A thcile one-step sol-gel method was used to prepare CdTe nanocrystals（NCs） doped silica microspheres with luxuriant thiol group on their surface using 3-mercaptopropyl trimethoxysilane（MPTMS） as organosilane in t...A thcile one-step sol-gel method was used to prepare CdTe nanocrystals（NCs） doped silica microspheres with luxuriant thiol group on their surface using 3-mercaptopropyl trimethoxysilane（MPTMS） as organosilane in the aqueous solution. As the ligand and organosilane, MPTMS ensured the doping efficiency of CdTe NCs by ligand exchange and a large thiol group exposed to the solution to activate the surface of silica microspheres. The remodeled sol-gel process was performed at a lower temperature, which protected the thiol groups from degradation. Meanwhile, the particle size and size distribution can be controlled by varying synthesis conditions, such as the stirring rate and the reaction temperature. This user-friendly method provides a plattbrm tbr immobilization of chemical groups such as carboxyl for combination of bioactive and diagnostic molecules at the surface of CdTe NCs doped silica micro- spheres through thiol-ene chemistry for high-throughput microarrays.展开更多
基金Supported by the National Program on Key Research ＆ Development Program Sub-project, China（No.2016YFC0800901- Z01 ） and the National Natural Science Foundation o f China（Nos.21271082, 21301066, 21371068, 21401073）.
文摘A thcile one-step sol-gel method was used to prepare CdTe nanocrystals（NCs） doped silica microspheres with luxuriant thiol group on their surface using 3-mercaptopropyl trimethoxysilane（MPTMS） as organosilane in the aqueous solution. As the ligand and organosilane, MPTMS ensured the doping efficiency of CdTe NCs by ligand exchange and a large thiol group exposed to the solution to activate the surface of silica microspheres. The remodeled sol-gel process was performed at a lower temperature, which protected the thiol groups from degradation. Meanwhile, the particle size and size distribution can be controlled by varying synthesis conditions, such as the stirring rate and the reaction temperature. This user-friendly method provides a plattbrm tbr immobilization of chemical groups such as carboxyl for combination of bioactive and diagnostic molecules at the surface of CdTe NCs doped silica micro- spheres through thiol-ene chemistry for high-throughput microarrays.
