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Cement and Lime Stabilization Effect on the Evolutivity of an Expansive Overconsolidated Clay
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作者 Mohamed Khemissa 《Journal of Civil Engineering and Architecture》 2024年第3期134-140,共7页
This paper presents and analyzes the results of a series of compaction,fragmentability and damage tests performed on an expansive overconsolidated clay treated with cement and lime.This clay was obtained from the urba... This paper presents and analyzes the results of a series of compaction,fragmentability and damage tests performed on an expansive overconsolidated clay treated with cement and lime.This clay was obtained from the urban site of Sidi-Hadjrès city(wilaya of M'sila,Algeria),where significant damages frequently appears in the road infrastructures,roadway systems and light structures.Tests results obtained show that the geotechnical parameters values deduced from these tests are concordant and confirm the evolutivity of this natural clay treated with composed Portland cement or extinct lime and compacted under optimum Proctor conditions. 展开更多
关键词 Expansive clay evolutivity treatment CEMENT LIME fragmentability coefficient damage coefficient
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Progressive fragmentation of granular assemblies within rockslides: Insights from discrete-continuous numerical modeling
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作者 JIANG Hui ZHOU Yuande +2 位作者 WANG Jinting DU Xiuli HUANG Hailong 《Journal of Mountain Science》 SCIE CSCD 2024年第4期1174-1189,共16页
Rock fragmentation plays a critical role in rock avalanches,yet conventional approaches such as classical granular flow models or the bonded particle model have limitations in accurately characterizing the progressive... Rock fragmentation plays a critical role in rock avalanches,yet conventional approaches such as classical granular flow models or the bonded particle model have limitations in accurately characterizing the progressive disintegration and kinematics of multi-deformable rock blocks during rockslides.The present study proposes a discrete-continuous numerical model,based on a cohesive zone model,to explicitly incorporate the progressive fragmentation and intricate interparticle interactions inherent in rockslides.Breakable rock granular assemblies are released along an inclined plane and flow onto a horizontal plane.The numerical scenarios are established to incorporate variations in slope angle,initial height,friction coefficient,and particle number.The evolutions of fragmentation,kinematic,runout and depositional characteristics are quantitatively analyzed and compared with experimental and field data.A positive linear relationship between the equivalent friction coefficient and the apparent friction coefficient is identified.In general,the granular mass predominantly exhibits characteristics of a dense granular flow,with the Savage number exhibiting a decreasing trend as the volume of mass increases.The process of particle breakage gradually occurs in a bottom-up manner,leading to a significant increase in the angular velocities of the rock blocks with increasing depth.The simulation results reproduce the field observations of inverse grading and source stratigraphy preservation in the deposit.We propose a disintegration index that incorporates factors such as drop height,rock mass volume,and rock strength.Our findings demonstrate a consistent linear relationship between this index and the fragmentation degree in all tested scenarios. 展开更多
关键词 Rock fragmentation ROCKSLIDE Numerical modelling Discrete-continuous modelling RUNOUT Cohesive zone model
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Effects of landscape fragmentation of plantation forests on carbon storage in the Loess Plateau,China
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作者 LEI Hangyu DUAN Dantong +3 位作者 CHEN Yi GUO Huifeng LI Jiangtao LI Xiang 《Journal of Arid Land》 SCIE CSCD 2024年第2期266-281,共16页
Tree plantation and forest restoration are the major strategies for enhancing terrestrial carbon sequestration and mitigating climate change.The Grain for Green Project in China has positively impacted global carbon s... Tree plantation and forest restoration are the major strategies for enhancing terrestrial carbon sequestration and mitigating climate change.The Grain for Green Project in China has positively impacted global carbon sequestration and the trend towards fragmentation of plantation forests.Limited studies have been conducted on changes in plantation biomass and stand structure caused by fragmentation,and the effect of fragmentation on the carbon storage of plantation forests remains unclear.This study evaluated the differences between carbon storage and stand structure in black locust forests in fragmented and continuous landscape in the Ansai District,China and discussed the effects of ecological significance of four landscape indices on carbon storage and tree density.We used structural equation modelling to explore the direct and indirect effects of fragmentation,edge,abiotic factors,and stand structure on above-ground carbon storage.Diameter at breast height(DBH)in fragmented forests was 53.3%thicker,tree density was 40.9%lower,and carbon storage was 49.8%higher than those in continuous forests;for all given DBH>10 cm,the trees in fragmented forests were shorter than those in continuous forests.The patch area had a negative impact on carbon storage,i.e.,the higher the degree of fragmentation,the lower the density of the tree;and fragmentation and distance to edge(DTE)directly increased canopy coverage.However,canopy coverage directly decreased carbon storage,and fragmentation directly increased carbon storage and tree density.In non-commercial forests,fragmentation reduces the carbon storage potential of plantation,and the influence of patch area,edge,and patchy connection on plantation should be considered when follow-up trees are planted and for the plantation management.Thus,expanding the area of plantation patches,repairing the edges of complex-shaped patches,enhancing the connectivity of similar patches,and applying nutrients to plantation forests at regular intervals are recommended in fragmented areas of the Loess Plateau. 展开更多
