Polymerase-tautomeric Model for Untargeted Delayed Base Substitution Mutations Formation during Error-prone and SOS Replication of Double-stranded DNA Containing Thymine and Adenine in Some Rare Tautomeric Forms

Polymerase-tautomeric model for untargeted delayed base substitution mutations is proposed.Structural analysis of bases insertion showed that any canonical bases may be inserted opposite rare tautomeric forms of thymine T3*,adenines A2*and A4*so that between them hydrogen bonds are formed.Canonical adenine and cytosine can be incorporated opposite canonical thymine only.Canonical thymine and guanine can be incorporated opposite canonical adenine only.If in the synthesis of DNA containing rare tautomeric forms of thymine T3*,adenines A2*and A4*,involved DNA polymerases with relatively high fidelity of synthesis,mutations not appear.However,if further DNA synthesis will involve DNA polymerases having a low fidelity of synthesis,there may be base substitution mutations.It was shown that the conclusion made in the Tomasetti and Vogelstein cancer risk model that the formation of about 67%of all mutations was not caused by exposure to any mutagens is erroneous.

Significance of dormant forms of Helicobacter pylori in ulcerogenesis

Nearly half of the global population are carriers of Helicobacter pylori(H. pylori),a Gram-negative bacterium that persists in the healthy human stomach. H. pylori can be a pathogen and causes development of peptic ulcer disease in a certain state of the macroorganism. It is well established that H. pylori infection is the main cause of chronic gastritis and peptic ulcer disease(PUD). Decontamination of the gastric mucosa with various antibiotics leads to H. pylori elimination and longer remission in this disease. However,the reasons for repeated detection of H. pylori in recurrent PUD after its successful eradication remain unclear. The reason for the redetection of H. pylori in recurrent PUD can be either reinfection or ineffective anti-Helicobacter therapy. The administration of antibacterial drugs can lead not only to the emergence of resistant strains of microorganisms,but also contribute to the conversion of H. pylori into the resting(dormant) state. The dormant forms of H. pylori have been shown to play a potential role in the development of relapses of PUD. The paper discusses morphological H. pylori forms,such as S-shaped,C-shaped,U-shaped,and coccoid ones. The authors proposes the classification of H. pylori according to its morphological forms and viability.

Comparative Study on Spatial Forms of Ancient Waterside Towns Based on Google Earth Pro-Taking the Example of Qingmuchuan,Fenghuang and Houliu in Southern Shaanxi,China

The purpose of this study is to address the problem of ancient towns dying out in developing countries,particularly China.Intensifying conflicts between human settlements and the natural environment are described,and guidelines are proposed for the development of waterside ancient towns in China’s southern Shaanxi Province in the interest of conserving cultural and natural heritage.The towns of Qingmuchuan,Fenghuang and Houliu were selected as representative examples due to their strong reputation among tourists.They have the characteristics of traditional southern Shaanxi towns,but each has a completely different layout,space and structure.The comparative findings of this research provide a point of reference for establishing guidelines to preserve the integrity of ancient towns worldwide.In this paper,we compare the geographical conditions with the layout and texture of the streets by Google Earth Pro.And we analyze the details of spaces along the river zones,architectural styles and building decorations in order to research the relationship between the natural environment and the human settlement conditions.We note the unfortunate common trend of commercial development steadily taking over the natural environment,particularly the rivers and unique elements of the old towns.Finally,we summarize the similarities and differences of the spatial forms among these towns and put forward proposals for the further development of ancient towns.This research is important for all regions which stand to lose their national treasures.Consequently,measures should be to taken to curtail hyper development before we lose our historicscenery.

Bell’s Ternary Quadratic Forms and Tunnel’s Congruent Number Criterion Revisited

Bell’s theorem determines the number of representations of a positive integer in terms of the ternary quadratic forms x2+by2+cz2 with b,c {1,2,4,8}. This number depends only on the number of representations of an integer as a sum of three squares. We present a modern elementary proof of Bell’s theorem that is based on three standard Ramanujan theta function identities and a set of five so-called three-square identities by Hurwitz. We use Bell’s theorem and a slight extension of it to find explicit and finite computable expressions for Tunnel’s congruent number criterion. It is known that this criterion settles the congruent number problem under the weak Birch-Swinnerton-Dyer conjecture. Moreover, we present for the first time an unconditional proof that a square-free number n 3(mod 8) is not congruent.

