The preservation of anatomical pieces in Veterinary Anatomy is essential since it is not possible to dissect all domestic species. Most techniques use reagents with high levels of toxicity such as formaldehyde. The ob...The preservation of anatomical pieces in Veterinary Anatomy is essential since it is not possible to dissect all domestic species. Most techniques use reagents with high levels of toxicity such as formaldehyde. The objective of this work was to develop a new preservation technique that uses reagents with zero toxicity and that allows obtaining preserved pieces suitable for anatomical studies. The alcohol propylene glycol technique was developed, the method of which uses a fixation step with alcohol, sodium chloride, commercial vinegar and subsequently the impregnation of the preservation solution made from propylene glycol and commercial vinegar, which are non-toxic. As a result of this work, adequately preserved sheep hearts were obtained that preserved their morphology with slight changes in size and weight, which did not affect their external and internal anatomical structure. Its coloration was not substantially affected, remaining a little lighter. The pieces obtained showed flexibility which allowed dissections to be carried out. The time to develop the technique was 20 days. A comparative study was carried out with the phenolated glycerin technique that uses toxic reagents (formaldehyde and phenol) and the pieces obtained with the alcohol propylene glycol technique were of better quality, observing that the pieces with phenolated glycerin tend to darken and are more rigid. And the time to develop the technique is 24 days. In conclusion, a preservation technique for anatomical pieces was developed that allowed the preservation of the organs under study, which allow their use for anatomical studies, and which have been preserved without changes until the time of this publication (8 months) and there are pieces preserved with this technique for 2 years.展开更多
Mitochondrial organelle transplantation (MOT) is an innovative strategy for the treatment of mitochondrial dysfunction such as cardiac ischemic reperfusion injuries, Parkinson’s diseases, brain and spinal cord injuri...Mitochondrial organelle transplantation (MOT) is an innovative strategy for the treatment of mitochondrial dysfunction such as cardiac ischemic reperfusion injuries, Parkinson’s diseases, brain and spinal cord injuries, and amyotrophic lateral sclerosis (ALS). However, one of the major challenges for widespread usage is a methodology for preservation of isolated mitochondria. Extracellular vesicles (EVs) are phospholipid bilayer-enclosed vesicles released from cells. EVs carry a cargo of proteins, nucleic acids, lipids, metabolites, and even organelles such as mitochondria. Purpose: To test if EVs enhance the stability of isolated mitochondria. Methods: We mixed isolated mitochondria of fibroblasts with EVs of mesenchymal stromal cells (imEVs) (9:1 in volume) and stored the mixture at 2°C - 6°C for different time periods. We measured morphology, mitochondrial membrane potential (MMP) and mitochondrial ATP content at 0, 2, 5 days. Key findings: After 2 days of storage, the mito-chondria without imEVs lost approximate 70% MMP (RFU: 1822 ± 68), compared to the fresh mitochondria (RFU: 5458 ± 52) (p 0.05). In agreement with MMP, mitochondria without imEVs lost significant mitochondrial ATP content (p 0.05), after 2 days of cold storage, compared to fresh mitochondria. Microscopy showed that imEVs promoted aggregation of isolated mitochondria. Summary: The preliminary data showed that imEVs enhanced the stability of isolated mitochondria in cold storage.展开更多
Tectonism is one of the dominant factors affecting the shale pore structure.However,the control of shale pore structure by tectonic movements is still controversial,which limits the research progress of shale gas accu...Tectonism is one of the dominant factors affecting the shale pore structure.However,the control of shale pore structure by tectonic movements is still controversial,which limits the research progress of shale gas accumulation mechanism in the complex tectonic region of southern China.In this study,34 samples were collected from two exploratory wells located in different tectonic locations.Diverse experiments,e.g.,organic geochemistry,XRD analysis,FE-SEM,low-pressure gas adsorption,and high-pressure mercury intrusion,were conducted to fully characterize the shale reservoir.The TOC,Ro,and mineral composition of the shale samples between the two wells are similar,which reflects that the shale samples of the two wells have proximate pores-generating capacity and pores-supporting capacity.However,the pore characteristics of shale samples from two wells are significantly different.Compared with the stabilized zone shale,the porosity,pore volume,and specific surface area of the deformed zone shale were reduced by 60.61%,64.85%,and 27.81%,respectively.Moreover,the macroscopic and fine pores were reduced by 54.01%and 84.95%,respectively.Fault activity and uplift denudation are not conducive to pore preservation,and the rigid basement of Huangling uplift can promote pore preservation.These three factors are important reasons for controlling the difference in pore structure between two wells shales.We established a conceptual model of shale pores evolution under different tectonic preservation conditions.This study is significant to clarify the scale of shale gas formation and enrichment in complex tectonic regions,and helps in the selection of shale sweet spots.展开更多
Xiazhuang uranium ore field,located in the southern part of the Nanling Metallogenic Belt,is considered one of the largest granite-related U regions in South China.In this paper,we contribute new apatite fission track...Xiazhuang uranium ore field,located in the southern part of the Nanling Metallogenic Belt,is considered one of the largest granite-related U regions in South China.In this paper,we contribute new apatite fission track data and thermal history modeling to constrain the exhumation history and evaluate preservation potential of the Xiazhuang Uranium ore field.Nine Triassic outcrop granite samples collected from different locations of Xiazhuang Uranium ore field yield AFT ages ranging from 43 to 24 Ma with similar mean confined fission track lengths ranging from 11.8±2.0 to 12.9±1.9μm and Dpar values between 1.01 and 1.51μm.The robustness time-temperature reconstructions of samples from the hanging wall of Huangpi fault show that the Xiazhuang Uranium ore field experienced a time of monotonous and slow cooling starting from middle Paleocene to middle Miocene(~60-10 Ma),followed by relatively rapid exhumation in the late Miocene(~10-5 Ma)and nearly thermal stability in the Pliocene-Quaternary(~5-0 Ma).The amount of exhumation after U mineralization since the Middle Paleogene was estimated as~4.3±1.8 km according to the integrated thermal history model.Previous studies indicate that the ore-forming ages of U deposits in the Xiazhuang ore field are mainly before Middle Paleocene and the mineralization depths are more than 4.4±1.2 km.Therefore,the exhumation history since middle Paleocene plays important roles in the preservation of the Xiazhuang Uranium ore field.展开更多
Biochar is a carbon sink material with the potential to improve water retention in various soils.However,for the long‐term maintenance of green infrastructure,there is an additional need to regulate the water content...Biochar is a carbon sink material with the potential to improve water retention in various soils.However,for the long‐term maintenance of green infrastructure,there is an additional need to regulate the water contents in the covers to maintain vegetation growth in semiarid conditions.In this study,biochar‐amended soil was combined with subsurface drip irrigation,and the water preservation characteristics of this treatment were investigated through a series of one‐dimensional soil column tests.To ascertain the best treatment method specific to semiarid climatic conditions,the test soil was amended with 0%,1%,3%,and 5%biochar.Automatic irrigation devices equipped with soil moisture sensors were used to control the subsurface water content with the aim of enhancing vegetation growth.Each soil column test lasted 150 h,during which the volumetric water contents and soil suction data were recorded.The experimental results reveal that the soil specimen amended with 3%biochar is the most water‐saving regardless of the time cost.Soil with a higher biochar content(e.g.,5%)consumes a more significant amount of water due to the enhancement of the water‐holding capacity.Based on the experimental results,it can be concluded that the appropriate ratio can be determined within 1%–3%,which can reduce not only the amount of irrigated/used water but also the time cost.Such technology can be explored for water content regulation in green infrastructure and the development of barriers for protecting the environment around deep underground waste containment.展开更多
