Foreign language teaching practice is developing rapidly,but research on foreign language teacher learning is currently relatively fragmented and unstructured.The book Foreign Language Teacher Learning,written by Prof...Foreign language teaching practice is developing rapidly,but research on foreign language teacher learning is currently relatively fragmented and unstructured.The book Foreign Language Teacher Learning,written by Professor Kang Yan from Capital Normal University,published in September 2022,makes a systematic introduction to foreign language teacher learning,which to some extent makes up for this shortcoming.Her book presents the lineage of foreign language teacher learning research at home and abroad,analyzes both theoretical and practical aspects,reviews the cuttingedge research results,and foresees the future development trend,painting a complete research picture for researchers in the field of foreign language teaching and teacher education as well as front-line teachers interested in foreign language teacher learning.This is an important inspiration for conducting foreign language teacher learning research in the future.And this paper makes a review of the book from aspects such as its content,major characteristics,contributions and limitations.展开更多
The expanding role of the Chinese language in international communications has become increasingly prominent as China’s comprehensive national power continues to grow,leading to a significant rise in the number of Ch...The expanding role of the Chinese language in international communications has become increasingly prominent as China’s comprehensive national power continues to grow,leading to a significant rise in the number of Chinese language learners.Since online teaching is not limited by time and space,its application is widespread.For beginners in the Chinese language,the Chinese characters are both a priority and a challenge.The“Chinese Character Classification,”also known as the“Six Writings,”is the earliest systematic theory of Chinese character structures,and teaching Chinese characters in categories based on the“Chinese Character Classification”is a method that fits the cognition of beginners.In order to teach Chinese characters in a targeted approach,based on the collection and analysis of the common errors of Chinese characters among beginners,(1)this paper proposes that(a)the intuitive method can be applied to teach pictographic characters,indicative characters,and associative compound characters in online teaching;(b)the inductive-deductive method of“basic characters to new characters”can be applied for the teaching of pictophonetic characters and associative compound characters;(c)the learning of character patterns should be approached in a whole-part-whole process,while importance should be attached to the suggestion of the frequency effect with a view to facilitating the online learning of Chinese characters for beginners.The aim of this paper is to provide some practical implications for the online teaching of Chinese characters to foreigners.展开更多
基于2003—2021年省际面板数据,根据耦合协调度模型测算我国省域双向FDI(foreign direct investment)互动发展水平,运用双向固定效应模型考察双向FDI互动对区域创业活跃度的影响。研究发现,双向FDI互动显著提升了区域创业活跃度,在影响...基于2003—2021年省际面板数据,根据耦合协调度模型测算我国省域双向FDI(foreign direct investment)互动发展水平,运用双向固定效应模型考察双向FDI互动对区域创业活跃度的影响。研究发现,双向FDI互动显著提升了区域创业活跃度,在影响过程中,经济增长和产业结构发挥正向调节作用,政府干预发挥逆向调节作用。异质性检验结果表明,在市场规模越大、创新能力越强和城市化水平越高的区域中,双向FDI互动越能促进区域创业活跃度提升。展开更多
Post-traumatic peritendinous adhesion presents a significant challenge in clinical medicine.This study proposes the use of diamond-like carbon(DLC)deposited on polylactic acid(PLA)membranes as a biophysical mechanism ...Post-traumatic peritendinous adhesion presents a significant challenge in clinical medicine.This study proposes the use of diamond-like carbon(DLC)deposited on polylactic acid(PLA)membranes as a biophysical mechanism for anti-adhesion barrier to encase ruptured tendons in tendon-injured rats.The results indicate that PLA/DLC composite membrane exhibits more efficient anti-adhesion effect than PLA membrane,with histological score decreasing from 3.12±0.27 to 2.20±0.22 and anti-adhesion effectiveness increasing from 21.61%to 44.72%.Mechanistically,the abundant C=O bond functional groups on the surface of DLC can reduce reactive oxygen species level effectively;thus,the phosphorylation of NF-κB and M1 polarization of macrophages are inhibited.Consequently,excessive inflammatory response augmented by M1 macrophage-originated cytokines including interleukin-6(IL-6),interleukin-1β(IL-1β),and tumor necrosis factor-α(TNF-α)is largely reduced.For biocompatibility evaluation,PLA/DLC membrane is slowly absorbed within tissue and displays prolonged barrier effects compared to traditional PLA membranes.Further studies show the DLC depositing decelerates the release of degradation product lactic acid and its induction of macrophage M2 polarization by interfering esterase and PLA ester bonds,which further delays the fibrosis process.It was found that the PLA/DLC membrane possess an efficient biophysical mechanism for treatment of peritendinous adhesion.展开更多
Under the background of complex international situation,how to build the special geo-economic space of China-Russia bor-der lies in strengthening their foreign trade resilience against external shocks.Based on empiric...Under the background of complex international situation,how to build the special geo-economic space of China-Russia bor-der lies in strengthening their foreign trade resilience against external shocks.Based on empirical evidence from ten prefecture-level China-Russia border regions in Northeast China,this paper analyzed the spatiotemporal evolution of foreign trade resilience under dif-ferent shocks.Furthermore,through the Panel Regression model,the mechanism of the industrial structure on the foreign trade resili-ence in contraction period and expansion period was discussed.The results showed that:1)from 2004 to 2021,foreign trade in China-Russia border regions experienced five phases.The overall foreign trade resilience was higher than expected,showing a rising volatility trend,but there was significant spatial heterogeneity in the ability of cities to cope with shocks.2)Highly specialized clusters were mainly concentrated in Yichun,Heihe and Da Hinggan Ling Prefecture,while Mudanjiang and Yanbian performed better in related and unrelated diversification.3)In different stages of economic system evolution,the response mode,degree and result of border foreign trade resilience to regional industrial structure showed obvious stage characteristics.During the contraction period,related diversifica-tion was more conducive to improving the resistance through risk spillovers.During the expansion period,specialization played a more significant role in improving regional resilience through self-reinforcing effect.These results are beneficial for expanding the resilience theory,ensuring border economic security and optimizing border industrial investment layout.展开更多
