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The Influence of CO_(2) Cured Manganese Slag on the Performance and Mechanical Properties of Ultra-High Performance Concrete
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作者 Ligai Bai Guihua Yang 《Fluid Dynamics & Materials Processing》 EI 2024年第8期1717-1730,共14页
The presence of toxic elements in manganese slag(MSG)poses a threat to the environment due to potential pollution.Utilizing CO_(2) curing on MS offers a promising approach to immobilize toxic substances within this ma... The presence of toxic elements in manganese slag(MSG)poses a threat to the environment due to potential pollution.Utilizing CO_(2) curing on MS offers a promising approach to immobilize toxic substances within this material,thereby mitigating their release into the natural surroundings.This study investigates the impact of CO_(2) cured MS on various rheological parameters,including slump flow,plastic viscosity(η),and yield shear stress(τ).Additionally,it assesses flexural and compressive strengths(f_(t) and f_(cu)),drying shrinkage rates(DSR),durability indicators(chloride ion migration coefficient(CMC),carbonization depth(CD)),and the leaching behavior of heavy metal elements.Microscopic examination via scanning electron microscopy(SEM)is employed to elucidate the underlying mechanisms.The results indicate that CO_(2) curing significantly enhances the slump flow of ultra-high performance concrete(UHPC)by up to 51.2%.Moreover,it reduces UHPC’sηandτby rates ranging from 0%to 52.7%and 0%to 40.2%,respectively.The DSR exhibits a linear increase corresponding to the mass ratio of CO_(2) cured MS.Furthermore,CO_(2) curing enhances both f_(t) and f_(cu) of UHPC by up to 28.7%and 17.6%,respectively.The electrical resistance is also improved,showing an increase of up to 53.7%.The relationship between mechanical strengths and electrical resistance follows a cubic relationship.The CO_(2) cured MS demonstrates a notable decrease in the CMC and CD by rates ranging from 0%to 52.6%and 0%to 26.1%,respectively.The reductions of leached chromium(Cr)and manganese(Mn)are up to 576.3%and 1312.7%,respectively.Overall,CO_(2) curing also enhances the compactness of UHPC,thereby demonstrating its potential to improve both mechanical and durability properties. 展开更多
关键词 CO_(2)curing manganese slag steel fibers mechanical strengths salt action
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生成式人工智能赋能本科生科研能力培养——ChatGPT支持的CUREs教学模式
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作者 吴忭 李凤鸣 胡艺龄 《现代远程教育研究》 北大核心 2024年第3期3-10,28,共9页
为促进高等教育中高素质创新人才培养,构建以学生为中心的科研训练与课程教学整合模式是有效途径。当前基于课程的本科生科研体验(CUREs)教学模式虽在增强学生对科学本质的理解等方面具有一定优势,但在激发学生研究动机方面存在一些不... 为促进高等教育中高素质创新人才培养,构建以学生为中心的科研训练与课程教学整合模式是有效途径。当前基于课程的本科生科研体验(CUREs)教学模式虽在增强学生对科学本质的理解等方面具有一定优势,但在激发学生研究动机方面存在一些不足。将支持高效反馈的生成式人工智能ChatGPT引入人机协作研究过程中,有助于改善学生的科研体验,推动科研项目化学习。通过对ChatGPT支持的CUREs教学模式的设计与实施,发现该模式有助于培养学生的科研能力,提升他们的科研知识水平、科研技能水平和科研情感水平。尽管学生认同该教学模式的有效性和易用性,但其实际效果的发挥仍需人类智慧的参与。未来需要持续升级和优化生成式人工智能技术,确保技术应用高效且符合伦理标准;应用生成式人工智能技术重构教学模式,并通过长周期、跨场域实践检验其应用效果;强调人工智能与人类智慧的互补协作,真正实现生成式人工智能赋能学生科研能力提升。 展开更多
关键词 生成式人工智能 ChatGPT 科研能力 cures 教学模式
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Curing Characteristics and Suitable Harvest Maturity of Fresh Flue-cured Tobacco Leaves in Ankang Tobacco Growing Areas 被引量:2
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作者 朱峰 饶智 +3 位作者 沈始权 孙福山 任杰 肖头杰 《Agricultural Science & Technology》 CAS 2015年第4期815-819,共5页
CuItivars K326, Yunyan 87 and Guiyan 4 were used to investigate the curing characteristics and suitabIe harvest maturity of fresh fIue-cured tobacco Ieaves in Ankang tobacco growing areas. ResuIts indicated that the w... CuItivars K326, Yunyan 87 and Guiyan 4 were used to investigate the curing characteristics and suitabIe harvest maturity of fresh fIue-cured tobacco Ieaves in Ankang tobacco growing areas. ResuIts indicated that the water Ioss of K326 was sIow,and the Ieaves were resistant to curing and reIative easiIy to cure. The water Ioss of Yunyan 87 and Guiyan 4 were quick, and the Ieaves with normal resistance to curing were reIative difficuIt to cure. For Guiyan 4, the shrinkage of CM1 maturity was the Iargest. For K326 and Yunyan 87, the shrinkages of CM2 maturity were the Iargest whiIe the shrinkage of CM1 maturity was the Iowest, but the difference did not reach statistical significance. The proportion of top-middIe-grade tobacco Ieaves and average price for K326 were the highest with XM2, CM2 and BM2 maturity, and for Yunyan 87 were XM1, CM3 and BM2 maturity. For K326, Ieaves with XM2, CM2 and BM2 maturity showed the balanced chemical components and the best smoking quality. 展开更多
关键词 FIue-cured tobacco Curing characteristic MATURITY Ankang City of Shaanxi Province
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Effects of Different Flue-curing Barns on Aroma Quality of Upper Flue-cured Tobacco Leaves of K326 被引量:2
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作者 詹军 周芳芳 +4 位作者 徐成龙 张晓龙 王柱石 陈初 朱海滨 《Agricultural Science & Technology》 CAS 2014年第11期2014-2019,共6页