With the recent technological developments,massive vehicular ad hoc networks(VANETs)have been established,enabling numerous vehicles and their respective Road Side Unit(RSU)components to communicate with oneanother.Th...With the recent technological developments,massive vehicular ad hoc networks(VANETs)have been established,enabling numerous vehicles and their respective Road Side Unit(RSU)components to communicate with oneanother.The best way to enhance traffic flow for vehicles and traffic management departments is to share thedata they receive.There needs to be more protection for the VANET systems.An effective and safe methodof outsourcing is suggested,which reduces computation costs by achieving data security using a homomorphicmapping based on the conjugate operation of matrices.This research proposes a VANET-based data outsourcingsystem to fix the issues.To keep data outsourcing secure,the suggested model takes cryptography models intoaccount.Fog will keep the generated keys for the purpose of vehicle authentication.For controlling and overseeingthe outsourced data while preserving privacy,the suggested approach considers the Trusted Certified Auditor(TCA).Using the secret key,TCA can identify the genuine identity of VANETs when harmful messages aredetected.The proposed model develops a TCA-based unique static vehicle labeling system using cryptography(TCA-USVLC)for secure data outsourcing and privacy preservation in VANETs.The proposed model calculatesthe trust of vehicles in 16 ms for an average of 180 vehicles and achieves 98.6%accuracy for data encryption toprovide security.The proposedmodel achieved 98.5%accuracy in data outsourcing and 98.6%accuracy in privacypreservation in fog-enabled VANETs.Elliptical curve cryptography models can be applied in the future for betterencryption and decryption rates with lightweight cryptography operations.展开更多
This study investigates the heat dissipation mechanism of the insulation layer and other plane insulation layers in the polar drilling rig system.Combining the basic theory of heat transfer with the environmental requ...This study investigates the heat dissipation mechanism of the insulation layer and other plane insulation layers in the polar drilling rig system.Combining the basic theory of heat transfer with the environmental requirements of polar drilling operations and the characteristics of polar drilling processes,we analyze the factors that affect the insulation effect of the drilling rig system.These factors include the thermal conductivity of the insulation material,the thickness of the insulation layer,ambient temperature,and wind speed.We optimize the thermal insulation material of the polar drilling rig system using a steady-state method to measure solid thermal conductivity.By analyzing the distribution of temperature in space after heating,we optimize the distribution and air outlet angle of the heater using Fluent hydrodynamics software.The results demonstrate that under polar conditions,polyisocyanurate with stable thermodynamic properties is selected as the thermal insulation material.The selection of thermal insulation material and thickness significantly affects the thermal insulation effect of the system but has little effect on its heating effect.Moreover,when the air outlet angle of the heater is set to 32.5°,the heating efficiency of the system can be effectively improved.According to heat transfer equations and heat balance theory,we determine that the heating power required for the system to reach 5°C is close to numerical simulation.展开更多
[Objectives]The paper was to investigate a method for the storage and preservation of Carica papaya utilizing chemical fungicides and composite biological coatings.[Methods]C.papaya fruits with red pulp sourced from L...[Objectives]The paper was to investigate a method for the storage and preservation of Carica papaya utilizing chemical fungicides and composite biological coatings.[Methods]C.papaya fruits with red pulp sourced from Lianjiang were utilized as test materials.The fruit epidermis was subjected to treatment with composite fungicidal coatings at ambient temperature,and the nutritional and physiological indicators of the fruits were measured at regular intervals.[Results]Under ambient temperature conditions,a chemical fungicide composite consisting of 300 mg/L fludioxonil and 250 mg/L propiconazole was employed to soak the fruits for a duration of 2 min.Subsequently,a composite biological coating formulated with 8 g/L KGM and 1.0%Zein at a pH of 7.0 was applied to the fruits.This treatment effectively inhibited the decline in the content of total soluble solids(TSS)and vitamin C(V C)in C.papaya,reduced the weight loss rate and the decay index,and enhanced the yellow ripening index.[Conclusions]This study establishes a foundation for the advancement of additional methods and techniques for the storage and preservation of C.papaya.展开更多
Oncofertility is an extremely significant topic that is increasingly being discussed owing to increased evidence indicating that fertility preservation does not affect the treatment outcomes of patients with cancer but...Oncofertility is an extremely significant topic that is increasingly being discussed owing to increased evidence indicating that fertility preservation does not affect the treatment outcomes of patients with cancer but significantly contributes to preserving life quality.The effect of chemotherapy can range from minimal effects to complete ovarian atrophy.Limited data are available on the effects of monoclonal antibodies and targeted therapies on the ovaries and fertility.Temporary ovarian suppression by administering a gonadotropin-releasing hormone agonist(GnRHa)during chemotherapy decreases the gonadotoxic effect of chemotherapy,thereby diminishing the chance of developing premature ovarian insufficiency(POI).At present,the concomitant administration of GnRH analogs during chemotherapy is the only accepted pharmacological method for preserving ovarian function.Notably,most randomized studies on the effectiveness of luteinizing hormone-releasing hormone agonists during chemotherapy in preventing POI have been conducted in women with breast cancer,with a considerably small number of studies on patients with hematological malignancies.Furthermore,most randomized controlled trials on breast cancer have revealed a decrease in treatment-induced POI risk,regardless of the hormone receptor status.In addition,studies on hematological malignancies have yielded negative results;nevertheless,thefindings must be interpreted with caution owing to numerous limitations.Current guidelines from the American Society of Clinical Oncology and ESMO Clinical Practice Guidelines recommend sperm,oocyte,and embryo cryopreservation as a standard practice and only offering GnRHa to patients when proven fertility preservation methods are not feasible.In this manuscript,we present a comprehensive literature overview on the application of ovarian suppression with GnRHa during chemotherapy in patients with cancer by addressing preclinical and clinical data,as well as future perspectives in thisfield that upcoming research should focus on.展开更多
The escalating prevalence of gastrointestinal cancers underscores the urgency for transformative approaches.Current treatment costs amount to billions of dollars annually,combined with the risks and comorbidities asso...The escalating prevalence of gastrointestinal cancers underscores the urgency for transformative approaches.Current treatment costs amount to billions of dollars annually,combined with the risks and comorbidities associated with invasive surgery.This highlights the importance of less invasive alternatives with organ preservation being a central aspect of the treatment paradigm.The current standard of care typically involves neoadjuvant systemic therapy followed by surgical resection.There is a growing interest in organ preservation approaches by way of minimizing extensive surgical resections.Endoscopic ablation has proven to be useful in precursor lesions,as well as in palliative cases of unrese-ctable disease.More recently,there has been an increase in reports on the utility of adjunct endoscopic ablative techniques for downstaging disease as well as contributing to non-surgical complete clinical response.This expansive field within endoscopic oncology holds great potential for advancing patient care.By addressing challenges,fostering collaboration,and embracing technological advancements,the gastrointestinal cancer treatment paradigm can shift towards a more sustainable and patient-centric future emphasizing organ and function preservation.This editorial examines the evolving landscape of endoscopic ablation strategies,emphasizing their potential to improve patient outcomes.We briefly review current applications of endoscopic ablation in the esophagus,stomach,duodenum,pancreas,bile ducts,and colon.展开更多