The detection of foreign object intrusion is crucial for ensuring the safety of railway operations.To address challenges such as low efficiency,suboptimal detection accuracy,and slow detection speed inherent in conven...The detection of foreign object intrusion is crucial for ensuring the safety of railway operations.To address challenges such as low efficiency,suboptimal detection accuracy,and slow detection speed inherent in conventional comprehensive video monitoring systems for railways,a railway foreign object intrusion recognition and detection system is conceived and implemented using edge computing and deep learning technologies.In a bid to raise detection accuracy,the convolutional block attention module(CBAM),including spatial and channel attention modules,is seamlessly integrated into the YOLOv5 model,giving rise to the CBAM-YOLOv5 model.Furthermore,the distance intersection-over-union_non-maximum suppression(DIo U_NMS)algorithm is employed in lieu of the weighted nonmaximum suppression algorithm,resulting in improved detection performance for intrusive targets.To accelerate detection speed,the model undergoes pruning based on the batch normalization(BN)layer,and Tensor RT inference acceleration techniques are employed,culminating in the successful deployment of the algorithm on edge devices.The CBAM-YOLOv5 model exhibits a notable 2.1%enhancement in detection accuracy when evaluated on a selfconstructed railway dataset,achieving 95.0%for mean average precision(m AP).Furthermore,the inference speed on edge devices attains a commendable 15 frame/s.展开更多
BACKGROUND A fish spike stuck in the throat is a common ear,nose,and throat(ENT)emergency.However,it is very rare for a fish spike to reach the thyroid tissue through the throat,which is very dangerous and can lead to...BACKGROUND A fish spike stuck in the throat is a common ear,nose,and throat(ENT)emergency.However,it is very rare for a fish spike to reach the thyroid tissue through the throat,which is very dangerous and can lead to pharyngeal fistula,cervical abscess,mediastinal abscess,and thyroid abscess.Proper and timely management can help reduce complications,especially in elderly patients.CASE SUMMARY In the case presented here,the causative factor was dentures,but improper management aggravated the condition.In the case presented here,an elderly woman with a history of accidentally swallowing fish bones for 20 d had a sensation of foreign bodies in her throat.Eventually,computed tomography(CT)of the neck showed that the left side of the thyroid gland had a dense shadow in the form of a stripe.CONCLUSION If a fishbone foreign body is not visible during endoscopic examination but the patient has significant symptoms,the surgeon should be aware that the fishbone may be lodged in the thyroid.To avoid a misdiagnosis,ultrasound,CT,and other tests can be used to clarify the diagnosis.T The first step in treating a fish bone in the thyroid gland is to determine the position of the foreign body and the extent of the infection,and to develop a personalized surgical plan for its removal.At the same time,scientific information should be made available to the general public so that people know that if a fish bone is accidentally lodged,they should not force it to be swallowed or be spit out by inducing vomiting,which are incorrect methods and may aggravate the condition or even cause it to migrate outside the cavity,leading to serious complications,as in this reported case.展开更多
BACKGROUND When an anorectal foreign body is found,its composition and shape should be evaluated,and a timely and effective treatment plan should be developed based on the patient's symptoms to avoid serious compl...BACKGROUND When an anorectal foreign body is found,its composition and shape should be evaluated,and a timely and effective treatment plan should be developed based on the patient's symptoms to avoid serious complications such as intestinal perforation caused by displacement of the foreign body.CASE SUMMARY A 54-year-old male was admitted to our outpatient clinic on June 3,2023,due to a rectal foreign body that had been embedded for more than 24 h.The patient reported using a glass electrode tube to assist in the recovery of prolapsed hemorrhoids,however,the electrode tube was inadvertently inserted into the anus and could not be removed by the patient.During hospitalization,the patient underwent surgery,and the foreign body was dragged into the rectum with the aid of colonoscopy.The anus was dilated with a comb-type pulling hook and an anal fistula pulling hook to widen the anus and remove the foreign body,and the local anal symptoms were then relieved with topical drugs.The patient was allowed to eat and drink,and an entire abdominal Computed tomography(CT)and colonoscopy were reviewed 3 d after surgery.CT revealed no foreign body residue and colonoscopy showed no metal or other residues in the colon and rectum,and no apparent intestinal tract damage.CONCLUSION The timeliness and rationality of the surgical and therapeutic options for this patient were based on a literature review of the clinical signs and conceivable conditions in such cases.The type,material and the potential risks of rectal foreign bodies should be considered.展开更多
Aiming at the limitations of the existing railway foreign object detection methods based on two-dimensional(2D)images,such as short detection distance,strong influence of environment and lack of distance information,w...Aiming at the limitations of the existing railway foreign object detection methods based on two-dimensional(2D)images,such as short detection distance,strong influence of environment and lack of distance information,we propose Rail-PillarNet,a three-dimensional(3D)LIDAR(Light Detection and Ranging)railway foreign object detection method based on the improvement of PointPillars.Firstly,the parallel attention pillar encoder(PAPE)is designed to fully extract the features of the pillars and alleviate the problem of local fine-grained information loss in PointPillars pillars encoder.Secondly,a fine backbone network is designed to improve the feature extraction capability of the network by combining the coding characteristics of LIDAR point cloud feature and residual structure.Finally,the initial weight parameters of the model were optimised by the transfer learning training method to further improve accuracy.The experimental results on the OSDaR23 dataset show that the average accuracy of Rail-PillarNet reaches 58.51%,which is higher than most mainstream models,and the number of parameters is 5.49 M.Compared with PointPillars,the accuracy of each target is improved by 10.94%,3.53%,16.96%and 19.90%,respectively,and the number of parameters only increases by 0.64M,which achieves a balance between the number of parameters and accuracy.展开更多
