply that universal predictions of what will happen under climate change scenarios across the globe will be difficult to make.展开更多
Nitrogen mineralization in forest soil was studied in laboratory by incubating undisturbed soil cores enclosed within PVC columns at different temperatures to compare the effect of fluctuating temperature with that of...Nitrogen mineralization in forest soil was studied in laboratory by incubating undisturbed soil cores enclosed within PVC columns at different temperatures to compare the effect of fluctuating temperature with that of constant temperature, and to find out whether soil nitrification shows linearity over time. The results showed that there was no significant difference between soil nitrification at fluctuating temperature and that at constant temperature, and suggested that it must be careful to make the conclusion that soil nitrification has linearity over time.展开更多
Natural ventilation is driven by either buoyancy forces or wind pressure forces or their combinations that inherit stochastic variation into ventilation rates. Since the ventilation rate is a nonlinear function of mul...Natural ventilation is driven by either buoyancy forces or wind pressure forces or their combinations that inherit stochastic variation into ventilation rates. Since the ventilation rate is a nonlinear function of multiple variable factors including wind speed, wind direction, internal heat source and building structural thermal mass, the conventional methods for quantifying ventilation rate simply using dominant wind direction and average wind speed may not accurately describe the characteristic performance of natural ventilation. From a new point of view, the natural ventilation performance of a single room building under fluctuating wind speed condition using the Monte-Carlo simulation approach was investigated by incorporating building facade thermal mass effect. Given a same hourly turbulence intensity distribution, the wind speeds with 1 rain frequency fluctuations were generated using a stochastic model, the modified GARCH model. Comparisons of natural ventilation profiles, effective ventilation rates, and air conditioning electricity use for a three-month period show statistically significant differences (for 80% confidence interval) between the new calculations and the traditional methods based on hourly average wind speed.展开更多
A narrow strip is used to control mean and fluctuating forces on a circular cylinder at Reynolds numbers from 2.0 ×10^4 to 1.0 ×^ 10^5. The axes of the strip and cylinder are parallel. The control parameters...A narrow strip is used to control mean and fluctuating forces on a circular cylinder at Reynolds numbers from 2.0 ×10^4 to 1.0 ×^ 10^5. The axes of the strip and cylinder are parallel. The control parameters are strip width ratio and strip position characterized by angle of attack and distance from the cylinder. Wind tunnel tests show that the vortex shedding from both sides of the cylinder can be suppressed, and mean drag and fluctuating lift on the cylinder can be reduced if the strip is installed in an effective zone downstream of the cylinder. A phenomenon of mono-side vortex shedding is found. The strip-induced local changes of velocity profiles in the near wake of the cylinder are measured, and the relation between base suction and peak value in the power spectrum of fluctuating lift is studied. The control mechanism is then discussed from different points of view.展开更多
The present work deals with an investigation of the self-starting aerodynamic characteristics of VAWT under fluctuating wind. In contrast to the previous studies, the rotational speed of the turbine is not fixed, the ...The present work deals with an investigation of the self-starting aerodynamic characteristics of VAWT under fluctuating wind. In contrast to the previous studies, the rotational speed of the turbine is not fixed, the rotation of the turbine is determined by the dynamic interaction between the fluctuating wind and turbine. A weak coupling method is developed to simulate the dynamic interaction between the fluctuating wind and passive rotation turbine, and the results show that if the fluctuating wind with appropriate fluctuation amplitude and frequency, the self-starting aerodynamic characteristics of VAWT will be enhanced. It is also found that compared with the fluctuation amplitude, the fluctuation frequency of the variation in wind velocity is shown to have a minor effect on the performance of the turbine. The analysis will provide straightforward physical insight into the self-starting aerodynamic characteristics of VAWT under fluctuating wind.展开更多
