The reaction of 5-(4-hydroxyphenyl)-10,15,20-triphenyl porphyrin with 2,6-dibromomethylpyridine and 4,4′-dicarboxyl-2,2′-bipyridine respectively gave 2,6-bis-[5,10,15-triphenyl-20-(4-phenoxymethyl)-porphyrin-yl]-pyr...The reaction of 5-(4-hydroxyphenyl)-10,15,20-triphenyl porphyrin with 2,6-dibromomethylpyridine and 4,4′-dicarboxyl-2,2′-bipyridine respectively gave 2,6-bis-[5,10,15-triphenyl-20-(4-phenoxymethyl)-porphyrin-yl]-pyridine(3) and 4,4′-di-[5,10,15-triphenyl-20-(p-phenoxycarbonyl)-porphyrin-yl]-2,2′-bipyridine (4). 5-[4-(4′- Bromobutoxy) phenyl]-10,15,20-triphenyl porphyrin reacted with 2,6-dihydroxymethylpyridine to give 2,6-bis-[5,10,15-triphenyl-20-(4-(p-phenoxy)-butoxymethyl)-porphyrin-yl]-pyridine(5). Those new compounds have been identified by1H NMR, IR, MS and UV-visible spectra, and elemental analysis. Key words bridged porphyrin - synthesis - structure characterization CLC number O 626.13 Foundation item: Supported by the National Natural Science Foundation of China (29972035)Biography: FU Shi-tao (1979-), male, Ph. D candidate, research direction: porphyrin chemistry.展开更多
1,3-bis[5-(4-ethyoxycarbonyl)phenyl-10,15,20-tri(4-chlorophenyl)porphyrin]-5-fluorouracil(A),1-[5-(4-ethoxycarbonyl)phenyl-10,15,20-tri(4-chlorophenyl)porphyrin]-5-fluorouracil(B) are synthesized.Their structures are ...1,3-bis[5-(4-ethyoxycarbonyl)phenyl-10,15,20-tri(4-chlorophenyl)porphyrin]-5-fluorouracil(A),1-[5-(4-ethoxycarbonyl)phenyl-10,15,20-tri(4-chlorophenyl)porphyrin]-5-fluorouracil(B) are synthesized.Their structures are characterized by UV-Vis,IR,1HNMR and MS.The synthesis and separation conditions of the target compounds are studied.The results show that the yield is higher when DMF is used as the solvent at 115 ℃ for 11 h.The products are separated via column chroma to graphy with silica gel(200-300) separation is more satisfactory as the eluent when the column is 3 cm in diameter and 12 cm in height.展开更多
5-Fluorouracil(5-FU) was an antimetabolite of the pyrimidine analogue type,which was frequently used for treating colorectal,gastric tract,and liver carcinomas etc.However,the clinical applications of 5-FU were greatl...5-Fluorouracil(5-FU) was an antimetabolite of the pyrimidine analogue type,which was frequently used for treating colorectal,gastric tract,and liver carcinomas etc.However,the clinical applications of 5-FU were greatly limited by its myelosuppression,and strong intestinal toxicity.Consequently,numerous research efforts had focused on the discovery of suitable carrier-linked prodrugs with high efficiency and low toxicity.In order to decline the toxicity of 5-FU,we synthesized 2-(5-fluorouracil-1-yl-acetamido) acetic acid by liquid coupling reaction with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride(EDC·HCl) and 1-hydroxybenzotriazole(HOBt) as a coupling reagent.And the structures of the synthesized compounds were assigned by 1H NMR,13C NMR,mass spectrometry,and infrared spectroscopy,etc.展开更多
文摘The reaction of 5-(4-hydroxyphenyl)-10,15,20-triphenyl porphyrin with 2,6-dibromomethylpyridine and 4,4′-dicarboxyl-2,2′-bipyridine respectively gave 2,6-bis-[5,10,15-triphenyl-20-(4-phenoxymethyl)-porphyrin-yl]-pyridine(3) and 4,4′-di-[5,10,15-triphenyl-20-(p-phenoxycarbonyl)-porphyrin-yl]-2,2′-bipyridine (4). 5-[4-(4′- Bromobutoxy) phenyl]-10,15,20-triphenyl porphyrin reacted with 2,6-dihydroxymethylpyridine to give 2,6-bis-[5,10,15-triphenyl-20-(4-(p-phenoxy)-butoxymethyl)-porphyrin-yl]-pyridine(5). Those new compounds have been identified by1H NMR, IR, MS and UV-visible spectra, and elemental analysis. Key words bridged porphyrin - synthesis - structure characterization CLC number O 626.13 Foundation item: Supported by the National Natural Science Foundation of China (29972035)Biography: FU Shi-tao (1979-), male, Ph. D candidate, research direction: porphyrin chemistry.
文摘1,3-bis[5-(4-ethyoxycarbonyl)phenyl-10,15,20-tri(4-chlorophenyl)porphyrin]-5-fluorouracil(A),1-[5-(4-ethoxycarbonyl)phenyl-10,15,20-tri(4-chlorophenyl)porphyrin]-5-fluorouracil(B) are synthesized.Their structures are characterized by UV-Vis,IR,1HNMR and MS.The synthesis and separation conditions of the target compounds are studied.The results show that the yield is higher when DMF is used as the solvent at 115 ℃ for 11 h.The products are separated via column chroma to graphy with silica gel(200-300) separation is more satisfactory as the eluent when the column is 3 cm in diameter and 12 cm in height.
文摘5-Fluorouracil(5-FU) was an antimetabolite of the pyrimidine analogue type,which was frequently used for treating colorectal,gastric tract,and liver carcinomas etc.However,the clinical applications of 5-FU were greatly limited by its myelosuppression,and strong intestinal toxicity.Consequently,numerous research efforts had focused on the discovery of suitable carrier-linked prodrugs with high efficiency and low toxicity.In order to decline the toxicity of 5-FU,we synthesized 2-(5-fluorouracil-1-yl-acetamido) acetic acid by liquid coupling reaction with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride(EDC·HCl) and 1-hydroxybenzotriazole(HOBt) as a coupling reagent.And the structures of the synthesized compounds were assigned by 1H NMR,13C NMR,mass spectrometry,and infrared spectroscopy,etc.
