Spectroscopic characterization of clusters is crucial to understanding the structures and reaction mechanisms at the microscopic level,but it has been proven to be a grand challenge for neutral clusters because the ab...Spectroscopic characterization of clusters is crucial to understanding the structures and reaction mechanisms at the microscopic level,but it has been proven to be a grand challenge for neutral clusters because the absence of a charge makes it di伍cult for the size selection and detection.Infrared(IR)spectroscopy based on threshold photoionization using a tunable vacuum ultraviolet free electron laser(VUV-FEL)has recently been developed in the lab.The IR-VUV depletion and IR+VUV enhancement spectroscopic techniques open new avenues for size-selected IR spectroscopies of a large variety of neutral clusters without confinement(i.e.,an ultraviolet chromophore,a messenger tag,or a host matrix).The spectroscopic principles have been demonstrated by investigations of some neutral water clusters and some metal carbonyls.Here,the spectroscopic principles and their applications for neutral clusters are reviewed.展开更多
FELiChEM is a new experimental facility under construction at the University of Science and Technology of China（USTC）. Its core device is two free electron laser oscillators generating middle-infrared and far-infrar...FELiChEM is a new experimental facility under construction at the University of Science and Technology of China（USTC）. Its core device is two free electron laser oscillators generating middle-infrared and far-infrared laser and covering the spectral range of 2.5–200 μm. It will be a dedicated infrared light source aiming at energy chemistry research. We present the brief design of the FEL oscillators, with the emphasis put on the middle-infrared oscillator.Most of the basic parameters are determined and the anticipated performance of the output radiation is given. The first light of FELiChEM is targeted for the end of 2017.展开更多
FELiChEM is an infrared free electron laser（FEL） facility currently under construction, which consists of two oscillators generating middle-infrared and far-infrared laser covering the spectral range of 2.5–200 μm...FELiChEM is an infrared free electron laser（FEL） facility currently under construction, which consists of two oscillators generating middle-infrared and far-infrared laser covering the spectral range of 2.5–200 μm. In this paper, we numerically study the output characteristics of the middle-infrared oscillator with accurate cavity length detuning. Emphasis is put on the temporal structure of the micropulse and the corresponding spectral bandwidth.Taking the radiation wavelengths of 50 μm and 5 μm as examples, we show that the output pulse duration can be tuned in the range of 1–6 ps with corresponding bandwidth of 13%–0.2% by adjusting the cavity length detuning.In addition, a special discussion on the comb structure is presented, and it is indicated that the comb structure may arise in the output optical pulse when the normalized slippage length is much smaller than unity. This work has reference value for the operation of FELiChEM and other FEL oscillators.展开更多
An infrared oscillator FEL user facility will be built at the National Synchrotron Radiation Laboratory at in Hefei, China. In this paper, the parameter design of the oscillator FEL is discussed, and some original rel...An infrared oscillator FEL user facility will be built at the National Synchrotron Radiation Laboratory at in Hefei, China. In this paper, the parameter design of the oscillator FEL is discussed, and some original relevant approaches and expressions are presented. Analytic formulae are used to estimate the optical field gain and saturation power for the preliminary design. By considering both physical and technical constraints, the relation of the deflection parameter K to the undulator period is analyzed. This helps us to determine the ranges of the magnetic pole gap,the electron energy and the radiation wavelength. The relations and design of the optical resonator parameters are analyzed. Using dimensionless quantities, the interdependences between the radii of curvature of the resonator mirror and the various parameters of the optical resonator are clearly demonstrated. The effect of the parallel-plate waveguide is analyzed for the far-infrared oscillator FEL. The condition of the necessity of using a waveguide and the modified filling factor in the case of the waveguide are given, respectively.展开更多
