The effect of functional loads on free spanning pipeline's VIV response

During the operation and installation of offshore pipelines, high axial forces and pressures are experienced, and their effects cannot be neglected. In this article, the effect of internal flow velocity and functional loads on vortex-induced vibration （VIV） response is investigated. On the basis of the Hamilton principle, a differential equation was derived to describe the motion of a pinned-pinned tensioned spanning pipeline conveying fluid. The VIV response was calculated according to DNV-RP-F105 under different functional loads. The results showed that functional loads influence free spanning pipeline VIV response by changing the natural frequency. Internal flow velocity was found less important for VIV response than other functional load factors, such as effective axial force, because the speed in reality is not high enough to be significant. The research may provide a reference for sensitivity studies of the effect of functional loads on allowable free span lengths.

Cracked elastic substrate strip with functionally graded coating under thermal-mechanical loading

This paper investigates the functionally graded coating bonded to an elastic strip with a crack under thermal- mechanical loading. Considering some new boundary conditions, it is assumed that the temperature drop across the crack surface is the result of the thermal conductivity index which controls heat conduction through the crack region. By the Fourier transforms, the thermal-elastic mixed boundary value problems are reduced to a system of singular integral equations which can be approximately solved by applying the Chebyshev polynomials. The numerical computation methods for the temperature, the displacement field and the thermal stress intensity factors （TSIFs） are presented. The normal temperature distributions （NTD） with different parameters along the crack surface are analyzed by numerical examples. The influence of the crack position and the thermal-elastic non- homogeneous parameters on the TSIFs of modes I and 11 at the crack tip is presented. Results show that the variation of the thickness of the graded coating has a significant effect on the temperature jump across the crack surfaces when keeping the thickness of the substrate constant, and the thickness of functionally graded material （FGM） coating has a significant effect on the crack in the substrate. The results can be expected to be used for the purpose of gaining better understanding of the thermal-mechanical behavior of graded coatings.

Green's functions for uniformly distributed loads acting on an inclined line in a poroelastic layered site

Based on one type of practical Biot＇s equation and the dynamic-stiffness matrices ofa poroelastic soil layer and half-space, Green＇s functions were derived for unitformly distributed loads acting on an inclined line in a poroelastie layered site. This analysis overcomes significant problems in wave scattering due to local soil conditions and dynamic soil-structure interaction. The Green＇s functions can be reduced to the case of an elastic layered site developed by Wolf in 1985. Parametric studies are then carried out through two example problems.

Analytical solution for functionally graded anisotropic cantilever beam subjected to linearly distributed load

The bending problem of a functionally graded anisotropic cantilever beam subjected to a linearly distributed load is investigated. The analysis is based on the exact elasticity equations for the plane stress problem. The stress function is introduced and assumed in the form of a polynomial of the longitudinal coordinate. The expressions for stress components are then educed from the stress function by simple differentiation. The stress function is determined from the compatibility equation as well as the boundary conditions by a skilful deduction. The analytical solution is compared with FEM calculation, indicating a good agreement.

A hardening load transfer function for rock bolts and its calibration using distributed fiber optic sensing

Confinement of rock bolts by the surrounding rock formation has long been recognized as a positive contributor to the pull-out behavior,yet only a few experimental works and analytical models have been reported,most of which are based on the global rock bolt response evaluated in pull-out tests.This paper presents a laboratory experimental setup aiming to capture the rock formation effect,while using distributed fiber optic sensing to quantify the effect of the confinement and the reinforcement pull-out behavior on a more local level.It is shown that the behavior along the sample itself varies,with certain points exhibiting stress drops with crack formation.Some edge effects related to the kinematic freedom of the grout to dilate are also observed.Regardless,it was found that the mid-level response is quite similar to the average response along the sample.The ability to characterize the variation of the response along the sample is one of the many advantages high-resolution fiber optic sensing allows in such investigations.The paper also offers a plasticity-based hardening load transfer function,representing a"slice"of the anchor.The paper describes in detail the development of the model and the calibration/determination of its parameters.The suggested model captures well the coupled behavior in which the pull-out process leads to an increase in the confining stress due to dilative behavior.

