Based on the narrative theory of Shlomith Rimmon-Kenan,the present paper will analyze the close connection between the choice and order of the focalizers and the themes of the novel to show that they are chosen and ar...Based on the narrative theory of Shlomith Rimmon-Kenan,the present paper will analyze the close connection between the choice and order of the focalizers and the themes of the novel to show that they are chosen and arranged deliberately and accorded to its themes.展开更多
为了提高多视图深度估计结果精度,提出一种基于自适应空间特征增强的多视图深度估计算法。设计了由改进后的特征金字塔网络(feature pyramid network,FPN)和自适应空间特征增强(adaptive space feature enhancement,ASFE)组成的多尺度...为了提高多视图深度估计结果精度,提出一种基于自适应空间特征增强的多视图深度估计算法。设计了由改进后的特征金字塔网络(feature pyramid network,FPN)和自适应空间特征增强(adaptive space feature enhancement,ASFE)组成的多尺度特征提取模块,获取到具有全局上下文信息和位置信息的多尺度特征图像。通过残差学习网络对深度图进行优化,防止多次卷积操作出现重建边缘模糊的问题。通过分类的思想构建focal loss函数增强网络模型的判断能力。由实验结果可知,该算法在DTU(technical university of denmark)数据集上和CasMVSNet(Cascade MVSNet)算法相比,在整体精度误差、运行时间、显存资源占用上分别降低了14.08%、72.15%、4.62%。在Tanks and Temples数据集整体评价指标Mean上该模型优于其他算法,证明提出的基于自适应空间特征增强的多视图深度估计算法的有效性。展开更多
为解决自然条件下人脸表情识别易受角度、光线、遮挡物的影响以及人脸表情数据集各类表情数量不均衡等问题,提出基于Res2Net的人脸表情识别方法。使用Res2Net50作为特征提取的主干网络,在预处理阶段对图像随机翻转、缩放、裁剪进行数据...为解决自然条件下人脸表情识别易受角度、光线、遮挡物的影响以及人脸表情数据集各类表情数量不均衡等问题,提出基于Res2Net的人脸表情识别方法。使用Res2Net50作为特征提取的主干网络,在预处理阶段对图像随机翻转、缩放、裁剪进行数据增强,提升模型的泛化性。引入广义平均池化(generalized mean pooling, GeM)方式,关注图像中比较显著的区域,增强模型的鲁棒性;选用Focal Loss损失函数,针对表情类别不平衡和错误分类问题,提高较难识别表情的识别率。该方法在FER2013数据集上准确率达到了70.41%,相较于原Res2Net50网络提高了1.53%。结果表明,在自然条件下对人脸表情识别具有更好的准确性。展开更多
A compound varifocal lens based on electromagnetic drive technology is designed and fabricated, where the polydimethylsiloxane(PDMS) film acts as a driving component, while the PDMS biconvex lens and the plane-concave...A compound varifocal lens based on electromagnetic drive technology is designed and fabricated, where the polydimethylsiloxane(PDMS) film acts as a driving component, while the PDMS biconvex lens and the plane-concave lens form a coaxial compound lens system. The plane-concave lens equipped with driving coils is installed directly above the PDMS lens surrounded by the annular magnet. When different currents are applied, the annular magnet moves up and down, driving the PDMS film to undergo elastic deformation, and then resulting in longitudinal movement of the PDMS lens. The position change of the PDMS lens changes the focal length of the compound lens system. To verify the feasibility and practicability of this design, a prototype of our compound lens system is fabricated in experiment. Our proposed compound lens shows that its zoom ability reaches 9.28 mm when the current ranges from -0.20 A to 0.21 A.展开更多
Different from other normal modes of the Earth’s free oscillation that depend on all the six components(M_(rr),M_(tt),M_(pp),M_(rt),M_(rp),and M_(tp))of the centroid moment tensor,the amplitudes of the radial modes d...Different from other normal modes of the Earth’s free oscillation that depend on all the six components(M_(rr),M_(tt),M_(pp),M_(rt),M_(rp),and M_(tp))of the centroid moment tensor,the amplitudes of the radial modes depend on the M_(rr)component(e.g.,scalar moment(M_(0)),dip(δ),and slip(λ))and hypocenter depth of the focal mechanism,and hence can be easily used to constrain these parameters of the focal mechanism.In this study,we use the superconducting gravimeter(SG)records after the 2011 Tohoku earthquake to analyze the radial modes_(0)S_(0)and_(1)S_(0).Based on the solutions of the focal mechanism provided by the GCMT and USGS,we can obtain the theoretical amplitudes of these two radial modes.Comparing the theoretical amplitudes with the observation amplitudes,it is found that there are obvious differences between the former and the latter,which means that the GCMT and USGS focal mechanisms cannot well represent the real focal mechanism of the 2011 event.Taking the GCMT solution as a reference and changing the depth and the three parameters of the M_(rr)moment,the scalar moment(M_(0))and the dip(δ)have significant influences,but the effects of the slip(λ)and the depth are minor.After comparisons,we provide a new constraint(M_(0)=5.8±0.09×10^(22)N·m,δ=10.1±0.08°,λ=88°,and depth=20 km)for the focal mechanism of the 2011 event.In addition,we further determine the center frequency(1.631567±2.6e^(-6)mHz)and quality factor(2046.4±50.1)of the_(1)S_(0)mode.展开更多
This paper proposes a new network structure,namely the ProNet network.Retinal medical image segmentation can help clinical diagnosis of related eye diseases and is essential for subsequent rational treatment.The basel...This paper proposes a new network structure,namely the ProNet network.Retinal medical image segmentation can help clinical diagnosis of related eye diseases and is essential for subsequent rational treatment.The baseline model of the ProNet network is UperNet(Unified perceptual parsing Network),and the backbone network is ConvNext(Convolutional Network).A network structure based on depth-separable convolution and 1×1 convolution is used,which has good performance and robustness.We further optimise ProNet mainly in two aspects.One is data enhancement using increased noise and slight angle rotation,which can significantly increase the diversity of data and help the model better learn the patterns and features of the data and improve the model’s performance.Meanwhile,it can effectively expand the training data set,reduce the influence of noise and abnormal data in the data set on the model,and improve the accuracy and reliability of the model.Another is the loss function aspect,and we finally use the focal loss function.The focal loss function is well suited for complex tasks such as object detection.The function will penalise the loss carried by samples that the model misclassifies,thus enabling better training of the model to avoid these errors while solving the category imbalance problem as a way to improve image segmentation density and segmentation accuracy.From the experimental results,the evaluation metrics mIoU(mean Intersection over Union)enhanced by 4.47%,and mDice enhanced by 2.92% compared to the baseline network.Better generalization effects and more accurate image segmentation are achieved.展开更多