Objective: To analyze the application effect and value of dydrogesterone in the fertility preservation treatment of preeclampsia. Methods: Forty cases of patients with preeclampsia admitted to our hospital between Jan...Objective: To analyze the application effect and value of dydrogesterone in the fertility preservation treatment of preeclampsia. Methods: Forty cases of patients with preeclampsia admitted to our hospital between January 2023 and January 2024 were divided randomly into a control group and an observation group of 20 cases each. The control group applied progesterone to preserve the fetus, and the observation group applied dydrogesterone. The symptom relief time, hormone levels before and after treatment, as well as adverse drug reactions, and the effect of fetal preservation between the two groups were compared. Results: The time to relieve vaginal bleeding, abdominal pain. and lumbago in the observation group was shorter than that in the control group (P < 0.05). After treatment, the progesterone levels and incidence of adverse drug reactions in the observation group were lower than those in the control group (P < 0.05). The success rate of fertility preservation in the observation group was higher than that in the control group (P < 0.05). Conclusion: In the treatment of fetal preservation of preeclampsia, the application of dydrogesterone positively alleviated vaginal bleeding, abdominal pain, and lumbago, with mild adverse reactions and a good effect on fetal preservation.展开更多
Objective:To observe the application effects of anesthesia recovery nursing with heat preservation measures in patients undergoing general anesthesia surgery.Methods:300 cases of general anesthesia surgery patients in...Objective:To observe the application effects of anesthesia recovery nursing with heat preservation measures in patients undergoing general anesthesia surgery.Methods:300 cases of general anesthesia surgery patients in our hospital from March 2023 to February 2024 were selected and divided into the control group and the observation group according to the random number table method,each with 150 cases.The control group adopted conventional care,while the observation group was given anesthesia recovery care and heat preservation measures on the basis of conventional care.The wake-up time,extubation time,hospitalization time,and the incidence of adverse reactions were compared between the two groups and statistically analyzed.Results:The wake-up time of patients in the control group was 9.71±1.20 hours,and that of the observation group was 6.51±1.02 hours,with statistically significant differences(P<0.05);the extubation times of patients in the observation group and the control group after awakening were 8.52±0.41 min and 10.42±1.12 min,respectively,with statistically significant differences(P<0.05)The hospital stay after the operation in the observation group and the control group was 32.91±4.71 days and 37.24±3.34 days respectively,and the difference was statistically significant(P<0.05),and the incidence rate of adverse reactions after extubation in the observation group(3.33%)was significantly lower than that in the control group(10.00%)(P<0.05).Conclusion:In general anesthesia surgery patients,the implementation of anesthesia recovery nursing with heat preservation measures can significantly improve the physical condition of patients,effectively shorten the duration of surgery and patients’wake-up time,and improve their quality of life,which is worthy of clinical promotion and application.展开更多
This study is the first phase of research results from the student innovation project“Yunqiao Sunshine Health and Wellness Homestay”group at Chengdu Normal University.By analyzing the current state of the Sunshine H...This study is the first phase of research results from the student innovation project“Yunqiao Sunshine Health and Wellness Homestay”group at Chengdu Normal University.By analyzing the current state of the Sunshine Health and Wellness Tourism Area economy in the Panxi region of Sichuan,local policies,and the current state of Sunshine Health and Wellness homestays and hotels,this paper proposes the possibility of developing Sunshine Health and Wellness homestays and hotels through traditional Chinese medicine(TCM)health preservation methods.It also proposes development strategies for such hotels through a market survey SWOT analysis.展开更多
Online Social Networks (OSN) sites allow end-users to share agreat deal of information, which may also contain sensitive information,that may be subject to commercial or non-commercial privacy attacks. Asa result, gua...Online Social Networks (OSN) sites allow end-users to share agreat deal of information, which may also contain sensitive information,that may be subject to commercial or non-commercial privacy attacks. Asa result, guaranteeing various levels of privacy is critical while publishingdata by OSNs. The clustering-based solutions proved an effective mechanismto achieve the privacy notions in OSNs. But fixed clustering limits theperformance and scalability. Data utility degrades with increased privacy,so balancing the privacy utility trade-off is an open research issue. Theresearch has proposed a novel privacy preservation model using the enhancedclustering mechanism to overcome this issue. The proposed model includesphases like pre-processing, enhanced clustering, and ensuring privacy preservation.The enhanced clustering algorithm is the second phase where authorsmodified the existing fixed k-means clustering using the threshold approach.The threshold value is determined based on the supplied OSN data of edges,nodes, and user attributes. Clusters are k-anonymized with multiple graphproperties by a novel one-pass algorithm. After achieving the k-anonymityof clusters, optimization was performed to achieve all privacy models, suchas k-anonymity, t-closeness, and l-diversity. The proposed privacy frameworkachieves privacy of all three network components, i.e., link, node, and userattributes, with improved utility. The authors compare the proposed techniqueto underlying methods using OSN Yelp and Facebook datasets. The proposedapproach outperformed the underlying state of art methods for Degree ofAnonymization, computational efficiency, and information loss.展开更多
The Qiangtang Basin of the Tibetan Plateau,located in the eastern Tethys tectonic domain,is the largest new marine petroliferous region for exploration in China.The scientific drilling project consisting primarily of ...The Qiangtang Basin of the Tibetan Plateau,located in the eastern Tethys tectonic domain,is the largest new marine petroliferous region for exploration in China.The scientific drilling project consisting primarily of well QK-1 and its supporting shallow boreholes for geological surveys(also referred to as the Project)completed in recent years contributes to a series of new discoveries and insights into the oil and gas preservation conditions and source rock evaluation of the Qiangtang Basin.These findings differ from previous views that the Qiangtang Basin has poor oil and gas preservation conditions and lacks high-quality source rocks.As revealed by well QK-1 and its supporting shallow boreholes in the Project,the Qiangtang Basin hosts two sets of high-quality regional seals,namely an anhydrite layer in the Quemo Co Formation and the gypsum-bearing mudstones in the Xiali Formation.Moreover,the Qiangtang Basin has favorable oil and gas preservation conditions,as verified by the comprehensive study of the sealing capacity of seals,basin structure,tectonic uplift,magmatic activity,and groundwater motion.Furthermore,the shallow boreholes have also revealed that the Qiangtang Basin has high-quality hydrocarbon source rocks in the Upper Triassic Bagong Formation,which are thick and widely distributed according to the geological and geophysical data.In addition,the petroleum geological conditions,such as the type,abundance,and thermal evolution of organic matter,indicate that the Qiangtang Basin has great hydrocarbon-generating potential.展开更多
