Robust and fast fat suppression is a challenge in balanced steady-state free precession （SSFP） magnetic resonance imaging. Although single-acquisition phase-sensitive SSFP can provide fat-suppressed images in short ...Robust and fast fat suppression is a challenge in balanced steady-state free precession （SSFP） magnetic resonance imaging. Although single-acquisition phase-sensitive SSFP can provide fat-suppressed images in short scan time, phase errors, especially spatially-dependent phase shift, caused by a variety of factors may result in misplacement of fat and water voxels. In this paper, a novel phase correction algorithm was used to calibrate those phase errors during image reconstruction. This algorithm corrects phase by region growing, employing both the magnitude and the phase information of image pixels. Phantom and in vivo imagings were performed to validate the technique. As a result, excellent fat-suppressed images were acquired by using single-acquisition phase-sensitive SSFP with phase correction.展开更多
Differences in free fatty acid (FFA) compositions between low-fat (LF) and full-fat (FF: whole milk) goat cheeses were evaluated during 3 months at 4oC refrigeration. The two types of cheeses were manufactured using a...Differences in free fatty acid (FFA) compositions between low-fat (LF) and full-fat (FF: whole milk) goat cheeses were evaluated during 3 months at 4oC refrigeration. The two types of cheeses were manufactured using a bulk milk from the mixed herd of Saanen, Alpine, and Nubian goat breeds. LF cheeses were made using LF milk after cream separation. FFAs of all cheeses were extracted in diisoprophyl ether using polypropylene chromatography column, and FFA concentrations were quantified using a gas chromatograph equipped with a fused silica capillary column. Moisture, fat, protein contents (%) and pH of fresh LF and FF cheeses were: 55.1, 52.3;1.30, 25.6;35.7, 22.5;5.40, 5.42, respectively. The FFA contents (mg/g cheese) of fresh FF and LF cheeses prior to storage treatments for C4:0, C6:0, C8:0, C10:0, C12:0, C14:0, C16:0, C18:0, C18:1, and C18:2 were: 0.020, 0.072;0.070, 0.035;0.061, 0.055;0.181, 0.167;0.073, 0.047;0.174, 0.112;0.579, 0.152;0.308, 0.202;0.521, 0.174;and 0.057, 0.026, respectively. The respective FFA to total fatty acid ratios for 0, 1 and 3 months aged FF and LF cheeses were 8.44, 12.4;6.31, 16.91;12.03, 14.19. The LF cheeses generated more FFA than FF cheeses, while actual FFA content in FF cheese was significantly higher than in LF cheese. The FFA contents of LF cheese at 0, 1 and 3 months storage were 48.0, 96.8 and 36.4% of those of FF cheese, respectively. It was concluded LF cheese generated higher amount of FFA than FF cheese, although total FFA content was significantly (P<0.05) lower in LF cheese than in FF cheese.展开更多