[Objective] This study was conducted to compare the aroma quality of up-per leaves of K326 flue-cured in different barns, and provide theoretical references for the development and optimization of bulk curing barn and... [Objective] This study was conducted to compare the aroma quality of up-per leaves of K326 flue-cured in different barns, and provide theoretical references for the development and optimization of bulk curing barn and the supporting tech-niques. [Method] The upper leaves of K326 were flue-cured in a commonness barn, a four-shelf bulk curing barn and a three-shelf bulk curing barn separately, and then the contents of aroma components and taste quality indices of the finished leaves were measured and compared. [Result] The contents of total aroma components, chromoplast pigment degradation products, phenylalanine aroma components and neophytadiene showed no significant differences in the leaves flue-cured in four-shelf bulk curing barn and commonness barn, but were significantly or very significantly higher than those in the leaves flue-cured in three-shelf bulk curing barn. The con-tents of carotenoid degradation products, Mail ard reaction products, cembranes aro-ma components and total aroma components (except neophytadiene) showed no significant difference among the three treatments. The results of sensory evaluation revealed that the sensory taste of the leaves flue-cured in four-shelf bulk curing barn was the best, as the finished leaves had rich, delicate aroma, comfortable and clean aftertaste. The leaves flue-cured in commonness barn was better than those flue-cured in three-shelf bulk curing barn in aroma quality, amount and aftertaste. [Conclusion] The four-shelf bulk curing barn had a large volume for tobacco leaf processing, but a similar baking environment to the commonness barn, which is conducive to the formation and accumulation of aroma components, so the finished leaves had similar appearance and quality with those flue-cured in commonness barn. The upper flue-cured leaves in three-shelf bulk curing bran had poorer quality than those flue-cured in the other two barns. 展开更多
关键词 Bulk curing barn Commonness barn flue-cured tobacco K326 Upper leaf Aroma quality
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The Mechanism of Carotenoid Degradation in Flue-Cured Tobacco and Changes in the Related Enzyme Activities at the Leaf-Drying Stage During the Bulk Curing Process 被引量:6
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作者 SONG Zhao-peng LI Tong-shuai +3 位作者 ZHANG Yong-gang CAO Hui-jing GONG Chang-rong ZHANG Wei-jian 《Agricultural Sciences in China》 CSCD 2010年第9期1381-1388,共8页
The mechanism of carotenoid degradation and the changes in the activities of related enzymes in flue-cured tobacco at the leaf-drying stage during the bulk-curing process were studied in order to provide theoretical b... The mechanism of carotenoid degradation and the changes in the activities of related enzymes in flue-cured tobacco at the leaf-drying stage during the bulk-curing process were studied in order to provide theoretical basis for optimization of curing technology. The effect of different rising speeds of temperature on the carotenoid degradation and the related enzymes activities at the color-fixing stage during the bulk curing process was studied by using the electric-heated fluecuring barn designed by Henan Agricultural University, China, based on curing technology with yellowing at low temperature and moderate humidity and leaf drying at moderate humidity. The results showed that the carotenoid degradation components (β-carotene, lutein, neoxanthin, and violaxthin) decreased gradually at the color-fixing stage during the bulk curing process. The carotenoid degradation components viz.,β-carotene, lutein, neoxanthin, and violaxthin at the slow heating curing (T1) were relatively higher than the rapid heating curing (T2) accounting for 10, 2, 32 and 32% respectively, but there were no differences among treatments (P〉 0.05). The effect of different conditions of curing on the activities of enzymes related to carotenoids degradation were significant. The lipoxygenase, phenylalanine ammonialyase, peroxidase, and polyphenol oxidase enzymes had a bidirectional effect on the quality of tobacco leaves and it was beneficial to form more premise matter of aroma based on the higher enzyme activities at the early leaf-drying stage. The slow heating could regulate the change in various enzymes' activities reasonably, making cell redox reaction to reach the dynamic balance and make the degradation of carotenoids adequately. Meanwhile, it could avoid the occurrence of browning reaction and provide foundation for improving the quality of tobacco and optimization of technology for bulk curing and further enhancing aroma. 展开更多
关键词 bulk curing leaf-drying stage carotenoids mechanism of degradation enzyme
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Yield and Nicotine Content of Flue-Cured Tobacco as Affected by Soil Nitrogen Mineralization 被引量:41
