Treatment of N-t-butylbenzenesulfonamide with an excess of BuLi, followed by the reaction with methyl 2-（4-methylphenyl）propanoate, gave the corresponding 2-carboxybenzenesulfonamide, which underwent a sequence of c...Treatment of N-t-butylbenzenesulfonamide with an excess of BuLi, followed by the reaction with methyl 2-（4-methylphenyl）propanoate, gave the corresponding 2-carboxybenzenesulfonamide, which underwent a sequence of consecutive N-deprotective cyclization process mediated by TMSCI-NaI-MeCN reagent to afford the N-sulfonylimine. Following the bromination and ring expansion, 3-methyl-3-（4-methylphenyl）-2H-benzo[e][1,2]thiazine-l,l,4-trione was obtained. Optical resolution of the racemic benzosultam using （-）-menthoxyacetyl chloride, furnished the optically p.ure （＋）- and （-）-3-methyl-3-（4-methylphenyl）-2H- benzo[e][1,2]thiazine-1,1,4-triones, which were fluorinated with FC103 to produce the corresponding chiral N-F agents.展开更多
During the fixed bed tube furnace combustion experimental study,stimulated the calcium-based sorbent grain size and microstructured influencing factors to explain the fluorine retention effect influence law,and expoun...During the fixed bed tube furnace combustion experimental study,stimulated the calcium-based sorbent grain size and microstructured influencing factors to explain the fluorine retention effect influence law,and expounded the combustion fluorine retention agent developing principle,and probed into the high-temperature fluorine retention agent technical approach.The results show that the calcium-based sorbent particle grain size and pore structure also have the bigger influence on the combustion fluorine retention ef- fect,and reducing the calcium-based sorbent particle grain size and improving the calcium sorbent structure characteristics at very high temperature to enhance the fluorine retention effect is the important approach to the fluorine retention agent development.展开更多
基金the Scientific Research Foundation for the Returned Oversea Chinese Scholars of Shandong University.
文摘Treatment of N-t-butylbenzenesulfonamide with an excess of BuLi, followed by the reaction with methyl 2-（4-methylphenyl）propanoate, gave the corresponding 2-carboxybenzenesulfonamide, which underwent a sequence of consecutive N-deprotective cyclization process mediated by TMSCI-NaI-MeCN reagent to afford the N-sulfonylimine. Following the bromination and ring expansion, 3-methyl-3-（4-methylphenyl）-2H-benzo[e][1,2]thiazine-l,l,4-trione was obtained. Optical resolution of the racemic benzosultam using （-）-menthoxyacetyl chloride, furnished the optically p.ure （＋）- and （-）-3-methyl-3-（4-methylphenyl）-2H- benzo[e][1,2]thiazine-1,1,4-triones, which were fluorinated with FC103 to produce the corresponding chiral N-F agents.
基金the National Natural Science Foundation of China(50476032)China Postdoctoral Science Foundation(2004035555)New Century of Talents Scheme Projects of Universities in Liaoning Province(RC-04-04)
文摘During the fixed bed tube furnace combustion experimental study,stimulated the calcium-based sorbent grain size and microstructured influencing factors to explain the fluorine retention effect influence law,and expounded the combustion fluorine retention agent developing principle,and probed into the high-temperature fluorine retention agent technical approach.The results show that the calcium-based sorbent particle grain size and pore structure also have the bigger influence on the combustion fluorine retention ef- fect,and reducing the calcium-based sorbent particle grain size and improving the calcium sorbent structure characteristics at very high temperature to enhance the fluorine retention effect is the important approach to the fluorine retention agent development.