Background: Western diet, rich in saturated fatty acids and cholesterol, is associated with increased cardiovascular risk. We thus investigated in female mice the influence of this diet on plasma antioxidant status, v...Background: Western diet, rich in saturated fatty acids and cholesterol, is associated with increased cardiovascular risk. We thus investigated in female mice the influence of this diet on plasma antioxidant status, vascular wall thickening and cardiac function. Methods and Results: Adult female C57BL/6J wild type (WT) and LDLR–/– mice were fed a normal diet (ND) or a high-fat diet (HFD) for 17 weeks. HFD induced an increase in plasma lipids and vitamin C (Vit C) levels in both groups but at a much higher level in LDLR–/– and a decrease in plasma ascorbyl free radical levels to Vit C ratio (an endogenous oxidative stress index) in LDLR–/–. We only found a slight decrease in circulating antioxidant status evaluated by the Oxygen Radical Absorbance Capacity (ORAC) assay in WT, but not in LDLR–/–. Echocardiography evidenced an increase in arterial wall thickness in aortic arch at atherosclerosis predilection sites in HFD LDLR–/– as compared to ND LDLR–/– and HFD WT. This result was confirmed by histology. Further-more, histological examination of aortic valves showed an increase in atherosclerotic lesions. Our study, using echocardiography, show that chronic HFD does not induce any major modifications of systolic function in the both mice groups. Conclusions: High-fat intake in mice causes serious disturbances in lipid plasma levels associated to variations of circulating antioxidant status due, at least in part, to an increase in Vit C. At this stage, atherosclerotic lesions, observed in aortic arch and valve, do not impair cardiac function in HFD-fed mice.展开更多
目的:探究江苏省部分地区不同性别成年人脂肪质量随年龄增长的变化情况以及不同年龄段人群体质量指数(body fat index,BMI)和脂肪质量之间的关系。方法:收集2019年9月至2021年2月江苏省南京市、淮安市以及无锡市的体检人群数据,对符合...目的:探究江苏省部分地区不同性别成年人脂肪质量随年龄增长的变化情况以及不同年龄段人群体质量指数(body fat index,BMI)和脂肪质量之间的关系。方法:收集2019年9月至2021年2月江苏省南京市、淮安市以及无锡市的体检人群数据,对符合纳入标准人群进行体格检查和体成分检测,并分析其脂肪质量随年龄变化情况。结果:共收集2115名志愿者的基本信息,排除信息不全者46名,共纳入2069名进行研究分析。30岁以上成年人去脂体质量(fat free mass,FFM)随着年龄的增长呈现下降的趋势;30岁以上成年人的体脂肪量(body fat mass,BFM)、体脂百分比(percentage of body fat,PBF)、腰臀比(waist-hip ratio,WHR)和体脂指数(fat mass index,FMI)随着年龄的增长均呈现上升趋势,BFM、PBF和去脂体质量百分比(percentage of fat free mass,PFFM)在40岁出现显著上升,FFM和去脂体质量指数(fat free mass index,FFMI)在60岁开始出现显著下降。男性FMI在40岁出现显著上升,女性FMI从60岁出现显著上升。全年龄段成年人FFM随着BMI和腰围水平的升高呈上升趋势。结论:随着年龄的增长男性和女性的BFM、PBF和WHR均呈现上升趋势。各年龄段成年男性FFM显著高于女性,女性BFM、FMI、PBF和内脏脂肪面积显著高于男性。全年龄段成年人FFM随着BMI和WHR升高呈上升趋势。展开更多
基金Project partially supported by the National Natural Science Foundation of China (Grant Nos 10527003 and 60672104)the State Key Development Program for Basic Research of China (Grant No 2006CB705700-05)+1 种基金Joint Research Foundation of Beijing Education Committee (Grant No SYS100010401)Beijing Natural Science Foundation (Grant No 3073019)
文摘Robust and fast fat suppression is a challenge in balanced steady-state free precession （SSFP） magnetic resonance imaging. Although single-acquisition phase-sensitive SSFP can provide fat-suppressed images in short scan time, phase errors, especially spatially-dependent phase shift, caused by a variety of factors may result in misplacement of fat and water voxels. In this paper, a novel phase correction algorithm was used to calibrate those phase errors during image reconstruction. This algorithm corrects phase by region growing, employing both the magnitude and the phase information of image pixels. Phantom and in vivo imagings were performed to validate the technique. As a result, excellent fat-suppressed images were acquired by using single-acquisition phase-sensitive SSFP with phase correction.
