Changes on optical coherence tomography angiography and fluorescein angiography in eyes with neovascular age-related macular degeneration

AIM:lo evaluate the changes on optical coherence tomography angiography(OCTA) and fluorescein angiography(FA) and their correlation in neovascular agerelated macular degeneration(nAMD) before and after intravitreal aflibercept injections(IAIs).METHODS:In 43 treatment-na?ve patients with nAMD,choroidal neovascularization(CNV) in OCTA were morphologically and quantitatively analyzed before and after IAIs to determine whether they are correlated with leakage on FA or not.By combining CNV in OCTA and leakage in FA,lesions were characterized as three types:L+C+(with both CNV and leakage),L-C+(with CNV but without leakage),or L+C-lesion(with leakage outside CNV).RESULTS:Before IAI,while 27 eyes had L+C+lesion only,16 eyes had both L+C+and L-C+lesions simultaneously.Tiny capillaries and anastomosis in CNV were more developed in L+C+lesion,at 86.0% and58.1%,respectively,relative to 9.3% and 9.3% in L-C+lesions(P<0.001).After IAIs in 33 eyes,tiny capillaries and anastomosis were decreased in the lesions with cessation of leakage on FA(P<0.001 and P=0.001,respectively).In quantitative analysis,neovascularization length and numbers of junctions and endpoints were also significantly decreased.CONCLUSION:Leakage on FA is associated with CNV morphology in OCTA and remained so after IAls.Therefore,by carefully assessing the morphological and quantitative changes of CNV in OCTA before and after treatment,activity of nAMD is expected even though CNV on OCTA is not completely matched with fluorescein leakage.

The Natural History of Dry Type of Age-related Macular Degeneration

To study the natural history of dry type of age-related macular degeneration (AMD) and search for a sensitive method for detecting the development of the disease, the fundus fluorescein angiography, visual acuity, electroretinogram and FM 100-hue test were used to examine 75 eyes, 147 eyes, 73 eyes, and 94 eyes respectively. These examinations were taken at least twice during the follow-up periods. The average age was 63.2 years (50-80 years ). The average follow-up was 29.8 months with a range of 3-74 ...

Retinal circulation and its role in macular disorders in patients without systemic disease

AIM: To determine whether retinal circulatory changes play a role in the pathogenesis of macular disorders in patients who are otherwise healthy. METHODS: Patients with macular disorders that required angiographic imaging were included in this prospective case series. After a complete ocular exam,fluorescein angiography was performed using a standardized technique on the HRA-II(Heidelberg Engineering, Heidelberg, Germany) with special focus on the posterior pole. Only patients with good quality images were included in the analysis. Circulatory parameters recorded included the arm-choroid time,choroid-retinal artery, and finally the retinal artery-vein time. Zonal asymmetry(between the upper and lower zones divided by a line passing through the centre of the fovea) in transit times, if any was also noted. Appropriate statistical analysis was done. Circulation times were compared with age matched historical controls. Changes in retinal dye transit times relative to historical age matched controls, if any, were noted and compared between various disorders.RESULTS: A total of 156 eyes of 156 patients(120 males)were included in the study. Mean age: 49.14 ±14.93 y.Macular disorders studied were age related degeneration,polypoidal vasculopathy, central serous chorioretinopathy(CSCR) and parafoveal telangiectasia. Delayed circulation time was noted in CSCR patients only.CONCLUSION: CSCR patients appear to have delayed arterial filling, retinal circulatory disturbances do not seem to contribute to the pathogenesis of other macular disorders.

眼底造影荧光强度的计算机定量分析

目的 :建立眼底血管荧光造影 (fundusfluoresceinangiography ,FFA)中荧光强度定量图像分析方法 ,以评价眼底病变的病变程度和预后。方法 :分析湿性增龄性黄斑变性 (age -relatedmaculardegeneration ,AMD)患者FFA图像脉络膜新生血管膜 (choroidalneovascularizition ,CNV)渗漏强度在造影各期的变化趋势 ,分析正常眼底后极部 6.2 0mm2 区域的FFA荧光强度在造影各期的变化趋势 ,二者进行比较 ,验证荧光强度定量分析方法的客观性、有效性和实用性。结果 :湿性AMD患者的FFA图像CNV荧光素渗漏强度造影各期均显著高于正常眼底后极部 6.2 0mm2 区(P <0 .0 5或P <0 .0 1) ,动静脉期至 72 0秒差别具有非常显著性意义 (P <0 .0 1)。 180秒～ 3 0 0秒差别最明显。结论 :对眼底疾病的病变程度和预后进行评估 ,荧光强度计算机定量图像分析方法是比较客观。

老年性黄斑变性患者光学断层成像及荧光素眼底造影结果对比分析

目的以62例老年性黄斑变性患者作为本次研究的对象,探究对其采用光学断层成像以及荧光素眼底造影两种检查方法的临床检查效果并进行分析。方法本研究选取62例2014年3月至2015年9月期间在我院进行治疗的老年性黄斑变性患者作为研究对象,共计患眼90只,分别对其采用光学断层成像以及荧光素眼底造影两种检查方法进行检查,并对比两种检查方法的检查结果以及所得图像特点。结果在老年性黄斑变性患者的各个类型中,光学断层成像与荧光素眼底造影两种检查方法对地图状萎缩型、脉络膜新生血管型以及玻璃疣型的检出结果存在显著差异,有统计学价值;但在视网膜上皮脱落型的检出比较上,两种检查方法差异不显著。光学断层成像技术对地图状萎缩型以及玻璃疣型的老年性黄斑变性具有较高的检出率,而荧光素眼底造影技术对脉络新生血管型老年性黄斑变性具有较高的检出率。结论对老年性黄斑变性患者进行临床检查时,要根据患者的疾病类型选择合适的检查方法。光学断层成像以及荧光素眼底造影两种检查方法在临床应用上相互补充,相互结合,共同为老年性黄斑变性患者的临床诊断及治疗提供可靠的临床依据。