Objective:With the increasing application of vascular reconstruction in surgical procedures,allogeneic vessels are becoming more popular in clinical practice due to their abundant sources,precise diameter matching,imp...Objective:With the increasing application of vascular reconstruction in surgical procedures,allogeneic vessels are becoming more popular in clinical practice due to their abundant sources,precise diameter matching,improved histocompatibility,and higher long-term patency rate.This study aimed to investigate the protective effect of various preservation solutions on the function and structure of the isolated rat abdominal aorta preserved under hypothermal conditions.Methods:The study utilized a total of 150 Sprague-Dawley(SD)rats,with 144 rats allocated to the experimental groups and 6 rats allocated to the control groups.The abdominal aorta of the rats was chosen as the subject of our research.The aorta in the experimental groups were randomly assigned to 4 groups:University of Wisconsin(UW)solution group,histidine-tryptophan-ketoglutarate(HTK)solution group,normal saline(NS)group,and sodium lactate Ringer's solution(RS)group.Samples were subjected to examination after preservation periods of 1 day,3 days,5 days,7 days,14 days,30 days,and 90 days.Evaluation of vascular physiological function involved detecting and assessing vasoconstriction ability and measuring cell viability through the MTT test.Evaluation of the vascular wall structure involved tension tolerance tests and pathological staining.Results:The pathogen-positive rate in the HTK group and NS group at 1 month was 16.7%.Regarding the vascular skeleton structure,both the UW group and HTK group exhibited intact structures after 2 weeks of preservation,with slightly edematous collagen and elastic fibers,which was significantly better than that of the NS group and RS group.In terms of cell activity and contractile function,all preservation groups showed similar effects within 2 weeks.However,after 2 weeks,the UW group showed the most favorable preservation effect(P<0.05).In terms of vascular tension,different groups exhibited similar effects within 1 week.However,after 2 weeks,the UW group showed the best preservation effect(P<0.05).Conclusion:All 4 types of preservation solution had a preservation effect on the structure and function of isolated blood vessels during short-term hypothermal preservation.However,after 2-week preservation,the UW solution was found to be the most suitable solution for the preservation of blood vessels.展开更多
Hyperbolic systems of conservation laws in multiple spatial dimensions display features absent in the one-dimensional case,such as involutions and non-trivial stationary states.These features need to be captured by nu...Hyperbolic systems of conservation laws in multiple spatial dimensions display features absent in the one-dimensional case,such as involutions and non-trivial stationary states.These features need to be captured by numerical methods without excessive grid refine-ment.The active flux method is an extension of the finite volume scheme with additional point values distributed along the cell boundary.For the equations of linear acoustics,an exact evolution operator can be used for the update of these point values.It incorporates all multi-dimensional information.The active flux method is stationarity preserving,i.e.,it discretizes all the stationary states of the PDE.This paper demonstrates the experimental evidence for the discrete stationary states of the active flux method and shows the evolution of setups towards a discrete stationary state.展开更多
Breast cancer is the most common cancer in women worldwide, constituting 25% of all cancer diagnoses. Even though it is only affecting 4% - 6% of women under the age of 40, it remains the most...Breast cancer is the most common cancer in women worldwide, constituting 25% of all cancer diagnoses. Even though it is only affecting 4% - 6% of women under the age of 40, it remains the most common malignancy among younger patients. Advancement in the treatment and earlier detection gives excellent 5 years of survival. However, the standard treatment that comprises surgical-chemo radiation therapy or hormonal treatment often results in an increased incidence of treatment-induced infertility. Therefore, adding fertility preservation to primary cancer treatment may offer the best opportunity for future fertility. However, despite advancements in Assisted Reproductive Technology (ART), the uptake of fertility services in this group remains low. In this review, we highlighted the effect of all breast cancer treatments on women’s fertility, the effectiveness and safety of ART in breast cancer patients as well as the safety of pregnancy in breast cancer survivors. Our aim is to improve awareness of fertility preservation for breast cancer to ensure all women diagnosed with breast cancer have multidisciplinary approaches with early referral to fertility specialists to discuss regarding potential risks and benefits of fertility preservation to improve the uptake of fertility preservation among this group of patients.展开更多
The issue of plastic pollution has attracted widespread social attention.Gelatin is valued as a degradable bio-based material,especially as an edible active packaging material.However,the commonly used solution-castin...The issue of plastic pollution has attracted widespread social attention.Gelatin is valued as a degradable bio-based material,especially as an edible active packaging material.However,the commonly used solution-casting filmforming technology limits the mass production of gelatin films.In order to improve the production efficiency and enhance the commercial value of gelatin films,in this study,fish gelatin(FG)particles were successfully blended with essential oils(EOs)to prepare active films by melt extrusion technique,a common method for commercial plastics,and applied to bread preservation.FG and EOs showed good compatibility with each other.The elongation at break was enhanced in all samples of films containing EOs.The addition of EOs weakened the oxygen barrier properties of the FG films.The gelatin films containing clove EO showed the highest DPPH radical scavenging rate of 39.38%.The films containing oregano EO showed the highest antibacterial activity,with 98.84%and 99.86% against S.aureus and E.coli,respectively.The bread preservation results showed a slower microbial growth rate in the samples preserved by the active films.The bread samples preserved in commercial PE film showed mold on day 3,and the bread samples preserved in active gelatin film showed mold visible to the naked eye by day 7.This study demonstrates the potential of gelatin-based activated films for commercial application in baked goods preservation.展开更多
Suspended particulate barite crystals were detected in the water columns at four different stations near the 90°E ridge in the Indian Ocean.Four distinct morphological types of marine barites were distinguished:e...Suspended particulate barite crystals were detected in the water columns at four different stations near the 90°E ridge in the Indian Ocean.Four distinct morphological types of marine barites were distinguished:euhedral-subhedral crystals,oval or round crystals,rhombic crystals,and irregular crystals.The barite crystals in the study area are typically fine,with a dominant size of 1–3μm.The vertical distribution of barites is significantly affected by the formation and sedimentation processes.Barites begin to appear at a depth of 30 m and are formed primarily from the surface to the depth of 2000m with a concentration peak at the depth of 200m,where particles are coarser than those in the other layers.The barites begin to settle and dissolve once formed in the water column,resulting in finer barite particles and lower particle concentrations.The formation of barite crystals is related to biological processes associated with the decomposition of barium-rich skeletons in the microenvironment of decaying organic matter that is affected by the primary productivity and dissolved oxygen content in the water column.The dissolving process of barite crystals showed similar variation with the concentration of dissolved barium in ocean water,and the substitution of strontium for barite in crystals promotes the selective dissolution of barite and exerts an important impact on its morphology.It is approximately 33%of barites in the amount and 22%in the concentration to settle to the bottom of the water column compared to that observed in the main barite formation zone.展开更多
文摘The preservation of anatomical pieces in Veterinary Anatomy is essential since it is not possible to dissect all domestic species. Most techniques use reagents with high levels of toxicity such as formaldehyde. The objective of this work was to develop a new preservation technique that uses reagents with zero toxicity and that allows obtaining preserved pieces suitable for anatomical studies. The alcohol propylene glycol technique was developed, the method of which uses a fixation step with alcohol, sodium chloride, commercial vinegar and subsequently the impregnation of the preservation solution made from propylene glycol and commercial vinegar, which are non-toxic. As a result of this work, adequately preserved sheep hearts were obtained that preserved their morphology with slight changes in size and weight, which did not affect their external and internal anatomical structure. Its coloration was not substantially affected, remaining a little lighter. The pieces obtained showed flexibility which allowed dissections to be carried out. The time to develop the technique was 20 days. A comparative study was carried out with the phenolated glycerin technique that uses toxic reagents (formaldehyde and phenol) and the pieces obtained with the alcohol propylene glycol technique were of better quality, observing that the pieces with phenolated glycerin tend to darken and are more rigid. And the time to develop the technique is 24 days. In conclusion, a preservation technique for anatomical pieces was developed that allowed the preservation of the organs under study, which allow their use for anatomical studies, and which have been preserved without changes until the time of this publication (8 months) and there are pieces preserved with this technique for 2 years.
