The problem of track control is studied for a class of strict-feedback stochastic nonlinear systems in which unknown virtual control gain function is the main feature. First, the so-called stochastic LaSalle theory is...The problem of track control is studied for a class of strict-feedback stochastic nonlinear systems in which unknown virtual control gain function is the main feature. First, the so-called stochastic LaSalle theory is extended to some extent, and accordingly, the results of global ultimate boundedness for stochastic nonlinear systems are developed. Next, a new design scheme of fuzzy adaptive control is proposed. The advantage of it is that it does not require priori knowledge of virtual control gain function sign, which is usually demanded in many designs. At the same time, the track performance of closed-loop systems is improved by adaptive modifying the estimated error upper bound. By theoretical analysis, the signals of closed-loop systems are globally ultimately bounded in probability and the track error converges to a small residual set around the origin in 4th-power expectation.展开更多
The present opinion article, while dealing with the debated origin of “Severe Acute Respiratory Syndrome-Coronavirus-2” (SARS-CoV-2), the betacoronavirus responsible for “Corona Virus Disease-2019” (COVID-19), pro...The present opinion article, while dealing with the debated origin of “Severe Acute Respiratory Syndrome-Coronavirus-2” (SARS-CoV-2), the betacoronavirus responsible for “Corona Virus Disease-2019” (COVID-19), provides a speculative insight into the so-called “gain of function” (GOF), a process resulting in the acquirement of new phenotypic features on behalf of the viral pathogen. More in detail, a GOF-related phenomenon leading to increased SARS-CoV-2 virulence and/or transmissibility—as clearly exemplified by the “delta” and the “omicron” as well as by other “variants of concern”—would not necessarily imply that viral genetic manipulations made in the laboratory are its exclusive drivers, provided that GOF may also occur as a consequence of a natural selection process. In order to gain a better understanding of SARS-CoV-2 GOF and GOF-associated phenomena, an in-depth knowledge of the complex viral-host interaction dynamics is absolutely needed, while also paying special attention to the human-animal-viral ecological interfaces within an “ad hoc” multidisciplinary, “holistic”, scientific evidence-based and “One Health”-based approach.展开更多
Systems that are subject to both time-delay in state and input saturation are considered. We synthesize the anti-windup gain to enlarge the estimation of domain of attraction while guaranteeing the stability of the cl...Systems that are subject to both time-delay in state and input saturation are considered. We synthesize the anti-windup gain to enlarge the estimation of domain of attraction while guaranteeing the stability of the closed-loop system. An ellipsoid and a polyhedral set are used to bound the state of the system, which make a new sector condition valid. Other than an iterative algorithm, a direct designing algorithm is derived to compute the anti-windup compensator gain, which reduces the conservatism greatly. We analyze the delay-independent and delay-dependent cases, respectively. Finally, an optimization algorithm in the form of LMIs is constructed to compute the compensator gain which maximizes the estimation of domain of attraction. Numerical examples are presented to demonstrate the effectiveness of our approach.展开更多
AIM: To evaluate the body mass index(BMI) change in arthroplasty patients and its impact on the patients' functional results. METHODS: Between October 2010 and May 2013, 606 patients who were operated due to gonar...AIM: To evaluate the body mass index(BMI) change in arthroplasty patients and its impact on the patients' functional results. METHODS: Between October 2010 and May 2013, 606 patients who were operated due to gonarthrosis, coxarthrosis, aseptic loosening of the total knee and hip prosthesis were evaluated prospectively. Patients were operated by three surgeons in three medical centers. Patients who were between 30-90 years of age and who were underwent total knee arthroplasty, total hip arthroplasty, revision knee arthroplasty, or revision hip arthroplasty were included in the study. We excluded the patients who cannot tolerate our standard postoperative rehabilitation program. Additionally, patients who had systemic inflammatory diseases, diabetes mellitus, or endochrinopathies were excluded from the study. The remaining 513 patients comprised our study group. Preoperative functional joint scores, height, weightand BMI of all patients were recorded. We used the Knee Society Score(KSS) for knee and Harris Hip Score(HHS) for hip patients. Postoperative functional scores were measured at 1^(st), 6^(th) and 12^(th) months and recorded separately at outpatient visits. RESULTS: The mean age of the patients was 64.7(range: 30-90) years(207 males/306 females) and the mean follow-up duration was 14.3(range: 12-26) mo. We found that arthroplasty patients had weight gain and had an increase in BMI at the postoperative 1^(st), 6^(th) and 12^(th) months. The mean BMI of the patients was 27.7 preoperatively, 27.8 at the postoperative 1^(st) month, 28.1 at the 6^(th) month and 28.6 at the 12^(th) month(P < 0.01). At the last visit, the mean postoperative HHS of the hip arthroplasty patients was 82.2 ± 7.12(preoperatively, 52.3; 1st month, 78.2; 6^(th) month, 81.1; 12^(th) month, 82.2), and the mean KSS of the knee arthroplasty patients was 79.3 ± 4.31(preoperatively, 35.8; 1^(st) month, 75.2; 6^(th) month, 79.1; 12^(th) month, 79.3). Worse functional results were noted in the patients who had a BMI increase, however, this correlation was statistically significant only at the postoperative 6^(th) month(P = 0.03). CONCLUSION: To prevent the negative functional effects of this weight gain during the postoperative period, arthroplasty patients should be advised for weight control and risky patients should consult with a dietician.展开更多