This article examines the effects of reneging, server breakdown and server vacation on the various states of the batch arrivals queueing system with single server providing service to customers in three fluctuating mo...This article examines the effects of reneging, server breakdown and server vacation on the various states of the batch arrivals queueing system with single server providing service to customers in three fluctuating modes. In this queueing system, any batch arrival joins the queue if the server is busy or on vacation or under repair. However, if the server is free, one customer from the arriving batch joins the service immediately while others join the queue. In case of server breakdown, the customer whose service is interrupted returns back to the head of the queue. As soon as the server has is repaired, the server attends to the customer in mode 1. For this queueing system, customers that are impatient due to breakdown and server vacation may renege (leave the queue without getting service). Due to fluctuating modes of service delivery, the system may provide service with complete or reduced efficiency. Consequently, we construct the mathematical model and derive the probability generating functions of the steady state probabilities of several states of the system including the steady state queue size distribution. Further, we discuss some particular cases of the proposed queueing model. We present numerical examples in order to demonstrate the effects of server vacation and reneging on the various states of the system. The study revealed that an increase in reneging and a decrease in server vacation results in a decrease in server utilization and an increase in server’s idle time provided rates of server breakdown and repair completion are constant. In addition, the probability of server vacation, the probability of system is under repair and the probabilities that the server provides service in three fluctuating modes decreases due to an increase in reneging and a decrease in vacation completion rates.展开更多
To study the unsteady aerodynamic loads of high-speed trains in fluctuating crosswinds, the fluctuating winds of a moving point shifting with high-speed trains are calculated in this paper based on Cooper theory and h...To study the unsteady aerodynamic loads of high-speed trains in fluctuating crosswinds, the fluctuating winds of a moving point shifting with high-speed trains are calculated in this paper based on Cooper theory and harmonic superposition method. The computational fluid dynamics method is used to obtain the aerodynamic load coefficients at different mean yaw angles, and the aero- dynamic admittance function is introduced to calculate unsteady aerodynamic loads of high-speed trains in fluctuating winds. Using this method, the standard deviation and maximum value of the aerodynamic force (moment) are simulated. The results show that when the train speed is fixed, the varying mean wind speeds have large impact on the fluctuating value of the wind speeds and aerodynamic loads; in contrast, when the wind speed is fixed, the varying train speeds have little impact on the fluctuating value of the wind speeds or aerodynamic loads. The ratio of standard deviation to 0.SpKU2, or maximum value to 0.5pKU2, can be expressed as the function of mean yaw angle. The peak factors of the side force and roll moment are the same ( - 3.28), the peak factor of the lift force is - 3.33, and the peak factors of the yaw moment and pitch moment are also the same (- 3.77).展开更多
A single (independent of each other) protein motor system with fluctuating potential barrier and subject to sine electric field is investigated. We first derive the approximate Langevin equation of this system with ...A single (independent of each other) protein motor system with fluctuating potential barrier and subject to sine electric field is investigated. We first derive the approximate Langevin equation of this system with fluctuating potential barrier. Then from this approximate Langevin equation, we calculate the signal-to-noise ratio (SNR) in the adiabatic limit. The phenomenon of stochastic resonance is found for this protein motor system with fluctuating potential barrier.展开更多
文摘Biomonitoring using fish has been a popular method of assessing the toxic effects of cadmium concentrations of cadmium in water bodies and has led to bioaccumulation in fish contributing to various morphological alterations. Among the known effects of these alterations is developmental instability via fluctuating asymmetry (FA). The utilization of FA data is a simple yet effective method to evaluate the toxic effects of cadmium on the stability of development. This study used climbing perch (Anabas testudieneus) to assess the FA in the diameter of the eye because of low-level cadmium exposure. The left and right sides of the traits were measured once every four weeks for 16 weeks. The average measurements from both sides of the traits were used to calculate the FA value. Results found that the highest mean FA for the diameter of the eye was obtained in the highest treatment group, 0.015 mg/L. The results also indicate that increasing concentrations of cadmium exposure had a statistically significant effect on the FA of eye diameter. There was also a statistically significant interaction between the duration of exposure and treatment groups in FA of the diameter of the eye. The results from the study indicate that prolonged exposure to sub-lethal concentrations of cadmium can cause significant effects on the normal development of eyes in Anabas testudineus. This study can add to the body of research regarding fluctuating asymmetry as a tool to study developmental toxicants and assess other bilateral organs.