文摘Mitochondrial organelle transplantation (MOT) is an innovative strategy for the treatment of mitochondrial dysfunction such as cardiac ischemic reperfusion injuries, Parkinson’s diseases, brain and spinal cord injuries, and amyotrophic lateral sclerosis (ALS). However, one of the major challenges for widespread usage is a methodology for preservation of isolated mitochondria. Extracellular vesicles (EVs) are phospholipid bilayer-enclosed vesicles released from cells. EVs carry a cargo of proteins, nucleic acids, lipids, metabolites, and even organelles such as mitochondria. Purpose: To test if EVs enhance the stability of isolated mitochondria. Methods: We mixed isolated mitochondria of fibroblasts with EVs of mesenchymal stromal cells (imEVs) (9:1 in volume) and stored the mixture at 2°C - 6°C for different time periods. We measured morphology, mitochondrial membrane potential (MMP) and mitochondrial ATP content at 0, 2, 5 days. Key findings: After 2 days of storage, the mito-chondria without imEVs lost approximate 70% MMP (RFU: 1822 ± 68), compared to the fresh mitochondria (RFU: 5458 ± 52) (p 0.05). In agreement with MMP, mitochondria without imEVs lost significant mitochondrial ATP content (p 0.05), after 2 days of cold storage, compared to fresh mitochondria. Microscopy showed that imEVs promoted aggregation of isolated mitochondria. Summary: The preliminary data showed that imEVs enhanced the stability of isolated mitochondria in cold storage.
基金supported by the National Natural Science Foundation of China (42122017,41821002)the Hubei Provincial Natural Science Foundation of China (2020CFB501)+1 种基金the Shandong Provincial Key Research and Development Program (2020ZLYS08)the Independent innovation research program of China University of Petroleum (East China) (21CX06001A)。
文摘Tectonism is one of the dominant factors affecting the shale pore structure.However,the control of shale pore structure by tectonic movements is still controversial,which limits the research progress of shale gas accumulation mechanism in the complex tectonic region of southern China.In this study,34 samples were collected from two exploratory wells located in different tectonic locations.Diverse experiments,e.g.,organic geochemistry,XRD analysis,FE-SEM,low-pressure gas adsorption,and high-pressure mercury intrusion,were conducted to fully characterize the shale reservoir.The TOC,Ro,and mineral composition of the shale samples between the two wells are similar,which reflects that the shale samples of the two wells have proximate pores-generating capacity and pores-supporting capacity.However,the pore characteristics of shale samples from two wells are significantly different.Compared with the stabilized zone shale,the porosity,pore volume,and specific surface area of the deformed zone shale were reduced by 60.61%,64.85%,and 27.81%,respectively.Moreover,the macroscopic and fine pores were reduced by 54.01%and 84.95%,respectively.Fault activity and uplift denudation are not conducive to pore preservation,and the rigid basement of Huangling uplift can promote pore preservation.These three factors are important reasons for controlling the difference in pore structure between two wells shales.We established a conceptual model of shale pores evolution under different tectonic preservation conditions.This study is significant to clarify the scale of shale gas formation and enrichment in complex tectonic regions,and helps in the selection of shale sweet spots.
基金the Foundation of State Key Laboratory of Nuclear Resources and Environment(Grant Nos.NRE2021-01,2022NRE34)the National Natural Science Foundation of China(Grant No.42162013)+1 种基金the Third Xinjiang Scientific Expedition Program(Grant No.2022xjkk1301)the Fund of National Key Laboratory of Science and Technology on Remote Sensing Information and imagery Analysis,Beijing Research Institute of Uranium Geology(Grant No.6142A01210405).
文摘Xiazhuang uranium ore field,located in the southern part of the Nanling Metallogenic Belt,is considered one of the largest granite-related U regions in South China.In this paper,we contribute new apatite fission track data and thermal history modeling to constrain the exhumation history and evaluate preservation potential of the Xiazhuang Uranium ore field.Nine Triassic outcrop granite samples collected from different locations of Xiazhuang Uranium ore field yield AFT ages ranging from 43 to 24 Ma with similar mean confined fission track lengths ranging from 11.8±2.0 to 12.9±1.9μm and Dpar values between 1.01 and 1.51μm.The robustness time-temperature reconstructions of samples from the hanging wall of Huangpi fault show that the Xiazhuang Uranium ore field experienced a time of monotonous and slow cooling starting from middle Paleocene to middle Miocene(~60-10 Ma),followed by relatively rapid exhumation in the late Miocene(~10-5 Ma)and nearly thermal stability in the Pliocene-Quaternary(~5-0 Ma).The amount of exhumation after U mineralization since the Middle Paleogene was estimated as~4.3±1.8 km according to the integrated thermal history model.Previous studies indicate that the ore-forming ages of U deposits in the Xiazhuang ore field are mainly before Middle Paleocene and the mineralization depths are more than 4.4±1.2 km.Therefore,the exhumation history since middle Paleocene plays important roles in the preservation of the Xiazhuang Uranium ore field.