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作者 JU Xiao-Tang CHAO Feng-Chun +3 位作者 LI Chun-Jian JIANG Rong-Feng P. CHRISTIE ZHANG Fu-Suo 《Pedosphere》 SCIE CAS CSCD 2008年第2期227-235,共9页
Nitrogen(N)supply is the most important factor affecting yield and quality of flue-cured tobacco(FCT).A field experiment and an in situ incubation method were used to study the effects of soil N mineralization in the ... Nitrogen(N)supply is the most important factor affecting yield and quality of flue-cured tobacco(FCT).A field experiment and an in situ incubation method were used to study the effects of soil N mineralization in the later stages of growth on yield and nicotine content of FCT in Fenggang and Jinsha,Guizhou Province.The yield and market value of FCT at Fenggang were much lower than those at Jinsha.However,the nicotine content of middle and upper leaves was much higher at Fenggang than at Jinsha when the same rate of fertilizer N was applied,which might be due to a higher N supply capacity at the Fenggang site.At later stages of growth(7-16 weeks after transplanting),the soil net N mineralization at Fenggang(56 kg N ha^(-1))was almost double that at Jinsha(30 kg N ha^(-1)).While soil NH_4-N and NO_3-N were almost exhausted by the plants or leached 5 weeks after transplanting,the N taken up at the later growth stages at Fenggang were mainly derived from soil N mineralization,which contributed to a high nicotine content in the upper leaves.The order of soil N contribution to N buildup in different leaves was:upper leaves>middle leaves>lower leaves.Thus,soil N mineralization at late growth stages was an important factor affecting N accumulation and therefore the nicotine content in the upper leaves. 展开更多
关键词 flue cured tobacco nicotine content soil N mineralization tobacco quality tobacco yield
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Application of Polyurethane Curing Barn in Flue-cured Tobacco Production 被引量:1
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作者 Ang LI Qingzhi JANG +2 位作者 Wenjian ZHANG Zhong WANG Jun WAN 《Agricultural Biotechnology》 CAS 2016年第2期34-36,39,共4页
[ Objective] This study aimed to investigate the curing performance of polyurethane curing barn and reduce the cost of tobacco leaf flue-curing. [ Meth- odl The temperature control effect, curing effect and curing cos... [ Objective] This study aimed to investigate the curing performance of polyurethane curing barn and reduce the cost of tobacco leaf flue-curing. [ Meth- odl The temperature control effect, curing effect and curing cost of polyurethane curing barn and traditional bulk curing barn were analyzed and compared. [ Re- suit] The results showed that there were no significant differences in curing performance between two types of curing barns. Horizontal temperature differences in- creased slightly as the temperature rose. Specifically, horizontal temperature differences between each layer ranged from 0.2 ~C to 0.5 ~. Both two types of curing barns exhibited uniform air distribution. Polyurethane curing barn exhibited stable vertical temperature differences. Both two types of curing barns presented good curing effects with slight differences. Polyurethane curing barn exhibited higher economic benefits, lower coal cost, lower electricity cost, lower labor cost and lon- ger service life than traditional bulk curing barn, but its construction cost was higher. [ Conclusion] Polyurethane curing barn exhibits better curing performance with ~ood application prospects. 展开更多
关键词 Polyurethane curing barn Curing effect Curing cost
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Effect of CSH Crystal Nucleus on Steam-Free Cured Fly Ash Precast Concrete Components
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作者 Ruyi Luo Yanyan Hu +2 位作者 Tingshu He Xiaodong Ma Yongdong Xu 《Journal of Renewable Materials》 EI 2023年第9期3485-3500,共16页
The measures of steam curing and early-strengthening agents to promote the precast components to reach the target strength quickly can bring different degrees of damage to the concrete.Based on this,the new nanomateri... The measures of steam curing and early-strengthening agents to promote the precast components to reach the target strength quickly can bring different degrees of damage to the concrete.Based on this,the new nanomaterial CSH-the hydration product of cement effectively solves these measures’disadvantages,such as excessive energy consumption,thermal stress damage,and the introduction of external ions.In this paper,the effect of CSH on the early strength of precast fly ash concrete components was investigated in terms of setting time,workability,and mechanical properties and analyzed at the microscopic level using hydration temperature,XRD,and SEM.The results showed that under the same workability,CSH could significantly reduce the amount of admixture,shorten the final setting time,almost not affect the initial setting time,and accelerate the hydration of cement.At the optimum dose of 5%,the mechanical properties of the specimens were improved by more than 98%within 12 h of hydration,resulting in an earlier release time of 12 h and no risk of strength inversion later.The results of this paper give theoretical support to the behavior of precast components under steam-free curing. 展开更多