BACKGROUND Nasal trauma presents a risk of foreign body invasion into the nasal cavity.However,in the early treatment stage of nasal trauma,patients and doctors are not always aware of possible foreign body invasion,r...BACKGROUND Nasal trauma presents a risk of foreign body invasion into the nasal cavity.However,in the early treatment stage of nasal trauma,patients and doctors are not always aware of possible foreign body invasion,resulting in delayed detection.We describe the case of an adult patient admitted to the hospital due to left nasal congestion accompanied by yellow,purulent,and bloody discharge.CASE SUMMARY Consultation with the patient revealed a history of nasal trauma 30 years prior that did not receive thorough examinations and imaging during treatment,resulting in a glass fragment retained in the nasal cavity adjacent to the orbit.After admission,computerized tomography(CT)confirmed the presence of the foreign body in the patient’s left nasal–maxillary sinus.The nasal foreign body led to symptoms such as chronic sinusitis,nasal polyps,fungal infection,and deviated nasal septum.The foreign body was successfully removed by nasal endoscopy,polypectomy,sinus fungal removal,left middle turbinate conchoplasty,fenestration via the right inferior meatus,nasal endoscopic maxillary sinus cystectomy,and septolplasty.The operation was successful and without any complications.CONCLUSION CT scans should be performed in addition to necessary debridement sutures to avoid possible foreign body invasion during nasal trauma.Surgical planning should be tailored to the patient’s specific situation.The surgical method should be carefully selected,and sufficient preparation should be undertaken before the surgery to avoid possible displacement of the nasal foreign body.展开更多
BACKGROUND Colorectal foreign bodies are commonly encountered during surgery.They are frequently observed in men 20 to 90 years of age and have bimodal age distribution.Surgical management is necessary for cases of re...BACKGROUND Colorectal foreign bodies are commonly encountered during surgery.They are frequently observed in men 20 to 90 years of age and have bimodal age distribution.Surgical management is necessary for cases of rectal perforation.However,surgical site infections are the most common complications after colorectal surgery.CASE SUMMARY We discuss a case of rectal perforation in a patient who presented to our hospital 2 d after its occurrence.The perforation occurred as a result of the patient inserting a sex toy in his rectum.Severe peritonitis was attributable to delayed presentation.CONCLUSION Vacuum-assisted closure was performed to treat the wound,which healed well after therapy.No complications were noted.展开更多
BACKGROUND Prisons can be a reservoir for infectious diseases,including severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),due to the very intimate nature of the living spaces and the large number of people f...BACKGROUND Prisons can be a reservoir for infectious diseases,including severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),due to the very intimate nature of the living spaces and the large number of people forced to share them.AIM To investigate the SARS-CoV-2 epidemiology in prisons,this study evaluated the infection incidence rate in prisoners who underwent nasopharyngeal swabs.METHODS This is an observational cohort study.Data collection included information on prisoners who underwent nasopharyngeal swab testing for SARS-CoV-2 and the results.Nasopharyngeal swab tests for SARS-CoV-2 were performed between 15 February 2021 and 31 May 2021 for prisoners with symptoms and all new arrivals to the facility.Another section included information on the diagnosis of the disease according to the International Classification of Diseases,Ninth Revision,and Clinical Modification.RESULTS Up until the 31 May 2021,79.2%of the prisoner cohort(n=1744)agreed to a nasopharyngeal swab test(n=1381).Of these,1288 were negative(93.3%)and 85 were positive(6.2%).A significant association[relative risk(RR)]was found only for the risk of SARS-CoV-2 infection among foreigners compared to Italians[RR=2.4,95%confidence interval(CI):1.2-4.8].A positive association with SARS-CoV-2 infection was also found for inmates with at least one nervous system disorder(RR=4,95%CI:1.8-9.1).The SARS-CoV-2 incidence rate among prisoners is significantly lower than in the general population in Tuscany(standardized incidence ratio 0.7,95%CI:0.6-0.9).CONCLUSION In the prisoner cohort,screening and rapid access to health care for the immigrant population were critical to limiting virus transmission and subsequent morbidity and mortality in this vulnerable population.展开更多
After the decoupling of the US dollar from gold in 1971,US Treasuries replaced gold as the value benchmark of the international monetary system and acquired an exorbitant privilege.Subsequently,the total amount of US ...After the decoupling of the US dollar from gold in 1971,US Treasuries replaced gold as the value benchmark of the international monetary system and acquired an exorbitant privilege.Subsequently,the total amount of US debt exhibited an exponential expansion trend,unbound by any substantial constraints.The so-called debt ceiling is a partisan game rather than a rigid fiscal constraint on the United States.As long as there are no fundamental changes in the global monetary system,the international credit of US Treasuries will stay stable,and their trend of infinite expansion will be sustained.Massive quantitative easing policies have failed to significantly shake this stability,and the notion of global investors offloading US Treasuries is more an illusion than a fact.The exorbitant privilege of US Treasuries grants its federal government the“freedom to borrow,”shielding the American financial sector from due penalties during global financial crises and securing excessive returns in global capital cycles.In the old days when running“twin surpluses”on capital and current accounts,China kept the value of Renminbi low to support its export manufacturing sector along the southeast coast.As a result,China accumulated huge foreign exchange reserves,mainly US Treasuries.Nowadays,this practice is no longer necessary,yielding low returns and posing significant security risks.展开更多