关键词 landscape fragmentation PLANTATION carbon storage tree allometry tree density structural equation modelling
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Numerical and experimental investigation on hydraulic-electric rock fragmentation of heterogeneous granite
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作者 Xiaohua Zhu Ling He +3 位作者 Weiji Liu Yunxu Luo Youjian Zhang Wuji Tang 《International Journal of Mining Science and Technology》 SCIE EI CAS CSCD 2024年第1期15-29,共15页
Hydraulic-electric rock fragmentation(HERF)plays a significant role in improving the efficiency of high voltage pulse rock breaking.However,the underlying mechanism of HERF remains unclear.In this study,considering th... Hydraulic-electric rock fragmentation(HERF)plays a significant role in improving the efficiency of high voltage pulse rock breaking.However,the underlying mechanism of HERF remains unclear.In this study,considering the heterogeneity of the rock,microscopic thermodynamic properties,and shockwave time domain waveforms,based on the shockwave model,digital imaging technology and the discrete element method,the cyclic loading numerical simulations of HERF is achieved by coupling electrical,thermal,and solid mechanics under different formation temperatures,confining pressure,initial peak voltage,electrode bit diameter,and loading times.Meanwhile,the HERF discharge system is conducive to the laboratory experiments with various electrical parameters and the resulting broken pits are numerically reconstructed to obtain the geometric parameters.The results show that,the completely broken area consists of powdery rock debris.In the pre-broken zone,the mineral cementation of the rock determines the transition of type CⅠcracks to type CⅡand type CⅢcracks.Furthermore,the peak pressure of the shockwave increased with initial peak voltage but decreased with electrode bit diameter,while the wave front time reduced.Moreover,increasing well depth,formation temperature and confining pressure augment and inhibit HERF,but once confining pressure surpassed the threshold of 60 MPa for 152.40,215.90,and 228.60 mm electrode bits,and 40 MPa for 309.88 mm electrode bits,HERF is promoted.Additionally,for the same kind of rock,the volume and width of the broken pit increase with higher initial peak voltage and rock fissures will promote HERF.Eventually,the electrode drill bit with a 215.90 mm diameter is more suitable for drilling pink granite.This research contributes to a better microscopic understanding of HERF and provides valuable insights for electrode bit selection,as well as the optimization of circuit parameters for HERF technology. 展开更多
关键词 Hydraulic-electric rock fragmentation SHOCKWAVE Thermodynamics MICROCRACKS Weak Linear Parallel Bond Model
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Double casing warhead with sandwiched charge:The axial distribution of fragments velocities
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作者 Ping Ye Yongxiang Dong +5 位作者 Qitian Sun Peizhuo Shi Wang Yao Yongnan Li Yujing Li Mingze Li 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第4期201-216,共16页
The double casing warhead with sandwiched charge is a novel fragmentation warhead that can produce two groups of fragments with different velocity,and the previous work has presented a calculation formula to determine... The double casing warhead with sandwiched charge is a novel fragmentation warhead that can produce two groups of fragments with different velocity,and the previous work has presented a calculation formula to determine the maximum fragment velocity.The current work builds on the published formula to further develop a formula for calculating the axial distribution characteristics of the fragment velocity.For this type of warhead,the simulation of the dispersion characteristics of the detonation products at different positions shows that the detonation products at the ends have a much larger axial velocity than those in the middle,and the detonation products have a greater axial dispersion velocity when they are closer to the central axis.The loading process and the fragment velocity vary with the axial position for both casing layers,and the total velocity of the fragments is the vector sum of the radial velocity and the axial velocity.At the same axial position,the acceleration time of the inner casing is greater than that of the outer casing.For the same casing,the fragments generated at the ends have a longer acceleration time than the fragments from the middle.The proposed formula is validated with the X-ray radiography results of the four warheads previously tested experimentally and the 3D smoothedparticle hydrodynamics numerical simulation results of several series of new warheads with different configurations.The formula can accurately and reliably calculate the fragment velocity when the lengthto-diameter ratio of the charge is greater than 1.5 and the thickness of the casing is less than 20%its inner radius.This work thus provides a key reference for the theoretical analysis and the design of warheads with multiple casings. 展开更多
