4-Nonylphenol(NP)is a kind of estrogen belonging to the endocrine disrupter,widely used in various agricultural and industrial goods.However,extensive use of NP with direct release to environment poses high risks to b...4-Nonylphenol(NP)is a kind of estrogen belonging to the endocrine disrupter,widely used in various agricultural and industrial goods.However,extensive use of NP with direct release to environment poses high risks to both human health and ecosystems.Herein,for the first time,we developed near-infrared(NIR)responsive upconversion luminescence nanosensor for NP detection.The Förster resonance energy transfer based upconversion nanoparticles(UCNPs)-graphene oxide sensor offers highly selective and sensitive detection of NP in linear ranges of 5−200 ng/mL and 200−1000 ng/mL under 980 nm and 808 nm excitation,respectively,with LOD at 4.2 ng/mL.The sensors were successfully tested for NP detection in real liquid milk samples with excellent recovery results.The rare-earth fluoride based upconversion luminescence nanosensor with NIR excitation wavelength,holds promise for sensing food,environmental,and biological samples due to their high sensitivity,specific recognition,low LOD,negligible autofluorescence,along with the deep penetration of NIR excitation sources.展开更多
目的 探讨大鼠福尔马林致痛的可能机制。方法 雄性 SD大鼠 64只 ,随机分为对照组 ( NS组、福尔马林对照组 )和实验组 ( L a F组、L n F组 )。 NS组为正常对照组 ,L a F组、L n F组在同福尔马林对照组处理前分别给予 L -精氨酸 ( L - A...目的 探讨大鼠福尔马林致痛的可能机制。方法 雄性 SD大鼠 64只 ,随机分为对照组 ( NS组、福尔马林对照组 )和实验组 ( L a F组、L n F组 )。 NS组为正常对照组 ,L a F组、L n F组在同福尔马林对照组处理前分别给予 L -精氨酸 ( L - Arg) ,L - NG-硝基精氨酸甲酯 ( L - NAME)鞘内注射 ,在福尔马林处理后 1/ 2 h、0～ 1h分别检测大鼠脊髓 NOS及 Fos的表达及观察大鼠的行为学表现。结果 福尔马林对照组的缩腿舔爪时间长于 NS组、脊髓的NOS及 Fos表达显著强于 NS组 ,预先给予 L - Arg或 L - NAME分别能加强或抑制以上作用。结论 福尔马林致痛能引起大鼠脊髓背角 NO的释放 ,诱导展开更多
文摘4-Nonylphenol(NP)is a kind of estrogen belonging to the endocrine disrupter,widely used in various agricultural and industrial goods.However,extensive use of NP with direct release to environment poses high risks to both human health and ecosystems.Herein,for the first time,we developed near-infrared(NIR)responsive upconversion luminescence nanosensor for NP detection.The Förster resonance energy transfer based upconversion nanoparticles(UCNPs)-graphene oxide sensor offers highly selective and sensitive detection of NP in linear ranges of 5−200 ng/mL and 200−1000 ng/mL under 980 nm and 808 nm excitation,respectively,with LOD at 4.2 ng/mL.The sensors were successfully tested for NP detection in real liquid milk samples with excellent recovery results.The rare-earth fluoride based upconversion luminescence nanosensor with NIR excitation wavelength,holds promise for sensing food,environmental,and biological samples due to their high sensitivity,specific recognition,low LOD,negligible autofluorescence,along with the deep penetration of NIR excitation sources.
