General calculation formulas and recurrence relations of radial matrix elements for relativistic n-dimensional hydrogen atom of spin S=0

In this paper, the general calculation formulas of radial matrix elements for relativistic n-dimensional hydrogen atom of spin S=0 are obtained, and the recurrence relation of different power order radial matrix elements are also derived.

Research on Stoichiometry of Early-spring Herbs Functional Group in the Subtropical Artificial Wetland

[Objective]The aim was to carry out stoichiometry on the early-spring herbs functional group in subtropical artificial wetland.[Method]UV-Vis spectrophotometer was used for the determination of nitrate-nitrogen,ammonium nitrogen and phosphorus concentrations.Potassium persulfate absorptiometry was used for the measurement of total N content,while the flame photometer was used to detect the potassium and sodium concentration in plants.All the nutrient determination of plant samples were repeated for four times.[Result]The four nutrient concentrations in almost all samples were in the normal range of natural plant nutrition concentrations;in early-spring herbs functional groups,different species showed diversity on the nutrient concentrations;plant height had no significant effect on the nutrient concentrations in plants;the nutrient concentrations of non-grass group plants were higher than that of grass group plants;the nutrient concentrations of the annual herb were higher than that of perennial herbs.[Conclusion]The study had provided basis for the understanding of the effects of changes in nutritional conditions on species diversity,community structure and succession of the system.

Mechanism of improving skin barrier function in a mouse model of atopic dermatitis using Mahuang Lianqiao Chixiaodou decoction and its disassembled formula

Objective: To reveal the mechanism of Mahuang Lianqiao Chixiaodou decoction and its disassembled formula for improving the skin barrier function in a mouse model of atopic dermatitis(AD).Methods: Sixty specific-pathogen free male BALB/c mice were randomly divided into the control group,model group, whole formula group(WF), exterior-releasing formula group(ERF), interior-clearing formula group(ICF), and positive control group(PC). A mouse model of AD was established using the semiantigen 2,4-dinitrofluorobenzene induction method. The lesion scores, transepidermal water loss and p H, and skin histopathology of mice in each group were observed. The expressions of filaggrin, loricrin,and involucrin were detected by the streptavidin peroxidase immunohistochemical method and western blotting, and their mRNA expressions were detected by quantitative polymerase chain reaction.Results: Mice in the WF, ERF, ICF, and PC groups showed reduced skin lesion performance, improved histopathology, decreased skin lesion score, transepidermal water loss and pH, and upregulated expressions of proteins including filaggrin, loricrin, and involucrin, and their mRNAs. The most obvious regulatory effect was observed in the WF group, followed by the ICF, ERF, and PC groups, accordingly.Conclusions: Mahuang Lianqiao Chixiaodou decoction and its disassembled formula can improve the skin barrier function in a mouse model of AD by upregulating filaggrin, loricrin, and involucrin, and their mRNA expressions, and the most optimal effect was noted in the WF group, followed by the ICF and ERF groups, which suggests that the effect of clearing heat and resolving dampness in improving the skin barrier function of AD is more obvious and is one of the key treatments for AD.

Analysis of nutritional elements in Indian medicinal herbs used to cure general weakness

Concept of trace elements being “the Inorganic Switches” has evolved during last several decades. Ayurveda, the traditional Indian medicinal system also emphasises the importance of minor and trace elements in human health and disease. To evaluate elemental contents of some commonly used to cure general weakness, 3 medicine herbs namely Beezband (seeds), Gok-shur (fruit) and Talmakhana (seeds) have been analyzed for four minor (Na, K, Mg and Ca) and eight trace elements (Cr, Mn, Fe, Co, Ni, Cu, Zn and Cd) by atomic absorption spectrometry and flame photometry. Their accuracy was measured by replicate analyses. In general, elemental contents were found in varying amounts with large range. It is observed that many of medicinal herbs are enriched in one or more elements. Since these elements are bioavailable in natural form, probably in combination with organic constituents, these are likely to be easily assimilated by human Bodies. Besides them, two toxic elements Ni and Cd were also found in insignificant amounts as these are likely to have originated from environmental contamination.

