Ideal tissue engineering scaffolds need interconnected pores and high porosity to enable cell survival,migration,proliferation,and differentiation.However,obtaining a high-resolution structure is difficult with tradit...Ideal tissue engineering scaffolds need interconnected pores and high porosity to enable cell survival,migration,proliferation,and differentiation.However,obtaining a high-resolution structure is difficult with traditional one-temperature control fused deposition modeling(FDM).In this study,we propose a dual-temperature control method to improve printability.A numerical model is developed in which the viscosity is a function of temperature and shear rate to study the influence of two different temperature control modes.Quantitative tests are used to assess filament formation and shape fidelity,including one-dimensional filament printing,deposition at corners,fusion,and collapse.By using dual-temperature control,the width of the deposited poly(ε-caprolactone)filament is reduced to 50μm.The comparative results of both the experimental method and numerical simulation suggest that the dual-temperature control FDM can manufacture spatially arranged constructs and presents a promising application in tissue engineering。展开更多
FDM (fused deposition modeling) has become popular among Additive Manufacturing technologies due to its speed, geometric scalability, and low cost; however, the primitive nature of the FDM build surface fundamentall...FDM (fused deposition modeling) has become popular among Additive Manufacturing technologies due to its speed, geometric scalability, and low cost; however, the primitive nature of the FDM build surface fundamentally limits the utility of FDM in terms of reliability, autonomy, and material selection. Currently, FDM relies on adhesive forces between the first layer of a print and the build surface; depending on the materials involved, this adhesive bond may or may not be reliable. Thermal contraction between the build plate and build materials can break that bond, which causes warpage and delamination of the part from the build surface and subsequent failure of the part. Furthermore, with each print, the user must use tools or manual maneuvering to separate the printed part from the build surface as well as retexture or replace the used build surface. In this paper, we present a novel build platform that allows for a mechanical bond between the print and build surface by using dovetail-shaped features. The first layer of the print flows into the features and becomes mechanically captivated by the build platform. Once the print is completed, the platform is rolled or flexed open to release the part from the mechanical bond. This design not only lowers the risk of delamination during printing but also eliminates the need for a user to reset or replace the build surface between print jobs. The effectiveness of each geometry was determined by measuring the distance at the pinch point compared to the distance that the extrusion filled below the pinch point. The captivation ratio was measured to compare the different geometries tested and determine which direction of extrusion creates a better ratio.展开更多
Additive Manufacturing (AM) technologies have progressed in the past few years and many of them are now capable of producing functional parts instead of mere prototypes. AM provides a multitude of benefits, especially...Additive Manufacturing (AM) technologies have progressed in the past few years and many of them are now capable of producing functional parts instead of mere prototypes. AM provides a multitude of benefits, especially in design freedom. However, it still lacks industrial relevance because of the absence of comprehensive design rules for AM. Although AM is usually advertised as being the solution for all traditional manufacturing design limitations, the fact is that AM only replaces these limitations with a different set of restrictions. To fully exploit the advantages of AM, it is necessary to understand these limitations and consider them early during the design process. The establishment of design considerations in AM enables parts and process optimization. This paper discusses the design considerations that will lead to optimize part quality. Specifically, the work discusses the Fused Deposition Modeling (FDM) due to its common use and availability. These considerations are drawn from literature and from experiments done by the authors. The experiments done by the authors include an investigation for the influence of elevated service temperature on the performance of FDM PLA parts, benchmarking the capability of FDM to print overhangs and bridges without supports, studying the influence of processing parameters over dimensional accuracy, and the effect of processing parameters on the final FDM samples modulus of elasticity. The work presents a case study investigating the correct clearances for FDM parts and finally a redesign for AM case study of a support bracket originally manufactured using traditional manufacturing methods taking into consideration the design considerations discussed in this paper.展开更多