Ecological biomass allocation strategies in plant species with different life forms in a cold desert, China

Biomass allocation patterns among plant species are related to their adaptive ecological strategies. Ephemeral, ephemeroid and annual plant life forms represent three typical growth strategies of plants that grow in autumn and early spring in the cold deserts of China. These plants play an important role in reducing wind velocity in the desert areas. However, despite numerous studies, the strategies of biomass allocation among plant species with these three life forms remain contentious. In this study, we conducted a preliminary quadrat study during 2014–2016 in the southern part of the Gurbantunggut Desert, China, to investigate the allocation patterns of above-ground biomass(AGB) and below-ground biomass(BGB) at the individual level in 17 ephemeral, 3 ephemeroid and 4 annual plant species. Since ephemeral plants can germinate in autumn, we also compared biomass allocation patterns between plants that germinated in autumn 2015 and spring 2016 for 4 common ephemeral species. The healthy mature individual plants of each species were sampled and the AGB, BGB, total biomass(TB), leaf mass ratio(LMR) and root/shoot ratio(R/S) were calculated for 201 sample quadrats in the study area. We also studied the relationships between AGB and BGB of plants with the three different life forms(ephemeral, ephemeroid and annual). The mean AGB values of ephemeral, ephemeroid and annual plants were 0.806, 3.759 and 1.546 g/plant, respectively, and the mean BGB values were 0.106, 4.996 and 0.166 g/plant, respectively. The mean R/S value was significantly higher in ephemeroid plants(1.675) than in ephemeral(0.154) and annual(0.147) plants. The mean LMR was the highest in annual plants, followed by ephemeroid plants and ephemeral plants, reflecting the fact that annual plants allocate more biomass to leaves, associated with their longer life span. Biomass of ephemeral plants that germinated in autumn was significantly higher than those of corresponding plants that germinated in spring in terms of AGB, BGB and TB. However, the R/S value was similar in plants that germinated in autumn and spring. The slope of regression relationship between AGB and BGB differed significantly among the three plant life forms. These results support different biomass allocation hypotheses. Specifically, at the individual level, the AGB and BGB partitioning supports the allometric hypothesis for ephemeroid and annual plants and the isometric hypothesis for ephemeral plants.

Effects of different levels of compost application on amounts and distribution of organic nitrogen forms in soil particle size fractions subjected mainly to double cropping

Effects of different levels of compost application on the amounts and percentage distribution of organic N forms in whole soils and particle size fractions were investigated. Soil samples were collected from three plots: (a) F, only chemical fertilizers;(b) F+LC, chemical fertilizers plus low level of compost;(c) F+HC, chemical fertilizers plus high level of compost. Each soil sample was divided into five fractions: coarse sand-sized aggregate (CSA), medium sand-sized aggregate (MSA), fine sand-sized aggregate (FSA), silt-sized aggregate (SIA) and clay-sized aggregate (CLA) fractions. The sand fractions were subdivided into decayed plants (DP) and mineral particles (MP). The amounts of total N and different organic N forms in the whole soils as well as size fractions generally increased with increasing the amount of compost. In the whole soils, percentage distribution of non-hydrolysable-N and amino sugar-N increased by compost application while the distribution values of the hydrolysable ammonium- N and unidentified-N decreased. The application did not affect the distribution degree of amino acid-N. In the size fractions, the distribution values of most organic N forms increased in the CSA-DP, MSA-DP and FSA-DP fractions by compost application. In the CLA fractions, the amounts and percentage distribution of organic N forms were the highest, although the application caused decreases in their distribution values. These findings indicate that the CLA fraction merit close attention as an important reservoir of various organic N.

Multiplicative forms on Poisson groupoids

First,we prove a decomposition formula for any multiplicative differential form on a Lie groupoid G.Next,we prove that if G is a Poisson Lie groupoid,then the spaceΩ_(mult)·(G)of multiplicative forms on G has a differential graded Lie algebra(DGLA)structure.Furthermore,when combined withΩ·(M),which is the space of forms on the base manifold M of G,Ω_(mult)·(G)forms a canonical DGLA crossed module.This supplements a previously known fact that multiplicative multi-vector fields on G form a DGLA crossed module with the Schouten algebraΓ(∧·A)stemming from the Lie algebroid A of G.