The M6.2 earthquake in Jishishan,Gansu Province,on December 18,2023,caused extraordinary earthquake disasters.It was located in the northern part of the north−south seismic zone,which is a key area for earthquake moni...The M6.2 earthquake in Jishishan,Gansu Province,on December 18,2023,caused extraordinary earthquake disasters.It was located in the northern part of the north−south seismic zone,which is a key area for earthquake monitoring in China.The newly built dense strong motion stations in this area provide unprecedented conditions for high-precision earthquake relocation,especially the earthquake focal depth.This paper uses the newly built strong motion and traditional broadband seismic networks to relocate the source locations of the M3.0 and above aftershocks and to invert their focal mechanisms.The horizontal error of earthquake location is estimated to be 0.5−1 km,and the vertical error is 1−2 km.The focal depth range of aftershocks is 9.6−14.6 km,distributed in a 12-km-long strip with SSE direction.Aftershocks in the south are more concentrated horizontally and vertically,while aftershocks in the north are more scattered.The focal mechanisms of the main shock and aftershocks are relatively consistent,and the P-axis orientation is consistent with the regional strain direction.There is a seismic blank area of M3.0 and above,about 3−5 km between the main shock and aftershocks.It is suggested that the energy released by the main shock rupture is concentrated in this area.Based on the earthquake location and focal mechanism of the main shock,it is inferred that the Northern Lajishan fault zone is the seismogenic structure of the main shock,and the main shock did not occur on the main fault,but on a secondary fault.The initial rupture depth and centroid depth of the main shock were 12.8 and 14.0 km,respectively.The source rupture depth may not be the main reason for the severe earthquake disaster.展开更多
Road traffic safety can decrease when drivers drive in a low-visibility environment.The application of visual perception technology to detect vehicles and pedestrians in infrared images proves to be an effective means...Road traffic safety can decrease when drivers drive in a low-visibility environment.The application of visual perception technology to detect vehicles and pedestrians in infrared images proves to be an effective means of reducing the risk of accidents.To tackle the challenges posed by the low recognition accuracy and the substan-tial computational burden associated with current infrared pedestrian-vehicle detection methods,an infrared pedestrian-vehicle detection method A proposal is presented,based on an enhanced version of You Only Look Once version 5(YOLOv5).First,A head specifically designed for detecting small targets has been integrated into the model to make full use of shallow feature information to enhance the accuracy in detecting small targets.Second,the Focal Generalized Intersection over Union(GIoU)is employed as an alternative to the original loss function to address issues related to target overlap and category imbalance.Third,the distribution shift convolution optimization feature extraction operator is used to alleviate the computational burden of the model without significantly compromising detection accuracy.The test results of the improved algorithm show that its average accuracy(mAP)reaches 90.1%.Specifically,the Giga Floating Point Operations Per second(GFLOPs)of the improved algorithm is only 9.1.In contrast,the improved algorithms outperformed the other algorithms on similar GFLOPs,such as YOLOv6n(11.9),YOLOv8n(8.7),YOLOv7t(13.2)and YOLOv5s(16.0).The mAPs that are 4.4%,3%,3.5%,and 1.7%greater than those of these algorithms show that the improved algorithm achieves higher accuracy in target detection tasks under similar computational resource overhead.On the other hand,compared with other algorithms such as YOLOv8l(91.1%),YOLOv6l(89.5%),YOLOv7(90.8%),and YOLOv3(90.1%),the improved algorithm needs only 5.5%,2.3%,8.6%,and 2.3%,respectively,of the GFLOPs.The improved algorithm has shown significant advancements in balancing accuracy and computational efficiency,making it promising for practical use in resource-limited scenarios.展开更多
BACKGROUND In hepatology,the clinical use of endoscopic ultrasound(EUS)has experienced a notable increase in recent times.These applications range from the diagnosis to the treatment of various liver diseases.Therefor...BACKGROUND In hepatology,the clinical use of endoscopic ultrasound(EUS)has experienced a notable increase in recent times.These applications range from the diagnosis to the treatment of various liver diseases.Therefore,this systematic review summarizes the evidence for the diagnostic and therapeutic roles of EUS in liver diseases.AIM To examine and summarize the current available evidence of the possible roles of the EUS in making a suitable diagnosis in liver diseases as well as the therapeutic accuracy and efficacy.METHODS PubMed,Medline,Cochrane Library,Web of Science,and Google Scholar databases were extensively searched until October 2023.The methodological quality of the eligible articles was assessed using the Newcastle-Ottawa scale or Cochrane Risk of Bias tool.In addition,statistical analyses were performed using the Comprehensive Meta-Analysis software.RESULTS Overall,45 articles on EUS were included(28 on diagnostic role and 17 on therapeutic role).Pooled analysis demonstrated that EUS diagnostic tests had an accuracy of 92.4%for focal liver lesions(FLL)and 96.6%for parenchymal liver diseases.EUS-guided liver biopsies with either fine needle aspiration or fine needle biopsy had low complication rates when sampling FLL and parenchymal liver diseases(3.1%and 8.7%,respectively).Analysis of data from four studies showed that EUS-guided liver abscess had high clinical(90.7%)and technical success(90.7%)without significant complications.Similarly,EUS-guided interventions for the treatment of gastric varices(GV)have high technical success(98%)and GV obliteration rate(84%)with few complications(15%)and rebleeding events(17%).CONCLUSION EUS in liver diseases is a promising technique with the potential to be considered a first-line therapeutic and diagnostic option in selected cases.展开更多