关键词 Double casing warhead Sandwiched charge Fragment velocity Rarefaction wave Gurney formula Explosive loading
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The relationship between DNA fragmentation and the intensity of morphologically abnormal human spermatozoa
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作者 Mercedes González-Martínez Pascual Sánchez-Martín +2 位作者 Carmen López-Fernández Stephen D.Johnston Jaime Gosálvez 《Asian pacific Journal of Reproduction》 CAS 2024年第1期22-27,共6页
Objective:To determine the relationship between teratozoospermia and sperm DNA fragmentation(SDF)in the human ejaculate.Methods:This retrospective study included 100 normozoospermic men as a control cohort(abnormal fo... Objective:To determine the relationship between teratozoospermia and sperm DNA fragmentation(SDF)in the human ejaculate.Methods:This retrospective study included 100 normozoospermic men as a control cohort(abnormal forms>14%),210 patients with a high level of abnormal forms(≤4%)and 65 patients presenting with a moderate level of abnormal forms(>4%to≤14%)based on the World Health Organization definitions.Sperm morphology was assessed using bright field microscopy.Sperm DNA fragmentation was assessed using the sperm chromatin dispersion assay.Non-parametric analyses were conducted to examine the relationship between abnormal sperm morphology and sperm DNA fragmentation;receiver operating characteristic(ROC)analyses were conducted to assess sensitivity and specificity of this relationship.Results:A correlation analysis revealed that the higher the proportion of abnormal spermatozoa in the ejaculate,the higher the level of SDF(Spearman's Rho=-0.230;P<0.001).Significant differences in the proportion of SDF were found when all cohorts were compared(P<0.001);these significant differences were also retained when the different cohorts were compared pairwise.ROC analysis showed a moderate but significant predictive value for SDF to differentiate patients with different levels of teratozoospemia.Conclusions:Although analysis of a more continuous range of values for teratozoospermia would help further clarify any causal relationship with SDF,there is clearly a synergistic or coincident affiliation between these variables that needs to be acknowledged by the clinician when interpreting the spermiogram. 展开更多
关键词 TERATOZOOSPERMIA Sperm morphology Sperm DNA fragmentation Male factor Human reproduction Human fertility
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美国在内部纷争中走到新的“十字路口”
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作者 CICIR Task Force Zhang Wenzong 《Contemporary International Relations》 2024年第1期29-33,共5页
At the beginning of 2023, the Eurasia Group, a US-based global political risk consultancy, named “the fragmentation of the United States” as one of the top ten global risks in 2023. Looking back at 2023, there is no... At the beginning of 2023, the Eurasia Group, a US-based global political risk consultancy, named “the fragmentation of the United States” as one of the top ten global risks in 2023. Looking back at 2023, there is no better keyword to characterize the United States than “divided.” 展开更多
关键词 内部纷争 FRAGMENTATION KEYWORD
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Achievements and challenges of primate conservation in China
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作者 Bao-Guo Li He Zhang +21 位作者 Ming Li Xue-Long Jiang Peng-Fei Fan Jiang Zhou Song-Tao Guo Xiao-Guang Qi Jin-Hua Li Ji-Qi Lu Dong-Po Xia Liang-Wei Cui Zuo-Fu Xiang Qi-Hai Zhou Zhi-Pang Huang Cheng-Ming Huang Wen Xiao Hui-Jian Hu Zhi-Xin Zhou Ming-Yong Chen Da-Yong Li Peng-Lai Fan Yin Yang Ru-Liang Pan 《Zoological Research(Diversity and Conservation)》 2024年第1期66-74,共9页
The dual impact of climate change and human activities has precipitated a sharp decline in primate biodiversity globally.China is home to the most diverse primate species in the Northern hemisphere,which face severe e... The dual impact of climate change and human activities has precipitated a sharp decline in primate biodiversity globally.China is home to the most diverse primate species in the Northern hemisphere,which face severe ecological threats due to the expansion of modern agriculture,extensive exploitation and consumption of natural resources,and excessive land development during its transition from an agricultural to a modern society.In response,China has implemented various ecological conservation measures,including habitat restoration and protection.These efforts have made substantial strides in biodiversity conservation,with certain regions witnessing an increase in primate populations.In the current study,we conducted a systematic review of historical documents and field research data related to Chinese primates,evaluating the endangered status of primate species in China.Despite improvements in the habitats of most primate species and some population growth,many species still face severe threats,including declining and small populations.Species such as the Myanmar snub-nosed monkey(Rhinopithecus strykeri),eastern black crested gibbon(Nomascus nasutus),and Hainan gibbon(N.hainanus)remain particularly vulnerable due to their limited distribution ranges and extremely small populations.Insufficient scientific data,fragmented information,and not enough studies in conservation biology further compound the challenges.Moreover,there is a notable lack of detailed population monitoring data for species such as the Bengal slow loris(Nycticebus bengalensis),pygmy slow loris(N.pygmaeus),Indochinese gray langur(Trachypithecus crepusculus),Shortridge’s langur(T.shortridgei),and capped langur(T.pileatus),which hinders the development of practical and targeted conservation management strategies.Therefore,for national biodiversity conservation,there is an urgent need for specialized primate surveys,enhancing habitat protection and restoration,and increasing focus on cross-border conservation strategies and regional cooperation.There is also a need to establish a comprehensive and systematic research database platform,conduct continuous and in-depth research in primate biology,and actively engage in the scientific assessment of ecotourism.Additionally,strengthening public awareness and education on wildlife conservation remains essential.Such integrated and systematic efforts will provide scientific support for the current and future conservation and management of primate species in China. 展开更多