The “3 Genomic Numbers” Discovery: How Our Genome Single-Stranded DNA Sequence Is “Self-Designed” as a Numerical Whole

This article proves the existence of a hyper-precise global numerical meta-architecture unifying, structuring, binding and controlling the billion triplet codons constituting the sequence of single-stranded DNA of the entire human genome. Beyond the evolution and erratic mutations like transposons within the genome, it’s as if the memory of a fossil genome with multiple symmetries persists. This recalls the “intermingling” of information characterizing the fractal universe of chaos theory. The result leads to a balanced and perfect tuning between the masses of the two strands of the huge DNA molecule that constitute our genome. We show here how codon populations forming the single-stranded DNA sequences can constitute a critical approach to the understanding of junk DNA function. Then, we suggest revisiting certain methods published in our 2009 book “Codex Biogenesis”. In fact, we demonstrate here how the universal genetic code table is a powerful analytical filter to characterize single-stranded DNA sequences constituting chromosomes and genomes. We can then show that any genomic DNA sequence is featured by three numbers, which characterize it and its 64 codon populations with correlations greater than 99%. The number “1” is common to all sequences, expressing the second law of Chargaff. The other 2 numbers are related to each specific DNA sequence case characterizing life species. For example, the entire human genome is characterized by three remarkable numbers 1, 2, and Phi = 1.618 the golden ratio. Associated with each of these three numbers, we can match three axes of symmetry, then “imagine” a kind of hyperspace formed by these codon populations. Then we revisit the value (3-Phi)/2 which is probably universal and common to both the scale of quarks and atomic levels, balancing and tuning the whole human genome codon population. Finally, we demonstrate a new kind of duality between “form and substance” overlapping the whole human genome: we will show that—simultaneously with the duality between genes and junk DNA—there is a second layer of embedded hidden structure overlapping all the DNA of the whole human genome, dividing it into a second type of duality information/redundancy involving golden ratio proportions.

THE RESEARCH ON THE DISTRIBUTION AND FORMS OF HEAVY METALS IN THE XIANGJIANG RIVER SEDIMENTS

In this paper, the contents and various forms of Cd, Cu, Zn and Pb in the sediments of the Xiangjiang River have been investigated. The presentation of this paper focuses on the various forms and characteristics of the heavy metals in the column sediments at Xiawan Port of Zhuzhou, which has been severely polluted by a metallurgical plant.The forms of the heavy metals discussed in this paper are: The concentration of the exchangeable forms of Cd, Cu, Zn and Pb, in the forms of carbonates and Fe/ Mn oxide in water, the combination of Cu with organic matter and form, and the proportion of the residue form at each section have been studied.

Representations by Certain Sextenary Quadratic Forms Whose Coefficients Are 1, 2, 3 and 6

Here, we determine formulae, for the numbers of representations of a positive integer by certain sextenary quadratic forms whose coefficients are 1, 2, 3 and 6.

General Integral Formulasof （0, q）（q 〉 0）Differential Forms on the Analytic Varieties

In this paper, firstly using different method and technique we derive the cor-responding integral representation formulas of （0, q）（q 〉 0） differential forms for the twotypes of the bounded domains in complex submanifolds with codimension-m. Secondly weobtain the unified integral representation formulas of （0, q）（q 〉 0） differential forms for thegeneral bounded domain in complex submanifold with codimension-m, which include Hatzi-afratis formula, i.e. Koppelman type integral formula for the bounded domain with smoothboundary in analytic varieties. In particular, when m -- 0, we obtain the unified integralrepresentation formulas of （0, q）（q 〉 0） differential forms for general bounded domain in Cn,which are the generalization and the embodiment of Koppelman-Leray formula.