Esophageal perforation, a rare condition, can arise from iatrogenic, traumatic, or spontaneous origins. Even when therapy is initiated within the first 24 hours, it is associated with a mortality rate of up to 25%. Du...Esophageal perforation, a rare condition, can arise from iatrogenic, traumatic, or spontaneous origins. Even when therapy is initiated within the first 24 hours, it is associated with a mortality rate of up to 25%. Due to the varied initial presentation, treatment may be delayed, leading to poorer outcomes. Here, we present a unique case of a 27-year-old schizophrenic patient who initially presented with acute respiratory failure and septic shock and was ultimately diagnosed with cavitary pneumonia secondary to esophageal perforation.展开更多
BACKGROUND Benign rectal strictures can be categorized as primary(disease-related)and secondary(surgical anastomosis-related).Secondary strictures arise from surgical complications,whereas primary strictures have dive...BACKGROUND Benign rectal strictures can be categorized as primary(disease-related)and secondary(surgical anastomosis-related).Secondary strictures arise from surgical complications,whereas primary strictures have diverse etiologies,including various inflammatory conditions.Benign strictures are usually managed by surgery and endoscopy.We present an unusual etiology of benign rectal stricture caused by the repeated insertion of foreign objects into the rectum for sexual purposes,resulting in rectal injury and subsequent chronic inflammation.CASE SUMMARY A 53-year-old man presented to the outpatient clinic of the Colorectal Surgery Department with symptoms of chronic constipation and bloody stools.The patient previously experienced rectal injury due to foreign object insertion for sexual purposes.Colonoscopy revealed benign circumferential narrowing of the rectum.He underwent treatment by endoscopic argon plasma coagulation and balloon dilation and follow-up as an outpatient for 4 months.A colonoscopy at the end of the follow-up period revealed no evidence of rectal stricture relapse.CONCLUSION A history of rectal injury,followed by chronic inflammation,should be considered in patients with benign rectal strictures.Management with endoscopic argon plasma coagulation and balloon dilation can prevent the need for surgical resection of benign rectal strictures.展开更多
BACKGROUND The technological evolution of bronchoscopy has led to the widespread adoption of flexible techniques and their use for both diagnostic and therapeutic purposes.Currently,there is an active debate regarding...BACKGROUND The technological evolution of bronchoscopy has led to the widespread adoption of flexible techniques and their use for both diagnostic and therapeutic purposes.Currently,there is an active debate regarding the comparative efficacy and safety of rigid vs flexible bronchoscopy in the treatment of foreign body aspiration.AIM To evaluate our experience with tracheobronchial foreign body extraction using flexible bronchoscopy and provide a literature overview.METHODS This was a single-centre retrospective study.Twenty-four patients were enrolled between January 2017 and January 2023.Medical records of patients aged below 18 years who were admitted to authors’affiliated institution with a suspected diagnosis of foreign body aspiration were collected from hospital’s database to Microsoft Excel 2019.Data were analysed using MedCalc Statistical Software.RESULTS Patient ages varied from 9 months to 11 years.The median age was 23.5 months,95%confidence interval(CI)19.49-44.77.We observed age clustering in children with foreign body aspiration at our institution with three age subgroups:(1)0-25 months;(2)40-60 months;and(3)120-140 months.We expectancy of an organic tracheobronchial foreign body was significantly higher in 0-25 months subgroup than that in older ones when subgroups 40-60 and 120-140 months were combined together(odds ratio=10.0,95%CI:1.44-29.26,P=0.0197).Successful foreign body extraction was performed in all cases.Conversion to a rigid bronchoscope was not required in any of the cases.No major complications(massive bleeding,tracheobronchial tree perforation,or asphyxia)were observed.CONCLUSION Flexible bronchoscopy is an effective and safe method for tracheobronchial foreign body extraction in children.展开更多
This paper endeavours to elucidate the intricacies of Palestinian Paradiplomacy,focusing in the political impetus pioneered by its principle actors,namely the Palestine Liberation Organisation(PLO)and subsequently,the...This paper endeavours to elucidate the intricacies of Palestinian Paradiplomacy,focusing in the political impetus pioneered by its principle actors,namely the Palestine Liberation Organisation(PLO)and subsequently,the establishment of the Palestinian National Authority(PNA).Additionally,attention will be directed towards the creation of the Palestinian Ministry of Foreign Affairs(PMOFA)and its subsidiary,the Palestinian International Cooperation Agency(PICA),albeit briefly discussed.Drawing inspiration from Alexander S.Kuznetsov’s seminal work“Theory and Practice of Paradiplomacy:Subnational Governments in International Affairs”(2015),this paper tries to scrutinize the trajectory of Palestinian paradiplomacy and its evolutionary course over time.When it comes to activity and growth,Palestinian paradiplomacy has a unique profile.The way in which topics pertaining to nations are not yet recognized has a great deal of bearing on current discussions and academic research about urgent political concerns like the right to self-determination and human rights.The analysis of de facto states via the prism of paradiplomacy naturally arises from the dominant state recognition procedures in international politics.展开更多
文摘Foreign language teaching practice is developing rapidly,but research on foreign language teacher learning is currently relatively fragmented and unstructured.The book Foreign Language Teacher Learning,written by Professor Kang Yan from Capital Normal University,published in September 2022,makes a systematic introduction to foreign language teacher learning,which to some extent makes up for this shortcoming.Her book presents the lineage of foreign language teacher learning research at home and abroad,analyzes both theoretical and practical aspects,reviews the cuttingedge research results,and foresees the future development trend,painting a complete research picture for researchers in the field of foreign language teaching and teacher education as well as front-line teachers interested in foreign language teacher learning.This is an important inspiration for conducting foreign language teacher learning research in the future.And this paper makes a review of the book from aspects such as its content,major characteristics,contributions and limitations.