关键词 Fly ash concrete prefabricated components steam-free curing CSH crystal nucleus TOBERMORITE
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Comparative Analysis on Chemical Components and Sensory Quality of Aging Flue-Cured Tobacco from Four Main Tobacco Areas of China 被引量:22
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作者 SUN Jing-guo HE Jie-wang +4 位作者 WU Feng-guang TU Shu-xing YAN Tie-jun SI Hui XIE Hao 《Agricultural Sciences in China》 CAS CSCD 2011年第8期1222-1231,共10页
Complicated changes are happening during the aging process of flue-cured tobacco (FCT) and understanding of the changing components is of great significance in improving the quality,shortening aging time,and enhanci... Complicated changes are happening during the aging process of flue-cured tobacco (FCT) and understanding of the changing components is of great significance in improving the quality,shortening aging time,and enhancing production and economic efficiency in tobacco industry.The aging samples of FCT from four main producing areas of China,i.e.,Yunnan,Sichuan,Hubei,and Dongbei,were used to study the changing rule of the components such as alkali,acid,and carbohydrate as well as the aroma and their relationship with sensory quality;and based on the correlation among the components and the sensory quality index,multivariable models were established to predict the aging quality.The results showed that the sensory quality of FCT increased steadily during the aging time,and at the same time,the acidic components (total organic acids,volatile acids) increased gradually,while the alkaline substances (nicotine,volatile alkali),carbohydrate (total sugars,reducing sugar) and pH values showed a downward trend.Correlation analysis found that the sensory quality and pH values were negatively correlated (P0.05),while the sensory quality with total organic acids and aroma were positively correlated.The optimal model for predicting the quality of FCT was y=56.75-0.63x12+50.09x2-13.27x22,(y:sensory quality;x1:pH;x2:total organic acids).The average predicating error was 1.04% with maximum predicating error of 2.89% and the accuracy rate of above 97%. 展开更多
关键词 chemical component flue-cured tobacco AGING sensory quality regression model
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Proteomics Identification of Differentially Expressed Proteins Relevant for Nicotine Synthesis in Flue-Cured Tobacco Roots Before and After Decapitation 被引量:4
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作者 LIU Wei-qun GUO Hong-xiang LI Hao 《Agricultural Sciences in China》 CAS CSCD 2008年第9期1084-1090,共7页
Nicotine is a secondary substance synthesized in tobacco roots. In flue-cured tobacco planting, tobacco decapitation is an effective practice to promote nicotine biosynthesis by regulation of the redistribution of tot... Nicotine is a secondary substance synthesized in tobacco roots. In flue-cured tobacco planting, tobacco decapitation is an effective practice to promote nicotine biosynthesis by regulation of the redistribution of total nitrogen amounts. However, proteins relevant to nicotine synthesis in tobacco roots has not been identified and characterized yet. It is important to explore the regulation of nicotine biosynthesis in tobacco roots. To identify the proteins relevant to nicotine synthesis, the protein patterns in roots of flue-cured tobacco (cv. K326) before and after decapitation were analyzed. In the present study, the protein patterns in roots of flue-cured tobacco were analyzed by two-dimensional electrophoresis (2-DE), and the differentially-expressed spots were identified by matrix assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF-MS). Paired comparison of 2-DE maps revealed 26 spots of differentially-expressed proteins in roots before and after decapitation. Furthermore, nine differentially-expressed spots were identified. There were four proteins which were enzymes possibly involved in nicotine biosynthesis. In addition, the roles of the four enzymes in nicotine biosynthesis were discussed in a putative network. Our results would contribute to the understanding of the regulation pathway of nicotine biosynthesis and further to the molecular manipulation on the nicotine contents in flue-cured tobacco. 展开更多
关键词 flue-cured tobacco DECAPITATION ROOTS NICOTINE differential proteomics
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Effects of Different Flue-curing Technologies on Microscopic Structure of Flue-cured Tobacco Leaves 被引量:1
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作者 Guomin CUI Bojun WANG +4 位作者 Rongchun LI Anding XU Yiyin CHEN Chao YANG Min PU 《Agricultural Biotechnology》 CAS 2014年第2期28-34,共7页
