OBJECTIVE To review the clinical features and surgical treatment for patients with temporal lobe gangliogliomas. METHODS Patients with temporal lobe gangliogliomas who underwent resection of temporal lobe tumors, conf...OBJECTIVE To review the clinical features and surgical treatment for patients with temporal lobe gangliogliomas. METHODS Patients with temporal lobe gangliogliomas who underwent resection of temporal lobe tumors, confirmed by surgical pathology, seen between September 1998 and November 2004 at the West China hospital, were selected. Medical records were reviewed for age at diagnosis, age at onset of seizures, delay between seizure onset and tumor diagnosis, types and frequencies of seizures, EEG results, extent of surgery, and pathologic diagnosis. The follow-up periods varied from 12 to 60 months （mean 30 months）. RESULTS Eighteen patients were identified, including 14 males and 4 females. Age at operation ranged from 4 years to 34 years （mean 17.6 years）. All patients underwent at least one surgical procedure. Fifteen tumors were classified as WHO Grade I lesions, and 3 as WHO Grade Ⅱ lesions. None of patients experienced a tumor recurrence. Among the patients, 85% had complete and sustained seizure relief. CONCLUSION Complex partial seizures and auras were the common presenting symptom of these patients. The follow-up suggested good relief from the seizures after surgery and a low risk for tumor recurrence and malignant progression.展开更多
文摘OBJECTIVE To review the clinical features and surgical treatment for patients with temporal lobe gangliogliomas. METHODS Patients with temporal lobe gangliogliomas who underwent resection of temporal lobe tumors, confirmed by surgical pathology, seen between September 1998 and November 2004 at the West China hospital, were selected. Medical records were reviewed for age at diagnosis, age at onset of seizures, delay between seizure onset and tumor diagnosis, types and frequencies of seizures, EEG results, extent of surgery, and pathologic diagnosis. The follow-up periods varied from 12 to 60 months （mean 30 months）. RESULTS Eighteen patients were identified, including 14 males and 4 females. Age at operation ranged from 4 years to 34 years （mean 17.6 years）. All patients underwent at least one surgical procedure. Fifteen tumors were classified as WHO Grade I lesions, and 3 as WHO Grade Ⅱ lesions. None of patients experienced a tumor recurrence. Among the patients, 85% had complete and sustained seizure relief. CONCLUSION Complex partial seizures and auras were the common presenting symptom of these patients. The follow-up suggested good relief from the seizures after surgery and a low risk for tumor recurrence and malignant progression.