Amino functionalized chiral mesoporous silica nanoparticles for improved loading and release of poorly water-soluble drug

In the present paper, chiral mesoporous silica nano-cocoon(A-CMSN) functionalized with amino group was synthesized, and its loading and release of indomethacin(IMC), a poorly soluble drug, was studied. Due to the use of chiral anionic surfactants as a template, ACMSN possessed 2D hexagonal nano-cocoon morphology with curled channels on its surface, which was quite different from another 2D hexagonal mesoporous silica nanoparticles(MCM-41) with straightway channels. After being loaded into the two silica carriers by hydrogen bond, crystalline IMC converted to amorphous form, leading to the improved drug dissolution. And IMC loading capacity of A-CMSN was higher than MCM-41 because curled loading process originating from curvature chiral channels can hold more drug molecules. Compared with IMC, IMC loaded A-CMSN presented obviously fast release throughout the in vitro release experiment, while IMC loaded MCM-41 released faster than IMC at the initial 5 h then showed controlled slow release afterwards, which was closely related to the mesoporous silica nanoparticles and different channel mesostructures of these two carriers. A-CMSN possessed nano-cocoon morphology with curled 2D hexagonal channel and its channel length was shorter than MCM-41, therefore IMC molecules can easily get rid of the constraint of A-CMSN then to be surrounded by dissolution medium.

Complete solutions for elastic fields induced by point load vector in functionally graded material model with transverse isotropy

The paper develops and examines the complete solutions for the elastic field induced by the point load vector in a general functionally graded material(FGM)model with transverse isotropy.The FGMs are approximated with n-layered materials.Each of the n-layered materials is homogeneous and transversely isotropic.The complete solutions of the displacement and stress fields are explicitly expressed in the forms of fifteen classical Hankel transform integrals with ten kernel functions.The ten kernel functions are explicitly expressed in the forms of backward transfer matrices and have clear mathematical properties.The singular terms of the complete solutions are analytically isolated and expressed in exact closed forms in terms of elementary harmonic functions.Numerical results show that the computation of the complete solutions can be achieved with high accuracy and efficiency.

Comparison of Loading Functions in the Modelling of Automobile Aluminium Alloy Wheel under Static Radial Load

Formulation of exact loading function for radial loading situation has been a major challenge in wheel modeling. Hence, approximate loading functions such as Cosine, Boussinesq, Eye-bar, Polynomial, Hertzian etc., have been developed by different researchers. In this paper, analysis of different loading functions—Cosine (CLF), Boussinesq (BLF) and Eye-bar (ELF) at deferent inflation pressure of 0.3, 0.15 and 0 MPa at specified radial load of 4750N is carried out on a selected aluminium with ISO designation (6JX14H2;ET 42). The 3-D computer model of the wheel is generated and discretised into 3785 hexahedral elements and analysed with Creo Elements/Pro 5.0. Loading angle of 90 degree symmetric with the point of contact of the wheel with the ground is used for ELF, while 30 degrees contact angle is employed for both CLF and BLF. Von Mises stress is used as a basis for comparison of the different loading functions investigated with the experimental data obtained by Sherwood et al while the displacement values (as obtained from the FEM tool) are used as a basis for comparison of the different loading functions, as displacement is not covered by Sherwood et al. Results show that at 0.3MPa inflation pressure, the maximum stress value of CLF approaches the Sherwood value of about 14 MPa and that the CLF function values coincide with Sherwood values at three points along the curve, with values of about 13.8 MPa, 13 MPa and 6.4 MPa at about 0 degree, 15 degree and 20 degree respectively. The BLF value coincides with the Sherwood value at about 18 degree with a magnitude of about 10.6 MPa, while ELF equals the Sherwood value at magnitude of about 6.2 MPa at about 22 degree. At 0.15 and 0 MPa inflation pressure, values CLF, BLF and ELF deviate significantly from the Sherwood values (due to under inflation) with the maximum CLF stress value approaching a value of about 13 and 12MPa respectively. The CLF, BLF and the Sherwood values are the same at about 6 and 3 MPa at 0.15 and 0 MPa inflation pressure respectively. The displacement values for ELF are lesser than those of CLF and BLF for all range of values. The different loading functions values being equal the Sherwood values (used as refernce) at different points, with the CLF having more coincident points along the curve. Higher stress and displacement magnitudes are clustered between 0 degree and about 35 degree. Although, the CLF and BLF offer greater stress and displacement values than ELF, hence the type of loading function adapted for any analysis depends on the type of tyres to be fitted on the wheel. CLF and BLF offers greater prospect for non run flat tyres, while ELF is most suited for run flat tyres. In all cases the right inflation pressure as specified by the tyre manufacture should be employed in any analysis.