[Objective] This study aimed to compare the effects of Chinese quality-improving fragrunce-increasing tobacco flue-curing technology, Chinese three- stage tobaeeo flue-curing technology and Zimbabwean tobaceo flue-eur... [Objective] This study aimed to compare the effects of Chinese quality-improving fragrunce-increasing tobacco flue-curing technology, Chinese three- stage tobaeeo flue-curing technology and Zimbabwean tobaceo flue-euring technology on microscopie structure of flue-cured tobacco leaves to provide theoretical basis for tobacco flue-curing. [ Method ] Middle leaves of tobacco cultivar K326 were collected in Pengshui County of Chongqing City for flue-curing experiment using three flue-curing technologies. Leaf samples were collected regularly in the flue-curing process, to investigate the microscopic structure of flue-cured tobaceo leaves. [ Result] During three flue-curing processes, leaves, palisade tissues and sponge tissues shrank gradually. Three flue-euring processes exhibited significant differ- ences in the peak of tissue shrinkage : microscopic structure of flue-cured tobacco leaves in Chinese three-stage tobacco flue-curing process shrank earliest, follower by Chinese quality-improving fragrance-increasing tobacco flue-curing process; flue-eured tobacco leaves in Zimbabwean tobacco flue-curing process presented the latest shrinkage. At 84 h post-curing, leaf thickness in three flue-curing processes showed a descend order of Chinese three-stage tobacco flue-curing process 〉 Chinese quality-improving fragrance-increasing tobacco flue-curing process 〉 Zimbabwean tobacco flue-curing process. Upper and lower epidermal cells in Zimb- abwean tobacco flue-curing process ruptured earlier than other two flue-curing processes; eventually, the majority of cells ruptured and mixed with palisade tissues and sponge tissues. In Chinese quality-improving fragranee-increasing tobacco flue-curing process, only a small number of epidermal cells in dried leaves ruptured. Among three flue-curing technologies, Zimbabwean tobacco flue-curing technology exhibited the greatest damage to epidermal cells, followed by Chinese three-stage tobaceo flue-curing technology; Chinese quality-improving fragrance-increasing tobacco flue-curing technology had the minimum damage to epidermal cells. Mese- phyll cross-section exhibited significant morphological changes in stomata. To be specific, at 0 - 12 h post-curing, stomata of tobacco leaves closed with slightly prominent stamatal apparatuses on upper and lower epidermis; at 24 -72 h post-curing, stomata of tobaceo leaves changed gradually from opening to closure with significantly prominent stomatal apparatuses on upper and lower epidermis; at 84 h post-curing, stomata of tobacco leaves closed, and the majority of stomatal appa- ratuses were significantly prominent. In Chinese quality-improving fragrance-increasing tobacco flue-curing process, only a small number of epidermal ceils ruptured at 84 h pest-flue-curing; palisade tissues and sponge tissues shrank almost simultaneously. Significant gaps were observed between palisade tissues and between pal- isade tissues and sponge tissues. Chinese quality-improving fragrance-increasing tobacco flue-curing technology exhibited lower disorder level compared with other two flue-curing technologies. [ Conclusion] Chinese quality-improving fragrance-increasing tobacco flue-curlng technology was conducive to maintaining the micro- scopic structure integrity of flue-cured tobacco leaves and obtaining high-quality flue-cured tobacco leaves. 展开更多
关键词 flue-cured tobacco leaves flue-curing technologies Microscopic structure
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Effects of Different Flue-curing Technologies on Submicroscopic Structure of Flue-cured Tobacco Leaves 被引量:1
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作者 Guomin CUI Bojun WANG +4 位作者 Rongchun LI Anding XU Yiyin CHEN Chao YANG Min PU 《Agricultural Biotechnology》 CAS 2014年第1期43-49,共7页
[ Objective] This study aimed to compare the effects of low-temperature low-humidity tobacco flue-curing technology, moderate-temperature moderate- humidity tobacco flue-curing technology and moderate-temperature high... [ Objective] This study aimed to compare the effects of low-temperature low-humidity tobacco flue-curing technology, moderate-temperature moderate- humidity tobacco flue-curing technology and moderate-temperature high-humidity tobacco flue-curing technology on submicroscopic structure of flue-cured tobacco leaves to provide theoretical basis for tobacco flue-curing. [ Method] Middle leaves of tobacco cuhivar K326 were collected in Pengshui County of Chongqing City for flue-curing experiment using three flue-curing technologies. Leaf samples were collected regularly in the flue-curing process, to investigate the submicroscopic structure of flue-cured tobacco leaves. [ Result] Morphology changes and structural rupture of chloroplasts occurred at different time during three flue-curing proces- ses. In low-temperature low-humidity flue-curing process, morphology changes and structural rupture of chloroplasts occurred late but rapidly; in moderate-tempera- ture moderate-humidity