The influence derived from atmosphere transmitting of radar wave, in the application of high-resolution airborne Synthetic Aperture Radar (SAR) stereo positioning, may produce some phase errors, and eventually be intr...The influence derived from atmosphere transmitting of radar wave, in the application of high-resolution airborne Synthetic Aperture Radar (SAR) stereo positioning, may produce some phase errors, and eventually be introduced into positioning model. This paper described the principle of airborne SAR stereo positioning and the error sources of stereo positioning accuracy that arose from atmosphere transmitting, established a corresponding assess- ment model of atmosphere transmitting influence, and testified the model and the assessment principle taking the 1-m resolution airborne SAR images of Zigong City, Sichuan Province in China, as the test dataset. The test result has proved that the assessment model is reliable and reasonable. And, it has shown that the phase error arisen from time delay is the main error source during the atmosphere transmitting, which has much more influences on cross-track di- rection and introduces a stereo positioning error of about eight meters, but less on the along-track direction.展开更多
Identifying relevant animal challenge models adds to the complexity of human vaccine development. Murine challenge models have been the most utilized animal model for Chlamydia trachomatis vaccine development. The que...Identifying relevant animal challenge models adds to the complexity of human vaccine development. Murine challenge models have been the most utilized animal model for Chlamydia trachomatis vaccine development. The question arises as to whether the C. trachomatis or C. muridarum pre-clinical model is optimal. We compared C. muridarum and C. trachomatis intravaginal challenge models in a combined total of seventy-five studies evaluating potential vaccine candidates. In 100% (42/42) of C. muridarum studies, mice immunized with Chlamydia elementary bodies (EB) demonstrated a significant reduction in urogenital bacterial shedding as measured by qPCR (p C. trachomatis studies. We have evaluated proposed vaccine antigens in both models and observed immunization with Chlamydia major outer membrane protein (MOMP) vaccine formulations to be protective (p C. trachomatis model, and immunization with PmpD p82 translocator domain was not protective in either model. We also observed in both models that depletion of CD4+ T-cells in MOMP-immunized mice resulted in diminished protective immunity but animals were still able to reduce the infection level. In contrast, mice immunized with live EBs by intraperitoneal route did not require CD4+ T-cells to resolve urogenital infection from intravaginal challenge in either model. Overall, we have found the C. muridarum model to be a more robust, reliable, and reproducible model for vaccine antigen discovery.展开更多
基金Under the auspices of National High Technology Research and Development Program of China (No. 2001AA132010)
文摘The influence derived from atmosphere transmitting of radar wave, in the application of high-resolution airborne Synthetic Aperture Radar (SAR) stereo positioning, may produce some phase errors, and eventually be introduced into positioning model. This paper described the principle of airborne SAR stereo positioning and the error sources of stereo positioning accuracy that arose from atmosphere transmitting, established a corresponding assess- ment model of atmosphere transmitting influence, and testified the model and the assessment principle taking the 1-m resolution airborne SAR images of Zigong City, Sichuan Province in China, as the test dataset. The test result has proved that the assessment model is reliable and reasonable. And, it has shown that the phase error arisen from time delay is the main error source during the atmosphere transmitting, which has much more influences on cross-track di- rection and introduces a stereo positioning error of about eight meters, but less on the along-track direction.
文摘Identifying relevant animal challenge models adds to the complexity of human vaccine development. Murine challenge models have been the most utilized animal model for Chlamydia trachomatis vaccine development. The question arises as to whether the C. trachomatis or C. muridarum pre-clinical model is optimal. We compared C. muridarum and C. trachomatis intravaginal challenge models in a combined total of seventy-five studies evaluating potential vaccine candidates. In 100% (42/42) of C. muridarum studies, mice immunized with Chlamydia elementary bodies (EB) demonstrated a significant reduction in urogenital bacterial shedding as measured by qPCR (p C. trachomatis studies. We have evaluated proposed vaccine antigens in both models and observed immunization with Chlamydia major outer membrane protein (MOMP) vaccine formulations to be protective (p C. trachomatis model, and immunization with PmpD p82 translocator domain was not protective in either model. We also observed in both models that depletion of CD4+ T-cells in MOMP-immunized mice resulted in diminished protective immunity but animals were still able to reduce the infection level. In contrast, mice immunized with live EBs by intraperitoneal route did not require CD4+ T-cells to resolve urogenital infection from intravaginal challenge in either model. Overall, we have found the C. muridarum model to be a more robust, reliable, and reproducible model for vaccine antigen discovery.