基金Project supported by the State Grid Science and Technology Project(No.SGZJJXI0SYJS2101112)。
文摘A popular dynamical model for the vortex induced vibration(VIV)of a suspended flexible cable consists of two coupled equations.The first equation is a partial differential equation governing the cable vibration.The second equation is a wake oscillator that models the lift coefficient acting on the cable.The incoming wind acting on the cable is usually assumed as the uniform wind with a constant velocity,which makes the VIV model be a deterministic one.In the real world,however,the wind velocity is randomly fluctuant and makes the VIV of a suspended flexible cable be treated as a random vibration.In the present paper,the deterministic VIV model of a suspended flexible cable is modified to a random one by introducing the fluctuating wind.Using the normal mode approach,the random VIV system is transformed into an infinite-dimensional modal vibration system.Depending on whether a modal frequency is close to the aeolian frequency or not,the corresponding modal vibration is characterized as a resonant vibration or a non-resonant vibration.By applying the stochastic averaging method of quasi Hamiltonian systems,the response of modal vibrations in the case of resonance or non-resonance can be analytically predicted.Then,the random VIV response of the whole cable can be approximately calculated by superimposing the response of the most influential modal vibrations.Some numerical simulation results confirm the obtained analytical results.It is found that the intensity of the resonant modal vibration is much higher than that of the non-resonant modal vibration.Thus,the analytical results of the resonant modal vibration can be used as a rough estimation for the whole response of a cable.
文摘BACKGROUND Stapes ankylosis is a rare cause of conductive hearing loss,and stapes suprastructure fixation is extremely rare with fewer than 30 reported cases.Patients usually visit the clinic with non-progressive conductive hearing loss that typically began in the early years of life.CASE SUMMARY Herein,we report a case of a 37-year-old female with an isolated stapedial suprastructure fixation.The patient presented with unusual fluctuating auditory symptoms of tinnitus,ear fullness and mixed hearing loss.Pre-operative temporal bone computed tomography findings and operative findings revealed an isolated stapedial suprastructure fixation with monopod stapes caused by elongated pyramidal eminence.The hearing threshold recovered completely,and fluctuating auditory symptoms disappeared after the surgery.CONCLUSION This is the first report of stapedial suprastructure fixation with fluctuating auditory symptoms.Successful results are expected with surgical treatment.
基金the National Natural Science Foundation of China(Nos.12275082,12035006,12075085(HX))the Zhejiang Provincial Natural Science Foundation of China(No.LY21A050001(HX))the U.S.Department of Energy(No.DE-SC0012910(FW)).
文摘Relativistic isobar^(96)_(44)Ru+^(96)_(44)Ru and^(96)_(40)Zr+^(96)_(40)Zrcollisions have revealed intricate differences in their nuclear size and shape,inspiring unconventional studies of nuclear structure using relativistic heavy ion collisions.In this study,we investigate the relative differences in the mean multiplicityR_(<Nch>)and the secondR_(ε2)and third-order eccentricityR_(ε3)between isobar collisions using initial state Glauber models.It is found that initial fluctuations and nuclear deformations have negligible effects on R_(<Nch>)in most central collisions,while both are important for the R_(ε2)and R_(ε3),the degree of which is sensitive to the underlying nucleonic or sub-nucleonic degree of freedom.These features,compared to real data,may probe the particle production mechanism and the physics underlying nuclear structure.
基金supported by the National Natural Science Foundation of China(Nos.42276224 and 42206230)the Jilin Scientific and Technological Development Program(No.20190303083SF)+1 种基金the International Cooperation Key Laboratory of Underground Energy Development and Geological Restoration(No.YDZJ202102CXJD014)the Graduate Innovation Fund of Jilin University(No.2023CX100).
文摘As an important source of low-carbon,clean fossil energy,natural gas hydrate plays an important role in improving the global energy consumption structure.Developing the hydrate industry in the South China Sea is important to achieving‘carbon peak and carbon neutrality’goals as soon as possible.Deep-water areas subjected to the action of long-term stress and tectonic movement have developed complex and volatile terrains,and as such,the morphologies of hydrate-bearing sediments(HBSs)fluctuate correspondingly.The key to numerically simulating HBS morphologies is the establishment of the conceptual model,which represents the objective and real description of the actual geological body.However,current numerical simulation models have characterized HBSs into horizontal strata without considering the fluctuation characteristics.Simply representing the HBS as a horizontal element reduces simulation accuracy.Therefore,the commonly used horizontal HBS model and a model considering the HBS’s fluctuation characteristics with the data of the SH2 site in the Shenhu Sea area were first constructed in this paper.Then,their production behaviors were compared,and the huge impact of the fluctuation characteristics on HBS production was determined.On this basis,the key parameters affecting the depressurization production of the fluctuating HBSs were studied and optimized.The research results show that the fluctuation characteristics have an obvious influence on the hydrate production of HBSs by affecting their temperatures and pressure distributions,as well as the transmission of the pressure drop and methane gas discharge.Furthermore,the results show that the gas productivity of fluctuating HBSs was about 5%less than that of horizontal HBSs.By optimizing the depressurization amplitude,well length,and layout location of vertical wells,the productivity of fluctuating HBSs increased by about 56.6%.