flue-curing process and moderate-temperature high-humidity flue-curing process, morphology changes and structural rupture of chloroplasts occurred early but slowly. Among these three flue-curing processes, the speed of changes in mitochondria morphology, cristae number and membrane rupture pres- ented an upward order of low-temperature low-humidity flue-curing process 〈 moderate-temperature high-humidity flue-curlng process 〈 moderate-temperature moderate-humidity flue-curing process. In low-temperature low-humldity flue-curing process, starch granules in chloroplasts ruptured after flue-curing for 36 -48 h ; in moderate-temperature moderate-humidity flue-curing process, starch granules in chloroplasts ruptured after flue-curing for 24 - 36 h; in moderate-temperature high-humidity flue-curing process, starch granules in chloroplasts ruptured after flue-curing for 12 - 24 h. [ Conclusion ] Using low-temperature low-humidity flue- curing technology could prolong the maintenance duration of the submicroscopic structure integrity of flue-cured tobacco leaves, which was conducive to fully decom- posing and transforming substances in tobacco leaves and obtaining high-quality flue-cured tobacco leaves. 展开更多
关键词 flue-cured tobacco leaves flue-curing technologies Submicroscopic structure
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Hepatitis B cure:Current situation and prospects
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作者 Ya-Ping Li Chen-Rui Liu +1 位作者 Ling He Shuang-Suo Dang 《World Journal of Hepatology》 2024年第6期900-911,共12页
Achievement of a‘clinical cure’in chronic hepatitis B(CHB)implies sustained virological suppression and immunological control over the infection,which is the ideal treatment goal according to domestic and internatio... Achievement of a‘clinical cure’in chronic hepatitis B(CHB)implies sustained virological suppression and immunological control over the infection,which is the ideal treatment goal according to domestic and international CHB management guidelines.Clinical practice has shown encouraging results for specific patient cohorts using tailored treatment regimens.These regimens incorporate either nucleos(t)ide analogs,immunomodulatory agents such as pegylated interferonα,or a strategic combination of both,sequentially or concurrently administered.Despite these advancements in the clinical handling of hepatitis B,achieving a clinical cure remains elusive for a considerable subset of patients due to the number of challenges that preclude the realization of optimal treatment outcomes.These include,but are not limited to,the emergence of antiviral resistance,incomplete immune recovery,and the persistence of covalently closed circular DNA.Moreover,the variance in response to interferon therapy and the lack of definitive biomarkers for treatment cessation also contribute to the complexity of achieving a clinical cure.This article briefly overviews the current research progress and existing issues in pursuing a clinical cure for hepatitis B. 展开更多
关键词 Chronic hepatitis B Clinical cure Polyethylene glycol interferon Treatment strategies Research progress
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Relationship Between Hyperspectral Parameters and Physiological and Biochemical Indexes of Flue-Cured Tobacco Leaves 被引量:4
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作者 LI Xiang-yang LIU Guo-shun YANG Yong-feng ZHAO Chun-hua YU Qi-wei SONG Shi-xu 《Agricultural Sciences in China》 CAS CSCD 2007年第6期665-672,共8页
The experiment was set up for examining the physiological and biological indexes quickly and exactly, for obtaining information of tobacco-field fertilizing and tobacco growing. The ASD Field spec FR 2500 was used to ... The experiment was set up for examining the physiological and biological indexes quickly and exactly, for obtaining information of tobacco-field fertilizing and tobacco growing. The ASD Field spec FR 2500 was used to measure spectra reflectance of flue-cured tobacco and the relationship between hyperspectral parameters and biochemical contents (total nitrogen, chlorophyll, carotenoid), and physiological indexes (fresh weight, dry weight, moisture content) of flue-cured tobacco leaves was studied by correlation and stepwise regression statistic methods at different nitrogen and potassium levels. The results indicated that the spectra curves of different treatments had obvious rules and great diversities. There were high correlations between different types of spectra parameters and ten physiological and biochemical indexes of flue-cured tobacco leaves. Hyperspectral characteristic variables of ten physiological and biochemical indexes were found through stepwise regression, and SDr/SDb was the characteristic variable closest to seven biochemical contents. Simultaneously, the R2 and regression coefficient of equations reached 0.05 significant level and the equations had good estimating effects through the examination of other samples. Accordingly, this study suggested that the ten physiological and biochemical indexes could be estimated quickly by the estimating models, at the same time nitrogen-potassium fertilization and growth condition of flue-cured tobacco could be inspected. 展开更多
