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Specific killing effect of diphtheria toxin A fragment under control of DF3 promotor on human breast cancer cells
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作者 Ming Cai Wenguang Huang Wei Luo Sheng Pan Tao Yin 《The Chinese-German Journal of Clinical Oncology》 CAS 2007年第2期200-203,共4页
Objective: To study the effects of recombinant expression vector containing human breast cancer DF3 promotor and diphtheria toxin A fragment on human breast cancer cells. Methods: Constructing recombinant expression v... Objective: To study the effects of recombinant expression vector containing human breast cancer DF3 promotor and diphtheria toxin A fragment on human breast cancer cells. Methods: Constructing recombinant expression vector PGL3-DF3-DTA and transfecting it into human breast cancer cells of DF3 positive and negative. By means of RT-PCR to measure the expression of DTA in human breast cancer cells. MTT color-imetry was used to examine the effect of PGL3-DF3-DTA on growth of human breast cancer cells. By experiment on nude mice to observe the killing effect of PGL3-DF3-DTA on human breast cancer cells. Results: Recombinant expression vector PGL3-DF3-DTA was highly expressed in human breast cancer cell line of DF3 positive, and it could kill the human breast cancer cells not only in vitro but also in vivo. Conclusion: Recombinant expression vector PGL3-DF3-DTA could produce specific killing effect on human breast cancer cell line of DF3 positive. 展开更多
关键词 DF3 diphtheria toxin A fragment gene expression gene therapy breast cancer
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10-Million Atoms Simulation of First-Principle Package LS3DF
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作者 严昱瑾 李海波 +6 位作者 赵曈 汪林望 石林 刘涛 谭光明 贾伟乐 孙凝晖 《Journal of Computer Science & Technology》 SCIE EI CSCD 2024年第1期45-62,共18页
The growing demand for semiconductor devices simulation poses a big challenge for large-scale electronic structure calculations.Among various methods,the linearly scaling three-dimensional fragment(LS3DF)method exhibi... The growing demand for semiconductor devices simulation poses a big challenge for large-scale electronic structure calculations.Among various methods,the linearly scaling three-dimensional fragment(LS3DF)method exhibits excellent scalability in large-scale simulations.Based on algorithmic and system-level optimizations,we propose a highly scalable and highly efficient implementation of LS3DF on a domestic heterogeneous supercomputer equipped with acceler-ators.In terms of algorithmic optimizations,the original all-band conjugate gradient algorithm is refined to achieve faster convergence,and mixed precision computing is adopted to increase overall efficiency.In terms of system-level optimiza-tions,the original two-layer parallel structure is replaced by a coarse-grained parallel method.Optimization strategies such as multi-stream,kernel fusion,and redundant computation removal are proposed to increase further utilization of the com-putational power provided by the heterogeneous machines.As a result,our optimized LS3DF can scale to a 10-million sili-con atoms system,attaining a peak performance of 34.8 PFLOPS(21.2% of the peak).All the improvements can be adapt-ed to the next-generation supercomputers for larger simulations. 展开更多
关键词 single instruction multiple thread accelerator electronic structure high-performance computing linearly scaling three-dimensional fragment(ls3df)
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