Influence of blood glucose fluctuations on chemotherapy efficacy and safety in type 2 diabetes mellitus patients complicated with lung carcinoma

BACKGROUND Patients with type 2 diabetes mellitus(T2DM)have large fluctuations in blood glucose(BG),abnormal metabolic function and low immunity to varying degrees,which increases the risk of malignant tumor diseases and affects the efficacy of tumor chemotherapy.Controlling hyperglycemia may have important therapeutic implications for cancer patients.AIM To clarify the influence of BG fluctuations on chemotherapy efficacy and safety in T2DM patients complicated with lung carcinoma(LC).METHODS The clinical data of 60 T2DM+LC patients who presented to the First Affiliated Hospital of Ningbo University between January 2019 and January 2021 were retrospectively analyzed.All patients underwent chemotherapy and were grouped as a control group(CG;normal BG fluctuation with a mean fluctuation<3.9 mmol/L)and an observation group(OG;high BG fluctuation with a mean fluctuation≥3.9 mmol/L)based on their BG fluctuations,with 30 cases each.BGrelated indices,tumor markers,serum inflammatory cytokines and adverse reactions were comparatively analyzed.Pearson correlation analysis was performed to analyze the correlation between BG fluctuations and tumor markers.RESULTS The fasting blood glucose and 2-hour postprandial blood glucose levels in the OG were notably elevated compared with those in the CG,together with markedly higher mean amplitude of glycemic excursions(MAGE),mean of daily differences,largest amplitude of glycemic excursions and standard deviation of blood glucose(P<0.05).In addition,the OG exhibited evidently higher levels of carbohydrate antigen 19-9,carbohydrate antigen 125,carcinoembryonic antigen,neuron-specific enolase,cytokeratin 19,tumor necrosis factor-α,interleukin-6,and highsensitivity C-reactive protein than the CG(P<0.05).Pearson analysis revealed a positive association of MAGE with serum tumor markers.The incidence of adverse reactions was significantly higher in the OG than in the CG(P<0.05).CONCLUSION The greater the BG fluctuation in LC patients after chemotherapy,the more unfavorable the therapeutic effect of chemotherapy;the higher the level of tumor markers and inflammatory cytokines,the more adverse reactions the patient experiences.

Impact of initial fluctuations and nuclear deformations in isobar collisions

Relativistic isobar^(96)_(44)Ru+^(96)_(44)Ru and^(96)_(40)Zr+^(96)_(40)Zrcollisions have revealed intricate differences in their nuclear size and shape,inspiring unconventional studies of nuclear structure using relativistic heavy ion collisions.In this study,we investigate the relative differences in the mean multiplicityR_(<Nch>)and the secondR_(ε2)and third-order eccentricityR_(ε3)between isobar collisions using initial state Glauber models.It is found that initial fluctuations and nuclear deformations have negligible effects on R_(<Nch>)in most central collisions,while both are important for the R_(ε2)and R_(ε3),the degree of which is sensitive to the underlying nucleonic or sub-nucleonic degree of freedom.These features,compared to real data,may probe the particle production mechanism and the physics underlying nuclear structure.

Altered spontaneous brain activity patterns in hypertensive retinopathy using fractional amplitude of low-frequency fluctuations:a functional magnetic resonance imaging study

AIM:To study functional brain abnormalities in patients with hypertensive retinopathy(HR)and to discuss the pathophysiological mechanisms of HR by fractional amplitude of low-frequency fluctuations(fALFFs)method.METHODS:Twenty HR patients and 20 healthy controls(HCs)were respectively recruited.The age,gender,and educational background characteristics of the two groups were similar.After functional magnetic resonance imaging(fMRI)scanning,the subjects’spontaneous brain activity was evaluated with the fALFF method.Receiver operating characteristic(ROC)curve analysis was used to classify the data.Further,we used Pearson’s correlation analysis to explore the relationship between fALFF values in specific brain regions and clinical behaviors in patients with HR.RESULTS:The brain areas of the HR group with lower fALFF values than HCs were the right orbital part of the middle frontal gyrus(RO-MFG)and right lingual gyrus.In contrast,the values of fALFFs in the left middle temporal gyrus(MTG),left superior temporal pole(STP),left middle frontal gyrus(MFG),left superior marginal gyrus(SMG),left superior parietal lobule(SPL),and right supplementary motor area(SMA)were higher in the HR group.The results of a t-test showed that the average values of fALFFs were statistically significantly different in the HR group and HC group(P<0.001).The fALFF values of the left middle frontal gyrus in HR patients were positively correlated with anxiety scores(r=0.9232;P<0.0001)and depression scores(r=0.9682;P<0.0001).CONCLUSION:fALFF values in multiple brain regions of HR patients are abnormal,suggesting that these brain regions in HR patients may be dysfunctional,which may help to reveal the pathophysiological mechanisms of HR.