基金an outcome of the project of Sichuan University,“A Preliminary Study on Online Chinese Character Teaching Strategies for Teaching Chinese as a Foreign Language During the COVID-19 Pandemic,”Project No.2022 Self-Research-Overseas 008。
文摘The expanding role of the Chinese language in international communications has become increasingly prominent as China’s comprehensive national power continues to grow,leading to a significant rise in the number of Chinese language learners.Since online teaching is not limited by time and space,its application is widespread.For beginners in the Chinese language,the Chinese characters are both a priority and a challenge.The“Chinese Character Classification,”also known as the“Six Writings,”is the earliest systematic theory of Chinese character structures,and teaching Chinese characters in categories based on the“Chinese Character Classification”is a method that fits the cognition of beginners.In order to teach Chinese characters in a targeted approach,based on the collection and analysis of the common errors of Chinese characters among beginners,(1)this paper proposes that(a)the intuitive method can be applied to teach pictographic characters,indicative characters,and associative compound characters in online teaching;(b)the inductive-deductive method of“basic characters to new characters”can be applied for the teaching of pictophonetic characters and associative compound characters;(c)the learning of character patterns should be approached in a whole-part-whole process,while importance should be attached to the suggestion of the frequency effect with a view to facilitating the online learning of Chinese characters for beginners.The aim of this paper is to provide some practical implications for the online teaching of Chinese characters to foreigners.
文摘基于2003—2021年省际面板数据,根据耦合协调度模型测算我国省域双向FDI(foreign direct investment)互动发展水平,运用双向固定效应模型考察双向FDI互动对区域创业活跃度的影响。研究发现,双向FDI互动显著提升了区域创业活跃度,在影响过程中,经济增长和产业结构发挥正向调节作用,政府干预发挥逆向调节作用。异质性检验结果表明,在市场规模越大、创新能力越强和城市化水平越高的区域中,双向FDI互动越能促进区域创业活跃度提升。
基金supported by the National Natural Science Foundation of China(No.82172408,81772314,and 81922045)the Original Exploration project(22ZR1480300)+5 种基金Outstanding Academic Leaders(Youth)project(21XD1422900)of Shanghai Science and Technology Innovation Action PlanPrinciple Investigator Innovation Team of Both Shanghai Sixth People’s Hospital and Shanghai Institute of Nutrition and Health,Shanghai Jiao Tong University Medical College“Two-hundred Talent”Program(No.20191829)The Second Three-Year Action Plan for Promoting Clinical Skills and Clinical Innovation in Municipal Hospitals of Shanghai Shenkang(No.SHDC2020CR4032)Shanghai Excellent Academic Leader ProgramShanghai Engineering Research Center for Orthopaedic Material Innovation and Tissue Regeneration(No.20DZ2254100)China Postdoctoral Science Foundation(2023M742347).
文摘Post-traumatic peritendinous adhesion presents a significant challenge in clinical medicine.This study proposes the use of diamond-like carbon(DLC)deposited on polylactic acid(PLA)membranes as a biophysical mechanism for anti-adhesion barrier to encase ruptured tendons in tendon-injured rats.The results indicate that PLA/DLC composite membrane exhibits more efficient anti-adhesion effect than PLA membrane,with histological score decreasing from 3.12±0.27 to 2.20±0.22 and anti-adhesion effectiveness increasing from 21.61%to 44.72%.Mechanistically,the abundant C=O bond functional groups on the surface of DLC can reduce reactive oxygen species level effectively;thus,the phosphorylation of NF-κB and M1 polarization of macrophages are inhibited.Consequently,excessive inflammatory response augmented by M1 macrophage-originated cytokines including interleukin-6(IL-6),interleukin-1β(IL-1β),and tumor necrosis factor-α(TNF-α)is largely reduced.For biocompatibility evaluation,PLA/DLC membrane is slowly absorbed within tissue and displays prolonged barrier effects compared to traditional PLA membranes.Further studies show the DLC depositing decelerates the release of degradation product lactic acid and its induction of macrophage M2 polarization by interfering esterase and PLA ester bonds,which further delays the fibrosis process.It was found that the PLA/DLC membrane possess an efficient biophysical mechanism for treatment of peritendinous adhesion.