3 D printing is a method of rapid prototyping and manufacturing in which materials are deposited onto one another in layers to produce a three-dimensional object. Although 3 D printing was developed in the 1980 s and ...3 D printing is a method of rapid prototyping and manufacturing in which materials are deposited onto one another in layers to produce a three-dimensional object. Although 3 D printing was developed in the 1980 s and the technology has found widespread industrial applications for production from automotive parts to machine tools,its application in pharmaceutical area is still limited. However,the potential of 3 D printing in the pharmaceutical industry is now being recognized. The ability of 3 D printing to produce medications to exact specifications tailored to the needs of individual patients has indicated the possibility of developing personalized medicines. The technology allows dosage forms to be precisely printed in various shapes,sizes and textures that are difficult to produce using traditional techniques. However,there are various challenges associated with the proper application of3 D printing in the pharmaceutical sector which should be overcome to exploit the scope of this technology. In this review,an overview is provided on the various 3 D printing technologies used in fabrication of complex dosage forms along with their feasibility and limitations.展开更多
Recycled polypropylene filaments for fused filament fabrication were investigated with and without 14 wt% short fibre carbon reinforcements. The microstructure and mechanical properties of the filaments and 3D printed...Recycled polypropylene filaments for fused filament fabrication were investigated with and without 14 wt% short fibre carbon reinforcements. The microstructure and mechanical properties of the filaments and 3D printed specimens were characterized using scanning electron microscopy and standard tensile testing. It was observed that recycled polypropylene filaments with 14 wt% short carbon fibre reinforcement contained pores that were dispersed throughout the microstructure of the filament. A two-stage filament extrusion process was observed to improve the spatial distribution of carbon fibre reinforcement but did not reduce the pores. Recycled polypropylene filaments without reinforcement extruded at high screw speeds above 20 rpm contained a centreline cavity but no spatially distributed pores. However, this cavity is eliminated when extrusion is carried out at screw speeds below 20 rpm. For 3D printed specimens, interlayer cavities were observed larger for specimens printed from 14 wt% carbon fibre reinforced recycled polypropylene than those printed from unreinforced filaments. The values of tensile strength for the filaments were 21.82</span><span style="font-size:10pt;font-family:""> </span><span style="font-family:Verdana;">MPa and 24.22</span><span style="font-size:10pt;font-family:""> </span><span style="font-family:Verdana;">MPa, which reduced to 19.72</span><span style="font-size:10pt;font-family:""> </span><span style="font-family:Verdana;">MPa and 22.70</span><span style="font-size:10pt;font-family:""> </span><span style="font-family:Verdana;">MPa, respectively, for 3D printed samples using the filaments. Likewise, the young’s modulus of the filaments was 1208.6</span><span style="font-size:10pt;font-family:""> </span><span style="font-family:Verdana;">MPa and 1412.7</span><span style="font-size:10pt;font-family:""> </span><span style="font-family:Verdana;">MPa, which reduced to 961.5</span><span style="font-size:10pt;font-family:""> </span><span style="font-family:Verdana;">MPa and 1352.3</span><span style="font-size:10pt;font-family:""> </span><span style="font-family:Verdana;">MPa, respectively, for the 3D printed samples. The percentage elongation at failure for the recycled polypropylene filament was 9.83% but reduced to 3.84% for the samples printed with 14 wt% carbon fiber reinforced polypropylene filaments whose elongation to failure was 6.58%. The SEM observations on the fractured tensile test samples showed interlayer gaps between the printed and the adjacent raster layers. These gaps accounted for the reduction in the mechanical properties of the printed parts.展开更多
Additive manufacturing(AM),also known as 3D-printing(3DP)technology,is an advanced manufacturing technology that has developed rapidly in the past 40 years.However,the ceramic material printing is still challenging be...Additive manufacturing(AM),also known as 3D-printing(3DP)technology,is an advanced manufacturing technology that has developed rapidly in the past 40 years.However,the ceramic material printing is still challenging because of the issue of cracking.Indirect 3D printing has been designed and drawn attention because of its high manufacturing speed and low cost.Indirect 3D printing separates the one-step forming process of direct 3D printing into binding and material sintering,avoiding the internal stress caused by rapid cooling,making it possible to realize the highquality ceramic component with complex shape.This paper presents the research progress of leading indirect 3D printing technologies,including binder jetting(BJ),stereolithography(SLA),and fused deposition modeling(FDM).At present,the additive manufacturing of ceramic materials is mainly achieved through indirect 3D printing technology,and these materials include silicon nitride,hydroxyapatite functional ceramics,silicon carbide structural ceramics.展开更多
基金The authors gratefully acknowledge the support provided by the National Natural Science Foundation of China(Nos.52250006 and 52075482)the Starry Night Science Fund of Zhejiang University Shanghai Institute for Advanced Study(No.SNZJU-SIAS-004).