Comparison of perfectly matched layer and multi-transmitting formula artificial boundary condition based on hybrid finite element formulation

The theory of perfectly matched layer （PML） artificial boundary condition （ABC）, which is characterized by absorption any wave motions with arbitrary frequency and arbitrarily incident angle, is introduced. The construction process of PML boundary based on elastodynamic partial differential equation （PDE） system is developed. Combining with velocity-stress hybrid finite element formulation, the applicability of PML boundary is investigated and the numerical reflection of PML boundary is estimated. The reflectivity of PML and multi-transmitting formula （MTF） boundary is then compared based on body wave and surface wave simulations. The results show that although PML boundary yields some reflection, its absorption performance is superior to MTF boundary in the numerical simulations of near-fault wave propagation, especially in comer and large angle grazing incidence situations. The PML boundary does not arise any unstable phenomenon and the stability of PML boundary is better than MTF boundary in hybrid finite element method. For a specified problem and analysis tolerance, the computational efficiency of PML boundary is only a little lower than MTF boundary.

Wavy Distribution of Trace Elements in Phytolacca Samples from Different Areas

To study the distribution of 25 elements, i.e. Be, Cd, Ce, Cr, Cu, Dy, Er,Eu, Gd, Ge, Ho, La, Lu, Mo, Nd, Pb, Pr, Sm, Sr, Tb, Tl, Tm, Y, Yb and Zn in Phytolacca, atraditional Chinese medicinal herb, collected from nine areas of P. R. China. Methods Twenty-fiveelements in Phytolacca including essential elements, toxic elements and rare earth elements intraditional Chinese medicinal herbs from different areas were analyzed by ICP-MS. Results The 25elements in Phytolacca were determined by ICP-MS under optimized conditions. The detection limitswere 0.003 -0.71 ng·mL^(-1). The recoveries were 88% - 118% . The relative standard deviations ofthe measurements were 1.7% - 13.3%. Conclusion The determined concentrations of elements inPhytolacca acinosa Roxb vary from one area to another; however, the distribution tendency ofelements in all the samples is similar. The distribution tendency of rare earth elements inPhytolacca acinosa Roxb is consistent with that in nature.

Traditional Chinese medicine for prevention and treatment of hepatocarcinoma: From bench to bedside

Traditional Chinese medicine(TCM) has played a positive role in the management of hepatocarcinoma. Hepatocarcinoma patients may present Qi-stagnation, damp-heat, blood stasis, Qi-deficiency, Yin-deficiency and other TCM syndromes(Zheng). Modern treatments such as surgery, transarterial chemoembolization(TACE) and high intensity focus ultrasound treatment would influence the manifestation of TCM syndromes. Herbs with traditional efficacy of tonifying Qi, blood and Yin, soothing liver-Qi stagnation, clearing heat and detoxifying and dissolving stasis, have been demonstrated to be potent to prevent hepatocarcinogenesis. TCM has been widely used in all aspects of integrative therapy in hepatocarcinoma, including surgical resection, liver transplantation, TACE, local ablative therapies and even as monotherapy for middle-advanced stage hepatocarcinoma. Clinical practices have confirmed that TCM is effective to alleviate clinical symptoms, improve quality of life and immune function, prevent recurrence and metastasis, delay tumor progression, and prolong survival time in hepatocarcinoma patients. The effective mechanism of TCM against hepatocarcinoma is related to inducing apoptosis, autophagy, anoikis and cell senescence, arresting cell cycle, regulating immune function, inhibiting metastasis and angiogenesis, reversing drug resistance and enhancing effects of chemotherapy. Along with the progress of research in this field, TCM will contribute more to the prevention and treatment of hepatocarcinoma.

Research on Herb Pairs of Classical Formulae of ZHANG ZhongJing Using Big Data Technology

