BACKGROUND Helicobacter pylori(H.pylori)has been found to be associated with extragastrointestinal diseases,possibly including adverse food reactions(such as food allergy or intolerance).However,there are few studies ...BACKGROUND Helicobacter pylori(H.pylori)has been found to be associated with extragastrointestinal diseases,possibly including adverse food reactions(such as food allergy or intolerance).However,there are few studies on H.pylori and food allergy or intolerance,and the results are inconsistent.Food-specific immunoglobulin(Ig)G has been revealed to be associated with food allergy or intolerance and can be used as a marker to explore the correlation between H.pylori infection and food allergy or intolerance.AIM To explore the relationship between H.pylori infection and food-specific IgG METHODS We retrospectively analyzed the physical examination data of 21822 subjects from February 2014 to December 2018 in this study.H.pylori infection was detected using the 13C urea breath test.Food-specific IgG of eggs,milk and wheat in serum was assessed.Subjects were grouped according to H.pylori positivity,and the positive rates of three kinds of food-specific IgG were compared between the two groups.Multivariable logistic regression analysis was performed to elucidate the association between H.pylori infection and food-specific IgG.RESULTS The total infection rate of H.pylori was 39.3%,and the total food-specific IgGpositive rates of eggs,milk and wheat were 25.2%,9.0%and 4.9%,respectively.The infection rate of H.pylori was higher in males than in females,while the positive rates of food-specific IgG were lower in males than in females.The positive rates of food-specific IgG decreased with age in both males and females.In the H.pylori-positive groups,the positive rates of food-specific IgG of eggs,milk and wheat were all lower than those in the H.pylori-negative groups.Multivariate logistic regression analysis revealed that H.pylori infection was negatively correlated with the food-specific IgG-positive rates of eggs,milk and wheat(odds ratio value of eggs 0.844-0.873,milk 0.741-0.751 and wheat 0.755-0.788,in different models).CONCLUSION H.pylori infection was found to be negatively associated with the food-specific IgG of eggs,milk and wheat in Southwest China.展开更多
目的:对疑似食物不耐受疾病血清样本特异性抗体检测结果进行分析,初步了解儿童食物不耐受种类和特点,为疾病预防和儿童饮食计划制定提供参考。方法:选取2017年1月—2021年12月北京新世纪儿童医院收治的896例患儿。采用酶联免疫吸附试验(...目的:对疑似食物不耐受疾病血清样本特异性抗体检测结果进行分析,初步了解儿童食物不耐受种类和特点,为疾病预防和儿童饮食计划制定提供参考。方法:选取2017年1月—2021年12月北京新世纪儿童医院收治的896例患儿。采用酶联免疫吸附试验(ELISA)检测患儿血清中14种食物(牛肉、鸡肉、猪肉、鳕鱼、玉米、螃蟹、虾、鸡蛋、牛奶、蘑菇、大米、小麦、大豆、西红柿)中的特异性IgG(sIgG)抗体。结果:896份血清中,875份血清sIgG阳性,阳性率97.7%。鸡蛋(88.46%)、牛奶(83.20%)、小麦(55.43%)、西红柿(44.23%)sIgG阳性率较高,猪肉(2.86%)、牛肉(2.17%)sIg G阳性率较低。不同年龄组鸡蛋、小麦、西红柿、大豆、大米、虾、牛肉sIgG阳性率比较,差异有统计学意义(P<0.05)。不同性别s I g G阳性率比较,差异无统计学意义(P>0.05)。结论:北京新世纪儿童医院就诊儿童不耐受食物主要是鸡蛋和牛奶,其次是小麦、西红柿,不同年龄段不耐受食物存在显著差异,儿童饮食计划制定过程中应根据个体差异制定科学的个体饮食计划,有效规避不耐受食物,保证儿童健康成长。展开更多
基金by Key Research and Development Projects of the Ministry of Science and Technology,China,No.2017YFC0113901.
文摘BACKGROUND Helicobacter pylori(H.pylori)has been found to be associated with extragastrointestinal diseases,possibly including adverse food reactions(such as food allergy or intolerance).However,there are few studies on H.pylori and food allergy or intolerance,and the results are inconsistent.Food-specific immunoglobulin(Ig)G has been revealed to be associated with food allergy or intolerance and can be used as a marker to explore the correlation between H.pylori infection and food allergy or intolerance.AIM To explore the relationship between H.pylori infection and food-specific IgG METHODS We retrospectively analyzed the physical examination data of 21822 subjects from February 2014 to December 2018 in this study.H.pylori infection was detected using the 13C urea breath test.Food-specific IgG of eggs,milk and wheat in serum was assessed.Subjects were grouped according to H.pylori positivity,and the positive rates of three kinds of food-specific IgG were compared between the two groups.Multivariable logistic regression analysis was performed to elucidate the association between H.pylori infection and food-specific IgG.RESULTS The total infection rate of H.pylori was 39.3%,and the total food-specific IgGpositive rates of eggs,milk and wheat were 25.2%,9.0%and 4.9%,respectively.The infection rate of H.pylori was higher in males than in females,while the positive rates of food-specific IgG were lower in males than in females.The positive rates of food-specific IgG decreased with age in both males and females.In the H.pylori-positive groups,the positive rates of food-specific IgG of eggs,milk and wheat were all lower than those in the H.pylori-negative groups.Multivariate logistic regression analysis revealed that H.pylori infection was negatively correlated with the food-specific IgG-positive rates of eggs,milk and wheat(odds ratio value of eggs 0.844-0.873,milk 0.741-0.751 and wheat 0.755-0.788,in different models).CONCLUSION H.pylori infection was found to be negatively associated with the food-specific IgG of eggs,milk and wheat in Southwest China.
文摘目的:对疑似食物不耐受疾病血清样本特异性抗体检测结果进行分析,初步了解儿童食物不耐受种类和特点,为疾病预防和儿童饮食计划制定提供参考。方法:选取2017年1月—2021年12月北京新世纪儿童医院收治的896例患儿。采用酶联免疫吸附试验(ELISA)检测患儿血清中14种食物(牛肉、鸡肉、猪肉、鳕鱼、玉米、螃蟹、虾、鸡蛋、牛奶、蘑菇、大米、小麦、大豆、西红柿)中的特异性IgG(sIgG)抗体。结果:896份血清中,875份血清sIgG阳性,阳性率97.7%。鸡蛋(88.46%)、牛奶(83.20%)、小麦(55.43%)、西红柿(44.23%)sIgG阳性率较高,猪肉(2.86%)、牛肉(2.17%)sIg G阳性率较低。不同年龄组鸡蛋、小麦、西红柿、大豆、大米、虾、牛肉sIgG阳性率比较,差异有统计学意义(P<0.05)。不同性别s I g G阳性率比较,差异无统计学意义(P>0.05)。结论:北京新世纪儿童医院就诊儿童不耐受食物主要是鸡蛋和牛奶,其次是小麦、西红柿,不同年龄段不耐受食物存在显著差异,儿童饮食计划制定过程中应根据个体差异制定科学的个体饮食计划,有效规避不耐受食物,保证儿童健康成长。