关键词 flue-cured tobacco leaves hyperspectral parameters physiological and biochemical indexes
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Characteristics of Potassium-Enriched, Flue-Cured Tobacco Genotype in Potassium Absorption, Accumulation, and In-Ward Potassium Currents of Root Cortex 被引量:6
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作者 YNAG Tie-zhao LU Li-ming +1 位作者 XIA Wei FAN Jin-hua 《Agricultural Sciences in China》 CAS CSCD 2007年第12期1479-1486,共8页
This study was to investigate the main traits of potassium-enriched, flue-cured tobacco genotypes related to potassium absorption, accumulation, and in-ward potassium currents of the root cortex. Hydroponic methods, K... This study was to investigate the main traits of potassium-enriched, flue-cured tobacco genotypes related to potassium absorption, accumulation, and in-ward potassium currents of the root cortex. Hydroponic methods, K^+-depletion methods, and patch-clamp, whole-cell recordings were conducted to study the accumulation of dry matter and potassium in different organs, and to measure potassium absorption and dynamic and in-ward potassium currents in potassium-enriched, fluecured tobacco genotypes. The average dry weights of leaves and whole plant of potassium-enriched, flue-cured tobacco genotype ND202 were 10.20, and 14.85 g, respectively, higher than JYH (8.50 and 13.11 g, respectively) and NC2326 (8.39 and 12.72 g, respectively), when potassium concentration in the solution ranged from 0.1 to 50 mmol L^-1. Potassium accumulation in the leaves of ND202 was 18.6% higher than JYH and 34% higher than NC2326 when potassium concentration in the solution was superior to 0.5 mmol L^-1. The Vmax (the maximum velocity) of ND202 was 118.11 lamol FW g^-1 h^-1, obviously higher than that of JYH (58.87 μmol FW g^-1 h^-1) and NC2326 (64.40 μmol FW g^-1 h^-1). In the in-ward potassium currents, the absolute value of current density (pA/pF) of ND202 was 60, higher than that of JYH (50) and NC2326 (40). Potassium concentration in leaves, Vmax, and in-ward potassium currents, could be used to screen potassium-enriched, flue-cured tobacco genotypes. 展开更多
关键词 flue-cured tobacco potassium-enriched genotype potassium absorption potassium content in-wardpotassium currents
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Nitrogen Metabolism and Curing Characteristics of Flue-cured Tobacco Variety NC71
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作者 Cong ZHENG Wei LI +3 位作者 Bo LI Hongquan SUN Zhigang LU Yongfeng AI 《Asian Agricultural Research》 2021年第10期63-70,75,共9页
[Objectives]To explore the growth characteristics,nitrogen metabolism and curing characteristics of the new variety NC71 in strongly aromatic tobacco leaves production area.[Methods]With Yunyan 87 as the control and N... [Objectives]To explore the growth characteristics,nitrogen metabolism and curing characteristics of the new variety NC71 in strongly aromatic tobacco leaves production area.[Methods]With Yunyan 87 as the control and NC71 as the experimental material,the experiment was carried out in Nanyang tobacco area for two consecutive years to study the growth characteristics of tobacco plants,the activity of key enzymes in nitrogen metabolism,the content of secondary metabolites,and the differences of tobacco-related water content,PPO enzyme activity and total phenol content.[Results]NC71 plants had lower height,better appearance quality and lower nicotine,total sugar and chlorine content.NC71 high nitrogen treatment and Yunyan 87 medium nitrogen treatment had similar key enzyme activity of nitrogen metabolism,content of secondary metabolites;Yunyan 87 and NC71 were easy to cure and resistant to curing.[Conclusions]This study provides a reference for measuring the appropriate nitrogen application rate and optimizing the curing process from the activities of the key enzymes NR and GS in nitrogen metabolism at the mature stage of the variety. 展开更多
关键词 VARIETY Nitrogen metabolism Curing characteristics
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Modelling the Survival of Western Honey Bee Apis mellifera and the African Stingless Bee Meliponula ferruginea Using Semiparametric Marginal Proportional Hazards Mixture Cure Model
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作者 Patience Isiaho Daisy Salifu +1 位作者 Samuel Mwalili Henri E. Z. Tonnang 《Journal of Data Analysis and Information Processing》 2024年第1期24-39,共16页
