Effects of fumigation and washing with Shujin Huoluo decoction combined with Duhuo Parasitic decoction on TIMP-1 and PON1 levels in KOA patients

Objective:To study the effect of fumigation and washing with Shujin Huoluo Decoction combined with Duhuo Parasitic Decoction on Metalloproteinase inhibitor-1(TIMP-1)and Oxyphosphatase 1,PON1)level.Methods:A total of 100 KOA patients,59 males and 41 females,were selected for diagnosis and treatment in our hospital from November 2018 to November 2019.The patients were divided into the control group and the combined group with 50 patients each according to a completely random method.The control group was treated with Duhuo Parasitic Decoction and the combined group was treated with Duhuo Parasitic Decoction and Shujinhuoluo decoction.Detection of TIMP-1,PON1,Matrix metalloproteinase-3(MMP-3),C-reactive protease(CRP),Tumor necrosis factor-alpha(TNF-α)and Superoxide dismutase(SOD)levels.WOMAC score,Lysholm score,and VAS score were evaluated.Results:The levels of TIMP-1 and PON1 in the combined group were higher than those in the control group after treatment,and the levels of MMP-3 were lower than those in control group(P<0.05).The WOMAC score and VAS score of the combined group were lower than those of the control group,and the Lysholm score was higher than that of control group(P<0.05).The levels of CRP and TNF-αin the combined group were lower than those in the control group,and the SOD levels were higher than those in control group(P<0.05).The total effective rate of the combined group was higher than the total effective rate of control group(P<0.05).Conclusion:The combination of fumigation and washing with Shujin Huoluo Decoction and Duhuo Parasitic Decoction has a significant effect on the treatment of KOA patients.It improves the levels of TIMP-1 and PON1,improves the knee function of patients and pain.

Clinical observation on TCM fumigation and washing for treatment of diabetic peripheral neuropathy by self-made water-washing footbath

the quality of life seriously,and even lead to more servere complications.On the base of the well-controlled blood glucose,improving the symptoms of both lower limbs timely will has positive significance for enhancing the life quality of patients and preventing complications of limbs.This article makes a comprehensive study on the application of self-made water-washing footbath in the treatment of DPN by Chinese medicine fumigation.From March 2018 to April 2018 in our hospital 20 cases of DPN patients were collected and they were divided into observation group(treated by self-made water-washing footbath with herbs)and control group(treated by conventional barrels),10 cases in each.The results showed that Chinese medicine fumigation on both lower limbs has clinical curative effect to improve the symptoms of arthromyodynia caused by diabetes.It provide an alternative method of external treatment for DPN patients with numbness in both lower limbs which could alleviate their suffering and improve the quality of life significantly.