Transfusions of blood products are common in medical practice and can be lifesaving in certain situations. Potentially life threatening reactions could occur and physicians should be alerted. Here we describe a case o...Transfusions of blood products are common in medical practice and can be lifesaving in certain situations. Potentially life threatening reactions could occur and physicians should be alerted. Here we describe a case of thrombocytopenia that was induced by transfusion of fresh frozen plasma (FFP). A 52 years old male presented to the emergency department after two episodes of hematochezia that resolved spontaneously. Since he was anticoagulated for atrial fibrillation he was given a unit of FFP to reverse a slightly elevated INR. Within 6 hours from the administration of the FFP he developed an acute decrease only in his platelet count. He was managed conservatively and his thrombocytopenia started resolving gradually. After excluding other causes the potential diagnosis was fresh frozen plasma induced thrombocytopenia. The pathophysiologic mechanism is postulated to be immune mediated by passive transfer of antibodyies from the donor to the recipient. The antibodies that are described in the literature are anti-HPA-1a and anti-CD-36. We reported the event to the American Red Cross. Interestingly a male was the donor of the plasma while in all cases in the literature the donors are females with a prior history of pregnancy. Therefore this is the first reported case of a male blood donor whose blood product caused immune mediated thrombocytopenia post transfusion.展开更多
文摘Transfusions of blood products are common in medical practice and can be lifesaving in certain situations. Potentially life threatening reactions could occur and physicians should be alerted. Here we describe a case of thrombocytopenia that was induced by transfusion of fresh frozen plasma (FFP). A 52 years old male presented to the emergency department after two episodes of hematochezia that resolved spontaneously. Since he was anticoagulated for atrial fibrillation he was given a unit of FFP to reverse a slightly elevated INR. Within 6 hours from the administration of the FFP he developed an acute decrease only in his platelet count. He was managed conservatively and his thrombocytopenia started resolving gradually. After excluding other causes the potential diagnosis was fresh frozen plasma induced thrombocytopenia. The pathophysiologic mechanism is postulated to be immune mediated by passive transfer of antibodyies from the donor to the recipient. The antibodies that are described in the literature are anti-HPA-1a and anti-CD-36. We reported the event to the American Red Cross. Interestingly a male was the donor of the plasma while in all cases in the literature the donors are females with a prior history of pregnancy. Therefore this is the first reported case of a male blood donor whose blood product caused immune mediated thrombocytopenia post transfusion.
文摘目的 建立基于长短期记忆(longshort-termmemory,LSTM)神经网络的时间序列预测模型,对北京地区鲜(冻)肉制品铅含量进行风险评估与预测预警。方法 通过收集2011—2020年国家市场监督管理总局日常食品监督管理抽检数据,筛选出北京地区鲜(冻)肉制品的抽检数据,构建数据集并进行预处理,按照7:2:1的比例划分训练集、验证集和测试集,基于Tensorflow平台构建4层LSTM模型并进行训练,基于重大活动举办前10d的鲜(冻)肉制品铅含量数据,对未来1d的鲜(冻)肉制品铅含量风险进行预测。结果 经过50轮模型迭代训练,训练集和测试集Loss指标收敛至0.084,经过5次训练后的模型评估参数均方根误差(root mean square error,RMSE)为0.192,决定系数(coefficient of determination,R2_score)为0.916,模型误差较小、准确度较高。结论 基于LSTM的鲜(冻)肉制品铅含量风险预测模型整体性能较好,可应用于重大活动举办地的食品风险预测,并精准指导监督抽检。