文摘Ideal tissue engineering scaffolds need interconnected pores and high porosity to enable cell survival,migration,proliferation,and differentiation.However,obtaining a high-resolution structure is difficult with traditional one-temperature control fused deposition modeling(FDM).In this study,we propose a dual-temperature control method to improve printability.A numerical model is developed in which the viscosity is a function of temperature and shear rate to study the influence of two different temperature control modes.Quantitative tests are used to assess filament formation and shape fidelity,including one-dimensional filament printing,deposition at corners,fusion,and collapse.By using dual-temperature control,the width of the deposited poly(ε-caprolactone)filament is reduced to 50μm.The comparative results of both the experimental method and numerical simulation suggest that the dual-temperature control FDM can manufacture spatially arranged constructs and presents a promising application in tissue engineering。
文摘FDM (fused deposition modeling) has become popular among Additive Manufacturing technologies due to its speed, geometric scalability, and low cost; however, the primitive nature of the FDM build surface fundamentally limits the utility of FDM in terms of reliability, autonomy, and material selection. Currently, FDM relies on adhesive forces between the first layer of a print and the build surface; depending on the materials involved, this adhesive bond may or may not be reliable. Thermal contraction between the build plate and build materials can break that bond, which causes warpage and delamination of the part from the build surface and subsequent failure of the part. Furthermore, with each print, the user must use tools or manual maneuvering to separate the printed part from the build surface as well as retexture or replace the used build surface. In this paper, we present a novel build platform that allows for a mechanical bond between the print and build surface by using dovetail-shaped features. The first layer of the print flows into the features and becomes mechanically captivated by the build platform. Once the print is completed, the platform is rolled or flexed open to release the part from the mechanical bond. This design not only lowers the risk of delamination during printing but also eliminates the need for a user to reset or replace the build surface between print jobs. The effectiveness of each geometry was determined by measuring the distance at the pinch point compared to the distance that the extrusion filled below the pinch point. The captivation ratio was measured to compare the different geometries tested and determine which direction of extrusion creates a better ratio.
文摘Additive Manufacturing (AM) technologies have progressed in the past few years and many of them are now capable of producing functional parts instead of mere prototypes. AM provides a multitude of benefits, especially in design freedom. However, it still lacks industrial relevance because of the absence of comprehensive design rules for AM. Although AM is usually advertised as being the solution for all traditional manufacturing design limitations, the fact is that AM only replaces these limitations with a different set of restrictions. To fully exploit the advantages of AM, it is necessary to understand these limitations and consider them early during the design process. The establishment of design considerations in AM enables parts and process optimization. This paper discusses the design considerations that will lead to optimize part quality. Specifically, the work discusses the Fused Deposition Modeling (FDM) due to its common use and availability. These considerations are drawn from literature and from experiments done by the authors. The experiments done by the authors include an investigation for the influence of elevated service temperature on the performance of FDM PLA parts, benchmarking the capability of FDM to print overhangs and bridges without supports, studying the influence of processing parameters over dimensional accuracy, and the effect of processing parameters on the final FDM samples modulus of elasticity. The work presents a case study investigating the correct clearances for FDM parts and finally a redesign for AM case study of a support bracket originally manufactured using traditional manufacturing methods taking into consideration the design considerations discussed in this paper.
