Five neutral macromolecular polyester gadolinium (Ⅲ) complexes with pendant hydrophobic alkyland aromatic functional groups were prepared. The longitudinal relaxation rates of these complexes weremeasured. One of the...Five neutral macromolecular polyester gadolinium (Ⅲ) complexes with pendant hydrophobic alkyland aromatic functional groups were prepared. The longitudinal relaxation rates of these complexes weremeasured. One of these Gd (Ⅲ) complexes was chosen for the acute toxicity test and T_1-weighted imagingmeasurement. Preliminary results showed that. compared with Gd-DTPA. the neutral macromoleculargadolinium (Ⅲ) complexes provide higher T_1 relaxivity enhancement and longer function duration.展开更多
Dextran-poly（glycidyl methacrylate） （Dex-PGMA） nano-suitcases were synthesized efficiently via a graft copolymerization induced self-assembly （GISA） approach. On this basis, the Dex-PGMA nano-suitcases were modi...Dextran-poly（glycidyl methacrylate） （Dex-PGMA） nano-suitcases were synthesized efficiently via a graft copolymerization induced self-assembly （GISA） approach. On this basis, the Dex-PGMA nano-suitcases were modified with hydrazide, and the attachment of multiple chelated Gd（III） ions to the interior of the nano-suitcases affords nanoscale MRI contrast agents with high relaxivity values. The highly fenestrated dextran shell of the nano-suitcases assures water exchange which readily occurs between the surrounding environment and the Gd（III） ions encapsulated within the hybrid nano-suitcases. The complexation between the hydrophilic hydrazide interior of the nano-suitcases and Gd（III） ions results in an impressive Gd payload at 22.6 wt% in the hybrid nano-suitcases. The longitudinal relaxivity （rl） of the hybrid nano-suitcases is reported as 44.4 L/（mmol-s）, which is 9-14 folds of that of commercial Gd-DTPA agents. In vivo MRI studies demonstrate that the hybrid nano-suitcases accumulated in the lymph node of the rat due to their nanoscale dimensions and displayed strong signals in vivo. The results indicated that the hybrid nano-suitcases provide a promising platform for the diagnosis of lymph node related diseases.展开更多
【目的】比较5种常用钆对比剂(GBCAs)在实验室条件下在相同的稀释比和摩尔浓度下的顺磁性弛豫增强效能。【方法】收集5种常用GBCAs,包括2种线性及3种大环类GBCAs,并按照相同稀释比用蒸馏水将其制备成相同摩尔浓度的体模。在3.0 T MR扫...【目的】比较5种常用钆对比剂(GBCAs)在实验室条件下在相同的稀释比和摩尔浓度下的顺磁性弛豫增强效能。【方法】收集5种常用GBCAs,包括2种线性及3种大环类GBCAs,并按照相同稀释比用蒸馏水将其制备成相同摩尔浓度的体模。在3.0 T MR扫描仪上对人体志愿者及5组体模按照相同扫描方案和参数进行扫描后,在图像后处理工作站上画ROI测量体模、邻近小腿肌肉和周围空气的T_(1)WI信号强度和T_(1)值,并计算T_(1)WI相对信号强度(RSI)和T_(1)-mapping的T_(1)弛豫速率(R_(1))、计算信噪比(SNR)、对比噪声比(CNR)。分析5组体模溶液信号强度(Sp)、RSI、T_(1)值、R_(1)、SNR、CNR与GBCAs摩尔浓度的相关性,并比较5种GBCAs之间的Sp、RSI、T_(1)值、R_(1)、SNR和CNR的差异。【结果】5种GBCAs配备成相同摩尔浓度的稀释液,钆布醇原液使用容积最小。5种GBCAs的Sp、RSI与摩尔浓度均呈曲线相关(r_(s)=0),T_(1)值、SNR与摩尔浓度呈负相关(r_(s<)0),R_(1)、CNR和摩尔浓度呈正相关(r_(s)>0)。5种GBCAs之间的Sp、RSI、T_(1)值、R_(1)、SNR和CNR的差异无统计学意义,线性与大环类GBCAs之间的Sp、RSI、T_(1)值、R_(1)、SNR和CNR的差异无统计学意义。【结论】5种线性和大环类GBCAs蒸馏水体模在相同摩尔浓度下的T_(1)WI信号强度和T_(1)值无差异,并且过高和过低的GBCAs摩尔浓度都将使体模的T_(1)WI信号强度下降,而T_(1)值会随摩尔浓度的增加而持续下降。展开更多
基金Project supported by the Chinese Academy of Sciences and the State Sciences and Technology Commission of China.