关键词 PRIMATES BIODIVERSITY Habitat fragmentation Habitat restoration Conservation strategies
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Research on the Correlation Between rs2110385 Polymorphisms of the Visfatin Gene and Nonproliferative Diabetic Retinopathy
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作者 Min Zhang Rong Li +2 位作者 Wei-guo Ma Xiao-hong Yin Ya Li 《Journal of Clinical and Nursing Research》 2024年第2期220-227,共8页
Objective:To investigate the association between rs2110385 polymorphisms of the visfatin gene and the risk of type 2 diabetic retinopathy(DR).Methods:172 Han subjects were selected from Xi’an Shaanxi Province;140 pat... Objective:To investigate the association between rs2110385 polymorphisms of the visfatin gene and the risk of type 2 diabetic retinopathy(DR).Methods:172 Han subjects were selected from Xi’an Shaanxi Province;140 patients with type 2 diabetes mellitus(T2DM)and 32 normal controls(NC)were selected from our hospital.Patients with diabetes were divided into a non-DR group(T2DM)(n=69)and a nonproliferative diabetic retinopathy Group(DR)(n=71)after dilated fundus photography and fundus fluorescein angiography.rs2110385/AluⅠgenotypes were detected by standardized polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP),and the differences in the detection rates of different genotypes in the above populations were compared.Results:1)The visfatin level in the DR Group was significantly higher than that in the NC and T2DM groups(P<0.05).2)The frequency of GG genotype and G allele of rs2110385 in the DR Group were higher than those in the T2DM and NC groups(80.3,69.6,50.0,86.6,79,65.6,P<0.05).3)There were significant differences in allele frequency and genotype frequency distribution of rs2110385 between the DR Group and the NC group(P<0.01).Conclusion:Visfatin increased in the nonproliferative diabetic retinopathy group and could be a potential indicator for the clinical prediction of DR.The G allele of the rs2110385 polymorphic site may be related to the risk of DR. 展开更多
关键词 VISFATIN Diabetic retinopathy Single nucleotide polymorphism Polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)
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RAD-sequencing improves the genetic characterization of a threatened tree peony(Paeonia ludlowii)endemic to China:Implications for conservation 被引量:1
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作者 Yu-Juan Zhao Gen-Shen Yin Xun Gong 《Plant Diversity》 SCIE CAS CSCD 2023年第5期513-522,共10页
Compared with traditional genetic markers,genomic approaches have proved valuable to the conservation of endangered species.Paeonia ludlowii having rarely and pure yellow flowers,is one of the world’s most famous tre... Compared with traditional genetic markers,genomic approaches have proved valuable to the conservation of endangered species.Paeonia ludlowii having rarely and pure yellow flowers,is one of the world’s most famous tree peonies.However,only several wild populations remain in the Yarlung Zangbo Valley(Nyingchi and Shannan regions,Xizang)in China due to increasing anthropogenic impact on the natural habitats.We used genome-wide single nucleotide polymorphisms to elucidate the spatial pattern of genetic variation,population structure and demographic history of P.ludlowii from the fragmented region comprising the entire range of this species,aiming to provide a basis for conserving the genetic resources of this species.Unlike genetic uniformity among populations revealed in previous studies,we found low but varied levels of intra-population genetic diversity,in which lower genetic diversity was detected in the population in Shannan region compared to those in Nyingzhi region.These spatial patterns may be likely associated with different population sizes caused by micro-environment differences in these two regions.Additionally,low genetic differentiation among populations(Fst=0.0037)were detected at the species level.This line of evidence,combined with the result of significant genetic differentiation between the two closest populations and lack of isolation by distance,suggested that shared ancestry among now remnant populations rather than contemporary genetic connectivity resulted in subtle population structure.Demographic inference suggested that P.ludlowii probably experienced a temporal history of sharp population decline during the period of Last Glacial Maximum,and a subsequent bottleneck event resulting from prehistoric human activities on the Qinghai-Tibet Plateau.All these events,together with current habitat fragment and excavation might contribute to the endangered status of P.ludlowii.Our study improved the genetic characterization of the endangered tree peony(P.ludlowii)in China,and these genetic inferences should be considered when making different in situ and ex situ conservation actions for P.ludlowii in this evolutionary hotspot region. 展开更多