Dynamic stability analysis of porous functionally graded beams under hygro-thermal loading using nonlocal strain gradient integral model

We present a study on the dynamic stability of porous functionally graded(PFG)beams under hygro-thermal loading.The variations of the properties of the beams across the beam thicknesses are described by the power-law model.Unlike most studies on this topic,we consider both the bending deformation of the beams and the hygro-thermal load as size-dependent,simultaneously,by adopting the equivalent differential forms of the well-posed nonlocal strain gradient integral theory(NSGIT)which are strictly equipped with a set of constitutive boundary conditions(CBCs),and through which both the stiffness-hardening and stiffness-softening effects of the structures can be observed with the length-scale parameters changed.All the variables presented in the differential problem formulation are discretized.The numerical solution of the dynamic instability region(DIR)of various bounded beams is then developed via the generalized differential quadrature method(GDQM).After verifying the present formulation and results,we examine the effects of different parameters such as the nonlocal/gradient length-scale parameters,the static force factor,the functionally graded(FG)parameter,and the porosity parameter on the DIR.Furthermore,the influence of considering the size-dependent hygro-thermal load is also presented.

Effect of antidepressant treatment on water load test and cortisol changes in patients with functional dyspepsia

BACKGROUND： It has been demonstrated that patients with functional dyspepsia have experiences social life stress events, and accompanied by psychological disorders, mainly manifested as depression and anxiety.Mental factors can lead to excessive gastrointestinal consensual reaction, and result in different brain-gut axis disturbance, and then cause the gastrointestinal sensorimotor abnormality and endocrine changes.OBJECTIVE： To observe the effect of antidepressant treatment on the changes of water load and serum cortisol in patients with functional dyspepsia, and analyze the therapeutic mechanism.DESIGN： A comparative observation.SETTING： The First Affiliated Hospital o Zhengzhou University.PARTICIPANTS： Forty-five patients with functional dyspepsia accompanied by depression were selected from the Department of Gastroenterology, the First Affiliated Hospital of Zhengzhou University from July 2004 to July 2006, and they were 25 - 65 years of age, and their disease courses ranged 1 - 10 years. They were all accorded with the diagnostic standards for Rome Ⅱ functional dyspepsia functional dyspepsia. As the patients＇ will, they were divided into treatment group （n =30, 12 males and 18 females） and control group （n =15, 6 males and 9 females）, and there were no significant differences in the data between the two groups （P 〉 0.05）. The programs were discussed and agreed by the committee of medical ethics of the First Affiliated Hospital of Zhengzhou University. Informed contents were obtained from all the patients.METHODS： In the treatment group, the patients were treated with venlafaxine sustained release capsule （75 mg per day）, and those with sleep disorder were added by benzodiazepines （alprazolam）. In the control group, the patients were given routine treatments of antacid, prokinetics, etc. Before and after 8-week treatment, the following examinations were performed： ① The gastrointestinal symptoms were assessed according to the symptoms; ② The severity of depression was evaluated with Hamilton depression scale （HAMD）; ③The relaxation of proximal stomach was observed using water load test; ④ The serum level of cortisol was detected.MAIN OUTCOME MEASURES： ① Symptom score; ② HAMD score; ③ Water load amount; ④Serum level of cortisol.RESULTS： All the 45 patients were involved in the analysis of results. ① Symptom score： The scores of gastrointestinal symptoms were decreased as compared with those before treatment in both the treatment group and control group （P 〈 0.05）. ② HAMD scores： The scores of HAMD were decreased as compared with those before treatment in both the treatment group and control group （P 〈 0.05）. ③ Water load amount：The total effective rate was significantly higher in the treatment group than the control group （P 〈 0.05）. ④The serum levels of cortisol after treatment were significantly lower than those before treatment in the patients with severe gastrointestinal symptoms in the treatment group and control group （P 〈 0.05）.CONCLUSION： Antidepressants can normalize the cortisol level of patients with functional dyspepsia, and then decrease gastric sensitivity and ameliorates the receptive relaxation of proximal stomach, also increase the water load amount correspondingly, and finally control the gastrointestinal symptoms of functional dyspepsia.