商品房住宅区公共物业自治管理制度分析 以上海市水仙苑小区为例

The reform of the housing system in Shanghai has unexpectedly given rise to a self-governed property owners’ collective supervisory system, primarily in the form of Property Owners’ Supervisory Council (POSC), which has picked up some of the government’s administrative functions. Although this new, institutionalized management model has theoretically made democratic managerial participation at the grassroots level possible, it has brought about endless problems, overt and covert, shortly after its appearance, some of which are even alarming. A comprehensive analysis of the data collected over a long period of time has led to the conclusion that this system is a failure, attributable to the overt factor related to skills in reality and the covert “priori” factor that is masked by the former. The existence of such “priori” factor once again demonstrates the deep-rooted, traditional managerial logic: Positive operations is society need only to depend upon individuals’ unstable self-disciplined morality rather than to build a system. The current paper points out that any change in the socioeconomic structure that has long been subject to the power of politics is to inevitably incur a corresponding global structural accommodation, including politics itself. To respond to the two factors for the failure, system building in the two overlapping areas is a must.

关于UNIX（XENIX）下FORMS处理功能的实现

关于ＵＮＩＸ（ＸＥＮＩＸ）下ＦＯＲＭＳ处理功能的实现中国银行山西省分行信息科技处韩文清一、引言随着计算机应用水平的提高，多用户的ＵＮＩＸ（ＸＥＮＩＸ）操作系统在金融界得到广泛的应用，大量的应用软件系统是在ＵＮＩＸ／ＸＥＮＩＸ项下运转的，为了给用户提供...

Huaitang New Nine Forms of Needles of China Start a New Era of Acupuncture Therapy

"Nine forms of needles"were the nine kinds of ancientacupuncture tools,which were made of different stones and met-als in China,firstly recorded in the anctient monumental work,The Yellow Emperor’s Canon of Internal Medicine(722-221 B.C.).After that,except the filiform needle,the others had beenlost gradually.Fortunately,the eminent clinical acupuncturist

Genetics of Gossypol Content and Its Racemic Forms

Our goal is to develop elite lines with low total gossypol levels in the seed using conventional genetic techniques.There are a number of ways to reduce seed gossypol,including mechanical

Metabolism of minor isoforms of prion proteins Cytosolic prion protein and transmembrane prion protein

Transmissible spongiform encephalopathy or prion disease is triggered by the conversion from cellular prion protein to pathogenic prion protein. Growing evidence has concentrated on prion protein configuration changes and their correlation with prion disease transmissibility and patho- genicity. In vivo and in vitro studies have shown that several cytosolic forms of prion protein with specific topological structure can destroy intracellular stability and contribute to prion protein pathogenicity. In this study, the latest molecular chaperone system associated with endoplasmic re- ticulum-associated protein degradation, the endoplasmic reticulum resident protein quality-control system and the ubiquitination proteasome system, is outlined. The molecular chaperone system directly correlates with the prion protein degradation pathway. Understanding the molecular mechanisms will help provide a fascinating avenue for further investigations on prion disease treatment and prion protein-induced neurodegenerative diseases.

In situ atomic-scale observation of size-dependent (de) potassiation and reversible phase transformation in tetragonal FeSe anodes

Potassium-ion batteries(PIBs)are considered promising alternatives to lithium-ion batteries owing to cost-effective potassium resources and a suitable redox potential of-2.93 V(vs.-3.04 V for Li+/Li).However,the exploration of appro-priate electrode materials with the correct size for reversibly accommodating large K+ions presents a significant challenge.In addition,the reaction mecha-nisms and origins of enhanced performance remain elusive.Here,tetragonal FeSe nanoflakes of different sizes are designed to serve as an anode for PIBs,and their live and atomic-scale potassiation/depotassiation mechanisms are revealed for the first time through in situ high-resolution transmission electron micros-copy.We found that FeSe undergoes two distinct structural evolutions,sequen-tially characterized by intercalation and conversion reactions,and the initial intercalation behavior is size-dependent.Apparent expansion induced by the intercalation of K+ions is observed in small-sized FeSe nanoflakes,whereas unexpected cracks are formed along the direction of ionic diffusion in large-sized nanoflakes.The significant stress generation and crack extension originating from the combined effect of mechanical and electrochemical interactions are elucidated by geometric phase analysis and finite-element analysis.Despite the different intercalation behaviors,the formed products of Fe and K_(2)Se after full potassiation can be converted back into the original FeSe phase upon depotassiation.In particular,small-sized nanoflakes exhibit better cycling perfor-mance with well-maintained structural integrity.This article presents the first successful demonstration of atomic-scale visualization that can reveal size-dependent potassiation dynamics.Moreover,it provides valuable guidelines for optimizing the dimensions of electrode materials for advanced PIBs.