Experimental study on temperature fluctuations on plate surface induced by coaxial-jet flow

In nuclear reactors,temperature fluctuations of fluids may cause fatigue damage to adjacent structures;this is referred to as thermal striping.Research on thermal striping in the upper plenum has mainly focused on fluid fields.Few experimental studies have been reported on solid structures in a fluid field with a coaxial jet.This study entailed an experimental study of the temperature fluctuations in the fluid and on a plate surface caused by a coaxial jet.The temperature fluctuations of the fluid and plate surfaces located at different heights were analyzed.The cause of the temperature fluctuation was analyzed using a transient temperature distribution.The results show that the mixing of the hot and cold fluids gradually becomes uniform in the positive axial direction.The average surface temperatures tended to be consistent.When the jet reaches the plate surface,the swing of the jet center,contraction and expansion of the cold jet,and changes in the jet shape result in temperature fluctuations.The intensity of the temperature fluctuation was affected by the position.More attention should be paid when the plate is located at a lower height,and between the hot and cold-fluid nozzles.

Regularity analysis of resilient modulus for hot-mix asphalt with large temperature fluctuations

To evaluate the regularity of resilient modulus for hot-mix asphalt(HMA) under large temperature fluctuations,back propagation(BP) neural network technology was used to analyze the continuous change of HMA resilient modulus.Firstly,based on the abundant data,the training model of HMA resilient modulus was established by using BP neural network technology.Subsequently,BP neural network prediction and regression analysis were performed,and the prediction model of HMA resilient modulus at different temperatures(-50℃ to 60℃) was obtained,which fully considered multi-factor and nonlinearity.Finally,the fitted theoretical model can be used to evaluate the HMA performance under the condition of large temperature fluctuations,and the rationality of theoretical model was verified by taking Harbin region as an example.It was found that the relationship between HMA resilient modulus and temperatures can be described by inverse tangent function.And the key parameters of theoretical model can be used to evaluate the continuous change characteristics of HMA resilient modulus with large temperature fluctuations.The results can further improve the HMA performance evaluation system and have certain theoretical value.

Coordinated Control of Second-order Harmonic Voltage and Current Fluctuations in Cascaded H-bridge Inverter with Supercapacitor and DC-DC Stage at Variable Output Frequencies

In the cascaded H-bridge inverter(CHBI)with supercapacitor and dc-dc stage,inherent second-order harmonic power flows through each submodule(SM),causing fluctuations in both the dc-link voltage and the dc-dc current.There exist limitations in handling these fluctuations at variable output frequencies when employing proportional-integral(PI)control to the dc-dc stage.This paper aims to coordinately control these second-order harmonic voltage and current fluctuations in the CHBI.The presented method configures a specific second-order harmonic voltage reference,equipped with a maximum voltage fluctuation constraint and a suitable phase,for the dc-dc stage.A PI-resonant controller is used to track the configured reference.This allows for regulating the second-order harmonic fluctuation in the average dc-link voltage among the SMs within a certain value.Importantly,the second-order harmonic fluctuation in the dc-dc current can also be reduced.Simulation and experimental results demonstrate the effectiveness of the presented method.

结构、功能与涨落:社区治理韧性何以演进

社区作为“中国之治”的基础性治理单元,其韧性治理目标与“韧性城市建设”战略图景一致。按照耗散结构理论,社区韧性治理是一个关乎社区耗散结构何以生成的自适应性循环过程。由此,以结构、功能与涨落三要素为社区韧性系统的主要控制参量,在正反馈、自我强化与放大效应等非线性机制的作用下来考察城市社区这一“耗散结构”是可行的。在其运行逻辑上,社区空时结构与韧性功能的动态交互、韧性功能与社区涨落的治理调适以及社区空时结构与涨落的持续放大效应,共同推进社区治理韧性发展。在路径设计上,以有序“熵流”优化社区空时结构、有效“识别-响应-放大”社区涨落变动的非线性机制以及动态调适社区系统功能等韧性演进,应纳入耗散结构理论范式下韧性社区建设的政策工具集。

600 MW调峰机组水冷壁管失效原因分析

本文以某电厂600 MW超临界机组锅炉失效水冷壁管为研究对象,利用宏观形貌分析、化学成分分析、常温拉伸性能试验、金相分析等方法对失效原因进行了分析。分析结果显示,水冷壁管失效的主要原因为运行中锅炉温差波动较大,由于结构约束造成热膨胀受阻,导致管壁应力集中部位在交变应力的作用下形成疲劳裂纹,进而发生开裂失效。最后对防止此类失效提出了相关建议。