Since the inception of fluorine-18 fluorodeoxyglucose(F-18 FDG),positron emission tomography/computed tomography(PET/CT)utilizing F-18 FDG has become widely accepted as a valuable imaging modality in the field of onco...Since the inception of fluorine-18 fluorodeoxyglucose(F-18 FDG),positron emission tomography/computed tomography(PET/CT)utilizing F-18 FDG has become widely accepted as a valuable imaging modality in the field of oncology,with global prevalence in clinical practice.Given that a single Torso PET/CT scan encompasses the anatomical region from the skull base to the upper thigh,the detection of incidental abnormal focal hypermetabolism in areas of limited clinical interest is both feasible and not uncommon.Numerous investigations have been undertaken to delineate the distinctive features of these findings,yet the outcomes have proven inconclusive.The incongruent results of these studies present a challenge for physicians,leaving them uncertain about the appropriate course of action.This article provides a succinct overview of the characteristics of fluorodeoxyglucose,followed by a comprehensive discussion of the imaging findings and clinical significance associated with incidental focal abnormal F-18 FDG activity in several representative organs.In conclusion,while the prevalence of unrecognized malignancy varies across organs,malignancies account for a substantial proportion,ranging from approximately one-third to over half,of incidental focal uptake.In light of these rates,physicians are urged to exercise vigilance in not disregarding unexpected uptake,facilitating more assured clinical decisions,and advocating for further active evaluation.展开更多
Liver cancer is a prevalent malignant cancer,ranking third in terms of mortality rate.Metastasis and recurrence primarily contribute to the high mortality rate of liver cancer.Hepatocellular carcinoma(HCC)has low expr...Liver cancer is a prevalent malignant cancer,ranking third in terms of mortality rate.Metastasis and recurrence primarily contribute to the high mortality rate of liver cancer.Hepatocellular carcinoma(HCC)has low expression of focal adhesion kinase(FAK),which increases the risk of metastasis and recurrence.Nevertheless,the efficacy of FAK phosphorylation inhibitors is currently limited.Thus,investigating the mechanisms by which FAK affects HCC metastasis to develop targeted therapies for FAK may present a novel strategy to inhibit HCC metastasis.This study examined the correlation between FAK expression and the prognosis of HCC.Additionally,we explored the impact of FAK degradation on HCC metastasis through wound healing experiments,transwell invasion experiments,and a xenograft tumor model.The expression of proteins related to epithelial-mesenchymal transition(EMT)was measured to elucidate the underlying mechanisms.The results showed that FAK PROTAC can degrade FAK,inhibit the migration and invasion of HCC cells in vitro,and notably decrease the lung metastasis of HCC in vivo.Increased expression of E-cadherin and decreased expression of vimentin indicated that EMT was inhibited.Consequently,degradation of FAK through FAK PROTAC effectively suppressed liver cancer metastasis,holding significant clinical implications for treating liver cancer and developing innovative anti-neoplastic drugs.展开更多
BACKGROUND The Columbia classification identified five histological variants of focal segmental glomerulosclerosis(FSGS).The prognostic significance of these variants remains controversial.AIM To evaluate the relative...BACKGROUND The Columbia classification identified five histological variants of focal segmental glomerulosclerosis(FSGS).The prognostic significance of these variants remains controversial.AIM To evaluate the relative frequency,clinicopathologic characteristics,and medium-term outcomes of FSGS variants at a single center in Pakistan.METHODS This retrospective study was conducted at the Department of Nephrology,Sindh Institute of Urology and Transplantation,Karachi,Pakistan on all consecutive adults(≥16 years)with biopsy-proven primary FSGS from January 1995 to December 2017.Studied subjects were treated with steroids as a first-line therapy.The response rates,doubling of serum creatinine,and kidney failure(KF)with replacement therapy were compared between histological variants using ANOVA or Kruskal Wallis,and Chi-square tests as appropriate.Data were analyzed by SPSS version 22.0.P-value≤0.05 was considered significant.RESULTS A total of 401 patients were diagnosed with primary FSGS during the study period.Among these,352(87.7%)had a designated histological variant.The not otherwise specified(NOS)variant was the commonest,being found in 185(53.9%)patients,followed by the tip variant in 100(29.1%)patients.Collapsing(COL),cellular(CEL),and perihilar(PHI)variants were seen in 58(16.9%),6(1.5%),and 3(0.7%)patients,respectively.CEL and PHI variants were excluded from further analysis due to small patient numbers.The mean follow-up period was 36.5±29.2 months.Regarding response rates of variants,patients with TIP lesions achieved remission more frequently(59.5%)than patients with NOS(41.8%)and COL(24.52%)variants(P<0.001).The hazard ratio of complete response among patients with the COL variant was 0.163[95%confidence interval(CI):0.039-0.67]as compared to patients with NOS.The TIP variant showed a hazard ratio of 2.5(95%CI:1.61-3.89)for complete remission compared to the NOS variant.Overall,progressive KF was observed more frequently in patients with the COL variant,43.4%(P<0.001).Among these,24.53%of patients required kidney replacement therapy(P<0.001).The hazard ratio of doubling of serum creatinine among patients with the COL variant was 14.57(95%CI:1.87-113.49)as compared to patients with the TIP variant.CONCLUSION In conclusion,histological variants of FSGS are predictive of response to treatment with immunosuppressants and progressive KF in adults in our setup.展开更多