关键词 CONSERVATION Fragmentation Genetic structure Genetic variation PAEONIA RAD-sequencing
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Relationships between distribution characteristics of ceramic fragments and anti-penetration performance of ceramic composite bulletproof insert plates 被引量:1
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作者 Wen-hao Yu Wei-ping Li +3 位作者 Yi-fan Shangguan Xin-yang Ji Tian Ma Guo-qing Wu 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2023年第1期103-110,共8页
Through quantitative statistics and morphological characterization of ceramic fragments for ceramic composite bulletproof insert plates(CCBIPs),distribution characteristics of ceramic fragments within a specific size ... Through quantitative statistics and morphological characterization of ceramic fragments for ceramic composite bulletproof insert plates(CCBIPs),distribution characteristics of ceramic fragments within a specific size range were analyzed for different Armor Piercing Incendiary(API)and shot times.To quantitatively evaluate the effect of energy absorption for ceramic plates,a model of energy absorption during penetration for CCBIPs was established based on statistics of the size distribution of ceramic fragments(SDCF).Variation in the SDCF and its influence on energy absorption for CCBIPs were investigated.The results indicate that the distribution feature of ceramic fragments in the range of 0.25-2.25 mm is Gaussian distribution.Compared with Type 56 of API(56-API),ceramic fragments formed by 53-API with higher kinetic energy possess more quantity and more concentrated distribution,whose average equivalence size decreases by 6.5%,corresponding to increasing by 83.9%of estimated energy absorption.Besides,the ability of CCBIPs to resist the third shot is significantly weakened,whose estimated energy absorption decreases by 58.8%compared with the first shot.More concentrated distribution and fewer fragments are formed after the third shot,the average equivalence size of ceramic fragments increases by 6.9%,which may attribute to the micro-cracks induced by the previous two shots. 展开更多
关键词 Bulletproof insert plate Ceramic fragment Statistic Energy absorption Anti-penetration performance
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Unveiling the influence of dendrite characteristics on the slip/twinning activity and the strain hardening capacity of Mg-Sn-Li-Zn cast alloys 被引量:1
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作者 MS.Jalali A.Zarei-Hanzaki +5 位作者 M.Mosayebi H.R.Abedi M.Malekan M.Kahnooji E.Farabi Su-Hyeon Kim 《Journal of Magnesium and Alloys》 SCIE EI CAS CSCD 2023年第1期329-347,共19页
This work explores the correlation between the characteristics of the cast structure(dendrite growth pattern,dendrite morphology and macro-texture)and strain hardening capacity during high temperature deformation of M... This work explores the correlation between the characteristics of the cast structure(dendrite growth pattern,dendrite morphology and macro-texture)and strain hardening capacity during high temperature deformation of Mg-5Sn-0.3Li-0 and 3Zn multi-component alloys.The three dimensional(3D)morphology of the dendrite structure demonstrates the transition of the growth directions from<1123>,<1120>and<1122>to<1123>and<1120>due to the addition of Zn.The simultaneous effects of growing tendency and the decrement of dendrite coarsening rate at the solidification interval lead to dendrite morphology transition from the globular-like to the hyper-branch structure.This morphology transition results in the variation of the solidification macro-texture,which has effectively influenced the dominant deformation mechanisms(slip/twin activity).The higher activity of the slip systems increases the tendency of the dendrite arms for bending along the deformation direction and fragmentation.Apart from this,the dendrite holding hyper-branch structure with an average thickness below 20μm are more favorable for fragmentation.The dendrite fragmentation leads to considerable softening fractions,and as an effective strain compensation mechanism increases the workability of dendritic structure. 展开更多
关键词 Magnesium alloys Dendrite orientation selection Solidification texture Dendrite fragmentation 3-D tomography analysis Thermomechanical processing
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Analysis and design for the comprehensive ballistic and blast resistance of polyurea-coated steel plate 被引量:1
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作者 Dongyang Chu Yigang Wang +3 位作者 Shanglin Yang Zhijie Li Zhuo Zhuang Zhanli Liu 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2023年第1期35-51,共17页
Fragments and blast waves generated by explosions pose a serious threat to protective structures.In this paper,the impact resistance of polyurea-coated steel plate under complex dynamic loading is analyzed and designe... Fragments and blast waves generated by explosions pose a serious threat to protective structures.In this paper,the impact resistance of polyurea-coated steel plate under complex dynamic loading is analyzed and designed for improving comprehensive ballistic and blast resistance using the newly established computational evaluating model.Firstly,according to the thickness and placement effects of the coating on the impact resistance,the steel-core sandwich plates are designed,which are proved to own outstanding comprehensive ballistic and blast resistance.Besides,the distribution diagram of ballistic and blast resistance for different polyurea-coated steel plates is given to guide the design of protective structures applying in different explosion scenarios.Furthermore,the dynamic response of designed plates under two scenarios with combined fragments and blast loading is studied.The results show that the synergistic effect of the combined loading reduces both the ballistic and blast resistance of the polyurea-coated steel plate.Besides,the acting sequence of the fragments and blast affects the structural protective performance heavily.It is found that the first loading inducing structural large deformation or damage is dominant.When fragments impact first,the excellent unit-thickness ballistic performance of the structural front part is strongly needed for improving the comprehensive ballistic and blast resistance. 展开更多