基金Foundation of China(Grant No.52261160382)for financial support.
文摘Biochar is a carbon sink material with the potential to improve water retention in various soils.However,for the long‐term maintenance of green infrastructure,there is an additional need to regulate the water contents in the covers to maintain vegetation growth in semiarid conditions.In this study,biochar‐amended soil was combined with subsurface drip irrigation,and the water preservation characteristics of this treatment were investigated through a series of one‐dimensional soil column tests.To ascertain the best treatment method specific to semiarid climatic conditions,the test soil was amended with 0%,1%,3%,and 5%biochar.Automatic irrigation devices equipped with soil moisture sensors were used to control the subsurface water content with the aim of enhancing vegetation growth.Each soil column test lasted 150 h,during which the volumetric water contents and soil suction data were recorded.The experimental results reveal that the soil specimen amended with 3%biochar is the most water‐saving regardless of the time cost.Soil with a higher biochar content(e.g.,5%)consumes a more significant amount of water due to the enhancement of the water‐holding capacity.Based on the experimental results,it can be concluded that the appropriate ratio can be determined within 1%–3%,which can reduce not only the amount of irrigated/used water but also the time cost.Such technology can be explored for water content regulation in green infrastructure and the development of barriers for protecting the environment around deep underground waste containment.
文摘With the recent technological developments,massive vehicular ad hoc networks(VANETs)have been established,enabling numerous vehicles and their respective Road Side Unit(RSU)components to communicate with oneanother.The best way to enhance traffic flow for vehicles and traffic management departments is to share thedata they receive.There needs to be more protection for the VANET systems.An effective and safe methodof outsourcing is suggested,which reduces computation costs by achieving data security using a homomorphicmapping based on the conjugate operation of matrices.This research proposes a VANET-based data outsourcingsystem to fix the issues.To keep data outsourcing secure,the suggested model takes cryptography models intoaccount.Fog will keep the generated keys for the purpose of vehicle authentication.For controlling and overseeingthe outsourced data while preserving privacy,the suggested approach considers the Trusted Certified Auditor(TCA).Using the secret key,TCA can identify the genuine identity of VANETs when harmful messages aredetected.The proposed model develops a TCA-based unique static vehicle labeling system using cryptography(TCA-USVLC)for secure data outsourcing and privacy preservation in VANETs.The proposed model calculatesthe trust of vehicles in 16 ms for an average of 180 vehicles and achieves 98.6%accuracy for data encryption toprovide security.The proposedmodel achieved 98.5%accuracy in data outsourcing and 98.6%accuracy in privacypreservation in fog-enabled VANETs.Elliptical curve cryptography models can be applied in the future for betterencryption and decryption rates with lightweight cryptography operations.
基金supported by the Key-Area Research and Development Program of Guangdong Province,Research on the Method of Heat Preservation and Heating for the Drilling System of Polar Offshore Drilling Platform (No.2020B1111010001).
文摘This study investigates the heat dissipation mechanism of the insulation layer and other plane insulation layers in the polar drilling rig system.Combining the basic theory of heat transfer with the environmental requirements of polar drilling operations and the characteristics of polar drilling processes,we analyze the factors that affect the insulation effect of the drilling rig system.These factors include the thermal conductivity of the insulation material,the thickness of the insulation layer,ambient temperature,and wind speed.We optimize the thermal insulation material of the polar drilling rig system using a steady-state method to measure solid thermal conductivity.By analyzing the distribution of temperature in space after heating,we optimize the distribution and air outlet angle of the heater using Fluent hydrodynamics software.The results demonstrate that under polar conditions,polyisocyanurate with stable thermodynamic properties is selected as the thermal insulation material.The selection of thermal insulation material and thickness significantly affects the thermal insulation effect of the system but has little effect on its heating effect.Moreover,when the air outlet angle of the heater is set to 32.5°,the heating efficiency of the system can be effectively improved.According to heat transfer equations and heat balance theory,we determine that the heating power required for the system to reach 5°C is close to numerical simulation.
基金Supported by Guangdong Undergraduate Innovation Training Program(S202010580073)Zhaoqing Science and Technology Innovation Guidance Project(202304038003).
文摘[Objectives]The paper was to investigate a method for the storage and preservation of Carica papaya utilizing chemical fungicides and composite biological coatings.[Methods]C.papaya fruits with red pulp sourced from Lianjiang were utilized as test materials.The fruit epidermis was subjected to treatment with composite fungicidal coatings at ambient temperature,and the nutritional and physiological indicators of the fruits were measured at regular intervals.[Results]Under ambient temperature conditions,a chemical fungicide composite consisting of 300 mg/L fludioxonil and 250 mg/L propiconazole was employed to soak the fruits for a duration of 2 min.Subsequently,a composite biological coating formulated with 8 g/L KGM and 1.0%Zein at a pH of 7.0 was applied to the fruits.This treatment effectively inhibited the decline in the content of total soluble solids(TSS)and vitamin C(V C)in C.papaya,reduced the weight loss rate and the decay index,and enhanced the yellow ripening index.[Conclusions]This study establishes a foundation for the advancement of additional methods and techniques for the storage and preservation of C.papaya.
基金This work was supported by the Science Fund of the Republic of Serbia(IDEAS),Project Number:7750154(NPATPETTMPCB).Project Title:New Prognostic and Theranostic Potential of Enzymes Involved in CoTranscriptional Cleavage and Co-Translational Modification in Prostate,Colorectal,and Breast Cancer Tissue.
文摘Oncofertility is an extremely significant topic that is increasingly being discussed owing to increased evidence indicating that fertility preservation does not affect the treatment outcomes of patients with cancer but significantly contributes to preserving life quality.The effect of chemotherapy can range from minimal effects to complete ovarian atrophy.Limited data are available on the effects of monoclonal antibodies and targeted therapies on the ovaries and fertility.Temporary ovarian suppression by administering a gonadotropin-releasing hormone agonist(GnRHa)during chemotherapy decreases the gonadotoxic effect of chemotherapy,thereby diminishing the chance of developing premature ovarian insufficiency(POI).At present,the concomitant administration of GnRH analogs during chemotherapy is the only accepted pharmacological method for preserving ovarian function.Notably,most randomized studies on the effectiveness of luteinizing hormone-releasing hormone agonists during chemotherapy in preventing POI have been conducted in women with breast cancer,with a considerably small number of studies on patients with hematological malignancies.Furthermore,most randomized controlled trials on breast cancer have revealed a decrease in treatment-induced POI risk,regardless of the hormone receptor status.In addition,studies on hematological malignancies have yielded negative results;nevertheless,thefindings must be interpreted with caution owing to numerous limitations.Current guidelines from the American Society of Clinical Oncology and ESMO Clinical Practice Guidelines recommend sperm,oocyte,and embryo cryopreservation as a standard practice and only offering GnRHa to patients when proven fertility preservation methods are not feasible.In this manuscript,we present a comprehensive literature overview on the application of ovarian suppression with GnRHa during chemotherapy in patients with cancer by addressing preclinical and clinical data,as well as future perspectives in thisfield that upcoming research should focus on.