基金supported by the National Natural Science Foundation of China (No. 52075173)the Overseas Expertise Introduction Project for Discipline Innovation (No. B13020)
文摘In nuclear reactors,temperature fluctuations of fluids may cause fatigue damage to adjacent structures;this is referred to as thermal striping.Research on thermal striping in the upper plenum has mainly focused on fluid fields.Few experimental studies have been reported on solid structures in a fluid field with a coaxial jet.This study entailed an experimental study of the temperature fluctuations in the fluid and on a plate surface caused by a coaxial jet.The temperature fluctuations of the fluid and plate surfaces located at different heights were analyzed.The cause of the temperature fluctuation was analyzed using a transient temperature distribution.The results show that the mixing of the hot and cold fluids gradually becomes uniform in the positive axial direction.The average surface temperatures tended to be consistent.When the jet reaches the plate surface,the swing of the jet center,contraction and expansion of the cold jet,and changes in the jet shape result in temperature fluctuations.The intensity of the temperature fluctuation was affected by the position.More attention should be paid when the plate is located at a lower height,and between the hot and cold-fluid nozzles.
基金Supported by National Natural Science Foundation of China(No.82160195)Jiangxi Double-Thousand Plan High-Level Talent Project of Science and Technology Innovation(No.jxsq2023201036)+2 种基金Key R&D Program of Jiangxi Province(No.20223BBH80014)Science and Technology Project of Jiangxi Province Health Commission of Traditional Chinese Medicine(No.2022B258)Science and Technology Project of Jiangxi Health Commission(No.202210017).
文摘AIM:To study functional brain abnormalities in patients with hypertensive retinopathy(HR)and to discuss the pathophysiological mechanisms of HR by fractional amplitude of low-frequency fluctuations(fALFFs)method.METHODS:Twenty HR patients and 20 healthy controls(HCs)were respectively recruited.The age,gender,and educational background characteristics of the two groups were similar.After functional magnetic resonance imaging(fMRI)scanning,the subjects’spontaneous brain activity was evaluated with the fALFF method.Receiver operating characteristic(ROC)curve analysis was used to classify the data.Further,we used Pearson’s correlation analysis to explore the relationship between fALFF values in specific brain regions and clinical behaviors in patients with HR.RESULTS:The brain areas of the HR group with lower fALFF values than HCs were the right orbital part of the middle frontal gyrus(RO-MFG)and right lingual gyrus.In contrast,the values of fALFFs in the left middle temporal gyrus(MTG),left superior temporal pole(STP),left middle frontal gyrus(MFG),left superior marginal gyrus(SMG),left superior parietal lobule(SPL),and right supplementary motor area(SMA)were higher in the HR group.The results of a t-test showed that the average values of fALFFs were statistically significantly different in the HR group and HC group(P<0.001).The fALFF values of the left middle frontal gyrus in HR patients were positively correlated with anxiety scores(r=0.9232;P<0.0001)and depression scores(r=0.9682;P<0.0001).CONCLUSION:fALFF values in multiple brain regions of HR patients are abnormal,suggesting that these brain regions in HR patients may be dysfunctional,which may help to reveal the pathophysiological mechanisms of HR.
基金appreciate support from the projects of Science and Technology Project of Transportation Department of Heilongjiang Province(No.HJK2019B009)the Fundamental Research Funds for the Cornell University(No.2572021AW10)the Ludong Uni-versity to Introduce Talents Research Start-up Funding Project(No.20240050).