基金supported by Keimyung University Research Grant of 2017
文摘3 D printing is a method of rapid prototyping and manufacturing in which materials are deposited onto one another in layers to produce a three-dimensional object. Although 3 D printing was developed in the 1980 s and the technology has found widespread industrial applications for production from automotive parts to machine tools,its application in pharmaceutical area is still limited. However,the potential of 3 D printing in the pharmaceutical industry is now being recognized. The ability of 3 D printing to produce medications to exact specifications tailored to the needs of individual patients has indicated the possibility of developing personalized medicines. The technology allows dosage forms to be precisely printed in various shapes,sizes and textures that are difficult to produce using traditional techniques. However,there are various challenges associated with the proper application of3 D printing in the pharmaceutical sector which should be overcome to exploit the scope of this technology. In this review,an overview is provided on the various 3 D printing technologies used in fabrication of complex dosage forms along with their feasibility and limitations.
文摘Recycled polypropylene filaments for fused filament fabrication were investigated with and without 14 wt% short fibre carbon reinforcements. The microstructure and mechanical properties of the filaments and 3D printed specimens were characterized using scanning electron microscopy and standard tensile testing. It was observed that recycled polypropylene filaments with 14 wt% short carbon fibre reinforcement contained pores that were dispersed throughout the microstructure of the filament. A two-stage filament extrusion process was observed to improve the spatial distribution of carbon fibre reinforcement but did not reduce the pores. Recycled polypropylene filaments without reinforcement extruded at high screw speeds above 20 rpm contained a centreline cavity but no spatially distributed pores. However, this cavity is eliminated when extrusion is carried out at screw speeds below 20 rpm. For 3D printed specimens, interlayer cavities were observed larger for specimens printed from 14 wt% carbon fibre reinforced recycled polypropylene than those printed from unreinforced filaments. The values of tensile strength for the filaments were 21.82</span><span style="font-size:10pt;font-family:""> </span><span style="font-family:Verdana;">MPa and 24.22</span><span style="font-size:10pt;font-family:""> </span><span style="font-family:Verdana;">MPa, which reduced to 19.72</span><span style="font-size:10pt;font-family:""> </span><span style="font-family:Verdana;">MPa and 22.70</span><span style="font-size:10pt;font-family:""> </span><span style="font-family:Verdana;">MPa, respectively, for 3D printed samples using the filaments. Likewise, the young’s modulus of the filaments was 1208.6</span><span style="font-size:10pt;font-family:""> </span><span style="font-family:Verdana;">MPa and 1412.7</span><span style="font-size:10pt;font-family:""> </span><span style="font-family:Verdana;">MPa, which reduced to 961.5</span><span style="font-size:10pt;font-family:""> </span><span style="font-family:Verdana;">MPa and 1352.3</span><span style="font-size:10pt;font-family:""> </span><span style="font-family:Verdana;">MPa, respectively, for the 3D printed samples. The percentage elongation at failure for the recycled polypropylene filament was 9.83% but reduced to 3.84% for the samples printed with 14 wt% carbon fiber reinforced polypropylene filaments whose elongation to failure was 6.58%. The SEM observations on the fractured tensile test samples showed interlayer gaps between the printed and the adjacent raster layers. These gaps accounted for the reduction in the mechanical properties of the printed parts.
基金Project(51901020)supported by the National Natural Science Foundation of ChinaProject(2019JZZY010327)supported by Shandong Key Research and Development Plan,China+1 种基金Project(201942074001)supported by Aeronautical Science Foundation of ChinaProject(FRF-IP-20-05)supported by the Fundamental Research Funds for the Central Universities,China。
文摘Additive manufacturing(AM),also known as 3D-printing(3DP)technology,is an advanced manufacturing technology that has developed rapidly in the past 40 years.However,the ceramic material printing is still challenging because of the issue of cracking.Indirect 3D printing has been designed and drawn attention because of its high manufacturing speed and low cost.Indirect 3D printing separates the one-step forming process of direct 3D printing into binding and material sintering,avoiding the internal stress caused by rapid cooling,making it possible to realize the highquality ceramic component with complex shape.This paper presents the research progress of leading indirect 3D printing technologies,including binder jetting(BJ),stereolithography(SLA),and fused deposition modeling(FDM).At present,the additive manufacturing of ceramic materials is mainly achieved through indirect 3D printing technology,and these materials include silicon nitride,hydroxyapatite functional ceramics,silicon carbide structural ceramics.