Objective To analyze various herbal combinations in Treatise on Exogenous Febrile Diseases(Shang Han Lun,《伤寒论》)and Synopsis of Prescriptions of the Golden Chamber(Jin Gui Yao Lve,《金匮要略》),seeking to identify fundamental rules dictating the selection of herbal combinations through probability models and big data technology.Methods A total of 252 formulae were collected from Treatise on Exogenous Febrile Diseases(Shang Han Lun,《伤寒论》)and Synopsis of Prescriptions of the Golden Chamber(Jin Gui Yao Lve,《金匮要略》)by ZHANG Zhong-Jing.Formulae were then preprocessed with all herb names standardized.The concepts of candidate herb pair and candidate herb pair probability were proposed to analyze the rules of combinations in classical formulae based on probability statistics.MapReduce parallel computing framework of distributed big data technology was adopted to analyze large data samples combined with inverted index algorithm.Results The results showed that the core herbs were Glycyrrhizae Radix Rhizoma(Gan Cao,甘草),Cinnamomi Ramulus(Gui Zhi,桂枝),Zingiberis Rhizoma Recens(Sheng Jiang,生姜),Jujubae Fructus(Da Zao,大枣),Paeoniae Radix Alba(Bai Shao,白芍),etc.43 high-frequency pairs co-occurring 10 times or above were extracted,and 35 of these combinations were recognized as traditional herb pairs,such as Cinnamomi Ramulus(Gui Zhi,桂枝)-Glycyrrhizae Radix Rhizoma(Gan Cao,甘草),Zingiberis Rhizoma Recens(Sheng Jiang,生姜)-Jujubae Fructus(Da Zao,大枣),and Cinnamomi Ramulus(Gui Zhi,桂枝)-Ginseng Radix Et Rhizoma(Ren Shen,人参).The other 8 pairs of combinations,such as Paeoniae Radix Alba(Bai Shao,白芍)-Zingiberis Rhizoma Recens(Sheng Jiang,生姜),Paeoniae Radix Alba(Bai Shao,白芍)-Jujubae Fructus(Da Zao,大枣),and Zingiberis Rhizoma Recens(Sheng Jiang,生姜)-Ginseng Radix Et Rhizoma(Ren Shen,人参),were not defined traditionally,but in connection with commonly used herbs.Classical formulae took the core herbs as principles,focusing on tonifying deficiency,strengthening the spleen and the stomach,strengthening the healthy Qi,and eliminating pathogenic factors.The compatibility pattern of properties involved was mainly acrid and sweet,which reflected the compatibility laws of benefiting Qi and tonifying Yang,replenishing Qi and nourishing blood,etc.Conclusions The research of classical formulae provides common understanding of some basic rules that have been adopted to tackle common illnesses/diseases using herbal medicine.The results help to reinforce theoretical understanding and development of traditional Chinese medicine(TCM),and revealing the hidden rules of combination in TCM data.Analyzing wider data samples of various herbal combinations through computation and big data technology can further optimize the use of TCM.

A Multilayer Network Constructed for Herb and Prescription Efficacy Analysis

Chinese Medicine(CM)has been widely used as an important avenue for disease prevention and treatment in China especially in the form of CM prescriptions combining sets of herbs to address patients’symptoms and syndromes.However,the selection and compatibility of herbs are complex and abstract due to intrinsic relationships between herbal properties and their overall functions.Network analysis is applied to demonstrate the complex relationships between individual herbal efficacy and the overall function of CM prescriptions.To illustrate their connections and correlations,prescription function(PF),prescription herb(PH),and herbal efficacy(HE)intranetworks are proposed based on CM theory to identify relationships between herbs and prescriptions.These three networks are then connected by PF-PH and PH-HE interlayer networks adopting herb dosage to form a multidimensional heterogeneous network,a Prescription-Herb-Function Network(PHFN).The network is applied to 112 classic prescriptions from Treatise on Exogenous Febrile and Miscellaneous Diseases to illustrate the application of PHFN.The PHFN is constructed including 146 functions in PF intra network,89 herbs in the PH intra network,and 163 herbal efficacies in the HE intra network.The results show that herb pairs with synergistic actions have stronger relevance,such as licorice-cassia twig,licorice-Chinese date,fresh ginger-Chinese date,etc.The integration of dosage to the network helps to indicate the main herbs for cluster analysis and automatic formulation.PHFN also reveals the internal relationships between the functions of prescriptions and composed herbal efficacies.

An explicit method for numerical simulation of wave equations

In this paper, a method to develop a hierarchy of explicit recursion formulas for numerical simulation in an irregular grid for scalar wave equations is presented and its accuracy is illustrated via 2-D and 1-D models. Approaches to develop the stable formulas which are of 2M-order accuracy in both time and space with Mbeing a positive integer for regular grids are discussed and illustrated by constructing the second order （M= 1） and the fourth order （M = 2） recursion formulas.