基于旋转采样谱的海上风机叶片翼尖摆振特性评估

为了评估叶片旋转受风场作用的时频振动特性,本研究开展了基于旋转采样谱的海上风机叶片振动特性评估方法研究。以NREL-5 MW海上单桩风机叶片为研究对象,基于脉动风谱与旋转采样理论,对比分析了旋转风谱的能量扰动机制。然后,结合Prandtl叶尖损失修正和Grauert修正来评估叶片空气动力载荷,详细分析风机叶片翼尖在静止与运行状态下的摆振动力响应规律。结果表明,基于旋转采样谱的频域叶片翼尖摆振响应可准确表征风机叶片在运行状态下的1~3P(1~3倍风轮转动频率,0.2~0.6 Hz),同比湍流风作用的时域静态叶片摆振位移上限幅值增加42.21%,即考虑旋转效应对于叶片疲劳寿命评估具有重要工程价值。

PFS混凝-光催化氧化深度处理焦化废水试验研究

采用PFS混凝-光催化氧化剂法对经过二级生化处理后的焦化废水进行深度处理。在光催化氧化反应一定的条件下,考察了废水中影响TOC去除率的因素及废水处理效果,并与普通光催化氧化法TOC去除效果进行了对比。通过单因素试验确定的反应体系中各参数的最佳条件分别为:TiO2投加量为4 g/L,光照反应时间为4 h,pH为5.1,PFS投加量为700 mg/L,TOC去除率可达到81%。

恶性疟原虫传播阻断抗原Pfs25和Pfs48/45基因编码序列的体外扩增

目的：体外扩增编码恶性疟原虫传播阻断抗原Pfs和Pfs48／45的基因序列，为进一步对其进行克隆和体外高效表达创造条件。方法：特定寡核苷酸引物的设计、合成与纯化；恶性疟原虫FCC1／HN株体外培养；利用碱裂解法从培养的恶性疟原虫FCC1／HN株提取染色体DNA；PCR扩增和琼脂糖凝胶电泳分析。结果：从恶性疟原虫FCC1／HN株基因组DNA中特异扩增出编码Pfs25和Pfs48／45基因序列，其片段大小分别为657bp和1，359bp。而用间日疟原虫基因组DNA为模板作对照，无扩增条带出现。结论：体外扩增编码恶性疟原虫传播阻断抗原Pfs25和Pfs48／45基因序列与预期长度相符合，从而，为该基因的克隆、测序和表达奠定基础。

PFS絮凝-膜分离法处理含油食品废水的研究

采用PFS絮凝-膜分离法对含油食品废水进行处理。通过改变PFS的投加量、pH值、反应时间、膜操作温度和压力等条件,对废水中的油、COD、SS和NH3-N的去除率进行了研究,得到了较佳的工艺条件:PFS的投加量为70 mg/L,pH值为7,反应时间为60 m in,膜操作温度为40℃,压力为0.7 MPa,油、COD、SS和NH3-N的去除率分别达到98%、93%、92%和80%以上,出水水质达到《污水综合排放标准》的一级标准。

絮凝剂PFS和铁粉联合投加对含铅废水的吸附研究

采用絮凝剂PFS和铁粉联合去除工业废水中的铅。废水进入反应器后,通过铁粉的电化学反应的氧化还原,以及絮凝剂PFS的絮凝等作用的综合效应使重金属得以从废水中除去。试验结果表明,去除铅废水的最佳操作条件为：絮凝剂的投加量13 mg/L,铁粉的投加量20 mg/L,pH值6.5-7.5,水力停留时间5 h,采用连续曝气,曝气量0.2 L/min。

PPC和PFS联用去除水源水中Tl和Sb复合污染

为了去除地表水源水加标模拟的重金属铊(Tl)和锑(Sb)复合污染,采用了高锰酸盐复合药剂(PPC)和聚合硫酸铁(PFS)联用强化常规工艺;通过静态烧杯实验和微型移动式平台优化工艺参数,对去除铊和锑复合污染的影响因素(PPC投量、PFS投量和pH)进行分析.实验结果表明,组合工艺可保证水源水在Tl超标2～3倍(0.21～0.35μg.L-1),Sb超标3～4倍(15～20μg.L-1)的场合出水达标,对应的工艺参数是:pH控制在5.7～6.3,PPC投量控制在3 mg.L-1以上,聚铁投量控制在40 mg.L-1以上.PPC和PFS联用强化常规工艺可有效去除地表水源水加标模拟的铊(Tl)和锑(Sb)复合污染,并且PPC投量是影响Tl去除的主要因素,PFS投量和pH是影响Sb去除的主要因素.