基金Under the auspices of National Natural Science Foundation of China(No.42071162,42101165)。
文摘Under the background of complex international situation,how to build the special geo-economic space of China-Russia bor-der lies in strengthening their foreign trade resilience against external shocks.Based on empirical evidence from ten prefecture-level China-Russia border regions in Northeast China,this paper analyzed the spatiotemporal evolution of foreign trade resilience under dif-ferent shocks.Furthermore,through the Panel Regression model,the mechanism of the industrial structure on the foreign trade resili-ence in contraction period and expansion period was discussed.The results showed that:1)from 2004 to 2021,foreign trade in China-Russia border regions experienced five phases.The overall foreign trade resilience was higher than expected,showing a rising volatility trend,but there was significant spatial heterogeneity in the ability of cities to cope with shocks.2)Highly specialized clusters were mainly concentrated in Yichun,Heihe and Da Hinggan Ling Prefecture,while Mudanjiang and Yanbian performed better in related and unrelated diversification.3)In different stages of economic system evolution,the response mode,degree and result of border foreign trade resilience to regional industrial structure showed obvious stage characteristics.During the contraction period,related diversifica-tion was more conducive to improving the resistance through risk spillovers.During the expansion period,specialization played a more significant role in improving regional resilience through self-reinforcing effect.These results are beneficial for expanding the resilience theory,ensuring border economic security and optimizing border industrial investment layout.
基金supported in part by the Science and Technology Innovation Project of CHN Energy Shuo Huang Railway Development Company Ltd(No.SHTL-22-28)the Beijing Natural Science Foundation Fengtai Urban Rail Transit Frontier Research Joint Fund(No.L231002)the Major Project of China State Railway Group Co.,Ltd.(No.K2023T003)。
文摘The detection of foreign object intrusion is crucial for ensuring the safety of railway operations.To address challenges such as low efficiency,suboptimal detection accuracy,and slow detection speed inherent in conventional comprehensive video monitoring systems for railways,a railway foreign object intrusion recognition and detection system is conceived and implemented using edge computing and deep learning technologies.In a bid to raise detection accuracy,the convolutional block attention module(CBAM),including spatial and channel attention modules,is seamlessly integrated into the YOLOv5 model,giving rise to the CBAM-YOLOv5 model.Furthermore,the distance intersection-over-union_non-maximum suppression(DIo U_NMS)algorithm is employed in lieu of the weighted nonmaximum suppression algorithm,resulting in improved detection performance for intrusive targets.To accelerate detection speed,the model undergoes pruning based on the batch normalization(BN)layer,and Tensor RT inference acceleration techniques are employed,culminating in the successful deployment of the algorithm on edge devices.The CBAM-YOLOv5 model exhibits a notable 2.1%enhancement in detection accuracy when evaluated on a selfconstructed railway dataset,achieving 95.0%for mean average precision(m AP).Furthermore,the inference speed on edge devices attains a commendable 15 frame/s.
文摘BACKGROUND A fish spike stuck in the throat is a common ear,nose,and throat(ENT)emergency.However,it is very rare for a fish spike to reach the thyroid tissue through the throat,which is very dangerous and can lead to pharyngeal fistula,cervical abscess,mediastinal abscess,and thyroid abscess.Proper and timely management can help reduce complications,especially in elderly patients.CASE SUMMARY In the case presented here,the causative factor was dentures,but improper management aggravated the condition.In the case presented here,an elderly woman with a history of accidentally swallowing fish bones for 20 d had a sensation of foreign bodies in her throat.Eventually,computed tomography(CT)of the neck showed that the left side of the thyroid gland had a dense shadow in the form of a stripe.CONCLUSION If a fishbone foreign body is not visible during endoscopic examination but the patient has significant symptoms,the surgeon should be aware that the fishbone may be lodged in the thyroid.To avoid a misdiagnosis,ultrasound,CT,and other tests can be used to clarify the diagnosis.T The first step in treating a fish bone in the thyroid gland is to determine the position of the foreign body and the extent of the infection,and to develop a personalized surgical plan for its removal.At the same time,scientific information should be made available to the general public so that people know that if a fish bone is accidentally lodged,they should not force it to be swallowed or be spit out by inducing vomiting,which are incorrect methods and may aggravate the condition or even cause it to migrate outside the cavity,leading to serious complications,as in this reported case.
基金National Natural Science Foundation of China Project,No.82004374The Second Round of Construction Project of National TCM Academic Schools Inheritance Workshop of the State Administration of Traditional Chinese Medicine,No.[2019]62.
文摘BACKGROUND When an anorectal foreign body is found,its composition and shape should be evaluated,and a timely and effective treatment plan should be developed based on the patient's symptoms to avoid serious complications such as intestinal perforation caused by displacement of the foreign body.CASE SUMMARY A 54-year-old male was admitted to our outpatient clinic on June 3,2023,due to a rectal foreign body that had been embedded for more than 24 h.The patient reported using a glass electrode tube to assist in the recovery of prolapsed hemorrhoids,however,the electrode tube was inadvertently inserted into the anus and could not be removed by the patient.During hospitalization,the patient underwent surgery,and the foreign body was dragged into the rectum with the aid of colonoscopy.The anus was dilated with a comb-type pulling hook and an anal fistula pulling hook to widen the anus and remove the foreign body,and the local anal symptoms were then relieved with topical drugs.The patient was allowed to eat and drink,and an entire abdominal Computed tomography(CT)and colonoscopy were reviewed 3 d after surgery.CT revealed no foreign body residue and colonoscopy showed no metal or other residues in the colon and rectum,and no apparent intestinal tract damage.CONCLUSION The timeliness and rationality of the surgical and therapeutic options for this patient were based on a literature review of the clinical signs and conceivable conditions in such cases.The type,material and the potential risks of rectal foreign bodies should be considered.