BACKGROUND The association between congenital heart disease and chronic kidney disease is well known.Various mechanisms of kidney damage associated with congenital heart disease have been established.The etiology of k...BACKGROUND The association between congenital heart disease and chronic kidney disease is well known.Various mechanisms of kidney damage associated with congenital heart disease have been established.The etiology of kidneydisease has commonly been considered to be secondary to focal segmental glomerulosclerosis(FSGS),however,this has only been demonstrated in case reports and not in observational or clinical trials.AIM To identify baseline and clinical characteristics,as well as the findings in kidney biopsies of patients with congenital heart disease in our hospital.METHODS This is a retrospective observational study conducted at the Nephrology Depart-ment of the National Institute of Cardiology“Ignacio Chávez”.All patients over 16 years old who underwent percutaneous kidney biopsy from January 2000 to January 2023 with congenital heart disease were included in the study.RESULTS Ten patients with congenital heart disease and kidney biopsy were found.The average age was 29.00 years±15.87 years with pre-biopsy proteinuria of 6193 mg/24 h±6165 mg/24 h.The most common congenital heart disease was Fallot’s tetralogy with 2 cases(20%)and ventricular septal defect with 2(20%)cases.Among the 10 cases,one case of IgA nephropathy and one case of membranoproliferative glomerulonephritis associated with immune complexes were found,receiving specific treatment after histopathological diagnosis,delaying the initiation of kidney replacement therapy.Among remaining 8 cases(80%),one case of FSGS with perihilar variety was found,while the other 7 cases were non-specific FSGS.CONCLUSION Determining the cause of chronic kidney disease can help in delaying the need for kidney replacement therapy.In 2 out of 10 patients in our study,interventions were performed,and initiation of kidney replacement therapy was delayed.Prospective studies are needed to determine the usefulness of kidney biopsy in patients with congenital heart disease.展开更多
Actin, a highly conserved protein, plays a dominant role in Non-small cell lung cancer (NSCLC). Late diagnosis and the aggressive nature of NSCLC pose a significant threat. Studying the clinic pathological properties ...Actin, a highly conserved protein, plays a dominant role in Non-small cell lung cancer (NSCLC). Late diagnosis and the aggressive nature of NSCLC pose a significant threat. Studying the clinic pathological properties of NSCLC proteins is a potential alternative for developing treatment strategies. Towards this, 35 downregulated actin cytoskeletal proteins on NSCLC prognosis and treatment were studied by examining their protein-protein interactions, gene ontology enrichment terms, and signaling pathways. Using PubMed, various proteins in NSCLC were identified. The protein-protein interactions and functional associations of these proteins were examined using the STRING database. The focal adhesion signaling pathway was selected from all available KEGG and Wiki pathways because of its role in regulating gene expression, facilitating cell movement and reproduction, and significantly impacting NSCLC. The protein-protein interaction network of the 35 downregulated actin cytoskeleton proteins revealed that ACTG1, ACTR2, ACTR3, ANXA2, ARPC4, FLNA, TLN1, CALD1, MYL6, MYH9, MYH10, TPM1, TPM3, TPM4, PFN1, IQGAP1, MSN, and ZXY exhibited the highest number of interactions. Whereas HSPB1, CTNNA1, KRT17, KRT7, FLNB, SEPT2, and TUBA1B displayed medium interactions, while UTRN, TUBA1B, and DUSP23 had relatively fewer interactions. It was discovered that focal adhesions are critical in connecting membrane receptors with the actin cytoskeleton. In addition, protein kinases, phosphatases, and adapter proteins were identified as key signaling molecules in this process, greatly influencing cell shape, motility, and gene expression. Our analysis shows that the focal adhesion pathway plays a crucial role in NSCLC and is essential for developing effective treatment strategies and improving patient outcomes.展开更多
“The Law of Life”is one of Jack London’s representative works,depicting the story of an elderly Native American abandoned by his family,alone and waiting for life to fade away.This paper,based on narrative theory,a...“The Law of Life”is one of Jack London’s representative works,depicting the story of an elderly Native American abandoned by his family,alone and waiting for life to fade away.This paper,based on narrative theory,aims to explore how the author employs narrative techniques to present the image of the old man in the short story.The narrative techniques of dual focalization and dual narrative timelines in the text demonstrate the abandonment of the old man’s homeland and his inescapable death under a naturalistic view of life and reflect a desolate life picture of resignation towards death under naturalistic determinism,depicting a grim elderly world under the naturalistic concept of“survival of the fittest.”Studying this short story helps us reflect on the living conditions of the elderly and provides insights into how to better care for the elderly population amid the global trend of aging.展开更多
文摘Based on the narrative theory of Shlomith Rimmon-Kenan,the present paper will analyze the close connection between the choice and order of the focalizers and the themes of the novel to show that they are chosen and arranged deliberately and accorded to its themes.