文摘Five neutral macromolecular polyester gadolinium (Ⅲ) complexes with pendant hydrophobic alkyland aromatic functional groups were prepared. The longitudinal relaxation rates of these complexes weremeasured. One of these Gd (Ⅲ) complexes was chosen for the acute toxicity test and T_1-weighted imagingmeasurement. Preliminary results showed that. compared with Gd-DTPA. the neutral macromoleculargadolinium (Ⅲ) complexes provide higher T_1 relaxivity enhancement and longer function duration.
基金financially supported by the National Natural Science Foundation of China(Nos.21374061,81371703 and 81501571)the Marie Curie International Incoming Fellowship of the EU+2 种基金the Program for Professor of Special Appointment(Eastern Scholar)at Shanghai Institutions of Higher Learning“Shu Guang”project supported by Shanghai Municipal Education CommissionShanghai Education Development Foundation
文摘Dextran-poly（glycidyl methacrylate） （Dex-PGMA） nano-suitcases were synthesized efficiently via a graft copolymerization induced self-assembly （GISA） approach. On this basis, the Dex-PGMA nano-suitcases were modified with hydrazide, and the attachment of multiple chelated Gd（III） ions to the interior of the nano-suitcases affords nanoscale MRI contrast agents with high relaxivity values. The highly fenestrated dextran shell of the nano-suitcases assures water exchange which readily occurs between the surrounding environment and the Gd（III） ions encapsulated within the hybrid nano-suitcases. The complexation between the hydrophilic hydrazide interior of the nano-suitcases and Gd（III） ions results in an impressive Gd payload at 22.6 wt% in the hybrid nano-suitcases. The longitudinal relaxivity （rl） of the hybrid nano-suitcases is reported as 44.4 L/（mmol-s）, which is 9-14 folds of that of commercial Gd-DTPA agents. In vivo MRI studies demonstrate that the hybrid nano-suitcases accumulated in the lymph node of the rat due to their nanoscale dimensions and displayed strong signals in vivo. The results indicated that the hybrid nano-suitcases provide a promising platform for the diagnosis of lymph node related diseases.
文摘【目的】比较5种常用钆对比剂(GBCAs)在实验室条件下在相同的稀释比和摩尔浓度下的顺磁性弛豫增强效能。【方法】收集5种常用GBCAs,包括2种线性及3种大环类GBCAs,并按照相同稀释比用蒸馏水将其制备成相同摩尔浓度的体模。在3.0 T MR扫描仪上对人体志愿者及5组体模按照相同扫描方案和参数进行扫描后,在图像后处理工作站上画ROI测量体模、邻近小腿肌肉和周围空气的T_(1)WI信号强度和T_(1)值,并计算T_(1)WI相对信号强度(RSI)和T_(1)-mapping的T_(1)弛豫速率(R_(1))、计算信噪比(SNR)、对比噪声比(CNR)。分析5组体模溶液信号强度(Sp)、RSI、T_(1)值、R_(1)、SNR、CNR与GBCAs摩尔浓度的相关性,并比较5种GBCAs之间的Sp、RSI、T_(1)值、R_(1)、SNR和CNR的差异。【结果】5种GBCAs配备成相同摩尔浓度的稀释液,钆布醇原液使用容积最小。5种GBCAs的Sp、RSI与摩尔浓度均呈曲线相关(r_(s)=0),T_(1)值、SNR与摩尔浓度呈负相关(r_(s<)0),R_(1)、CNR和摩尔浓度呈正相关(r_(s)>0)。5种GBCAs之间的Sp、RSI、T_(1)值、R_(1)、SNR和CNR的差异无统计学意义,线性与大环类GBCAs之间的Sp、RSI、T_(1)值、R_(1)、SNR和CNR的差异无统计学意义。【结论】5种线性和大环类GBCAs蒸馏水体模在相同摩尔浓度下的T_(1)WI信号强度和T_(1)值无差异,并且过高和过低的GBCAs摩尔浓度都将使体模的T_(1)WI信号强度下降,而T_(1)值会随摩尔浓度的增加而持续下降。