文摘The escalating prevalence of gastrointestinal cancers underscores the urgency for transformative approaches.Current treatment costs amount to billions of dollars annually,combined with the risks and comorbidities associated with invasive surgery.This highlights the importance of less invasive alternatives with organ preservation being a central aspect of the treatment paradigm.The current standard of care typically involves neoadjuvant systemic therapy followed by surgical resection.There is a growing interest in organ preservation approaches by way of minimizing extensive surgical resections.Endoscopic ablation has proven to be useful in precursor lesions,as well as in palliative cases of unrese-ctable disease.More recently,there has been an increase in reports on the utility of adjunct endoscopic ablative techniques for downstaging disease as well as contributing to non-surgical complete clinical response.This expansive field within endoscopic oncology holds great potential for advancing patient care.By addressing challenges,fostering collaboration,and embracing technological advancements,the gastrointestinal cancer treatment paradigm can shift towards a more sustainable and patient-centric future emphasizing organ and function preservation.This editorial examines the evolving landscape of endoscopic ablation strategies,emphasizing their potential to improve patient outcomes.We briefly review current applications of endoscopic ablation in the esophagus,stomach,duodenum,pancreas,bile ducts,and colon.
文摘Objective: To analyze the application effect and value of dydrogesterone in the fertility preservation treatment of preeclampsia. Methods: Forty cases of patients with preeclampsia admitted to our hospital between January 2023 and January 2024 were divided randomly into a control group and an observation group of 20 cases each. The control group applied progesterone to preserve the fetus, and the observation group applied dydrogesterone. The symptom relief time, hormone levels before and after treatment, as well as adverse drug reactions, and the effect of fetal preservation between the two groups were compared. Results: The time to relieve vaginal bleeding, abdominal pain. and lumbago in the observation group was shorter than that in the control group (P < 0.05). After treatment, the progesterone levels and incidence of adverse drug reactions in the observation group were lower than those in the control group (P < 0.05). The success rate of fertility preservation in the observation group was higher than that in the control group (P < 0.05). Conclusion: In the treatment of fetal preservation of preeclampsia, the application of dydrogesterone positively alleviated vaginal bleeding, abdominal pain, and lumbago, with mild adverse reactions and a good effect on fetal preservation.
文摘Objective:To observe the application effects of anesthesia recovery nursing with heat preservation measures in patients undergoing general anesthesia surgery.Methods:300 cases of general anesthesia surgery patients in our hospital from March 2023 to February 2024 were selected and divided into the control group and the observation group according to the random number table method,each with 150 cases.The control group adopted conventional care,while the observation group was given anesthesia recovery care and heat preservation measures on the basis of conventional care.The wake-up time,extubation time,hospitalization time,and the incidence of adverse reactions were compared between the two groups and statistically analyzed.Results:The wake-up time of patients in the control group was 9.71±1.20 hours,and that of the observation group was 6.51±1.02 hours,with statistically significant differences(P<0.05);the extubation times of patients in the observation group and the control group after awakening were 8.52±0.41 min and 10.42±1.12 min,respectively,with statistically significant differences(P<0.05)The hospital stay after the operation in the observation group and the control group was 32.91±4.71 days and 37.24±3.34 days respectively,and the difference was statistically significant(P<0.05),and the incidence rate of adverse reactions after extubation in the observation group(3.33%)was significantly lower than that in the control group(10.00%)(P<0.05).Conclusion:In general anesthesia surgery patients,the implementation of anesthesia recovery nursing with heat preservation measures can significantly improve the physical condition of patients,effectively shorten the duration of surgery and patients’wake-up time,and improve their quality of life,which is worthy of clinical promotion and application.
文摘This study is the first phase of research results from the student innovation project“Yunqiao Sunshine Health and Wellness Homestay”group at Chengdu Normal University.By analyzing the current state of the Sunshine Health and Wellness Tourism Area economy in the Panxi region of Sichuan,local policies,and the current state of Sunshine Health and Wellness homestays and hotels,this paper proposes the possibility of developing Sunshine Health and Wellness homestays and hotels through traditional Chinese medicine(TCM)health preservation methods.It also proposes development strategies for such hotels through a market survey SWOT analysis.
文摘Online Social Networks (OSN) sites allow end-users to share agreat deal of information, which may also contain sensitive information,that may be subject to commercial or non-commercial privacy attacks. Asa result, guaranteeing various levels of privacy is critical while publishingdata by OSNs. The clustering-based solutions proved an effective mechanismto achieve the privacy notions in OSNs. But fixed clustering limits theperformance and scalability. Data utility degrades with increased privacy,so balancing the privacy utility trade-off is an open research issue. Theresearch has proposed a novel privacy preservation model using the enhancedclustering mechanism to overcome this issue. The proposed model includesphases like pre-processing, enhanced clustering, and ensuring privacy preservation.The enhanced clustering algorithm is the second phase where authorsmodified the existing fixed k-means clustering using the threshold approach.The threshold value is determined based on the supplied OSN data of edges,nodes, and user attributes. Clusters are k-anonymized with multiple graphproperties by a novel one-pass algorithm. After achieving the k-anonymityof clusters, optimization was performed to achieve all privacy models, suchas k-anonymity, t-closeness, and l-diversity. The proposed privacy frameworkachieves privacy of all three network components, i.e., link, node, and userattributes, with improved utility. The authors compare the proposed techniqueto underlying methods using OSN Yelp and Facebook datasets. The proposedapproach outperformed the underlying state of art methods for Degree ofAnonymization, computational efficiency, and information loss.
基金funded by projects of the National Natural Science Foundation of China(91955204,42241202)the Second Tibetan Plateau Scientific Expedition and Research(2019QZKK080301)a project entitled Tectonics,Sedimentation,Evolution,and Basic Petroleum Geology of the Qiangtang Basin(2021DJ0801)of the Forward-looking Basic Subjects of PetroChina’s 14th Five-Year Plan.
文摘The Qiangtang Basin of the Tibetan Plateau,located in the eastern Tethys tectonic domain,is the largest new marine petroliferous region for exploration in China.The scientific drilling project consisting primarily of well QK-1 and its supporting shallow boreholes for geological surveys(also referred to as the Project)completed in recent years contributes to a series of new discoveries and insights into the oil and gas preservation conditions and source rock evaluation of the Qiangtang Basin.These findings differ from previous views that the Qiangtang Basin has poor oil and gas preservation conditions and lacks high-quality source rocks.As revealed by well QK-1 and its supporting shallow boreholes in the Project,the Qiangtang Basin hosts two sets of high-quality regional seals,namely an anhydrite layer in the Quemo Co Formation and the gypsum-bearing mudstones in the Xiali Formation.Moreover,the Qiangtang Basin has favorable oil and gas preservation conditions,as verified by the comprehensive study of the sealing capacity of seals,basin structure,tectonic uplift,magmatic activity,and groundwater motion.Furthermore,the shallow boreholes have also revealed that the Qiangtang Basin has high-quality hydrocarbon source rocks in the Upper Triassic Bagong Formation,which are thick and widely distributed according to the geological and geophysical data.In addition,the petroleum geological conditions,such as the type,abundance,and thermal evolution of organic matter,indicate that the Qiangtang Basin has great hydrocarbon-generating potential.