文摘为了提高多视图深度估计结果精度,提出一种基于自适应空间特征增强的多视图深度估计算法。设计了由改进后的特征金字塔网络(feature pyramid network,FPN)和自适应空间特征增强(adaptive space feature enhancement,ASFE)组成的多尺度特征提取模块,获取到具有全局上下文信息和位置信息的多尺度特征图像。通过残差学习网络对深度图进行优化,防止多次卷积操作出现重建边缘模糊的问题。通过分类的思想构建focal loss函数增强网络模型的判断能力。由实验结果可知,该算法在DTU(technical university of denmark)数据集上和CasMVSNet(Cascade MVSNet)算法相比,在整体精度误差、运行时间、显存资源占用上分别降低了14.08%、72.15%、4.62%。在Tanks and Temples数据集整体评价指标Mean上该模型优于其他算法,证明提出的基于自适应空间特征增强的多视图深度估计算法的有效性。
文摘为解决自然条件下人脸表情识别易受角度、光线、遮挡物的影响以及人脸表情数据集各类表情数量不均衡等问题,提出基于Res2Net的人脸表情识别方法。使用Res2Net50作为特征提取的主干网络,在预处理阶段对图像随机翻转、缩放、裁剪进行数据增强,提升模型的泛化性。引入广义平均池化(generalized mean pooling, GeM)方式,关注图像中比较显著的区域,增强模型的鲁棒性;选用Focal Loss损失函数,针对表情类别不平衡和错误分类问题,提高较难识别表情的识别率。该方法在FER2013数据集上准确率达到了70.41%,相较于原Res2Net50网络提高了1.53%。结果表明,在自然条件下对人脸表情识别具有更好的准确性。
文摘A compound varifocal lens based on electromagnetic drive technology is designed and fabricated, where the polydimethylsiloxane(PDMS) film acts as a driving component, while the PDMS biconvex lens and the plane-concave lens form a coaxial compound lens system. The plane-concave lens equipped with driving coils is installed directly above the PDMS lens surrounded by the annular magnet. When different currents are applied, the annular magnet moves up and down, driving the PDMS film to undergo elastic deformation, and then resulting in longitudinal movement of the PDMS lens. The position change of the PDMS lens changes the focal length of the compound lens system. To verify the feasibility and practicability of this design, a prototype of our compound lens system is fabricated in experiment. Our proposed compound lens shows that its zoom ability reaches 9.28 mm when the current ranges from -0.20 A to 0.21 A.
基金supported by the National Natural Science Foundation of China(Grants:41974022 and 42192531)the Educational Commission of Hubei Province of China(Grant:2020CFA109)+1 种基金the Special Fund of Hubei Luojia Laboratory(grant#220100002)Key Laboratory of Geospace Environment and Geodesy,Ministry of Education,Wuhan University(grant#210204)。
文摘Different from other normal modes of the Earth’s free oscillation that depend on all the six components(M_(rr),M_(tt),M_(pp),M_(rt),M_(rp),and M_(tp))of the centroid moment tensor,the amplitudes of the radial modes depend on the M_(rr)component(e.g.,scalar moment(M_(0)),dip(δ),and slip(λ))and hypocenter depth of the focal mechanism,and hence can be easily used to constrain these parameters of the focal mechanism.In this study,we use the superconducting gravimeter(SG)records after the 2011 Tohoku earthquake to analyze the radial modes_(0)S_(0)and_(1)S_(0).Based on the solutions of the focal mechanism provided by the GCMT and USGS,we can obtain the theoretical amplitudes of these two radial modes.Comparing the theoretical amplitudes with the observation amplitudes,it is found that there are obvious differences between the former and the latter,which means that the GCMT and USGS focal mechanisms cannot well represent the real focal mechanism of the 2011 event.Taking the GCMT solution as a reference and changing the depth and the three parameters of the M_(rr)moment,the scalar moment(M_(0))and the dip(δ)have significant influences,but the effects of the slip(λ)and the depth are minor.After comparisons,we provide a new constraint(M_(0)=5.8±0.09×10^(22)N·m,δ=10.1±0.08°,λ=88°,and depth=20 km)for the focal mechanism of the 2011 event.In addition,we further determine the center frequency(1.631567±2.6e^(-6)mHz)and quality factor(2046.4±50.1)of the_(1)S_(0)mode.