An explicit method for numerical simulation of wave equations: 3D wave motion

In this paper, an explicit method is generalized from 1D and 2D models to a 3D model for numerical simulation of wave motion, and the corresponding recursion formulas are developed for 3D irregular grids. For uniform cubic grids, the approach used to establish stable formulas with 2M-order accuracy is discussed in detail, with M being a positive integer, and is illustrated by establishing second order （M=1） recursion formulas. The theoretical results presented in this paper are demonstrated through numerical testing.

Trace heavy metals and harmful elements in roots and rhizomes of herbs:Screening level analysis and health risk assessment

Objective:Heavy metal and harmful element contamination are frequently reported in Chinese herbal medicines(CHMs),and roots and rhizomes parts showed a higher content than other parts.To investigate the residue level and assess the potential human health risk of heavy metals and harmful elements in roots and rhizomes,720 batches of the sample representing 20 species of herbs from different sources were collected.Methods:The content of Pb,Cd,As,Hg,and Cu in the digests was determined using ICP-MS.The chronic hazard index estimate based on non-cancer hazard quotient(HQ)was applied for potential health risk assessment of Pb,Cd,As,Hg,and Cu via consumption of CHMs.Results:Compared with the Chinese limit standard(Chinese Pharmacopoeia Commission,2020 edition)of Pb,Cd,As,Hg,and Cu in Ginseng Radix et Rhizoma,the exceedance percentage of Pb in total samples was 14.1%,which were generally far higher than Cd,As,Hg,and Cu.Health risk assessment results based on hazard quotient calculating showed that total HQ of Cu,Pb,As,Cd,and Hg in Pulsatillae Radix and Clematidis Radix et Rhizoma exceeded 1,with the value of 1.543 and 1.235.Besides,Arsenic had the highest HQ value(0.957)in Pulsatillae Radix.Conclusion:Consuming raw materials of Pulsatillae Radix and Clematidis Radix et Rhizoma may pose a potential risk and Arsenic residues in Pulsatillae Radix deserved special attention.

Behavior of galvanized steel tube subjected to web crippling

The details of a research study of galvanized steel tube under web crippling were presented. A total of 48 galvanized steel square hollow sections with different boundary conditions, loading conditions, bearing lengths and web slenderness were tested. The experimental scheme, failure modes, load-displacement curves and strain intensity distribution curves were also presented. The investigation was focused on the effects of loading condition, bearing length and slenderness on web crippling ultimate capacity, initial compressive stiffness and ductility of galvanized steel tube. The results show that web crippling ultimate capacity increases linearly with the increase of the bearing length under EOF and IOF loading condition. In the end-flange and ITF loading conditions, strain intensity of the centerline of web reaches the peak and decreases progressively from central web to flanges. Finite element models were developed to numerically simulate the tests in terms of failure modes and ultimate capacity. Web crippling strength of galvanized steel tube increases linearly with the increase of the ratio of the bearing length to web thickness and decrease of web slenderness. The effect of ratio of galvanized layer thickness to web thickness on web crippling strength is small. Based on the results of the parametric study, a number of calculation formulas proposed in this work can be successfully employed as a design rule for predicting web crippling ultimate capacity of galvanized steel tube under four loading and boundary conditions.

改进蚁群算法的送餐机器人路径规划

蚁群算法拥有良好的全局性、自组织性、鲁棒性,但传统蚁群算法存在许多不足之处。为此,针对算法在路径规划问题中的缺陷,在传统蚁群算法的状态转移公式中,引入目标点距离因素和引导素,加快算法收敛性和改善局部最优缺陷。在带时间窗的车辆路径问题(vehicle routing problem with time windows,VRPTW)上,融合蚁群算法和遗传算法,并将顾客时间窗宽度以及机器人等待时间加入蚁群算法状态转移公式中,以及将蚁群算法的解作为遗传算法的初始种群,提高遗传算法的初始解质量,然后进行编码,设置违反时间窗约束和载重量的惩罚函数和适应度函数,在传统遗传算法的交叉、变异操作后加入了破坏-修复基因的操作来优化每一代新解的质量,在Solomon Benchmark算例上进行仿真,对比算法改进前后的最优解,验证算法可行性。最后在餐厅送餐问题中把带有障碍物的仿真环境路径规划问题和VRPTW问题结合,使用改进后的算法解决餐厅环境下送餐机器人对顾客服务配送问题。