关键词 POLYUREA Ballistic and blast resistance Combined fragments and blast loading
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Future therapeutic implications of new molecular mechanism of colorectal cancer 被引量:1
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作者 Sen Lu Cheng-You Jia Jian-She Yang 《World Journal of Gastroenterology》 SCIE CAS 2023年第16期2359-2368,共10页
High incidence(10.2%)and mortality(9.2%)rates led to the ranking of colorectal cancer(CRC)as the second most malignant tumor spectrum worldwide in 2020.Treatment strategies are becoming highly dependent on the molecul... High incidence(10.2%)and mortality(9.2%)rates led to the ranking of colorectal cancer(CRC)as the second most malignant tumor spectrum worldwide in 2020.Treatment strategies are becoming highly dependent on the molecular characteristics of CRC.The classical theories accept two models depicting the origin of CRC:The progression of adenoma to cancer and transformation from serrated polyps to cancer.However,the molecular mechanism of CRC development is very complex.For instance,CRCs originating from laterally spreading tumors(LST)do not adhere to any of these models and exhibit extremely serious progression and poor outcomes.In this article,we present another possible pathway involved in CRC development,particularly from LST,with important molecular characteristics,which would facilitate the design of a novel strategy for targeted therapy. 展开更多
关键词 Colorectal cancer Laterally spreading tumors Molecular mechanism Truncated adenomatous polyposis coli mutation Golgi fragmentation Cancerous mechanism
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Dynamic response of UHMWPE plates under combined shock and fragment loading 被引量:1
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作者 Chun-Zheng Zhao Lu-Sheng Qiang +4 位作者 Rui Zhang Qian-Cheng Zhang Jun-Yang Zhong Zhen-Yu Zhao Tian Jian Lu 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2023年第9期9-23,共15页
Ultra-high molecular weight polyethylene(UHMWPE)fiber composite has been extensively used to construct lightweight protective structures against ballistic impacts,yet little is known about its performance when subject... Ultra-high molecular weight polyethylene(UHMWPE)fiber composite has been extensively used to construct lightweight protective structures against ballistic impacts,yet little is known about its performance when subjected to combined blast and fragment impacts.Built upon a recently developed laboratory-scale experimental technique to generate simulated combined loading through the impact of a fragment-foam composite projectile launched from a light gas gun,the dynamic responses of fullyclamped UHMWPE plates subjected to combined loading were characterized experimentally,with corresponding deformation and failure modes compared with those measured with simulated blast loading alone.Subsequently,to explore the underlying physical mechanisms,three-dimensional(3D)numerical simulations with the method of finite elements(FE)were systematically carried out.Numerical predictions compared favorably well with experimental measurements,thus validating the feasibility of the established FE model.Relative to the case of blast loading alone,combined blast and fragment loading led to larger maximum deflections of clamped UHMWPE plates.The position of the FSP in the foam sabot affected significantly the performance of a UHMWPE target,either enhancing or decreasing its ballistic resistance.When the blast loading and fragment impact arrived simultaneously at the target,its ballistic resistance was superior to that achieved when subjected to fragment impact alone,and benefited from the accelerated movement of the target due to simultaneous blast loading. 展开更多
关键词 UHMWPE composite Ballistic performance Combined blast and fragment loading Impact test Finite element simulation
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Numerical study on the dynamic fracture of explosively driven cylindrical shells
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作者 Zhi-yong Yin Xiao-wei Chen 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2023年第9期154-168,共15页
Research on the expansion and fracture of explosively driven metal shells has been a key issue in weapon development and structural protection.It is important to study and predict the failure mode,fracture mechanism,a... Research on the expansion and fracture of explosively driven metal shells has been a key issue in weapon development and structural protection.It is important to study and predict the failure mode,fracture mechanism,and fragment distribution characteristics of explosively driven metal shells.In this study,we used the finite element-smoothed particle hydrodynamics(FE-SPH)adaptive method and the fluid-structure interaction method to perform a three-dimensional numerical simulation of the expansion and fracture of a metal cylindrical shell.Our method combined the advantages of the FEM and SPH,avoiding system mass loss,energy loss,and element distortion;in addition,the proposed method had a good simulation effect on