文摘This paper proposes a new network structure,namely the ProNet network.Retinal medical image segmentation can help clinical diagnosis of related eye diseases and is essential for subsequent rational treatment.The baseline model of the ProNet network is UperNet(Unified perceptual parsing Network),and the backbone network is ConvNext(Convolutional Network).A network structure based on depth-separable convolution and 1×1 convolution is used,which has good performance and robustness.We further optimise ProNet mainly in two aspects.One is data enhancement using increased noise and slight angle rotation,which can significantly increase the diversity of data and help the model better learn the patterns and features of the data and improve the model’s performance.Meanwhile,it can effectively expand the training data set,reduce the influence of noise and abnormal data in the data set on the model,and improve the accuracy and reliability of the model.Another is the loss function aspect,and we finally use the focal loss function.The focal loss function is well suited for complex tasks such as object detection.The function will penalise the loss carried by samples that the model misclassifies,thus enabling better training of the model to avoid these errors while solving the category imbalance problem as a way to improve image segmentation density and segmentation accuracy.From the experimental results,the evaluation metrics mIoU(mean Intersection over Union)enhanced by 4.47%,and mDice enhanced by 2.92% compared to the baseline network.Better generalization effects and more accurate image segmentation are achieved.
文摘The M6.2 earthquake in Jishishan,Gansu Province,on December 18,2023,caused extraordinary earthquake disasters.It was located in the northern part of the north−south seismic zone,which is a key area for earthquake monitoring in China.The newly built dense strong motion stations in this area provide unprecedented conditions for high-precision earthquake relocation,especially the earthquake focal depth.This paper uses the newly built strong motion and traditional broadband seismic networks to relocate the source locations of the M3.0 and above aftershocks and to invert their focal mechanisms.The horizontal error of earthquake location is estimated to be 0.5−1 km,and the vertical error is 1−2 km.The focal depth range of aftershocks is 9.6−14.6 km,distributed in a 12-km-long strip with SSE direction.Aftershocks in the south are more concentrated horizontally and vertically,while aftershocks in the north are more scattered.The focal mechanisms of the main shock and aftershocks are relatively consistent,and the P-axis orientation is consistent with the regional strain direction.There is a seismic blank area of M3.0 and above,about 3−5 km between the main shock and aftershocks.It is suggested that the energy released by the main shock rupture is concentrated in this area.Based on the earthquake location and focal mechanism of the main shock,it is inferred that the Northern Lajishan fault zone is the seismogenic structure of the main shock,and the main shock did not occur on the main fault,but on a secondary fault.The initial rupture depth and centroid depth of the main shock were 12.8 and 14.0 km,respectively.The source rupture depth may not be the main reason for the severe earthquake disaster.
文摘Road traffic safety can decrease when drivers drive in a low-visibility environment.The application of visual perception technology to detect vehicles and pedestrians in infrared images proves to be an effective means of reducing the risk of accidents.To tackle the challenges posed by the low recognition accuracy and the substan-tial computational burden associated with current infrared pedestrian-vehicle detection methods,an infrared pedestrian-vehicle detection method A proposal is presented,based on an enhanced version of You Only Look Once version 5(YOLOv5).First,A head specifically designed for detecting small targets has been integrated into the model to make full use of shallow feature information to enhance the accuracy in detecting small targets.Second,the Focal Generalized Intersection over Union(GIoU)is employed as an alternative to the original loss function to address issues related to target overlap and category imbalance.Third,the distribution shift convolution optimization feature extraction operator is used to alleviate the computational burden of the model without significantly compromising detection accuracy.The test results of the improved algorithm show that its average accuracy(mAP)reaches 90.1%.Specifically,the Giga Floating Point Operations Per second(GFLOPs)of the improved algorithm is only 9.1.In contrast,the improved algorithms outperformed the other algorithms on similar GFLOPs,such as YOLOv6n(11.9),YOLOv8n(8.7),YOLOv7t(13.2)and YOLOv5s(16.0).The mAPs that are 4.4%,3%,3.5%,and 1.7%greater than those of these algorithms show that the improved algorithm achieves higher accuracy in target detection tasks under similar computational resource overhead.On the other hand,compared with other algorithms such as YOLOv8l(91.1%),YOLOv6l(89.5%),YOLOv7(90.8%),and YOLOv3(90.1%),the improved algorithm needs only 5.5%,2.3%,8.6%,and 2.3%,respectively,of the GFLOPs.The improved algorithm has shown significant advancements in balancing accuracy and computational efficiency,making it promising for practical use in resource-limited scenarios.