We have known since 1976 that cancer evolves clonally from one initiated<span style="font-family:;" "=""><span> normal human cell, the </span><i><span>first cell&...We have known since 1976 that cancer evolves clonally from one initiated<span style="font-family:;" "=""><span> normal human cell, the </span><i><span>first cell</span></i><span>. Today we see that this fact has been overshadowed from federal funding choice of the mutation theory (MT), which not yet has shown tumorigenesis-initiation in normal human cells. Our suggested, death signaled, stress model from time delayed S-period (replication slowness), causing repair instability from under-replicated lesions in repetitive DNAs, herein has the objective of revealing, significant literature support from a mini-review. We reasoned that early versus late S-period stress would </span><span>have different outcomes: early the slowness affecting mitotic slippage with</span> <span>diploid re-replication to 4n cells whereas late-S, with milder stress effect,</span><span> pro</span><span>ducing diploid cells. In cancer burden, near-half is diploid, but tetraploid</span><span> solid tumors have the attention. The initial 4n cells were special with orderly genomic reductive division to diploid first cells with measurable fitness-gain from hours-reduced total cell cycle time. Experimental data from Coxsakie-B3 virus infected normal fibroblasts, reiterated 4n cell production from </span><span>death-s</span><span>ignaled recovery-cells with progressive cell-phenotypic changes to polygon</span><span>al </span><span>and roundness cell-shapes, indistinguishable from diagnostic/prognostic </span><span>cancer </span><span>morphology. The 4n cells showed a self-inflicted 90</span></span><span style="font-family:;" "=""><span><span style="color:#4F4F4F;white-space:normal;background-color:#FFFFFF;"><span style="color:#4F4F4F;white-space:normal;background-color:#FFFFFF;">°</span></span></span><span> turn of the 4n nucleus</span></span><span style="font-family:;" "=""> <span>before division, affecting a perpendicular orientation of the fitness-gained</span><span> first cells relative to neighboring cells. In an illustrated cell cycle drawing with early and late S-period stress, it became clear that coding genes on borders of repair unstable satellite, repetitive DNA regions, could become mutated. We found these mutations to be tumor SMGs (significantly mutated genes). Evidential material was presented for loss of function genetics driving tumorigenesis to a parasitic lifestyle.</span></span>展开更多
基金Supported by National Natural Science Foundation of P. R. China (60572070, 60325311, 60534010) Natural Science Foundation of Liaoning Province (20022030)
文摘The problem of track control is studied for a class of strict-feedback stochastic nonlinear systems in which unknown virtual control gain function is the main feature. First, the so-called stochastic LaSalle theory is extended to some extent, and accordingly, the results of global ultimate boundedness for stochastic nonlinear systems are developed. Next, a new design scheme of fuzzy adaptive control is proposed. The advantage of it is that it does not require priori knowledge of virtual control gain function sign, which is usually demanded in many designs. At the same time, the track performance of closed-loop systems is improved by adaptive modifying the estimated error upper bound. By theoretical analysis, the signals of closed-loop systems are globally ultimately bounded in probability and the track error converges to a small residual set around the origin in 4th-power expectation.
文摘The present opinion article, while dealing with the debated origin of “Severe Acute Respiratory Syndrome-Coronavirus-2” (SARS-CoV-2), the betacoronavirus responsible for “Corona Virus Disease-2019” (COVID-19), provides a speculative insight into the so-called “gain of function” (GOF), a process resulting in the acquirement of new phenotypic features on behalf of the viral pathogen. More in detail, a GOF-related phenomenon leading to increased SARS-CoV-2 virulence and/or transmissibility—as clearly exemplified by the “delta” and the “omicron” as well as by other “variants of concern”—would not necessarily imply that viral genetic manipulations made in the laboratory are its exclusive drivers, provided that GOF may also occur as a consequence of a natural selection process. In order to gain a better understanding of SARS-CoV-2 GOF and GOF-associated phenomena, an in-depth knowledge of the complex viral-host interaction dynamics is absolutely needed, while also paying special attention to the human-animal-viral ecological interfaces within an “ad hoc” multidisciplinary, “holistic”, scientific evidence-based and “One Health”-based approach.