Classical survival analysis assumes all subjects will experience the event of interest, but in some cases, a portion of the population may never encounter the event. These survival methods further assume independent s... Classical survival analysis assumes all subjects will experience the event of interest, but in some cases, a portion of the population may never encounter the event. These survival methods further assume independent survival times, which is not valid for honey bees, which live in nests. The study introduces a semi-parametric marginal proportional hazards mixture cure (PHMC) model with exchangeable correlation structure, using generalized estimating equations for survival data analysis. The model was tested on clustered right-censored bees survival data with a cured fraction, where two bee species were subjected to different entomopathogens to test the effect of the entomopathogens on the survival of the bee species. The Expectation-Solution algorithm is used to estimate the parameters. The study notes a weak positive association between cure statuses (ρ1=0.0007) and survival times for uncured bees (ρ2=0.0890), emphasizing their importance. The odds of being uncured for A. mellifera is higher than the odds for species M. ferruginea. The bee species, A. mellifera are more susceptible to entomopathogens icipe 7, icipe 20, and icipe 69. The Cox-Snell residuals show that the proposed semiparametric PH model generally fits the data well as compared to model that assume independent correlation structure. Thus, the semi parametric marginal proportional hazards mixture cure is parsimonious model for correlated bees survival data. 展开更多
关键词 Mixture cure Models Clustered Survival Data Correlation Structure Cox-Snell Residuals EM Algorithm Expectation-Solution Algorithm
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Effect of Different Intercropping Methods on the Reduction of Heavy Metal Content in Flue-Cured Tobacco 被引量:1
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作者 Chen Yunfei Cheng Wenzhang +1 位作者 Jiang Zhilin Qiang Jiye 《Meteorological and Environmental Research》 CAS 2018年第2期84-86,共3页
Heavy metals not only adversely affect the quality of tobacco leaves,but also have very adverse effects on human health. In order to find out the effective cultivation method of controlling heavy metal content in flue... Heavy metals not only adversely affect the quality of tobacco leaves,but also have very adverse effects on human health. In order to find out the effective cultivation method of controlling heavy metal content in flue-cured tobacco,the content of four kinds of heavy metals in soil and tobacco leaves in different intercropping treatments was tested. The results showed that there were significant differences between the effects of intercropping on the content of some heavy metals in soil and tobacco leaves. Different interplanting methods had a positive effect on the reduction of heavy metal content in tobacco leaves and play a very important and positive role in actual production. 展开更多
关键词 flue-cured tobacco INTERCROPPING Heavy metals HEALTH
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基于改进CURE聚类的运营商用户云数据挖掘方法
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作者 雷中锋 徐秀 +3 位作者 张艳菲 曲延庆 宋强 刘良 《电脑编程技巧与维护》 2024年第4期62-64,共3页
为了优化运营商用户云数据挖掘效果、提升数据挖掘质量,开展基于改进CURE聚类的运营商用户云数据挖掘方法研究。首先,确定运营商用户云数据来源,采集与预处理运营商用户云数据。其次,设计数据挖掘关联规则,得出不同用户云数据之间的关... 为了优化运营商用户云数据挖掘效果、提升数据挖掘质量,开展基于改进CURE聚类的运营商用户云数据挖掘方法研究。首先,确定运营商用户云数据来源,采集与预处理运营商用户云数据。其次,设计数据挖掘关联规则,得出不同用户云数据之间的关联性。最后,利用改进CURE聚类算法,设计运营商用户云数据挖掘流程,输出聚类结果作为数据挖掘结果,并建立数据仓库,集中存储和管理用户云数据挖掘结果。实验结果表明,运用提出的方法,数据挖掘轮廓系数更接近1,聚类合理,挖掘效果优势显著,应用效果较好。 展开更多
关键词 改进cure聚类 运营商 用户 云数据 挖掘
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Risk Regionalization of Drought for Flue-cured Tobacco Planting in Qujing City Based on GIS 被引量:1
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作者 Pu Jicun Cheng Jiali +2 位作者 Zhang Maosong Yuan Jiafeng Bai Bo 《Meteorological and Environmental Research》 CAS 2019年第5期119-124,共6页
The risk regionalization of drought for flue-cured tobacco planting in Qujing City was studied to provide reference for drawing on advantages and avoiding disadvantages in flue-cured tobacco planting,disaster reductio... The risk regionalization of drought for flue-cured tobacco planting in Qujing City was studied to provide reference for drawing on advantages and avoiding disadvantages in flue-cured tobacco planting,disaster reduction,and disaster relief services.According to the production practice of flue-cured tobacco and local climate analysis,the risk of disaster-causing factors,sensitivity of disaster-breeding environment,vulnerability of carriers,and disaster prevention and reduction capability were analyzed and evaluated quantitatively.Secondly,starting from the formation mechanism of drought,a risk assessment model of the meteorological disaster was established by GIS technology.Finally,the risk assessment and regionalization of drought in the critical periods for drought-stricken flue-cured tobacco (transplanting period,root extending stage and vigorous growth period) in Qujing City were carried out.The results showed that in Qujing City,the risk areas of drought for flue-cured tobacco planting were divided into five grades in the transplanting period and six grades in the root extending stage and vigorous growth period. 展开更多
关键词 GIS technology DROUGHT Risk REGIONALIZATION flue-cured TOBACCO PLANTING in Qujing CITY
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