化疗交替靶向药物治疗对EGFR突变阳性的晚期NSCLC患者PFS及OS的影响

目的观察化疗交替靶向药物治疗对EGFR突变阳性的晚期非小细胞肺癌患者PFS及OS的影响。方法选取100例EGFR突变阳性的晚期NSCLC患者作为研究对象,将患者分为2组,A组为吉西他滨+顺铂/卡铂化疗交替吉非替尼组,B组为单用吉非替尼组。比较患者治疗过程中的耐受情况、不良反应的发生率和总缓解率(ORR);对比A、B组患者的肿瘤无进展生存期(PFS)、总生存期(OS)和患者生活质量评分(Qo L)。结果 2组患者的不良反应发生率无统计学差异(P>0.05),治疗期间A组5例患者因无法耐受不良反应而退出,B组4例患者退出。A组患者ORR为68.89%,B组ORR为47.86%,差异具有统计学意义(P<0.05)。A组患者的PFS、OS和Qo L高于B组,差异具有统计学意义(P<0.05)。结论化疗交替靶向药物在晚期EGFR突变阳性的NSCLC的治疗中具有显著的临床疗效,值得在临床上进行推广和应用。

加载絮凝与PFS+PAM絮凝处理含氟废水对比试验研究

采用小试对配制的4种质量浓度(低、中低、中高和高质量浓度)含氟废水进行了加载絮凝与聚合硫酸铁(PFS)+聚丙烯酰胺(PAM)二段絮凝对比试验研究。根据对出水上清液的氟质量浓度、总铅质量浓度、浊度及污泥含水率的分析,综合评价了两种工艺处理性能。结果表明,加载絮凝工艺对4种质量浓度含氟废水的各项净水效能均优于PFS+PAM二段絮凝,且在相同PFS投加量下,加载絮凝工艺产生的污泥含水率更低。

Pfs25蛋白单克隆抗体的制备及双抗体夹心ELISA的建立

目的:制备恶性疟原虫子孢子囊表面膜蛋白Pfs25的单克隆抗体(mAb),建立检测Pfs25蛋白的双抗体夹心ELISA方法。方法:纯化毕赤酵母表达的重组Pfs25蛋白,并免疫BALB/c小鼠,采用骨髓瘤细胞Sp2/0与免疫BALB/c鼠脾细胞杂交的细胞融合技术,通过间接ELISA检测获得分泌抗Pfs25抗体的阳性杂交瘤细胞株,通过免疫F1鼠诱生腹水,纯化腹水,并进行mAb的各项生物学鉴定。辣根过氧化物酶(HRP)标记纯化后的抗体,以4B7为包被抗体,1B4为酶标抗体,建立了双抗体夹心ELISA法。结果:获得3株抗Pfs25的杂交瘤细胞株,其中2株有良好的稳定性和特异性。并建立了双抗体夹心ELISA检测法,检测有效范围在0.07～1 mg/mL,其检测灵敏度为41.6 ng/mL。结论:成功制备抗Pfs25蛋白的单克隆抗体,并建立了一种可用于Pfs25蛋白检测的双抗体夹心ELISA法,为Pfs25蛋白制备传播阻断型疟疾疫苗奠定了基础。

硫铁矿烧渣制备PFS、PFPS及其除浊效果比较

以硫铁矿烧渣为原料,采用胶体分散法新工艺制备得到聚合硫酸铁(PFS),然后在PFS溶液中加入磷酸钠得到聚磷硫酸铁 (PFPS)。研究了影响PFPS盐基度的因素,以及PFS、PFPS的除浊效果。结果表明,采用胶体分散法制备PFS的工艺独特,无污染物氮 氧化物的产生。实验还表明,PFPS的絮凝效果明显好于PFS。PFPS投放量以及盐基度适宜时可达到最佳除浊效果。

PFS盐基度与絮凝性能关系分析

通过分散和活性染料染色废水絮凝处理实验,探讨聚合硫酸铁(PFS)的盐基度与其絮凝性能之间的关系.结果表明,在适宜的pH值和投加量条件下,聚合硫酸铁的盐基度在10%～16%时,絮凝效果较好,色度去除率为80%以上.当PFS盐基度为13.43%时,处理效果最好,色度去除率达95%.

PAC与PFS深度处理垃圾渗滤液出水的对比研究

针对垃圾渗滤液经生化处理后出水CODCr和色度偏高,可生化性差(BOD5/CODCr≤0.1)的特点,为进一步去除CODCr,降低色度,采用PAC和PFS两种混凝剂对出水进行处理,并对两者的混凝效果进行比较。试验表明,PFS最佳投加量为0.7 mL.L-1,CODCr去除率达到74.3%,色度去除率88.6%;PAC最佳投加量为1 g.L-1,去除率达到51.9%,色度去除率达到77.8%。无论从CODCr或色度的去除率来看,PFS的混凝效果均优于PAC。