the interaction between detonation waves and the cylindrical shell.The simulated detonation wave propagation,shell damage morphology,and fragment velocity distribution were in good agreement with theoretical and experimental results.We divided the fragments into three regions based on their shape characteristics.We analyzed the failure mode and formation process of fragments in different regions.The numerical results reproduced the phenomenon in which cracks initiated from the inner surface and extended to the outer surface of the cylindrical shell along the 45°or 135°shear direction.In addition,fragments composed of elements are identified,and the mass and characteristic lengths of typical fragments at a stable time are provided.Furthermore,the mass and size distribution characteristics of the fragments were explored,and the variation in the fitting results of the classical distribution function under different explosion pressures was examined.Finally,based on mathematical derivation,the distribution formula of fragment velocity was improved.The improved formula provided higher accuracy and could be used to analyze any metal cylindrical shells with different length-to-diameter ratios. 展开更多
关键词 Metal cylindrical shell Shear failure Fragment distribution Numerical simulation Fragment velocity
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Exploring the regulatory mechanism of tRNA-derived fragments 36 in acute pancreatitis based on small RNA sequencing and experiments
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作者 Xi-Rui Fan Yun Huang +4 位作者 Yu Su Si-Jin Chen Yu-Lu Zhang Wei-Kang Huang Hui Wang 《World Journal of Gastroenterology》 SCIE CAS 2023年第30期4642-4656,共15页
BACKGROUND Acute pancreatitis(AP)is a disease featuring acute inflammation of the pancreas and histological destruction of acinar cells.Approximately 20%of AP patients progress to moderately severe or severe pancreati... BACKGROUND Acute pancreatitis(AP)is a disease featuring acute inflammation of the pancreas and histological destruction of acinar cells.Approximately 20%of AP patients progress to moderately severe or severe pancreatitis,with a case fatality rate of up to 30%.However,a single indicator that can serve as the gold standard for prognostic prediction has not been discovered.Therefore,gaining deeper insights into the underlying mechanism of AP progression and the evolution of the disease and exploring effective biomarkers are important for early diagnosis,progression evaluation,and precise treatment of AP.AIM To determine the regulatory mechanisms of tRNA-derived fragments(tRFs)in AP based on small RNA sequencing and experiments.METHODS Small RNA sequencing and functional enrichment analyses were performed to identify key tRFs and the potential mechanisms in AP.Reverse transcription quantitative polymerase chain reaction(RT-qPCR)was conducted to determine tRF expression.AP cell and mouse models were created to investigate the role of tRF36 in AP progression.Lipase,amylase,and cytokine levels were assayed to examine AP progression.Ferritin expression,reactive oxygen species,malondialdehyde,and ferric ion levels were assayed to evaluate cellular ferroptosis.RNA pull down assays and methylated RNA immunoprecipitation were performed to explore the molecular mechanisms.RESULTS RT-qPCR results showed that tRF36 was significantly upregulated in the serum of AP patients,compared to healthy controls.Functional enrichment analysis indicated that target genes of tRF36 were involved in ferroptosisrelated pathways,including the Hippo signaling pathway and ion transport.Moreover,the occurrence of pancreatic cell ferroptosis was detected in AP cells and mouse models.The results of interference experiments and AP cell models suggested that tRF-36 could promote AP progression through the regulation of ferroptosis.Furthermore,ferroptosis gene microarray,database prediction,and immunoprecipitation suggested that tRF-36 accelerated the progression of AP by recruiting insulin-like growth factor 2 mRNA binding protein 3(IGF2BP3)to the p53 mRNA m6A modification site by binding to IGF2BP3,which enhanced p53 mRNA stability and promoted the ferroptosis of pancreatic follicle cells.CONCLUSION In conclusion,regulation of nuclear pre-mRNA domain-containing protein 1B promoted AP development by regulating the ferroptosis of pancreatic cells,thereby acting as a prospective therapeutic target for AP.In addition,this study provided a basis for understanding the regulatory mechanisms of tRFs in AP. 展开更多
关键词 Acute pancreatitis tRNA-derived fragments tRNA-derived fragments 36 Mouse models Ferroptosis Reverse transcription quantitative polymerase chain reaction
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Structural characterization and mass spectrometry fragmentation signatures of macrocyclic alkanes isolated from a Sydney Basin torbanite,Australia
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作者 Xianxin Meng Hong Lu +2 位作者 Zhirong Zhang Ping’an Peng John K.Volkman 《Acta Geochimica》 EI CAS CSCD 2023年第3期488-494,共7页