Amyloid fibrils are widely recognized as a cause of serious amyloidosis such as Alzheimer’s disease. Although dissociation of amyloid fibril aggregates is expected to lead to a decrease in the toxicity of the fibrils...Amyloid fibrils are widely recognized as a cause of serious amyloidosis such as Alzheimer’s disease. Although dissociation of amyloid fibril aggregates is expected to lead to a decrease in the toxicity of the fibrils in cells, the fibril structure is robust under physiological conditions. We have irradiated amyloid fibrils with a free-electron laser (FEL) tuned to mid-infrared frequencies to induce dissociation of the aggregates into monomer forms. We have previously succeeded in dissociating fibril structures of a short peptide of the thyroid hormone by tuning the oscillation frequency to the amide I band, but the detailed structural changes of the peptide have not yet been determined at a high spatial resolution. Synchrotron-radiation infrared microscopy (SR-IRM) is a powerful tool for in situ analysis of minute structural changes of various materials, and in this study, the feasibility of SR-IRM for analyzing the microscopic conformational changes of amyloid fibrils after FEL irradiation was investigated. Reflection spectra of the amyloid fibril surface showed that the amide I peaks shifted to higher wave numbers after the FEL irradiation, indicating that the initial β-sheet-rich structure transformed into a mixture of non-ordered and turn-like peptide conformations. This result demonstrates that conformational changes of the fibril structure after the FEL irradiation can be observed at a high spatial resolution using SR-IRM analysis and the FEL irradiation system can be useful for dissociation of amyloid aggregates.展开更多
Generation of intense, fully coherent radiation with wide spectral coverage has been a long-standing challenge for laser technologies. Several techniques have been developed in recent years to extend the spectral cove...Generation of intense, fully coherent radiation with wide spectral coverage has been a long-standing challenge for laser technologies. Several techniques have been developed in recent years to extend the spectral coverage in optical physics, but none of them hold the potential to produce X-ray laser pulses with very high-peak power. Urgent demands for intense X-ray light sources have prompted the development of free-electron lasers(FELs), which have been proved to be very useful tools in many scientific areas. In this paper, we give an overview of the basic principle of FELs, techniques for realizing fully coherent FELs, and the development of fully coherent FEL facilities in China.展开更多
FEL has some advantages: its wavelength is tunable in a wide range; light beam quality is good and it has an ultra-short pulse construction. So it is applied in the fields of material, nonlinear optics and biomedicine...FEL has some advantages: its wavelength is tunable in a wide range; light beam quality is good and it has an ultra-short pulse construction. So it is applied in the fields of material, nonlinear optics and biomedicine. BFEL operated successfully, making China become a country having infrared FEL by using RF linear accelerator following America, Netherlands and France. A saturation oscillation was made at the end of展开更多
The cavity-based X-ray free-electron laser(XFEL)has promise in producing fully coherent pulses with a bandwidth of a few meV and very stable intensity,whereas the currently existing self-amplified spontaneous emission...The cavity-based X-ray free-electron laser(XFEL)has promise in producing fully coherent pulses with a bandwidth of a few meV and very stable intensity,whereas the currently existing self-amplified spontaneous emission(SASE)XFEL is capable of generating ultra-short pulses with chaotic spectra.In general,a cavity-based XFEL can provide a spectral brightness three orders of magnitude higher than that of the SASE mode,thereby opening a new door for cutting-edge scientific research.With the development of superconducting MHz repetition-rate XFEL facilities such as FLASH,European-XFEL,LCLS-II,and SHINE,practical cavity-based XFEL operations are becoming increasingly achievable.In this study,megahertz cavity enhanced X-ray generation(MING)is proposed based on China’s first hard XFEL facility-SHINE,which we refer to as MING@SHINE.展开更多
A single-channel far-infrared （FIR） laser interferometer was developed to measure the line averaged electron density on the EAST tokamak. The structure of the single-channel FIR laser interferometer is described in ...A single-channel far-infrared （FIR） laser interferometer was developed to measure the line averaged electron density on the EAST tokamak. The structure of the single-channel FIR laser interferometer is described in detail. The evolution of density sawtooth oscillation was measured by means the FIR laser interferometer, and was identified by electron cyclotron emission （ECE） signals and soft X-ray intensity. The discharges with and without sawtooth were compared with each other in the Hugill diagram.展开更多
基金This work was supported by the National Natural Science Foundation of China(No.92061203 and No.21688102)the Strategic Priority Research Program of Chinese Academy of Sciences(XDB17000000)+3 种基金International Partnership Program of Chinese Academy of Sciences(121421KYSB20170012)Chinese Academy of Sciences(GJJSTD20190002)K.C.Wong Education Foundation(GJTD-2018-06)Dalian Institute of Chemical Physics(DICP DCLS201702).