THE DYADIC GREEN'S FUNCTION IN A LOADED RECTANGULAR WAVEGUIDE AND ITS APPLICATION

This paper presents a method to derive the Dyadic Green’s Function(DGF)ofa loaded rectangular waveguide by using the image method.In the calculation of the DGF,we use the integral transformation and replace the multi-infinite summation by a single one;thus it greatly simplifies the calculation and saves computer time.As an example of the DGF’sapplication,we give the moment method’s scattering field calculation of a metal sphere resting onthe broad wall of the loaded rectangular waveguide.Results of our calculations well agree withboth data of experiments performed in our laboratory and those are published.It is easy to seethat the method used in this paper can be expanded to other related waveguide problems.

HALF-SPACE GREENS'S FUNCTION DUE TO A SPATIALLY HARMONIC LINE LOAD AND SCATTERED FIELDS IN THE FAR FIELD REGION

Half-space Green's function due to a spatially harmonic line load has been expressed as a sum of the full-space Green's functions and a 2-D integral representation of the reflected waves by the free surface of the half-space.By using the obtained half-space Green's function,an integral rep- resentation of the scattered waves by a cylindrical obstacle is then derived.Finally,by analyzing the far-zone behavior of the integrands of the integral representation.the far-field pattern of the scattered waves in a half-space obtained.

Nonlinear analysis on dynamic buckling of eccentrically stiffened functionally graded material toroidal shell segment surrounded by elastic foundations in thermal environment and under time-dependent torsional loads

The nonlinear analysis with an analytical approach on dynamic torsional buckling of stiffened functionally graded thin toroidal shell segments is investigated. The shell is reinforced by inside stiffeners and surrounded by elastic foundations in a thermal environment and under a time-dependent torsional load. The governing equations are derived based on the Donnell shell theory with the yon Karman geometrical nonlinearity, the Stein and McElman assumption, the smeared stiffeners technique, and the Galerkin method. A deflection function with three terms is chosen. The thermal parameters of the uniform temperature rise and nonlinear temperature conduction law are found in an explicit form. A closed-form expression for determining the static critical torsional load is obtained. A critical dynamic torsional load is found by the fourth-order Runge-Kutta method and the Budiansky-Roth criterion. The effects of stiffeners, foundations, material, and dimensional parameters on dynamic responses of shells are considered.

Kautz Function Based Continuous-Time Model Predictive Controller for Load Frequency Control in a Multi-Area Power System

A continuous-time Model Predictive Controller was proposed using Kautz function in order to improve the performance of Load Frequency Control(LFC).A dynamic model of an interconnected power system was used for Model Predictive Controller(MPC)design.MPC predicts the future trajectory of the dynamic model by calculating the optimal closed loop feedback gain matrix.In this paper,the optimal closed loop feedback gain matrix was calculated using Kautz function.Being an Orthonormal Basis Function(OBF),Kautz function has an advantage of solving complex pole-based nonlinear system.Genetic Algorithm(GA)was applied to optimally tune the Kautz function-based MPC.A constraint based on phase plane analysis was implemented with the cost function in order to improve the robustness of the Kautz function-based MPC.The proposed method was simulated with three area interconnected power system and the efficiency of the proposed method was measured and exhibited by comparing with conventional Proportional and Integral(PI)controller and Linear Quadratic Regulation(LQR).

A Theoretical Analysis of Functionally Graded Beam under Thermal Loading

Modeling of the behavior for Functionally Graded Beam (FGB) under thermal loading is introduced in the present work. The material properties are assumed to vary according to power function along the thickness of the beam. The effects of several parameters such as thermal expansion parameter, thermal conductivity and modulus of elasticity on the resultant axial stress of the FG beam have been studied. For thermal loading the steady state of heat conduction with power and exponentially variations through the thickness of FGB, is considered. The results obtained show that temperature distribution plays very important parameter controlling thermal resultant distribution of stresses and strains.

PARALLEL ADAPTIVELY MODIFIED CHARACTERISTIC BASIS FUNCTION METHOD BASED ON STATIC LOAD BALANCE

Characteristic Basis Function Method (CBFM) is a novel approach for analyzing the ElectroMagnetic (EM) scattering from electrically large objects. Based on dividing the studied object into small blocks, the CBFM is suitable for parallel computing. In this paper, a static load balance parallel method is presented by combining Message Passing Interface (MPI) with Adaptively Modified CBFM (AMCBFM). In this method, the object geometry is partitioned into distinct blocks, and the serial number of blocks is sent to related nodes according to a certain rule. Every node only needs to calculate the information on local blocks. The obtained results confirm the accuracy and efficiency of the proposed method in speeding up solving large electrical scale problems.