文摘To evaluate the regularity of resilient modulus for hot-mix asphalt(HMA)under large temperature fluctuations,back propagation(BP)neural network technology was used to analyze the continuous change of HMA resilient modulus.Firstly,based on the abundant data,the training model of HMA resilient modulus was established by using BP neural network technology.Subsequently,BP neural network prediction and regression analysis were performed,and the prediction model of HMA resilient modulus at different temperatures(50C to 60C)was obtained,which fully considered multi-factor and nonlinearity.Finally,the fitted theoretical model can be used to evaluate the HMA performance under the condition of large temperature fluctuations,and the rationality of theoretical model was verified by taking Harbin region as an example.It was found that the relationship between HMA resilient modulus and temperatures can be described by inverse tangent function.And the key parameters of theoretical model can be used to evaluate the continuous change characteristics of HMA resilient modulus with large temperature fluctuations.The results can further improve the HMA performance evaluation system and have certain theoretical value.
基金funded by the National Natural Science Foundation of China(Grant Number 52075361)Shanxi Province Science and Technology Major Project(Grant Number 20201102003)+3 种基金Lvliang Science and Technology Guidance Special Key R&D Project(Grant Number 2022XDHZ08)National Natural Science Foundation of China(Grant Number 51905367)Shanxi Natural Science Foundation General Project(Grant Numbers 202103021224271,202203021211201)Shanxi Province Key Research and Development Plan(Grant Number 202102020101013).
文摘In the fiber winding process,strong disturbance,uncertainty,strong coupling,and fiber friction complicate the winding constant tension control.In order to effectively reduce the influence of these problems on the tension output,this paper proposed a tension fluctuation rejection strategy based on feedforward compensation.In addition to the bias harmonic curve of the unknown state,the tension fluctuation also contains the influence of bounded noise.A tension fluctuation observer(TFO)is designed to cancel the uncertain periodic signal,in which the frequency generator is used to estimate the critical parameter information.Then,the fluctuation signal is reconstructed by a third-order auxiliary filter.The estimated signal feedforward compensates for the actual tension fluctuation.Furthermore,a time-varying parameters fractional-order PID controller(TPFOPID)is realized to attenuate the bounded noise in the fluctuation.Finally,TPFOPID is enhanced by TFO and applied to control a tension control system considering multi-source disturbances.The stability of the method is analyzed by using the Lyapunov theorem.Finally,numerical simulations verify that the proposed scheme improves the tracking ability and robustness of the system in response to tension fluctuations.
基金Supported by Chronic Disease Management Center for Thoracic Tumor,The Affiliated Hospital of Medical School of Ningbo University,No.2021MGZX-07Natural Science Foundation of Ningbo,No.2019A610238.
文摘BACKGROUND Patients with type 2 diabetes mellitus(T2DM)have large fluctuations in blood glucose(BG),abnormal metabolic function and low immunity to varying degrees,which increases the risk of malignant tumor diseases and affects the efficacy of tumor chemotherapy.Controlling hyperglycemia may have important therapeutic implications for cancer patients.AIM To clarify the influence of BG fluctuations on chemotherapy efficacy and safety in T2DM patients complicated with lung carcinoma(LC).METHODS The clinical data of 60 T2DM+LC patients who presented to the First Affiliated Hospital of Ningbo University between January 2019 and January 2021 were retrospectively analyzed.All patients underwent chemotherapy and were grouped as a control group(CG;normal BG fluctuation with a mean fluctuation<3.9 mmol/L)and an observation group(OG;high BG fluctuation with a mean fluctuation≥3.9 mmol/L)based on their BG fluctuations,with 30 cases each.BGrelated indices,tumor markers,serum inflammatory cytokines and adverse reactions were comparatively analyzed.Pearson correlation analysis was performed to analyze the correlation between BG fluctuations and tumor markers.RESULTS The fasting blood glucose and 2-hour postprandial blood glucose levels in the OG were notably elevated compared with those in the CG,together with markedly higher mean amplitude of glycemic excursions(MAGE),mean of daily differences,largest amplitude of glycemic excursions and standard deviation of blood glucose(P<0.05).In addition,the OG exhibited evidently higher levels of carbohydrate antigen 19-9,carbohydrate antigen 125,carcinoembryonic antigen,neuron-specific enolase,cytokeratin 19,tumor necrosis factor-α,interleukin-6,and highsensitivity C-reactive protein than the CG(P<0.05).Pearson analysis revealed a positive association of MAGE with serum tumor markers.The incidence of adverse reactions was significantly higher in the OG than in the CG(P<0.05).CONCLUSION The greater the BG fluctuation in LC patients after chemotherapy,the more unfavorable the therapeutic effect of chemotherapy;the higher the level of tumor markers and inflammatory cytokines,the more adverse reactions the patient experiences.