基金supported by a grant from the National Key Research and Development Project(2023YFB4302100)Key Research and Development Project of Jiangxi Province(No.20232ACE01011)Independent Deployment Project of Ganjiang Innovation Research Institute,Chinese Academy of Sciences(E255J001).
文摘Aiming at the limitations of the existing railway foreign object detection methods based on two-dimensional(2D)images,such as short detection distance,strong influence of environment and lack of distance information,we propose Rail-PillarNet,a three-dimensional(3D)LIDAR(Light Detection and Ranging)railway foreign object detection method based on the improvement of PointPillars.Firstly,the parallel attention pillar encoder(PAPE)is designed to fully extract the features of the pillars and alleviate the problem of local fine-grained information loss in PointPillars pillars encoder.Secondly,a fine backbone network is designed to improve the feature extraction capability of the network by combining the coding characteristics of LIDAR point cloud feature and residual structure.Finally,the initial weight parameters of the model were optimised by the transfer learning training method to further improve accuracy.The experimental results on the OSDaR23 dataset show that the average accuracy of Rail-PillarNet reaches 58.51%,which is higher than most mainstream models,and the number of parameters is 5.49 M.Compared with PointPillars,the accuracy of each target is improved by 10.94%,3.53%,16.96%and 19.90%,respectively,and the number of parameters only increases by 0.64M,which achieves a balance between the number of parameters and accuracy.
文摘BACKGROUND Nasal trauma presents a risk of foreign body invasion into the nasal cavity.However,in the early treatment stage of nasal trauma,patients and doctors are not always aware of possible foreign body invasion,resulting in delayed detection.We describe the case of an adult patient admitted to the hospital due to left nasal congestion accompanied by yellow,purulent,and bloody discharge.CASE SUMMARY Consultation with the patient revealed a history of nasal trauma 30 years prior that did not receive thorough examinations and imaging during treatment,resulting in a glass fragment retained in the nasal cavity adjacent to the orbit.After admission,computerized tomography(CT)confirmed the presence of the foreign body in the patient’s left nasal–maxillary sinus.The nasal foreign body led to symptoms such as chronic sinusitis,nasal polyps,fungal infection,and deviated nasal septum.The foreign body was successfully removed by nasal endoscopy,polypectomy,sinus fungal removal,left middle turbinate conchoplasty,fenestration via the right inferior meatus,nasal endoscopic maxillary sinus cystectomy,and septolplasty.The operation was successful and without any complications.CONCLUSION CT scans should be performed in addition to necessary debridement sutures to avoid possible foreign body invasion during nasal trauma.Surgical planning should be tailored to the patient’s specific situation.The surgical method should be carefully selected,and sufficient preparation should be undertaken before the surgery to avoid possible displacement of the nasal foreign body.
文摘BACKGROUND Colorectal foreign bodies are commonly encountered during surgery.They are frequently observed in men 20 to 90 years of age and have bimodal age distribution.Surgical management is necessary for cases of rectal perforation.However,surgical site infections are the most common complications after colorectal surgery.CASE SUMMARY We discuss a case of rectal perforation in a patient who presented to our hospital 2 d after its occurrence.The perforation occurred as a result of the patient inserting a sex toy in his rectum.Severe peritonitis was attributable to delayed presentation.CONCLUSION Vacuum-assisted closure was performed to treat the wound,which healed well after therapy.No complications were noted.
文摘BACKGROUND Prisons can be a reservoir for infectious diseases,including severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),due to the very intimate nature of the living spaces and the large number of people forced to share them.AIM To investigate the SARS-CoV-2 epidemiology in prisons,this study evaluated the infection incidence rate in prisoners who underwent nasopharyngeal swabs.METHODS This is an observational cohort study.Data collection included information on prisoners who underwent nasopharyngeal swab testing for SARS-CoV-2 and the results.Nasopharyngeal swab tests for SARS-CoV-2 were performed between 15 February 2021 and 31 May 2021 for prisoners with symptoms and all new arrivals to the facility.Another section included information on the diagnosis of the disease according to the International Classification of Diseases,Ninth Revision,and Clinical Modification.RESULTS Up until the 31 May 2021,79.2%of the prisoner cohort(n=1744)agreed to a nasopharyngeal swab test(n=1381).Of these,1288 were negative(93.3%)and 85 were positive(6.2%).A significant association[relative risk(RR)]was found only for the risk of SARS-CoV-2 infection among foreigners compared to Italians[RR=2.4,95%confidence interval(CI):1.2-4.8].A positive association with SARS-CoV-2 infection was also found for inmates with at least one nervous system disorder(RR=4,95%CI:1.8-9.1).The SARS-CoV-2 incidence rate among prisoners is significantly lower than in the general population in Tuscany(standardized incidence ratio 0.7,95%CI:0.6-0.9).CONCLUSION In the prisoner cohort,screening and rapid access to health care for the immigrant population were critical to limiting virus transmission and subsequent morbidity and mortality in this vulnerable population.