Effect of immunotherapy combined with intravenous chemotherapy on the tumor load,immune function and cancer cell proliferation activity in patients with advanced colon cancer

Objective: To study the effect of immunotherapy combined with intravenous chemotherapy on the tumor load, immune function and cancer cell proliferation activity in patients with advanced colon cancer. Methods: A total of 90 patients with advanced colon cancer who were treated in Second People's Hospital of Yibin between December 2014 and January 2017 were collected and divided into control group (n=45) and observation group (n=45) by random number table. Control group received routine intravenous chemotherapy, and the observation group received immunotherapy combined with intravenous chemotherapy. The levels of specific tumor markers and Th17/Treg cytokines in serum as well as proliferation gene expression in the lesion tissue were determined. Results: Before treatment, the differences in levels of specific tumor markers and Th17/Treg cytokines in serum as well as proliferation gene expression in lesion tissue were not statistically significant between the two groups. After treatment, PTN, CCSA-1, IL-17 and IL-23 levels in serum as well as GTPBP4 and PIK3CB mRNA expression in lesion tissue of both groups of patients were lower than those before treatment while IL-10 and IL-35 levels in serum as well as FAM96B, MS4A12 and FRAT1 mRNA expression in lesion tissue were higher than those before treatment, and PTN, CCSA-1, IL-17 and IL-23 levels in serum as well as GTPBP4 and PIK3CB mRNA expression in lesion tissue of observation group were lower than those of control group while IL-10 and IL-35 levels in serum as well as FAM96B, MS4A12 and FRAT1 mRNA expression in lesion tissue were higher than those of control group. Conclusion: Immunotherapy combined with intravenous chemotherapy can effectively reduce the tumor load, optimize cellular immune function and inhibit tumor cell proliferation in patients with advanced colon cancer.

Translation of Culture-Loaded Words in Tales of Hulan River from the Perspective of Functional Equivalence Theory

This research analyzes the culture-loaded words in English version of Tales of Hulan River bases on functional equivalence theory.The major point is what strategies Howard Goldblatt uses to achieve the equivalences in semantic message,stylistic message,cultural message and response of readers,and the reasons why he uses them.This thesis contains four chapters,starting with the background,significances and the organization of the research.Chapter two introduces Tales of Hulan River as well as Xiao Hong and Howard Goldblatt,as well as the functional equivalence theory.To analyze the translation strategies of Goldblatt,chapter three divided the culture-loaded words into three categories,which is dialect,custom and proverb respectively,in this translation work of Tales of Hulan River from the perspective of functional equivalence theory.Last one is conclusion,summarizing the whole research.This paper highlights the translating of this novel into different languages and the spreading of Chinese culture.

Resilience of coastal bridges under extreme wave-induced loads

Records of wave-induced damage on coastal bridges during natural hazards have been well documented over the past two decades.It is of utmost importance to decipher the loading mechanism and enhance the resilience of coastal bridges during extreme wave-inducing events.Quantification of vulnerability of these structures is an essential step in designing a resilient bridge system.Recently,considerable efforts have been made to study the force applied and the response of coastal bridge systems during extreme wave loading conditions.Although remarkable progress can be found in the quantification of load and response of coastal superstructures,very few studies assessed coastal bridge resiliency against extreme wave-induced loads.This paper adopts a simplified and practical technique to analyze and assess the resilience of coastal bridges exposed to extreme waves.Component-level and system-level fragility analyses form the basis of the resiliency analysis where the recovery functions are adopted based on the damage levels.It is shown that wave period has the highest contribution to the variation of bridge resiliency.Moreover,this study presents the uncertainty quantification in resiliency variation due to changes in wave load intensity.Results show that the bridge resiliency becomes more uncertain as the intensity of wave parameters increases.Finally,possible restoration strategies based on the desired resilience level and the attitude of decision-makers are also discussed.

MINER RULE CONSIDERING FUZZINESS OF STRESS DAMAGE UNDER DIFFERENT LOAD SEQUENCES

Since the traditional Miner rule ignores the influence of the load sequence on the fatigue life, the fuzzy rules are used to analyze the fuzziness of the fatigue damage caused by the stress nearby the fatigue limit under different load sequences. The improved fuzzy Miner rule can reflect the influence of the load sequence on the fatigue life. Results of the example show that the prediction error can be reduced from 61.6% to 21.7%.