Individual hydrocarbons identified to be macrocyclic alkanes in a torbanite from the Sydney Basin(Australia)were successfully isolated from its extracts using preparative gas chromatography and analyzed by NMR.Saturat... Individual hydrocarbons identified to be macrocyclic alkanes in a torbanite from the Sydney Basin(Australia)were successfully isolated from its extracts using preparative gas chromatography and analyzed by NMR.Saturated cyclic structures were confirmed by single peaks in the NMR~1H and~(13)C spectra indicating single forms of H and C atoms exist in these biomarker molecules.This is consistent with the methylene unit in a ring system assignment of the macrocyclic alkanes and accounts for a formula of(CH2)n.The unusual molecular structures of these compounds are consistent with those that were identified from previous GC retention index data and co-injection with a standard supports the previous research.The mass spectral fragmentation behaviors of representative cyclic alkanes were further investigated by comparing them with the mass spectra of isolated individual macrocyclic alkanes.The characteristic fragment ions in the macrocyclic alkanes of(M–28)+and base peaks of m/z 97,111,125,etc.,can be assigned as being generated by simple a-/i-cleavage and hydrogen rearrangement.These fragmentation pathways combined with retention indices should assist in differentiating these compounds from monounsaturated alkenes and alkylated monocyclics having similar mass spectral characteristics in other geological samples. 展开更多
关键词 Macrocyclic alkanes Torbanite NMR Preparative GC MS fragmentation
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Design of Multi-layered Protection Against Guided Mortar Threats Yhrough Numerical Modeling
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作者 Bonny Thawani Seng Kiat Lim +2 位作者 Laura Brown Richard Critchley Rachael Hazael 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2023年第11期55-65,共11页
The trade—off between protection and weight is a constant consideration when designing a portable protective solution.Greater mobility is a desirable attribute and protection must therefore adapt,prompting a demand f... The trade—off between protection and weight is a constant consideration when designing a portable protective solution.Greater mobility is a desirable attribute and protection must therefore adapt,prompting a demand for lightweight,simple to construct,low-cost and effective ballistic protection systems.High strength and ductility,wave spreading capability and good energy absorption are key properties for ballistic protection.Four materials,polycarbonate,Kevlar?-epoxy,polyurethane foam,and aluminium alloy,possess these properties and were selected for analysis by numerical simulation.Multilayered configurations were proven to be an optimal solution,by exploiting the advantages of each material without having large penalties of mass and cost.Numerical modelling using ANSYS AUTODYN?is used to simulate monolithic and multi-layered target configurations,to obtain the penetration mitigation performance.The results are analysed to select configurations based on different requirements,such as lowest cost,lowest mass,best performance,and optimal configuration which balanced the three key parameters mentioned.The optimal configuration of Aluminium,Kevlar-Epoxy,Polyurethane,and Polycarbonate has layers with thickness of 7,3,38,2 mm respectively with a total mass of 7.97 kg,total cost of$39.86 and penetration of 29.34%(14.67 mm).Polynomial relationships between performance and mass/cost are also determined. 展开更多
关键词 Hydrocode FRAGMENTATION High velocity Composite structures FOAMS
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Ballistic response of skin simulant against fragment simulating projectiles
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作者 Punit Kumar Pandey Atul Harmukh +2 位作者 M.K.Khan M.A.Iqbal S.G.Ganpule 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2023年第12期70-82,共13页
The response of biological phantoms against high velocity impact is actively sought for applications in defense,space,soft robotics and sensing.Towards this end,we study the ballistic response of silicone based skin s... The response of biological phantoms against high velocity impact is actively sought for applications in defense,space,soft robotics and sensing.Towards this end,we study the ballistic response of silicone based skin simulant against fragment impact.Using a pneumatic gas gun setup,six chisel-nosed and three regular shaped(sphere,cylinder,and cube)fragments were impacted on the skin simulant.The resulting skin simulant response was studied in terms of ballistic limit velocities,energy densities,failure pattern,and the mechanics of interaction.The results indicate that the shape of the fragment affects the ballistic limit velocities.The ballistic limit velocities,energy densities of the chisel-nosed fragment simulating projectiles were relatively insensitive to the size(mass),except for the smallest(0.16 g)and largest(2.79 g)chisel-nosed fragment.For the same size(1 g),ballistic limit velocities and failure are dependent on the shape of the fragment.The skin simulant failed by combined plugging and elastic hole enlargement.Failure in the spherical fragment was dominated by the elastic hole enlargement,whereas plugging failure was dominant in all other fragments.The spherical,cylindrical,and chisel-nosed fragments created circular cavities,and the cubical fragment created a square cavity.In the case of the spherical fragment,slipping of the fragment within the skin simulant was seen.Cubical fragments created lateral cracks emanating from the corners of the square cavity.Interestingly,for all the fragments,the maximum deformation corresponding to the perforation was lower than the non-perforation indicating rate dependent,stress driven failure.The maximum deformation was also dependent on the shape of the fragment.Overall,these results provide unique insights into the mechanical response of a soft simulant against ballistic impact.Results have utility in the calibration and validation of computational models,design of personal protective equipment,and antipersonnel systems. 展开更多
关键词 Skin simulant FRAGMENT Impact Ballistic limit velocity Energy density FAILURE
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