基金Project supported by the National Natural Science Foundation of China(No.11132008)
文摘A new averaged general dynamic equation (GDE) for nanoparticles in the turbulent flow is derived by considering the combined effect of convection, Brownian diffusion, turbulent diffusion, turbulent coagulation, and fluctuating coagulation. The equation is solved with the Taylor-series expansion moment method in a turbulent pipe flow. The experiments are performed. The numerical results of particle size distribu- tion correlate well with the experimental data. The results show that, for a turbulent nanoparticulate flow, a fluctuating coagulation term should be included in the averaged particle GDE. The larger the Schmidt number is and the lower the Reynolds number is, the smaller the value of ratio of particle diameter at the outlet to that at the inlet is. At the outlet, the particle number concentration increases from the near-wall region to the near-center region. The larger the Schmidt number is and the higher the Reynolds num- ber is, the larger the difference in particle number concentration between the near-wall region and near-center region is. Particle polydispersity increases from the near-center region to the near-wall region. The particles with a smaller Schmidt number and the flow with a higher Reynolds number show a higher polydispersity. The degree of particle polydispersity is higher considering fluctuating coagulation than that without considering fluctuating coagulation.
文摘This paper examines the hypothesis that non-native plant invasions are related to fluctuating resource availability as proposed by Davis et al. (2000). I measured relative functional responses of both invasive and native plants to changed resource availability due to nutrient enrichment and rainfall, and to increased disturbance. Data are presented from studies in two contrasting ecosystems. First is a series of glasshouse and field experiments on the invader Hieracium lepidulum and associated invasive and native species in subalpine temperate New Zealand. Second is a field study of invasive and native plant responses to altered disturbance regimes and rainfall from tropical savannas of north eastern Australia. Invaders responded differently from native species to changes in resource availability in both subalpine and tropical studies. However, invaders differed among themselves showing that different species exploit different functional niches to invade their respective habitats. These findings contribute to the contention that the fluctuating resource hypothesis does not provide a universal explanation for plant invasions. The diverse functional responses to increased resource availability among invaders in this and previous studies suggest that the cause of invasion depends on unique combinations of habitat and functional attributes of invaders and native assemblages. Such findings imply that universal predictions of what will happen under climate change scenarios across the globe will be difficult to make.
文摘Nitrogen mineralization in forest soil was studied in laboratory by incubating undisturbed soil cores enclosed within PVC columns at different temperatures to compare the effect of fluctuating temperature with that of constant temperature, and to find out whether soil nitrification shows linearity over time. The results showed that there was no significant difference between soil nitrification at fluctuating temperature and that at constant temperature, and suggested that it must be careful to make the conclusion that soil nitrification has linearity over time.
文摘Natural ventilation is driven by either buoyancy forces or wind pressure forces or their combinations that inherit stochastic variation into ventilation rates. Since the ventilation rate is a nonlinear function of multiple variable factors including wind speed, wind direction, internal heat source and building structural thermal mass, the conventional methods for quantifying ventilation rate simply using dominant wind direction and average wind speed may not accurately describe the characteristic performance of natural ventilation. From a new point of view, the natural ventilation performance of a single room building under fluctuating wind speed condition using the Monte-Carlo simulation approach was investigated by incorporating building facade thermal mass effect. Given a same hourly turbulence intensity distribution, the wind speeds with 1 rain frequency fluctuations were generated using a stochastic model, the modified GARCH model. Comparisons of natural ventilation profiles, effective ventilation rates, and air conditioning electricity use for a three-month period show statistically significant differences (for 80% confidence interval) between the new calculations and the traditional methods based on hourly average wind speed.
基金the National Natural Science Foundation of China(10172087 and 10472124).
文摘A narrow strip is used to control mean and fluctuating forces on a circular cylinder at Reynolds numbers from 2.0 ×10^4 to 1.0 ×^ 10^5. The axes of the strip and cylinder are parallel. The control parameters are strip width ratio and strip position characterized by angle of attack and distance from the cylinder. Wind tunnel tests show that the vortex shedding from both sides of the cylinder can be suppressed, and mean drag and fluctuating lift on the cylinder can be reduced if the strip is installed in an effective zone downstream of the cylinder. A phenomenon of mono-side vortex shedding is found. The strip-induced local changes of velocity profiles in the near wake of the cylinder are measured, and the relation between base suction and peak value in the power spectrum of fluctuating lift is studied. The control mechanism is then discussed from different points of view.