Occurrence of Different Forms and Implications of Compound Specific Sterols in Continental Sediments of the Northeast South China Sea

The South China Sea(SCS) is one of the most productive and accumulative marginal shelves of organic carbon in the world. To expound the transformation and preservation of organic carbon in the Northeast SCS, where abundant oil and gas resources have been reported, compound specific sterols in free(FR), base hydrolytic(BH), and acid hydrolytic(AH) forms were analyzed in surface and columnar sediments in May, 2016. The results showed that the total contents of sterols detected ranged from 0.15 to 3.74 ppm dry weight in the surface sediments, and gradually decreased from 3.41 to0.17 ppm dry weight from surface to deep sediments, in which cholesterol(27^(△5)) was the most abundant component. Sterols mainly existed in the BH form(54.51%-74.20%), followed by the FR form(25.50%-45.49%) and then the AH form(0-3.77%) in turn, in the surface sediments. BH and FR sterols accounted for 0-49.08% and 50.92%-100% in the columnar sediments, while AH sterols were undetectable. The contents of specific sterols indicated that, the primary source of marine organic carbon was about 5 times as much as that from terrestrial input. More and more FR sterols transformed into BH sterols with increasing sedimentary depth, and BH sterols absolutely dominated in sediment depths under 25 cm. The forms of Sterols C27 were maintained at a relative consistence state, but Sterols C28 to C30 degraded gradually during the sedimentation process. It was suggested that the stability of sterols, based on the chemical structures, might be the primary factor controlling their degradation and preservation in deeper sediments. These results would help to understand the organic carbon(OC) transformation in a hydrate formation area in a marginal sea.

Level of Macronutrients and Microelements of Blood Plasma in Different Forms of Pulmonary Tuberculosis

By the method of atomic emission spectrometry with inductively coupled plasma, the content of macro and microelements in the blood plasma of 35 practically healthy people living in the Northern region of Azerbaijan and in the Nizhny Novgorod region of the Russian Federation was studied as well as of 23 patients with pulmonary tuberculosis with different phases of the disease. The elemental homeostasis of the blood plasma did not significantly differ depending on the region of residence, except for the potassium level (by 1.3 times greater for Russians) and strontium (by 10 times higher among the inhabitants of the Northern region of Azerbaijan). In patients with focal pulmonary tuberculosis, there were no significant differences in the content of elements in the blood plasma. With pulmonary tuberculosis, accompanied by decomposition processes, the content of calcium, copper, zinc and iron in blood plasma significantly increases in comparison with healthy people. Analysis of the level of these macro- and microelements can be used to determine the transition of the early form of pulmonary tuberculosis to infiltrative and/or cavernous forms, in which the patient becomes epidemiologically dangerous to others.

Substrate colonization and relative abundance of immature forms of black flies (Diptera: Simuliidae) in river Mada, Nasarawa State Nigeria

Black flies, vectors of Onchocercavolvulus, are known to colonize fast flowing sections of rivers.A study on aspects of ecology of immature forms of black flies was conducted at River Mada. Larvae and Pupae of the Genus: Simulium were prospected on natural substrates found at various water currents along the course of the river over a 12-month period. Larvae of six speciesand pupae of three species were identified colonizing different substrates in the river. A total of 443 larvae and 142 pupae were collected, and thepeak month of collection was April. 405 (91.4%) larvae were identified as S.damnosum sl while 38 (8.6%) comprised S. adersi, S.hargreavesi, S.cervicornotum, S. bovisand S.vorax. 110 (77.5%) of the pupae collected were S.damnosumsl while 32 (22.5%) were S.adersi, and S.hargreavesi. The larvae unlike pupae appeared to be non discriminatory in substrate colonization and current preference. Paucity of the population of immature forms is observed and attributed primarily to scarcity of suitable substrates and other factors also discussed herein.