Background Surface modification by ion implantation-deposition is well established in materials science and can be an effective way to improve biocompatibility. The aim of this study is to evaluate the chemical compos...Background Surface modification by ion implantation-deposition is well established in materials science and can be an effective way to improve biocompatibility. The aim of this study is to evaluate the chemical composition of a modified titanium （Ti） surface after zinc （Zn） ion implantation and deposition and examine the effect of the modification on the formation of cellular focal adhesion plaques in vitro. Methods cp-Ti discs were modified with Zn ion implantation and deposition via PIIID. The chemical composition of the surface modification was characterized by X-ray photoelectron spectroscopy （XPS）. The formation of focal adhesion plaques on the modified Ti was investigated with human osteoblast-like MG-63 cells that were seeded onto the Ti surfaces and quantified by morphometric analysis under a confocal microscope. Results XPS data revealed that the modified Zn-Ti surface consisted of Ti, oxygen, Zn, and carbon. In addition, Gaussian fitting of the spectra indicated that the modified surface contained titanium dioxide and zinc oxide. After 6 hours of MG-63 cell culture, there were significantly more focal adhesion plaques on the modified surfaces than observed on the nonmodified Ti （P 〈0.05）. Conclusion Zn ion implantation and deposition greatly improved the biocompatibility of Ti for the growth of MG-63 cells.展开更多
基金This study was supported by grants from Beijing Natural Science Foundation of China （No. 7112124） and No.52 Postdoctoral Foundation of China.
文摘Background Surface modification by ion implantation-deposition is well established in materials science and can be an effective way to improve biocompatibility. The aim of this study is to evaluate the chemical composition of a modified titanium （Ti） surface after zinc （Zn） ion implantation and deposition and examine the effect of the modification on the formation of cellular focal adhesion plaques in vitro. Methods cp-Ti discs were modified with Zn ion implantation and deposition via PIIID. The chemical composition of the surface modification was characterized by X-ray photoelectron spectroscopy （XPS）. The formation of focal adhesion plaques on the modified Ti was investigated with human osteoblast-like MG-63 cells that were seeded onto the Ti surfaces and quantified by morphometric analysis under a confocal microscope. Results XPS data revealed that the modified Zn-Ti surface consisted of Ti, oxygen, Zn, and carbon. In addition, Gaussian fitting of the spectra indicated that the modified surface contained titanium dioxide and zinc oxide. After 6 hours of MG-63 cell culture, there were significantly more focal adhesion plaques on the modified surfaces than observed on the nonmodified Ti （P 〈0.05）. Conclusion Zn ion implantation and deposition greatly improved the biocompatibility of Ti for the growth of MG-63 cells.