文摘After the decoupling of the US dollar from gold in 1971,US Treasuries replaced gold as the value benchmark of the international monetary system and acquired an exorbitant privilege.Subsequently,the total amount of US debt exhibited an exponential expansion trend,unbound by any substantial constraints.The so-called debt ceiling is a partisan game rather than a rigid fiscal constraint on the United States.As long as there are no fundamental changes in the global monetary system,the international credit of US Treasuries will stay stable,and their trend of infinite expansion will be sustained.Massive quantitative easing policies have failed to significantly shake this stability,and the notion of global investors offloading US Treasuries is more an illusion than a fact.The exorbitant privilege of US Treasuries grants its federal government the“freedom to borrow,”shielding the American financial sector from due penalties during global financial crises and securing excessive returns in global capital cycles.In the old days when running“twin surpluses”on capital and current accounts,China kept the value of Renminbi low to support its export manufacturing sector along the southeast coast.As a result,China accumulated huge foreign exchange reserves,mainly US Treasuries.Nowadays,this practice is no longer necessary,yielding low returns and posing significant security risks.
文摘Esophageal perforation, a rare condition, can arise from iatrogenic, traumatic, or spontaneous origins. Even when therapy is initiated within the first 24 hours, it is associated with a mortality rate of up to 25%. Due to the varied initial presentation, treatment may be delayed, leading to poorer outcomes. Here, we present a unique case of a 27-year-old schizophrenic patient who initially presented with acute respiratory failure and septic shock and was ultimately diagnosed with cavitary pneumonia secondary to esophageal perforation.
文摘BACKGROUND Benign rectal strictures can be categorized as primary(disease-related)and secondary(surgical anastomosis-related).Secondary strictures arise from surgical complications,whereas primary strictures have diverse etiologies,including various inflammatory conditions.Benign strictures are usually managed by surgery and endoscopy.We present an unusual etiology of benign rectal stricture caused by the repeated insertion of foreign objects into the rectum for sexual purposes,resulting in rectal injury and subsequent chronic inflammation.CASE SUMMARY A 53-year-old man presented to the outpatient clinic of the Colorectal Surgery Department with symptoms of chronic constipation and bloody stools.The patient previously experienced rectal injury due to foreign object insertion for sexual purposes.Colonoscopy revealed benign circumferential narrowing of the rectum.He underwent treatment by endoscopic argon plasma coagulation and balloon dilation and follow-up as an outpatient for 4 months.A colonoscopy at the end of the follow-up period revealed no evidence of rectal stricture relapse.CONCLUSION A history of rectal injury,followed by chronic inflammation,should be considered in patients with benign rectal strictures.Management with endoscopic argon plasma coagulation and balloon dilation can prevent the need for surgical resection of benign rectal strictures.
文摘BACKGROUND The technological evolution of bronchoscopy has led to the widespread adoption of flexible techniques and their use for both diagnostic and therapeutic purposes.Currently,there is an active debate regarding the comparative efficacy and safety of rigid vs flexible bronchoscopy in the treatment of foreign body aspiration.AIM To evaluate our experience with tracheobronchial foreign body extraction using flexible bronchoscopy and provide a literature overview.METHODS This was a single-centre retrospective study.Twenty-four patients were enrolled between January 2017 and January 2023.Medical records of patients aged below 18 years who were admitted to authors’affiliated institution with a suspected diagnosis of foreign body aspiration were collected from hospital’s database to Microsoft Excel 2019.Data were analysed using MedCalc Statistical Software.RESULTS Patient ages varied from 9 months to 11 years.The median age was 23.5 months,95%confidence interval(CI)19.49-44.77.We observed age clustering in children with foreign body aspiration at our institution with three age subgroups:(1)0-25 months;(2)40-60 months;and(3)120-140 months.We expectancy of an organic tracheobronchial foreign body was significantly higher in 0-25 months subgroup than that in older ones when subgroups 40-60 and 120-140 months were combined together(odds ratio=10.0,95%CI:1.44-29.26,P=0.0197).Successful foreign body extraction was performed in all cases.Conversion to a rigid bronchoscope was not required in any of the cases.No major complications(massive bleeding,tracheobronchial tree perforation,or asphyxia)were observed.CONCLUSION Flexible bronchoscopy is an effective and safe method for tracheobronchial foreign body extraction in children.
文摘This paper endeavours to elucidate the intricacies of Palestinian Paradiplomacy,focusing in the political impetus pioneered by its principle actors,namely the Palestine Liberation Organisation(PLO)and subsequently,the establishment of the Palestinian National Authority(PNA).Additionally,attention will be directed towards the creation of the Palestinian Ministry of Foreign Affairs(PMOFA)and its subsidiary,the Palestinian International Cooperation Agency(PICA),albeit briefly discussed.Drawing inspiration from Alexander S.Kuznetsov’s seminal work“Theory and Practice of Paradiplomacy:Subnational Governments in International Affairs”(2015),this paper tries to scrutinize the trajectory of Palestinian paradiplomacy and its evolutionary course over time.When it comes to activity and growth,Palestinian paradiplomacy has a unique profile.The way in which topics pertaining to nations are not yet recognized has a great deal of bearing on current discussions and academic research about urgent political concerns like the right to self-determination and human rights.The analysis of de facto states via the prism of paradiplomacy naturally arises from the dominant state recognition procedures in international politics.