基金Projects(61105086,51505347)supported by the National Natural Science Foundation of China
文摘The present work deals with an investigation of the self-starting aerodynamic characteristics of VAWT under fluctuating wind. In contrast to the previous studies, the rotational speed of the turbine is not fixed, the rotation of the turbine is determined by the dynamic interaction between the fluctuating wind and turbine. A weak coupling method is developed to simulate the dynamic interaction between the fluctuating wind and passive rotation turbine, and the results show that if the fluctuating wind with appropriate fluctuation amplitude and frequency, the self-starting aerodynamic characteristics of VAWT will be enhanced. It is also found that compared with the fluctuation amplitude, the fluctuation frequency of the variation in wind velocity is shown to have a minor effect on the performance of the turbine. The analysis will provide straightforward physical insight into the self-starting aerodynamic characteristics of VAWT under fluctuating wind.
文摘This article examines the effects of reneging, server breakdown and server vacation on the various states of the batch arrivals queueing system with single server providing service to customers in three fluctuating modes. In this queueing system, any batch arrival joins the queue if the server is busy or on vacation or under repair. However, if the server is free, one customer from the arriving batch joins the service immediately while others join the queue. In case of server breakdown, the customer whose service is interrupted returns back to the head of the queue. As soon as the server has is repaired, the server attends to the customer in mode 1. For this queueing system, customers that are impatient due to breakdown and server vacation may renege (leave the queue without getting service). Due to fluctuating modes of service delivery, the system may provide service with complete or reduced efficiency. Consequently, we construct the mathematical model and derive the probability generating functions of the steady state probabilities of several states of the system including the steady state queue size distribution. Further, we discuss some particular cases of the proposed queueing model. We present numerical examples in order to demonstrate the effects of server vacation and reneging on the various states of the system. The study revealed that an increase in reneging and a decrease in server vacation results in a decrease in server utilization and an increase in server’s idle time provided rates of server breakdown and repair completion are constant. In addition, the probability of server vacation, the probability of system is under repair and the probabilities that the server provides service in three fluctuating modes decreases due to an increase in reneging and a decrease in vacation completion rates.
基金supported by the 2013 Doctoral Innovation Funds of Southwest Jiaotong Universitythe Fundamental Research Funds for the Central Universities,the National Key Technology R&D Program of China (2009BAG12A01-C09)the High-Speed Railway Basic Research Fund Key Project (U1234208)
文摘To study the unsteady aerodynamic loads of high-speed trains in fluctuating crosswinds, the fluctuating winds of a moving point shifting with high-speed trains are calculated in this paper based on Cooper theory and harmonic superposition method. The computational fluid dynamics method is used to obtain the aerodynamic load coefficients at different mean yaw angles, and the aero- dynamic admittance function is introduced to calculate unsteady aerodynamic loads of high-speed trains in fluctuating winds. Using this method, the standard deviation and maximum value of the aerodynamic force (moment) are simulated. The results show that when the train speed is fixed, the varying mean wind speeds have large impact on the fluctuating value of the wind speeds and aerodynamic loads; in contrast, when the wind speed is fixed, the varying train speeds have little impact on the fluctuating value of the wind speeds or aerodynamic loads. The ratio of standard deviation to 0.SpKU2, or maximum value to 0.5pKU2, can be expressed as the function of mean yaw angle. The peak factors of the side force and roll moment are the same ( - 3.28), the peak factor of the lift force is - 3.33, and the peak factors of the yaw moment and pitch moment are also the same (- 3.77).
基金The project supported by the National Natural Science Foundation of China under Grant No.10375009by SRF for ROCS,SEM,and by K.C.Wong Magna Fund in Ningbo University of China
文摘A single (independent of each other) protein motor system with fluctuating potential barrier and subject to sine electric field is investigated. We first derive the approximate Langevin equation of this system with fluctuating potential barrier. Then from this approximate Langevin equation, we calculate the signal-to-noise ratio (SNR) in the adiabatic limit. The phenomenon of stochastic resonance is found for this protein motor system with fluctuating potential barrier.