基金Supported by National Natural Science Foundation of P.R.China (60474045)973 Program of P.R.China (2002CB312200)the project sponsored by the Scientific Research Foundation for the Returned Overseas Chinese Scholars of State Education Ministry, Zhejiang Province, and Zhejiang University
文摘Systems that are subject to both time-delay in state and input saturation are considered. We synthesize the anti-windup gain to enlarge the estimation of domain of attraction while guaranteeing the stability of the closed-loop system. An ellipsoid and a polyhedral set are used to bound the state of the system, which make a new sector condition valid. Other than an iterative algorithm, a direct designing algorithm is derived to compute the anti-windup compensator gain, which reduces the conservatism greatly. We analyze the delay-independent and delay-dependent cases, respectively. Finally, an optimization algorithm in the form of LMIs is constructed to compute the compensator gain which maximizes the estimation of domain of attraction. Numerical examples are presented to demonstrate the effectiveness of our approach.
文摘AIM: To evaluate the body mass index(BMI) change in arthroplasty patients and its impact on the patients' functional results. METHODS: Between October 2010 and May 2013, 606 patients who were operated due to gonarthrosis, coxarthrosis, aseptic loosening of the total knee and hip prosthesis were evaluated prospectively. Patients were operated by three surgeons in three medical centers. Patients who were between 30-90 years of age and who were underwent total knee arthroplasty, total hip arthroplasty, revision knee arthroplasty, or revision hip arthroplasty were included in the study. We excluded the patients who cannot tolerate our standard postoperative rehabilitation program. Additionally, patients who had systemic inflammatory diseases, diabetes mellitus, or endochrinopathies were excluded from the study. The remaining 513 patients comprised our study group. Preoperative functional joint scores, height, weightand BMI of all patients were recorded. We used the Knee Society Score(KSS) for knee and Harris Hip Score(HHS) for hip patients. Postoperative functional scores were measured at 1^(st), 6^(th) and 12^(th) months and recorded separately at outpatient visits. RESULTS: The mean age of the patients was 64.7(range: 30-90) years(207 males/306 females) and the mean follow-up duration was 14.3(range: 12-26) mo. We found that arthroplasty patients had weight gain and had an increase in BMI at the postoperative 1^(st), 6^(th) and 12^(th) months. The mean BMI of the patients was 27.7 preoperatively, 27.8 at the postoperative 1^(st) month, 28.1 at the 6^(th) month and 28.6 at the 12^(th) month(P < 0.01). At the last visit, the mean postoperative HHS of the hip arthroplasty patients was 82.2 ± 7.12(preoperatively, 52.3; 1st month, 78.2; 6^(th) month, 81.1; 12^(th) month, 82.2), and the mean KSS of the knee arthroplasty patients was 79.3 ± 4.31(preoperatively, 35.8; 1^(st) month, 75.2; 6^(th) month, 79.1; 12^(th) month, 79.3). Worse functional results were noted in the patients who had a BMI increase, however, this correlation was statistically significant only at the postoperative 6^(th) month(P = 0.03). CONCLUSION: To prevent the negative functional effects of this weight gain during the postoperative period, arthroplasty patients should be advised for weight control and risky patients should consult with a dietician.
文摘We have known since 1976 that cancer evolves clonally from one initiated<span style="font-family:;" "=""><span> normal human cell, the </span><i><span>first cell</span></i><span>. Today we see that this fact has been overshadowed from federal funding choice of the mutation theory (MT), which not yet has shown tumorigenesis-initiation in normal human cells. Our suggested, death signaled, stress model from time delayed S-period (replication slowness), causing repair instability from under-replicated lesions in repetitive DNAs, herein has the objective of revealing, significant literature support from a mini-review. We reasoned that early versus late S-period stress would </span><span>have different outcomes: early the slowness affecting mitotic slippage with</span> <span>diploid re-replication to 4n cells whereas late-S, with milder stress effect,</span><span> pro</span><span>ducing diploid cells. In cancer burden, near-half is diploid, but tetraploid</span><span> solid tumors have the attention. The initial 4n cells were special with orderly genomic reductive division to diploid first cells with measurable fitness-gain from hours-reduced total cell cycle time. Experimental data from Coxsakie-B3 virus infected normal fibroblasts, reiterated 4n cell production from </span><span>death-s</span><span>ignaled recovery-cells with progressive cell-phenotypic changes to polygon</span><span>al </span><span>and roundness cell-shapes, indistinguishable from diagnostic/prognostic </span><span>cancer </span><span>morphology. The 4n cells showed a self-inflicted 90</span></span><span style="font-family:;" "=""><span><span style="color:#4F4F4F;white-space:normal;background-color:#FFFFFF;"><span style="color:#4F4F4F;white-space:normal;background-color:#FFFFFF;">°</span></span></span><span> turn of the 4n nucleus</span></span><span style="font-family:;" "=""> <span>before division, affecting a perpendicular orientation of the fitness-gained</span><span> first cells relative to neighboring cells. In an illustrated cell cycle drawing with early and late S-period stress, it became clear that coding genes on borders of repair unstable satellite, repetitive DNA regions, could become mutated. We found these mutations to be tumor SMGs (significantly mutated genes). Evidential material was presented for loss of function genetics driving tumorigenesis to a parasitic lifestyle.</span></span>