文摘Spectroscopic characterization of clusters is crucial to understanding the structures and reaction mechanisms at the microscopic level,but it has been proven to be a grand challenge for neutral clusters because the absence of a charge makes it di伍cult for the size selection and detection.Infrared(IR)spectroscopy based on threshold photoionization using a tunable vacuum ultraviolet free electron laser(VUV-FEL)has recently been developed in the lab.The IR-VUV depletion and IR+VUV enhancement spectroscopic techniques open new avenues for size-selected IR spectroscopies of a large variety of neutral clusters without confinement(i.e.,an ultraviolet chromophore,a messenger tag,or a host matrix).The spectroscopic principles have been demonstrated by investigations of some neutral water clusters and some metal carbonyls.Here,the spectroscopic principles and their applications for neutral clusters are reviewed.
基金Supported by National Natural Science Foundation of China(21327901)
文摘FELiChEM is a new experimental facility under construction at the University of Science and Technology of China（USTC）. Its core device is two free electron laser oscillators generating middle-infrared and far-infrared laser and covering the spectral range of 2.5–200 μm. It will be a dedicated infrared light source aiming at energy chemistry research. We present the brief design of the FEL oscillators, with the emphasis put on the middle-infrared oscillator.Most of the basic parameters are determined and the anticipated performance of the output radiation is given. The first light of FELiChEM is targeted for the end of 2017.
基金Supported by National Natural Science Foundation of China(21327901,11205156)
文摘FELiChEM is an infrared free electron laser（FEL） facility currently under construction, which consists of two oscillators generating middle-infrared and far-infrared laser covering the spectral range of 2.5–200 μm. In this paper, we numerically study the output characteristics of the middle-infrared oscillator with accurate cavity length detuning. Emphasis is put on the temporal structure of the micropulse and the corresponding spectral bandwidth.Taking the radiation wavelengths of 50 μm and 5 μm as examples, we show that the output pulse duration can be tuned in the range of 1–6 ps with corresponding bandwidth of 13%–0.2% by adjusting the cavity length detuning.In addition, a special discussion on the comb structure is presented, and it is indicated that the comb structure may arise in the output optical pulse when the normalized slippage length is much smaller than unity. This work has reference value for the operation of FELiChEM and other FEL oscillators.
基金Supported by National Nature Science Foundation of China(21327901,11375199)
文摘An infrared oscillator FEL user facility will be built at the National Synchrotron Radiation Laboratory at in Hefei, China. In this paper, the parameter design of the oscillator FEL is discussed, and some original relevant approaches and expressions are presented. Analytic formulae are used to estimate the optical field gain and saturation power for the preliminary design. By considering both physical and technical constraints, the relation of the deflection parameter K to the undulator period is analyzed. This helps us to determine the ranges of the magnetic pole gap,the electron energy and the radiation wavelength. The relations and design of the optical resonator parameters are analyzed. Using dimensionless quantities, the interdependences between the radii of curvature of the resonator mirror and the various parameters of the optical resonator are clearly demonstrated. The effect of the parallel-plate waveguide is analyzed for the far-infrared oscillator FEL. The condition of the necessity of using a waveguide and the modified filling factor in the case of the waveguide are given, respectively.