文摘BACKGROUND In hepatology,the clinical use of endoscopic ultrasound(EUS)has experienced a notable increase in recent times.These applications range from the diagnosis to the treatment of various liver diseases.Therefore,this systematic review summarizes the evidence for the diagnostic and therapeutic roles of EUS in liver diseases.AIM To examine and summarize the current available evidence of the possible roles of the EUS in making a suitable diagnosis in liver diseases as well as the therapeutic accuracy and efficacy.METHODS PubMed,Medline,Cochrane Library,Web of Science,and Google Scholar databases were extensively searched until October 2023.The methodological quality of the eligible articles was assessed using the Newcastle-Ottawa scale or Cochrane Risk of Bias tool.In addition,statistical analyses were performed using the Comprehensive Meta-Analysis software.RESULTS Overall,45 articles on EUS were included(28 on diagnostic role and 17 on therapeutic role).Pooled analysis demonstrated that EUS diagnostic tests had an accuracy of 92.4%for focal liver lesions(FLL)and 96.6%for parenchymal liver diseases.EUS-guided liver biopsies with either fine needle aspiration or fine needle biopsy had low complication rates when sampling FLL and parenchymal liver diseases(3.1%and 8.7%,respectively).Analysis of data from four studies showed that EUS-guided liver abscess had high clinical(90.7%)and technical success(90.7%)without significant complications.Similarly,EUS-guided interventions for the treatment of gastric varices(GV)have high technical success(98%)and GV obliteration rate(84%)with few complications(15%)and rebleeding events(17%).CONCLUSION EUS in liver diseases is a promising technique with the potential to be considered a first-line therapeutic and diagnostic option in selected cases.
文摘Since the inception of fluorine-18 fluorodeoxyglucose(F-18 FDG),positron emission tomography/computed tomography(PET/CT)utilizing F-18 FDG has become widely accepted as a valuable imaging modality in the field of oncology,with global prevalence in clinical practice.Given that a single Torso PET/CT scan encompasses the anatomical region from the skull base to the upper thigh,the detection of incidental abnormal focal hypermetabolism in areas of limited clinical interest is both feasible and not uncommon.Numerous investigations have been undertaken to delineate the distinctive features of these findings,yet the outcomes have proven inconclusive.The incongruent results of these studies present a challenge for physicians,leaving them uncertain about the appropriate course of action.This article provides a succinct overview of the characteristics of fluorodeoxyglucose,followed by a comprehensive discussion of the imaging findings and clinical significance associated with incidental focal abnormal F-18 FDG activity in several representative organs.In conclusion,while the prevalence of unrecognized malignancy varies across organs,malignancies account for a substantial proportion,ranging from approximately one-third to over half,of incidental focal uptake.In light of these rates,physicians are urged to exercise vigilance in not disregarding unexpected uptake,facilitating more assured clinical decisions,and advocating for further active evaluation.
基金supported by the National Natural Science Foundation of China Fund Project(82272956).
文摘Liver cancer is a prevalent malignant cancer,ranking third in terms of mortality rate.Metastasis and recurrence primarily contribute to the high mortality rate of liver cancer.Hepatocellular carcinoma(HCC)has low expression of focal adhesion kinase(FAK),which increases the risk of metastasis and recurrence.Nevertheless,the efficacy of FAK phosphorylation inhibitors is currently limited.Thus,investigating the mechanisms by which FAK affects HCC metastasis to develop targeted therapies for FAK may present a novel strategy to inhibit HCC metastasis.This study examined the correlation between FAK expression and the prognosis of HCC.Additionally,we explored the impact of FAK degradation on HCC metastasis through wound healing experiments,transwell invasion experiments,and a xenograft tumor model.The expression of proteins related to epithelial-mesenchymal transition(EMT)was measured to elucidate the underlying mechanisms.The results showed that FAK PROTAC can degrade FAK,inhibit the migration and invasion of HCC cells in vitro,and notably decrease the lung metastasis of HCC in vivo.Increased expression of E-cadherin and decreased expression of vimentin indicated that EMT was inhibited.Consequently,degradation of FAK through FAK PROTAC effectively suppressed liver cancer metastasis,holding significant clinical implications for treating liver cancer and developing innovative anti-neoplastic drugs.