文摘Differences in free fatty acid (FFA) compositions between low-fat (LF) and full-fat (FF: whole milk) goat cheeses were evaluated during 3 months at 4oC refrigeration. The two types of cheeses were manufactured using a bulk milk from the mixed herd of Saanen, Alpine, and Nubian goat breeds. LF cheeses were made using LF milk after cream separation. FFAs of all cheeses were extracted in diisoprophyl ether using polypropylene chromatography column, and FFA concentrations were quantified using a gas chromatograph equipped with a fused silica capillary column. Moisture, fat, protein contents (%) and pH of fresh LF and FF cheeses were: 55.1, 52.3;1.30, 25.6;35.7, 22.5;5.40, 5.42, respectively. The FFA contents (mg/g cheese) of fresh FF and LF cheeses prior to storage treatments for C4:0, C6:0, C8:0, C10:0, C12:0, C14:0, C16:0, C18:0, C18:1, and C18:2 were: 0.020, 0.072;0.070, 0.035;0.061, 0.055;0.181, 0.167;0.073, 0.047;0.174, 0.112;0.579, 0.152;0.308, 0.202;0.521, 0.174;and 0.057, 0.026, respectively. The respective FFA to total fatty acid ratios for 0, 1 and 3 months aged FF and LF cheeses were 8.44, 12.4;6.31, 16.91;12.03, 14.19. The LF cheeses generated more FFA than FF cheeses, while actual FFA content in FF cheese was significantly higher than in LF cheese. The FFA contents of LF cheese at 0, 1 and 3 months storage were 48.0, 96.8 and 36.4% of those of FF cheese, respectively. It was concluded LF cheese generated higher amount of FFA than FF cheese, although total FFA content was significantly (P<0.05) lower in LF cheese than in FF cheese.
文摘Background: Western diet, rich in saturated fatty acids and cholesterol, is associated with increased cardiovascular risk. We thus investigated in female mice the influence of this diet on plasma antioxidant status, vascular wall thickening and cardiac function. Methods and Results: Adult female C57BL/6J wild type (WT) and LDLR–/– mice were fed a normal diet (ND) or a high-fat diet (HFD) for 17 weeks. HFD induced an increase in plasma lipids and vitamin C (Vit C) levels in both groups but at a much higher level in LDLR–/– and a decrease in plasma ascorbyl free radical levels to Vit C ratio (an endogenous oxidative stress index) in LDLR–/–. We only found a slight decrease in circulating antioxidant status evaluated by the Oxygen Radical Absorbance Capacity (ORAC) assay in WT, but not in LDLR–/–. Echocardiography evidenced an increase in arterial wall thickness in aortic arch at atherosclerosis predilection sites in HFD LDLR–/– as compared to ND LDLR–/– and HFD WT. This result was confirmed by histology. Further-more, histological examination of aortic valves showed an increase in atherosclerotic lesions. Our study, using echocardiography, show that chronic HFD does not induce any major modifications of systolic function in the both mice groups. Conclusions: High-fat intake in mice causes serious disturbances in lipid plasma levels associated to variations of circulating antioxidant status due, at least in part, to an increase in Vit C. At this stage, atherosclerotic lesions, observed in aortic arch and valve, do not impair cardiac function in HFD-fed mice.
文摘目的:探究江苏省部分地区不同性别成年人脂肪质量随年龄增长的变化情况以及不同年龄段人群体质量指数(body fat index,BMI)和脂肪质量之间的关系。方法:收集2019年9月至2021年2月江苏省南京市、淮安市以及无锡市的体检人群数据,对符合纳入标准人群进行体格检查和体成分检测,并分析其脂肪质量随年龄变化情况。结果:共收集2115名志愿者的基本信息,排除信息不全者46名,共纳入2069名进行研究分析。30岁以上成年人去脂体质量(fat free mass,FFM)随着年龄的增长呈现下降的趋势;30岁以上成年人的体脂肪量(body fat mass,BFM)、体脂百分比(percentage of body fat,PBF)、腰臀比(waist-hip ratio,WHR)和体脂指数(fat mass index,FMI)随着年龄的增长均呈现上升趋势,BFM、PBF和去脂体质量百分比(percentage of fat free mass,PFFM)在40岁出现显著上升,FFM和去脂体质量指数(fat free mass index,FFMI)在60岁开始出现显著下降。男性FMI在40岁出现显著上升,女性FMI从60岁出现显著上升。全年龄段成年人FFM随着BMI和腰围水平的升高呈上升趋势。结论:随着年龄的增长男性和女性的BFM、PBF和WHR均呈现上升趋势。各年龄段成年男性FFM显著高于女性,女性BFM、FMI、PBF和内脏脂肪面积显著高于男性。全年龄段成年人FFM随着BMI和WHR升高呈上升趋势。