系统辨证脉学指导下的经方临床应用

经方具有药味精简、配伍严谨、力专效显的特点,为后世所推崇,但在实际应用中却存在诸多难点,使得临床应用受限。系统辨证脉学将脉象要素与经方方证相结合,能够更全面地反映疾病病因病机,为经方的应用提供更加准确的依据。介绍1例头晕案例,详细描述其脉象要素特征及有辨证意义的“证”,将脉象要素与“方证”使用相结合,处方经典方剂,取得较好临床疗效。将脉诊与经方相结合,可以提高经方的临床应用效果,此临床辨证思路值得推广。

二维层状盆地地震动附加放大特征研究:SV波入射

发展了一种基于谱元法和多次透射边界的平面SV波入射下二维复杂场地波动数值模拟方法。基于该方法,模拟分析了31条地震波输入下二维典型层状沉积盆地中的各场点相比其对应的一维土层模型的模拟地震动的附加放大特征,分析了放大系数对于输入地震波的敏感性。结果表明,该方法具有较高精度和良好的高频稳定性。不同地震波输入下,盆地地面运动及其放大特征存在较大差别。水平分量上平均反应谱放大系数的较大值(最大1.2左右)集中在盆地边缘区域及周期等于0.5倍~0.7倍自振周期附近,垂直分量上较大放大系数(最大0.9左右)紧邻盆地角点且周期为0.3倍自振周期处。同时,盆地对不同周期地震动的放大特征,以及不同位置点的谱放大系数随周期的变化规律均表现出明显不同,相对短周期地震动的盆地边缘效应最为强烈,而相对长周期地震动的放大作用明显减弱。此外,盆地边缘区域的放大系数对输入波最为敏感,不同地震波输入下放大系数值在较大范围内变化;而盆地中间区域的放大系数对输入波不敏感,其值的变化范围相对较小。

系统辨证脉学指导下“脉方相应”新模式的构建

方剂是中医学防治疾病的基本措施之一,其整体功效与疾病的病机相对应,以调节机体整体平衡。脉诊的目的是通过诊察脉象之所得,总结梳理病因、病机,服务于疾病的判断分析和治疗过程。通过脉象特征分析,可以推导疾病的病因、病机、预后转归,从而确定治则治法与方剂药物。脉象和方剂在病机方面存在明确的内在契合关系,通过分析此关系,临床可以达到“证从脉出,方随证立”的目的。系统辨证脉学以其客观实在性,在揭示潜在病因病机、状态性病因病机等方面有其自身的优势,分析推理结果可以直接作为选择方药、调整药味、剂量和配伍关系的依据,从而建立全新的脉方相应新模式。

中医药预防大肠息肉术后复发证型证素分布及用药规律研究

目的:探讨近二十年各医家预防大肠息肉术后复发证型证素分布及用药规律,为中医药预防大肠息肉术后复发提供新的思路。方法:以各医家处方为切入点,提取处方涉及的证候类型、病位证素、病性证素及药物组成,基于中医传承辅助平台(V2.5)软件,运用关联规则、系统熵聚类等一系列高级的数据挖掘方法,总结处方的证型证素分布、用药频次、性味、归经、药物相关性以及聚类情况。结果:共收集到数据库相关文献所载预防大肠息肉复发的处方105首,涉及中医证型30种,中药186味。其中核心药物组合139对,潜在常用药对157对,新处方3首。结论:脾胃虚弱是大肠息肉的核心病机,治疗当以健脾益胃为基础,根据不同患者血瘀、湿阻、痰凝、热毒等的差异,佐以活血、祛湿、化痰、清热之法,标本兼治,方获良效。

方剂学课程思政研究概览

该文探讨方剂学课程思政的研究现状,为深入挖掘思政元素,广泛开辟实施途径集成更多的策略与方法。全面梳理方剂学教学中开展课程思政的相关文献,分析方剂学课程思政在全国各院校开展的实际情况,结合专业内容对可公知公用的思政元素融入策略、思政内涵等进行全面总结,同时探索课程思政的实施途径。共纳入源于全国28家单位的38篇文献,通过讲授式、案例式、讨论式、竞赛式和情景模拟式等教学方法,将精术尚德、传承守正、刻苦钻研、勇于创新和家国情怀等思政内涵悄然渗透到方剂学总论到各论的19个章节中。方剂学作为思政教育与专业课充分融合的主阵地,在以立德树人为根本任务的高校中医药人才培养过程中正发挥着巨大作用。