文摘BACKGROUND The Columbia classification identified five histological variants of focal segmental glomerulosclerosis(FSGS).The prognostic significance of these variants remains controversial.AIM To evaluate the relative frequency,clinicopathologic characteristics,and medium-term outcomes of FSGS variants at a single center in Pakistan.METHODS This retrospective study was conducted at the Department of Nephrology,Sindh Institute of Urology and Transplantation,Karachi,Pakistan on all consecutive adults(≥16 years)with biopsy-proven primary FSGS from January 1995 to December 2017.Studied subjects were treated with steroids as a first-line therapy.The response rates,doubling of serum creatinine,and kidney failure(KF)with replacement therapy were compared between histological variants using ANOVA or Kruskal Wallis,and Chi-square tests as appropriate.Data were analyzed by SPSS version 22.0.P-value≤0.05 was considered significant.RESULTS A total of 401 patients were diagnosed with primary FSGS during the study period.Among these,352(87.7%)had a designated histological variant.The not otherwise specified(NOS)variant was the commonest,being found in 185(53.9%)patients,followed by the tip variant in 100(29.1%)patients.Collapsing(COL),cellular(CEL),and perihilar(PHI)variants were seen in 58(16.9%),6(1.5%),and 3(0.7%)patients,respectively.CEL and PHI variants were excluded from further analysis due to small patient numbers.The mean follow-up period was 36.5±29.2 months.Regarding response rates of variants,patients with TIP lesions achieved remission more frequently(59.5%)than patients with NOS(41.8%)and COL(24.52%)variants(P<0.001).The hazard ratio of complete response among patients with the COL variant was 0.163[95%confidence interval(CI):0.039-0.67]as compared to patients with NOS.The TIP variant showed a hazard ratio of 2.5(95%CI:1.61-3.89)for complete remission compared to the NOS variant.Overall,progressive KF was observed more frequently in patients with the COL variant,43.4%(P<0.001).Among these,24.53%of patients required kidney replacement therapy(P<0.001).The hazard ratio of doubling of serum creatinine among patients with the COL variant was 14.57(95%CI:1.87-113.49)as compared to patients with the TIP variant.CONCLUSION In conclusion,histological variants of FSGS are predictive of response to treatment with immunosuppressants and progressive KF in adults in our setup.
文摘BACKGROUND The association between congenital heart disease and chronic kidney disease is well known.Various mechanisms of kidney damage associated with congenital heart disease have been established.The etiology of kidneydisease has commonly been considered to be secondary to focal segmental glomerulosclerosis(FSGS),however,this has only been demonstrated in case reports and not in observational or clinical trials.AIM To identify baseline and clinical characteristics,as well as the findings in kidney biopsies of patients with congenital heart disease in our hospital.METHODS This is a retrospective observational study conducted at the Nephrology Depart-ment of the National Institute of Cardiology“Ignacio Chávez”.All patients over 16 years old who underwent percutaneous kidney biopsy from January 2000 to January 2023 with congenital heart disease were included in the study.RESULTS Ten patients with congenital heart disease and kidney biopsy were found.The average age was 29.00 years±15.87 years with pre-biopsy proteinuria of 6193 mg/24 h±6165 mg/24 h.The most common congenital heart disease was Fallot’s tetralogy with 2 cases(20%)and ventricular septal defect with 2(20%)cases.Among the 10 cases,one case of IgA nephropathy and one case of membranoproliferative glomerulonephritis associated with immune complexes were found,receiving specific treatment after histopathological diagnosis,delaying the initiation of kidney replacement therapy.Among remaining 8 cases(80%),one case of FSGS with perihilar variety was found,while the other 7 cases were non-specific FSGS.CONCLUSION Determining the cause of chronic kidney disease can help in delaying the need for kidney replacement therapy.In 2 out of 10 patients in our study,interventions were performed,and initiation of kidney replacement therapy was delayed.Prospective studies are needed to determine the usefulness of kidney biopsy in patients with congenital heart disease.
文摘Actin, a highly conserved protein, plays a dominant role in Non-small cell lung cancer (NSCLC). Late diagnosis and the aggressive nature of NSCLC pose a significant threat. Studying the clinic pathological properties of NSCLC proteins is a potential alternative for developing treatment strategies. Towards this, 35 downregulated actin cytoskeletal proteins on NSCLC prognosis and treatment were studied by examining their protein-protein interactions, gene ontology enrichment terms, and signaling pathways. Using PubMed, various proteins in NSCLC were identified. The protein-protein interactions and functional associations of these proteins were examined using the STRING database. The focal adhesion signaling pathway was selected from all available KEGG and Wiki pathways because of its role in regulating gene expression, facilitating cell movement and reproduction, and significantly impacting NSCLC. The protein-protein interaction network of the 35 downregulated actin cytoskeleton proteins revealed that ACTG1, ACTR2, ACTR3, ANXA2, ARPC4, FLNA, TLN1, CALD1, MYL6, MYH9, MYH10, TPM1, TPM3, TPM4, PFN1, IQGAP1, MSN, and ZXY exhibited the highest number of interactions. Whereas HSPB1, CTNNA1, KRT17, KRT7, FLNB, SEPT2, and TUBA1B displayed medium interactions, while UTRN, TUBA1B, and DUSP23 had relatively fewer interactions. It was discovered that focal adhesions are critical in connecting membrane receptors with the actin cytoskeleton. In addition, protein kinases, phosphatases, and adapter proteins were identified as key signaling molecules in this process, greatly influencing cell shape, motility, and gene expression. Our analysis shows that the focal adhesion pathway plays a crucial role in NSCLC and is essential for developing effective treatment strategies and improving patient outcomes.
文摘“The Law of Life”is one of Jack London’s representative works,depicting the story of an elderly Native American abandoned by his family,alone and waiting for life to fade away.This paper,based on narrative theory,aims to explore how the author employs narrative techniques to present the image of the old man in the short story.The narrative techniques of dual focalization and dual narrative timelines in the text demonstrate the abandonment of the old man’s homeland and his inescapable death under a naturalistic view of life and reflect a desolate life picture of resignation towards death under naturalistic determinism,depicting a grim elderly world under the naturalistic concept of“survival of the fittest.”Studying this short story helps us reflect on the living conditions of the elderly and provides insights into how to better care for the elderly population amid the global trend of aging.