文摘Amyloid fibrils are widely recognized as a cause of serious amyloidosis such as Alzheimer’s disease. Although dissociation of amyloid fibril aggregates is expected to lead to a decrease in the toxicity of the fibrils in cells, the fibril structure is robust under physiological conditions. We have irradiated amyloid fibrils with a free-electron laser (FEL) tuned to mid-infrared frequencies to induce dissociation of the aggregates into monomer forms. We have previously succeeded in dissociating fibril structures of a short peptide of the thyroid hormone by tuning the oscillation frequency to the amide I band, but the detailed structural changes of the peptide have not yet been determined at a high spatial resolution. Synchrotron-radiation infrared microscopy (SR-IRM) is a powerful tool for in situ analysis of minute structural changes of various materials, and in this study, the feasibility of SR-IRM for analyzing the microscopic conformational changes of amyloid fibrils after FEL irradiation was investigated. Reflection spectra of the amyloid fibril surface showed that the amide I peaks shifted to higher wave numbers after the FEL irradiation, indicating that the initial β-sheet-rich structure transformed into a mixture of non-ordered and turn-like peptide conformations. This result demonstrates that conformational changes of the fibril structure after the FEL irradiation can be observed at a high spatial resolution using SR-IRM analysis and the FEL irradiation system can be useful for dissociation of amyloid aggregates.
基金supported by the National Key Research and Development Program of China(No.2016YFA0401900)the National Natural Science Foundation of China(Nos.11475250 and11775293)+1 种基金the Young Elite Scientist Sponsorship Program of CAST(2015QNRC001)the Ten Thousand Talent Program
文摘Generation of intense, fully coherent radiation with wide spectral coverage has been a long-standing challenge for laser technologies. Several techniques have been developed in recent years to extend the spectral coverage in optical physics, but none of them hold the potential to produce X-ray laser pulses with very high-peak power. Urgent demands for intense X-ray light sources have prompted the development of free-electron lasers(FELs), which have been proved to be very useful tools in many scientific areas. In this paper, we give an overview of the basic principle of FELs, techniques for realizing fully coherent FELs, and the development of fully coherent FEL facilities in China.
基金Project supported by the Plan of National High Technology of China
文摘FEL has some advantages: its wavelength is tunable in a wide range; light beam quality is good and it has an ultra-short pulse construction. So it is applied in the fields of material, nonlinear optics and biomedicine. BFEL operated successfully, making China become a country having infrared FEL by using RF linear accelerator following America, Netherlands and France. A saturation oscillation was made at the end of
基金supported by the CAS Project for Young Scientists in Basic Research(No.YSBR-042)the National Natural Science Foundation of China(Nos.12125508,11935020)+1 种基金Program of Shanghai Academic/Technology Research Leader(No.21XD1404100)Shanghai Pilot Program for Basic Research–Chinese Academy of Science,Shanghai Branch(No.JCYJSHFY-2021-010).
文摘The cavity-based X-ray free-electron laser(XFEL)has promise in producing fully coherent pulses with a bandwidth of a few meV and very stable intensity,whereas the currently existing self-amplified spontaneous emission(SASE)XFEL is capable of generating ultra-short pulses with chaotic spectra.In general,a cavity-based XFEL can provide a spectral brightness three orders of magnitude higher than that of the SASE mode,thereby opening a new door for cutting-edge scientific research.With the development of superconducting MHz repetition-rate XFEL facilities such as FLASH,European-XFEL,LCLS-II,and SHINE,practical cavity-based XFEL operations are becoming increasingly achievable.In this study,megahertz cavity enhanced X-ray generation(MING)is proposed based on China’s first hard XFEL facility-SHINE,which we refer to as MING@SHINE.
基金National Natural Science Foundation of China(Nos.10475078,10675127,10675126,10675124,10605028)
文摘A single-channel far-infrared （FIR） laser interferometer was developed to measure the line averaged electron density on the EAST tokamak. The structure of the single-channel FIR laser interferometer is described in detail. The evolution of density sawtooth oscillation was measured by means the FIR laser interferometer, and was identified by electron cyclotron emission （ECE） signals and soft X-ray intensity. The discharges with and without sawtooth were compared with each other in the Hugill diagram.