文摘Objective:With the increasing application of vascular reconstruction in surgical procedures,allogeneic vessels are becoming more popular in clinical practice due to their abundant sources,precise diameter matching,improved histocompatibility,and higher long-term patency rate.This study aimed to investigate the protective effect of various preservation solutions on the function and structure of the isolated rat abdominal aorta preserved under hypothermal conditions.Methods:The study utilized a total of 150 Sprague-Dawley(SD)rats,with 144 rats allocated to the experimental groups and 6 rats allocated to the control groups.The abdominal aorta of the rats was chosen as the subject of our research.The aorta in the experimental groups were randomly assigned to 4 groups:University of Wisconsin(UW)solution group,histidine-tryptophan-ketoglutarate(HTK)solution group,normal saline(NS)group,and sodium lactate Ringer's solution(RS)group.Samples were subjected to examination after preservation periods of 1 day,3 days,5 days,7 days,14 days,30 days,and 90 days.Evaluation of vascular physiological function involved detecting and assessing vasoconstriction ability and measuring cell viability through the MTT test.Evaluation of the vascular wall structure involved tension tolerance tests and pathological staining.Results:The pathogen-positive rate in the HTK group and NS group at 1 month was 16.7%.Regarding the vascular skeleton structure,both the UW group and HTK group exhibited intact structures after 2 weeks of preservation,with slightly edematous collagen and elastic fibers,which was significantly better than that of the NS group and RS group.In terms of cell activity and contractile function,all preservation groups showed similar effects within 2 weeks.However,after 2 weeks,the UW group showed the most favorable preservation effect(P<0.05).In terms of vascular tension,different groups exhibited similar effects within 1 week.However,after 2 weeks,the UW group showed the best preservation effect(P<0.05).Conclusion:All 4 types of preservation solution had a preservation effect on the structure and function of isolated blood vessels during short-term hypothermal preservation.However,after 2-week preservation,the UW solution was found to be the most suitable solution for the preservation of blood vessels.
文摘Hyperbolic systems of conservation laws in multiple spatial dimensions display features absent in the one-dimensional case,such as involutions and non-trivial stationary states.These features need to be captured by numerical methods without excessive grid refine-ment.The active flux method is an extension of the finite volume scheme with additional point values distributed along the cell boundary.For the equations of linear acoustics,an exact evolution operator can be used for the update of these point values.It incorporates all multi-dimensional information.The active flux method is stationarity preserving,i.e.,it discretizes all the stationary states of the PDE.This paper demonstrates the experimental evidence for the discrete stationary states of the active flux method and shows the evolution of setups towards a discrete stationary state.
文摘Breast cancer is the most common cancer in women worldwide, constituting 25% of all cancer diagnoses. Even though it is only affecting 4% - 6% of women under the age of 40, it remains the most common malignancy among younger patients. Advancement in the treatment and earlier detection gives excellent 5 years of survival. However, the standard treatment that comprises surgical-chemo radiation therapy or hormonal treatment often results in an increased incidence of treatment-induced infertility. Therefore, adding fertility preservation to primary cancer treatment may offer the best opportunity for future fertility. However, despite advancements in Assisted Reproductive Technology (ART), the uptake of fertility services in this group remains low. In this review, we highlighted the effect of all breast cancer treatments on women’s fertility, the effectiveness and safety of ART in breast cancer patients as well as the safety of pregnancy in breast cancer survivors. Our aim is to improve awareness of fertility preservation for breast cancer to ensure all women diagnosed with breast cancer have multidisciplinary approaches with early referral to fertility specialists to discuss regarding potential risks and benefits of fertility preservation to improve the uptake of fertility preservation among this group of patients.
基金supported by the Program of Shanghai Tobacco Group Open Fund (20210105).
文摘The issue of plastic pollution has attracted widespread social attention.Gelatin is valued as a degradable bio-based material,especially as an edible active packaging material.However,the commonly used solution-casting filmforming technology limits the mass production of gelatin films.In order to improve the production efficiency and enhance the commercial value of gelatin films,in this study,fish gelatin(FG)particles were successfully blended with essential oils(EOs)to prepare active films by melt extrusion technique,a common method for commercial plastics,and applied to bread preservation.FG and EOs showed good compatibility with each other.The elongation at break was enhanced in all samples of films containing EOs.The addition of EOs weakened the oxygen barrier properties of the FG films.The gelatin films containing clove EO showed the highest DPPH radical scavenging rate of 39.38%.The films containing oregano EO showed the highest antibacterial activity,with 98.84%and 99.86% against S.aureus and E.coli,respectively.The bread preservation results showed a slower microbial growth rate in the samples preserved by the active films.The bread samples preserved in commercial PE film showed mold on day 3,and the bread samples preserved in active gelatin film showed mold visible to the naked eye by day 7.This study demonstrates the potential of gelatin-based activated films for commercial application in baked goods preservation.
基金supported by the COMRA Major Project(No.DY135-S1-01-09)the Opening Foundation of Key Laboratory of Submarine Geosciences and Prospecting Techniques,Ocean University of China(No.SGPT-2019OF-02).
文摘Suspended particulate barite crystals were detected in the water columns at four different stations near the 90°E ridge in the Indian Ocean.Four distinct morphological types of marine barites were distinguished:euhedral-subhedral crystals,oval or round crystals,rhombic crystals,and irregular crystals.The barite crystals in the study area are typically fine,with a dominant size of 1–3μm.The vertical distribution of barites is significantly affected by the formation and sedimentation processes.Barites begin to appear at a depth of 30 m and are formed primarily from the surface to the depth of 2000m with a concentration peak at the depth of 200m,where particles are coarser than those in the other layers.The barites begin to settle and dissolve once formed in the water column,resulting in finer barite particles and lower particle concentrations.The formation of barite crystals is related to biological processes associated with the decomposition of barium-rich skeletons in the microenvironment of decaying organic matter that is affected by the primary productivity and dissolved oxygen content in the water column.The dissolving process of barite crystals showed similar variation with the concentration of dissolved barium in ocean water,and the substitution of strontium for barite in crystals promotes the selective dissolution of barite and exerts an important impact on its morphology.It is approximately 33%of barites in the amount and 22%in the concentration to settle to the bottom of the water column compared to that observed in the main barite formation zone.