Objective To investigate the mutations of mitochondrial genome in a pedigree with suspected maternally inherited diabetes and deafness and to explore the correlations between the mutations and clinical features. Meth...Objective To investigate the mutations of mitochondrial genome in a pedigree with suspected maternally inherited diabetes and deafness and to explore the correlations between the mutations and clinical features. Methods Genomic DNA was isolated from blood leucocytes of each member of the pedigree. The mitochondrial genome was amplified with 24-pair primers that could cover the entire mitochondrial DNA. Direct sequencing of PCR products was used to identify any mitochondrial DNA mutations. Results Family members on the maternal side all harbored the tRNA^Lcu（UUR） A3243G mutation. The paternal side family members did not have the mutation. The age-of-onset of diabetes of the 4 maternal side family members was 15, 41, 44, and 65 years old, and their corresponding heteroplasmy level of the mutation was 34.5%, 14.9%, 14.6%, and 5.9%, respectively. The age-of-onset of diabetes and heteroplasmy level of A3243G mutation were negatively correlated with a correlation coefficient of -0.980（P=0.02）. Meanwhile, patient with high heteroplasmy level of A3243G mutation had relatively low severity of disease. Moreover, 6 reported polymorphisms and 2 new variants were found. Conclusions The main cause of diabetes in this pedigree is the tRNA^Lcu（UUR） A3243G mutation. However, other gene variants may contribute to its pathogenicity. The heteroplasmy level of the tRNA^Lcu（UUR） A3243G mutation is positively associated with earlier age-of-onset and increasing severity of diabetes.展开更多
This paper proposes a new approach for multi-objective robust control. The approach extends the standard generalized l2 (Gl2) and generalized H2 (GH2) conditions to a set of new linear matrix inequality (LMI) constra...This paper proposes a new approach for multi-objective robust control. The approach extends the standard generalized l2 (Gl2) and generalized H2 (GH2) conditions to a set of new linear matrix inequality (LMI) constraints based on a new stability condition. A technique for variable parameterization is introduced to the multi-objective control problem to preserve the linearity of the synthesis variables. Consequently, the multi-channel multi-objective mixed Gl2/GH2 control problem can be solved less conservatively using computationally tractable algorithms developed in the paper.展开更多
Suppose R is a principal ideal ring, R^＊ is a multiplicative group which is composed of all reversible elements in R, and Mn（R）, GL（n,R）, SL（n,R） are denoted by,Mn（R）={A=（aij）n×n｜aij∈R,i,j=1,2…,n},G...Suppose R is a principal ideal ring, R^＊ is a multiplicative group which is composed of all reversible elements in R, and Mn（R）, GL（n,R）, SL（n,R） are denoted by,Mn（R）={A=（aij）n×n｜aij∈R,i,j=1,2…,n},GL（n,R）={g｜g∈Mn（R）,det g∈R^＊},SL（n,R）={g∈GL（n,R）｜det g=1},SL（n,R）≤G≤GL（n,R）（n≥3）,respectively,then basing on these facts, this paper mainly focus on discussing all extended groups of Gr={（O D^A B）∈G｜A∈GL（r,R）,（1≤r〈n）}in G when R is a principal ideal ring.展开更多
文摘Objective To investigate the mutations of mitochondrial genome in a pedigree with suspected maternally inherited diabetes and deafness and to explore the correlations between the mutations and clinical features. Methods Genomic DNA was isolated from blood leucocytes of each member of the pedigree. The mitochondrial genome was amplified with 24-pair primers that could cover the entire mitochondrial DNA. Direct sequencing of PCR products was used to identify any mitochondrial DNA mutations. Results Family members on the maternal side all harbored the tRNA^Lcu（UUR） A3243G mutation. The paternal side family members did not have the mutation. The age-of-onset of diabetes of the 4 maternal side family members was 15, 41, 44, and 65 years old, and their corresponding heteroplasmy level of the mutation was 34.5%, 14.9%, 14.6%, and 5.9%, respectively. The age-of-onset of diabetes and heteroplasmy level of A3243G mutation were negatively correlated with a correlation coefficient of -0.980（P=0.02）. Meanwhile, patient with high heteroplasmy level of A3243G mutation had relatively low severity of disease. Moreover, 6 reported polymorphisms and 2 new variants were found. Conclusions The main cause of diabetes in this pedigree is the tRNA^Lcu（UUR） A3243G mutation. However, other gene variants may contribute to its pathogenicity. The heteroplasmy level of the tRNA^Lcu（UUR） A3243G mutation is positively associated with earlier age-of-onset and increasing severity of diabetes.
基金Project supported by the National Natural Science Foundation ofChina (No. 60374028) and the Scientific Research Foundation forReturned Overseas Chinese Scholars Ministry of Education (No.[2004]176)
文摘This paper proposes a new approach for multi-objective robust control. The approach extends the standard generalized l2 (Gl2) and generalized H2 (GH2) conditions to a set of new linear matrix inequality (LMI) constraints based on a new stability condition. A technique for variable parameterization is introduced to the multi-objective control problem to preserve the linearity of the synthesis variables. Consequently, the multi-channel multi-objective mixed Gl2/GH2 control problem can be solved less conservatively using computationally tractable algorithms developed in the paper.
基金Foundation item： Supported by the National Natural Science Foundation of China（10771093）
文摘Suppose R is a principal ideal ring, R^＊ is a multiplicative group which is composed of all reversible elements in R, and Mn（R）, GL（n,R）, SL（n,R） are denoted by,Mn（R）={A=（aij）n×n｜aij∈R,i,j=1,2…,n},GL（n,R）={g｜g∈Mn（R）,det g∈R^＊},SL（n,R）={g∈GL（n,R）｜det g=1},SL（n,R）≤G≤GL（n,R）（n≥3）,respectively,then basing on these facts, this paper mainly focus on discussing all extended groups of Gr={（O D^A B）∈G｜A∈GL（r,R）,（1≤r〈n）}in G when R is a principal ideal ring.
